Professor | Jianfeng Chen | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Jianfeng Chen
Contact Information	jfchen@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Jianfeng Chen

Contact Information

jfchen@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1996-09 to 2001-05 Ph.D.: Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1991-09 to 1996-07 Bachelor of Science: Fudan University
Work Experience	2007-01 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher 2001-09 to 2006-12 - Harvard Medical School - Postdoctoral Fellow
Awards	2008: Second Prize, Provincial Level - Recognition of Leucyl-tRNA Synthetase Substrate Recognition 2000: First Prize, Provincial Level - Aminoacyl-tRNA Synthetase and its Interaction with Related tRNA

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1996-09 to 2001-05 Ph.D.: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1991-09 to 1996-07 Bachelor of Science: Fudan University

Work Experience

2007-01 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
2001-09 to 2006-12 - Harvard Medical School - Postdoctoral Fellow

Awards

2008: Second Prize, Provincial Level - Recognition of Leucyl-tRNA Synthetase Substrate Recognition
2000: First Prize, Provincial Level - Aminoacyl-tRNA Synthetase and its Interaction with Related tRNA

Areas of Focus	Regulation of Cell Adhesion Molecules in Inflammation and Cancer
Publications	Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction., Chen Jianfeng, Lin CD, Li Y, Zhang YB, Liu ZY, Mu X, Gu CJ, Liu J, Li YT, Li GH, Chen JF, 2021 Identification and characterization of a monoclonal antibody blocking the SARS-CoV-2 spike protein-ACE2 interaction., MengYa Yuan, YaoYing Wan, Cui Liu, Yue Li, ZhaoYuan Liu, ChangDong Lin, JianFeng Chen, 2021 继往开来谱新篇，携手共建新时代, 陈剑峰, 2020 发热通过Hsp90-α4整合素热感应信号通路促进T淋巴细胞迁移, 林昶东, 张有华, Kun, Zhang, YaJuan, Zheng, Ling, Lu, HaiShuang, Chang, Hui, Yang, YanRong, Yang, YaoYing, Wan, ShiHui, Wang, MengYa, Yuan, ZhanJun, Yan, RongGuang, Zhang, YongNing, He, GaoXiang, Ge, Dianqing, Wu, 陈剑峰, 2020 Specific gut microbiome signature predicts the early-stage lung cancer., Zheng, Yajuan, Fang, Zhaoyuan, Xue, Yun, Zhang, Jian, Zhu, Junjie, Gao, Renyuan, Yao, Shun, Ye, Yi, Wang, Shihui, Lin, Changdong, Chen, Shiyang, Huang, Hsinyi, Hu, Liang, Jiang, GeNing, Qin, Huanlong, Zhang, Peng, Chen, Jianfeng, Ji, Hongbin, 2020 Mucin-Like Domain of Mucosal Addressin Cell Adhesion Molecule-1 Facilitates Integrin α4β7-Mediated Cell Adhesion Through Electrostatic Repulsion., MengYa Yuan, YanRong Yang, Yue Li, ZhanJun Yan, ChangDong Lin, JianFeng Chen, 2020 A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis., Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng, Jianfeng Chen, 2020 Regulation of immune cell trafficking by febrile temperatures., Lin, ChangDong, Chen, JianFeng, 2019 Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins., ChangDong Lin, YouHua Zhang, Kun Zhang, YaJuan Zheng, Ling Lu, HaiShuang Chang, Hui Yang, YanRong Yang, YaoYing Wan, ShiHui Wang, MengYa Yuan, ZhanJun Yan, RongGuang Zhang, YongNing He, GaoXiang Ge, Dianqing Wu, JianFeng Chen, 2019 DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation., Qian Xiao, Jibo Wu, WeiJia Wang, Shiyang Chen, Yingxia Zheng, Xiaoqing Yu, Katrina Meeth, Mahnaz Sahraei, Alfred L M Bothwell, Lieping Chen, Marcus Bosenberg, Jianfeng Chen, Veronika Sexl, Le Sun, Lin Li, Wenwen Tang, Dianqing Wu, 2018 Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation., ShiHui Wang, ChenYu Wu, YueBin Zhang, QingLu Zhong, Hao Sun, WenPeng Cao, GaoXiang Ge, GuoHui Li, X Frank Zhang, JianFeng Chen, 2018 Intramembrane ionic protein-lipid interaction regulates integrin structure and function., Jun Guo, Youhua Zhang, Hua Li, Huiying Chu, Qinshu Wang, Shutan Jiang, Yan Li, Hongbin Shen, Guohui Li, Jianfeng Chen, Chenqi Xu, 2018 TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus., Chen Jianfeng, 2017 Static compression induces ECM remodeling and integrin α2β1 expression and signaling in a rat tail caudal intervertebral disc degeneration model., Chen Jianfeng, 2017 细胞微环境对免疫细胞黏附与迁移的调控, 张海龙, 路玲, 郑雅娟, 袁萌芽, 陈剑峰, 2016 Kindlin-3 Is Essential for the Resting alpha 4 beta 1 Integrin-mediated Firm Cell Adhesion under Shear Flow Conditions., Lu, Ling, Lin, ChangDong, Yan, ZhanJun, Wang, Shu, Zhang, YouHua, Wang, ShiHui, Wang, JunLei, Liu, Cui, Chen, JianFeng, 2016 Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy., YouHua Zhang, YouDong Pan, ChangDong Lin, YaJuan Zheng, Hao Sun, HaiLong Zhang, JunLei Wang, MengYa Yuan, Tao Duan, QiaoLing Du, JianFeng Chen, 2016 Minor Type IV Collagen alpha 5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1., Xiao, Qian, Jiang, Yan, Liu, Qingbo, Yue, Jiao, Liu, Chunying, Zhao, Xiaotong, Qiao, Yuemei, Ji, Hongbin, Chen, Jianfeng, Ge, Gaoxiang, 2015 Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity., Chen Jianfeng, 2015 Mechanisms Underlying Integrin Deactivation., Chen Jianfeng, 2015 Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation., Du, QiaoLing, Pan, YouDong, Zhang, YouHua, Zhang, HaiLong, Zheng, YaJuan, Lu, Ling, Wang, JunLei, Duan, Tao, Chen, JianFeng, 2014 The hydrophobic contacts between the center of βI domain and α1/α7 helices hold integrin α4β7 in low-affinity state., Chen Jianfeng, 2014 Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing., Hao Sun, Jie Liu, YaJuan Zheng, YouDong Pan, Kun Zhang, JianFeng Chen, 2014 Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation., Cheng, Tao, Liu, Qingbo, Zhang, Rui, Zhang, Ying, Chen, Jianfeng, Yu, Ronghuan, Ge, Gaoxiang, 2014 Disruption of disulfide-restriction at integrin knees induces activation and ligand-independent signaling of α4β7., Chen Jianfeng, 2013 The Unique Disulfide Bond-stabilized W1 β4-β1 Loop in the α4 β-Propeller Domain Regulates Integrin α4β7 Affinity and Signaling., Jiao Yue, Kun Zhang, JianFeng Chen, 2013 Structural specializations of α 4 β 7 , an integrin that mediates rolling adhesion., Yamei Yu, Jianghai Zhu, LiZhi Mi, Thomas Walz, Hao Sun, JianFeng Chen, Timothy A Springer, 2012 The regulation of integrin function by divalent cations., Zhang, Kun, Chen, JianFeng, 2012 Identification, characterization and epitope mapping of a human monoclonal antibody J19 that specifically recognizes the activated integrin a4b7., Chen Jianfeng, 2012 Role of Integrins in Regulating Proteases to Mediate Extracellular Matrix Remodeling., Jiao Yue, Kun Zhang, JianFeng Chen, 2012 The mechanism of integrin affinity regulation., Chen Jianfeng, 2011 The CC′ and DE Loops in Ig Domains 1 and 2 of MAdCAM-1 Play Different Roles in MAdCAM-1 Binding to Low- and High-affinity Integrin α4β7., Hao Sun, YuMei Wu, JunPeng Qi, YouDong Pan, Gaoxiang Ge, JianFeng Chen, 2011 Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha(4)beta(7)., Pan, YouDong, Zhang, Kun, Qi, JunPeng, Yue, Jiao, Springer, Timothy A, Chen, JianFeng, 2010 Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin., Yongli Shan, Lihou Yu, Yan Li, Youdong Pan, Qiangge Zhang, Fubin Wang, Jianfeng Chen, Xueliang Zhu, 2009 Aberrant activation of integrin α 4 β 7 suppresses lymphocyte migration to the gut., Eun Jeong Park, J Rodrigo Mora, Christopher V Carman, JianFeng Chen, Yoshiteru Sasaki, Guiying Cheng, Ulrich H von Andrian, Motomu Shimaoka, 2007 Regulation of outside-in signaling and affinity by the beta(2) I domain of integrin alpha(L)beta(2)., Chen, JianFeng, Yang, Wei, Kim, Minsoo, Carman, Christopher V, Springer, Timothy A, 2006 Importance of force linkage in mechanochemistry of adhesion receptors., Astrof, Nathan S, Salas, Azucena, Shimaoka, Motomu, Chen, JianFeng,

Areas of Focus

Regulation of Cell Adhesion Molecules in Inflammation and Cancer

Publications

Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction., Chen Jianfeng, Lin CD, Li Y, Zhang YB, Liu ZY, Mu X, Gu CJ, Liu J, Li YT, Li GH, Chen JF, 2021
Identification and characterization of a monoclonal antibody blocking the SARS-CoV-2 spike protein-ACE2 interaction., MengYa Yuan, YaoYing Wan, Cui Liu, Yue Li, ZhaoYuan Liu, ChangDong Lin, JianFeng Chen, 2021
继往开来谱新篇，携手共建新时代, 陈剑峰, 2020
发热通过Hsp90-α4整合素热感应信号通路促进T淋巴细胞迁移, 林昶东, 张有华, Kun, Zhang, YaJuan, Zheng, Ling, Lu, HaiShuang, Chang, Hui, Yang, YanRong, Yang, YaoYing, Wan, ShiHui, Wang, MengYa, Yuan, ZhanJun, Yan, RongGuang, Zhang, YongNing, He, GaoXiang, Ge, Dianqing, Wu, 陈剑峰, 2020
Specific gut microbiome signature predicts the early-stage lung cancer., Zheng, Yajuan, Fang, Zhaoyuan, Xue, Yun, Zhang, Jian, Zhu, Junjie, Gao, Renyuan, Yao, Shun, Ye, Yi, Wang, Shihui, Lin, Changdong, Chen, Shiyang, Huang, Hsinyi, Hu, Liang, Jiang, GeNing, Qin, Huanlong, Zhang, Peng, Chen, Jianfeng, Ji, Hongbin, 2020
Mucin-Like Domain of Mucosal Addressin Cell Adhesion Molecule-1 Facilitates Integrin α4β7-Mediated Cell Adhesion Through Electrostatic Repulsion., MengYa Yuan, YanRong Yang, Yue Li, ZhanJun Yan, ChangDong Lin, JianFeng Chen, 2020
A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis., Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng, Jianfeng Chen, 2020
Regulation of immune cell trafficking by febrile temperatures., Lin, ChangDong, Chen, JianFeng, 2019
Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins., ChangDong Lin, YouHua Zhang, Kun Zhang, YaJuan Zheng, Ling Lu, HaiShuang Chang, Hui Yang, YanRong Yang, YaoYing Wan, ShiHui Wang, MengYa Yuan, ZhanJun Yan, RongGuang Zhang, YongNing He, GaoXiang Ge, Dianqing Wu, JianFeng Chen, 2019
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation., Qian Xiao, Jibo Wu, WeiJia Wang, Shiyang Chen, Yingxia Zheng, Xiaoqing Yu, Katrina Meeth, Mahnaz Sahraei, Alfred L M Bothwell, Lieping Chen, Marcus Bosenberg, Jianfeng Chen, Veronika Sexl, Le Sun, Lin Li, Wenwen Tang, Dianqing Wu, 2018
Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation., ShiHui Wang, ChenYu Wu, YueBin Zhang, QingLu Zhong, Hao Sun, WenPeng Cao, GaoXiang Ge, GuoHui Li, X Frank Zhang, JianFeng Chen, 2018
Intramembrane ionic protein-lipid interaction regulates integrin structure and function., Jun Guo, Youhua Zhang, Hua Li, Huiying Chu, Qinshu Wang, Shutan Jiang, Yan Li, Hongbin Shen, Guohui Li, Jianfeng Chen, Chenqi Xu, 2018
TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus., Chen Jianfeng, 2017
Static compression induces ECM remodeling and integrin α2β1 expression and signaling in a rat tail caudal intervertebral disc degeneration model., Chen Jianfeng, 2017
细胞微环境对免疫细胞黏附与迁移的调控, 张海龙, 路玲, 郑雅娟, 袁萌芽, 陈剑峰, 2016
Kindlin-3 Is Essential for the Resting alpha 4 beta 1 Integrin-mediated Firm Cell Adhesion under Shear Flow Conditions., Lu, Ling, Lin, ChangDong, Yan, ZhanJun, Wang, Shu, Zhang, YouHua, Wang, ShiHui, Wang, JunLei, Liu, Cui, Chen, JianFeng, 2016
Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy., YouHua Zhang, YouDong Pan, ChangDong Lin, YaJuan Zheng, Hao Sun, HaiLong Zhang, JunLei Wang, MengYa Yuan, Tao Duan, QiaoLing Du, JianFeng Chen, 2016
Minor Type IV Collagen alpha 5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1., Xiao, Qian, Jiang, Yan, Liu, Qingbo, Yue, Jiao, Liu, Chunying, Zhao, Xiaotong, Qiao, Yuemei, Ji, Hongbin, Chen, Jianfeng, Ge, Gaoxiang, 2015
Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity., Chen Jianfeng, 2015
Mechanisms Underlying Integrin Deactivation., Chen Jianfeng, 2015
Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation., Du, QiaoLing, Pan, YouDong, Zhang, YouHua, Zhang, HaiLong, Zheng, YaJuan, Lu, Ling, Wang, JunLei, Duan, Tao, Chen, JianFeng, 2014
The hydrophobic contacts between the center of βI domain and α1/α7 helices hold integrin α4β7 in low-affinity state., Chen Jianfeng, 2014
Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing., Hao Sun, Jie Liu, YaJuan Zheng, YouDong Pan, Kun Zhang, JianFeng Chen, 2014
Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation., Cheng, Tao, Liu, Qingbo, Zhang, Rui, Zhang, Ying, Chen, Jianfeng, Yu, Ronghuan, Ge, Gaoxiang, 2014
Disruption of disulfide-restriction at integrin knees induces activation and ligand-independent signaling of α4β7., Chen Jianfeng, 2013
The Unique Disulfide Bond-stabilized W1 β4-β1 Loop in the α4 β-Propeller Domain Regulates Integrin α4β7 Affinity and Signaling., Jiao Yue, Kun Zhang, JianFeng Chen, 2013
Structural specializations of α 4 β 7 , an integrin that mediates rolling adhesion., Yamei Yu, Jianghai Zhu, LiZhi Mi, Thomas Walz, Hao Sun, JianFeng Chen, Timothy A Springer, 2012
The regulation of integrin function by divalent cations., Zhang, Kun, Chen, JianFeng, 2012
Identification, characterization and epitope mapping of a human monoclonal antibody J19 that specifically recognizes the activated integrin a4b7., Chen Jianfeng, 2012
Role of Integrins in Regulating Proteases to Mediate Extracellular Matrix Remodeling., Jiao Yue, Kun Zhang, JianFeng Chen, 2012
The mechanism of integrin affinity regulation., Chen Jianfeng, 2011
The CC′ and DE Loops in Ig Domains 1 and 2 of MAdCAM-1 Play Different Roles in MAdCAM-1 Binding to Low- and High-affinity Integrin α4β7., Hao Sun, YuMei Wu, JunPeng Qi, YouDong Pan, Gaoxiang Ge, JianFeng Chen, 2011
Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha(4)beta(7)., Pan, YouDong, Zhang, Kun, Qi, JunPeng, Yue, Jiao, Springer, Timothy A, Chen, JianFeng, 2010
Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin., Yongli Shan, Lihou Yu, Yan Li, Youdong Pan, Qiangge Zhang, Fubin Wang, Jianfeng Chen, Xueliang Zhu, 2009
Aberrant activation of integrin α 4 β 7 suppresses lymphocyte migration to the gut., Eun Jeong Park, J Rodrigo Mora, Christopher V Carman, JianFeng Chen, Yoshiteru Sasaki, Guiying Cheng, Ulrich H von Andrian, Motomu Shimaoka, 2007
Regulation of outside-in signaling and affinity by the beta(2) I domain of integrin alpha(L)beta(2)., Chen, JianFeng, Yang, Wei, Kim, Minsoo, Carman, Christopher V, Springer, Timothy A, 2006
Importance of force linkage in mechanochemistry of adhesion receptors., Astrof, Nathan S, Salas, Azucena, Shimaoka, Motomu, Chen, JianFeng,

Cell Adhesion Inflammation Cancer Molecular Regulation Integrins Signal Transduction Immune Response Cell Migration Protein Interaction Therapeutic Targets

Changdong Lin - Tongji University

Bing Du - East China Normal University

Fangwei Wang - Zhejiang University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us