Professor | Zhuo Chen | Asia Growth Partners

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Name	Zhuo Chen
Contact Information	zchen@fjirsm.ac.cn
Language ability	Chinese, English
Province	Fujian

Upload Avatar (500 x 500)

Name

Zhuo Chen

Contact Information

zchen@fjirsm.ac.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Awards	Provincial Talent Introduction Innovation Award (2018): Provincial level CAS Haixi Institute Award (2018): Research Institute (School) Advanced Individual in Women's Contribution (2017): Research Institute (School) Danida Fellowship (2012): National level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Awards

Provincial Talent Introduction Innovation Award (2018): Provincial level
CAS Haixi Institute Award (2018): Research Institute (School)
Advanced Individual in Women's Contribution (2017): Research Institute (School)
Danida Fellowship (2012): National level

Areas of Focus	Early tumor screening and targeted therapy Photodynamic killing of pathogenic microorganisms Discovery of related targets in cardiovascular and cerebrovascular diseases Research and development of drugs for major diseases such as metabolic diseases
Publications	A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate, Jincan Chen, Yang Zhou, Meiru Song, Yijian Chen, Dong Wang, Yunmei Huang, Ping Hu, Chen He, Tao Dai, Lei Zhang, Mingdong Huang, Zhuo Chen, Peng Xu, 2023 AIEgen-sensitized lanthanide nanocrystals as luminescent probes for intracellular Fe3+ monitoring, Fan Liu, Wusen Zhou, Xingjun Li, Zhuo Li, Shan Lu, Xiaoying Shang, Chong Tan, Ping Hu, Zhuo Chen, Xueyuan Chen, 2023 A multi-functional nano-system combining PI3K-110 alpha/Beta inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency, Ruikun Lin, Lei Zhang, Biwei Ye, Yanan Wang, YiDong Li, Hsu Jason, Wenzhen Liu, Ping Hu, Jincan Chen, ZheSheng Chen, Zhuo Chen, 2023 Lanthanide Upconversion Nanoplatforms for Advanced Bacteria-Targeted Detection and Therapy, Li, Zhuo, Lu, Shan, Li, Xingjun, Chen, Zhuo, Chen, Xueyuan, 2023 Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers, Zhang, Lei, Ye, Biwei, Chen, Zhuo, Chen, ZheSheng, 2023 A novel near-infrared responsive lanthanide upconversion nanoplatform for drug delivery based on photocleavage of cypate, 刘若湄, 冯艳辉, 李卓, 卢珊, 关天用, 李幸俊, 刘䶮, 陈卓, 陈学元, 2022 An intelligent photosensitizer that selectively kills Gram-positive pathogenic cocci while preventing harm to beneficial bacilli, Wang, Le, Pan, Xiaohong, Tang, Shuzhi, Wang, Yaqi, Shi, Haixing, Wang, Huanhuan, Liu, Wenzhen, Chen, Zhuo, 2022 An AIE photosensitizer with unquenched fluorescence based on nitrobenzoic acid for tumor-targeting and image-guided photodynamic therapy, Wang, Yaqi, Pan, Xiaohong, Dai, Tao, Wang, Le, Shi, Haixing, Wang, Huanhuan, Chen, Zhuo, 2022 基于cypate光裂解的新型近红外光响应稀土上转换纳米载药系统, 刘若湄, 冯艳辉, 李卓, 卢珊, 关天用, 李幸俊, 刘, 陈卓, 陈学元, 2022 Restricting Bond Rotations by Ring Fusion: A Novel Molecular Design Strategy to Improve Photodynamic Antibacterial Efficacy of AIE Photosensitizers, Shi, Haixing, Pan, Xiaohong, Wang, Yaqi, Wang, Huanhuan, Liu, Wenzhen, Wang, Le, Chen, Zhuo, 2022 Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells, Zhang, Lei, Ye, Biwei, Lin, Yunfeng, Li, YiDong, Wang, JingQuan, Chen, Zhuo, Ping, FengFeng, Chen, ZheSheng, 2022 An advanced multifunctional prodrug combining photodynamic therapy with chemotherapy for highly efficient and precise tumor ablation, Hu, Ping, Xu, Gan, Yang, DeChao, Liu, JianYong, Chen, Zhuo, Huang, Mingdong, 2022 Synergistic Lysozyme-Photodynamic Therapy Against Resistant Bacteria based on an Intelligent Upconversion Nanoplatform, Li, Zhuo, Lu, Shan, Liu, Wenzhen, Dai, Tao, Ke, Jianxi, Li, Xingjun, Li, Renfu, Zhang, Yuxiang, Chen, Zhuo, Chen, Xueyuan, 2021 Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086, He, Chen, Zhang, Lei, Liu, Wenzhen, Huang, Yunmei, Hu, Ping, Dai, Tao, Xu, Jianhua, Chen, Zhuo, 2021 Mechanisms of thrombosis and research progress on targeted antithrombotic drugs, Zhang, Lei, Li, Zhen, Ye, Xianren, Chen, Zhuo, Chen, ZheSheng, 2021 A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy, Wang, Huanhuan, Pan, Xiaohong, Wang, Yaqi, Liu, Wenzhen, Dai, Tao, Yuan, Binbin, Chen, Xueyuan, Chen, Zhuo, 2021 一种基于大肠杆菌驱动药物递送系统增强光动力治疗的肿瘤靶向策略, 戴涛, 叶发荣, 胡萍, 潘小宏, 陈锦灿, 黄云梅, 王欢欢, 张蕾, 黄明东, 刘见永, 苏建强, 陈学元, 陈卓, 2021 基于硝基苯甲酸结构的新型AIE光敏剂的光动力抗菌作用, 王欢欢, 潘小宏, 王亚琪, 刘雯珍, 戴涛, 袁彬彬, 陈学元, 陈卓, 2021 循环肿瘤细胞上皮-间质转化对肿瘤发生发展的影响及其临床应用潜力, 王乐, 张志强, 陈建松, 陈卓, 2021 A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system, Dai, Tao, Ye, Farong, Hu, Ping, Pan, Xiaohong, Chen, Jincan, Huang, Yunmei, Wang, Huanhuan, Zhang, Lei, Huang, Mingdong, Liu, Jianyong, Su, Jianqiang, Chen, Xueyuan, Chen, Zhuo, 2021 Recent progress in antitumor functions of the intracellular antibodies, Lin, Yunfeng, Chen, Zhuo, Hu, Chaohua, Chen, ZheSheng, Zhang, Lei, 2020 Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel, Li, Linlin, Chen, Dan, Zheng, Ke, Jiang, Libin, Dai, Tao, Yang, Ling, Jiang, Longguang, Chen, Zhuo, Yuan, Cai, Huang, Mingdong, 2020 A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment, Hu, Ping, Shang, Le, Chen, Jincan, Chen, Xuzheng, Chen, Chun, Hong, Wanjin, Huang, Mingdong, Xu, Peng, Chen, Zhuo, 2020 Multiplexed intracellular detection based on dual-excitation/dual-emission upconversion nanoprobes, Ke, Jianxi, Lu, Shan, Li, Zhuo, Shang, Xiaoying, Li, Xingjun, Li, Renfu, Tu, Datao, Chen, Zhuo, Chen, Xueyuan, 2020 Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistant Acinetobacter baumannii based on lanthanide nanoparticles, Liu, Wenzhen, Zhang, Yuxiang, You, Wenwu, Su, Jianqiang, Yu, Shaohua, Dai, Tao, Huang, Yunmei, Chen, Xueyuan, Song, Xiaorong, Chen, Zhuo, 2020 Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis, Wang, Dong, Yang, Yongshuai, Wang, Yu, Proulle, Valerie, Andreasen, Peter A, Hong, Wanjin, Chen, Zhuo, Huang, Mingdong, Xu, Peng, 2020 Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating photodynamic therapy, photothermal therapy, and enzyme inhibition, Wang, Dong, Liu, Wenzhen, Wang, Le, Wang, Yu, Liao, Christopher Kai, Chen, Jincan, Hu, Ping, Hong, Wanjin, Huang, Mingdong, Chen, Zhuo, Xu, Peng, 2020 Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells, Liu, Jihao, Chen, Zhuo, Huang, Mingdong, Tang, Shuzhi, Wang, Qianchao, Hu, Ping, Gupta, Pranav, Ashby, Charles R, Chen, ZheSheng, Zhang, Lei, 2020 The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer, Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, ZheSheng Chen, 2020 Research Progress of Structure Based Antitumor Drug Design, Zhang Lei, Chen Zhuo, 2020 Broadband excitable NIR-II luminescent nano-bioprobes based on CuInSe2 quantum dots for the detection of circulating tumor cells, Lian, Wei, Tu, Datao, Hu, Ping, Song, Xiaorong, Gong, Zhongliang, Chen, Tao, Song, Jibin, Chen, Zhuo, Chen, Xueyuan, 2020 Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression, Sun, Jing, Zhang, Yuxiang, Su, Jianqiang, Dai, Tao, Chen, Jincan, Zhang, Lei, Wang, Huanhuan, Liu, Wenzhen, Huang, Mingdong, Chen, Zhuo, 2020 Specific inhibition of plasminogen activator inhibitor 1 reduces blood glucose level by lowering TNF-a, Tang, Shuzhi, Liu, Wenzhen, Pan, Xiaohong, Liu, Libin, Yang, Yongshuai, Wang, Dong, Xu, Peng, Huang, Mingdong, Chen, Zhuo, 2020 Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions, Li, Xiuxiu

Areas of Focus

Early tumor screening and targeted therapy
Photodynamic killing of pathogenic microorganisms
Discovery of related targets in cardiovascular and cerebrovascular diseases
Research and development of drugs for major diseases such as metabolic diseases

Publications

A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate, Jincan Chen, Yang Zhou, Meiru Song, Yijian Chen, Dong Wang, Yunmei Huang, Ping Hu, Chen He, Tao Dai, Lei Zhang, Mingdong Huang, Zhuo Chen, Peng Xu, 2023
AIEgen-sensitized lanthanide nanocrystals as luminescent probes for intracellular Fe3+ monitoring, Fan Liu, Wusen Zhou, Xingjun Li, Zhuo Li, Shan Lu, Xiaoying Shang, Chong Tan, Ping Hu, Zhuo Chen, Xueyuan Chen, 2023
A multi-functional nano-system combining PI3K-110 alpha/Beta inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency, Ruikun Lin, Lei Zhang, Biwei Ye, Yanan Wang, YiDong Li, Hsu Jason, Wenzhen Liu, Ping Hu, Jincan Chen, ZheSheng Chen, Zhuo Chen, 2023
Lanthanide Upconversion Nanoplatforms for Advanced Bacteria-Targeted Detection and Therapy, Li, Zhuo, Lu, Shan, Li, Xingjun, Chen, Zhuo, Chen, Xueyuan, 2023
Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers, Zhang, Lei, Ye, Biwei, Chen, Zhuo, Chen, ZheSheng, 2023
A novel near-infrared responsive lanthanide upconversion nanoplatform for drug delivery based on photocleavage of cypate, 刘若湄, 冯艳辉, 李卓, 卢珊, 关天用, 李幸俊, 刘䶮, 陈卓, 陈学元, 2022
An intelligent photosensitizer that selectively kills Gram-positive pathogenic cocci while preventing harm to beneficial bacilli, Wang, Le, Pan, Xiaohong, Tang, Shuzhi, Wang, Yaqi, Shi, Haixing, Wang, Huanhuan, Liu, Wenzhen, Chen, Zhuo, 2022
An AIE photosensitizer with unquenched fluorescence based on nitrobenzoic acid for tumor-targeting and image-guided photodynamic therapy, Wang, Yaqi, Pan, Xiaohong, Dai, Tao, Wang, Le, Shi, Haixing, Wang, Huanhuan, Chen, Zhuo, 2022
基于cypate光裂解的新型近红外光响应稀土上转换纳米载药系统, 刘若湄, 冯艳辉, 李卓, 卢珊, 关天用, 李幸俊, 刘, 陈卓, 陈学元, 2022
Restricting Bond Rotations by Ring Fusion: A Novel Molecular Design Strategy to Improve Photodynamic Antibacterial Efficacy of AIE Photosensitizers, Shi, Haixing, Pan, Xiaohong, Wang, Yaqi, Wang, Huanhuan, Liu, Wenzhen, Wang, Le, Chen, Zhuo, 2022
Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells, Zhang, Lei, Ye, Biwei, Lin, Yunfeng, Li, YiDong, Wang, JingQuan, Chen, Zhuo, Ping, FengFeng, Chen, ZheSheng, 2022
An advanced multifunctional prodrug combining photodynamic therapy with chemotherapy for highly efficient and precise tumor ablation, Hu, Ping, Xu, Gan, Yang, DeChao, Liu, JianYong, Chen, Zhuo, Huang, Mingdong, 2022
Synergistic Lysozyme-Photodynamic Therapy Against Resistant Bacteria based on an Intelligent Upconversion Nanoplatform, Li, Zhuo, Lu, Shan, Liu, Wenzhen, Dai, Tao, Ke, Jianxi, Li, Xingjun, Li, Renfu, Zhang, Yuxiang, Chen, Zhuo, Chen, Xueyuan, 2021
Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086, He, Chen, Zhang, Lei, Liu, Wenzhen, Huang, Yunmei, Hu, Ping, Dai, Tao, Xu, Jianhua, Chen, Zhuo, 2021
Mechanisms of thrombosis and research progress on targeted antithrombotic drugs, Zhang, Lei, Li, Zhen, Ye, Xianren, Chen, Zhuo, Chen, ZheSheng, 2021
A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy, Wang, Huanhuan, Pan, Xiaohong, Wang, Yaqi, Liu, Wenzhen, Dai, Tao, Yuan, Binbin, Chen, Xueyuan, Chen, Zhuo, 2021
一种基于大肠杆菌驱动药物递送系统增强光动力治疗的肿瘤靶向策略, 戴涛, 叶发荣, 胡萍, 潘小宏, 陈锦灿, 黄云梅, 王欢欢, 张蕾, 黄明东, 刘见永, 苏建强, 陈学元, 陈卓, 2021
基于硝基苯甲酸结构的新型AIE光敏剂的光动力抗菌作用, 王欢欢, 潘小宏, 王亚琪, 刘雯珍, 戴涛, 袁彬彬, 陈学元, 陈卓, 2021
循环肿瘤细胞上皮-间质转化对肿瘤发生发展的影响及其临床应用潜力, 王乐, 张志强, 陈建松, 陈卓, 2021
A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system, Dai, Tao, Ye, Farong, Hu, Ping, Pan, Xiaohong, Chen, Jincan, Huang, Yunmei, Wang, Huanhuan, Zhang, Lei, Huang, Mingdong, Liu, Jianyong, Su, Jianqiang, Chen, Xueyuan, Chen, Zhuo, 2021
Recent progress in antitumor functions of the intracellular antibodies, Lin, Yunfeng, Chen, Zhuo, Hu, Chaohua, Chen, ZheSheng, Zhang, Lei, 2020
Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel, Li, Linlin, Chen, Dan, Zheng, Ke, Jiang, Libin, Dai, Tao, Yang, Ling, Jiang, Longguang, Chen, Zhuo, Yuan, Cai, Huang, Mingdong, 2020
A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment, Hu, Ping, Shang, Le, Chen, Jincan, Chen, Xuzheng, Chen, Chun, Hong, Wanjin, Huang, Mingdong, Xu, Peng, Chen, Zhuo, 2020
Multiplexed intracellular detection based on dual-excitation/dual-emission upconversion nanoprobes, Ke, Jianxi, Lu, Shan, Li, Zhuo, Shang, Xiaoying, Li, Xingjun, Li, Renfu, Tu, Datao, Chen, Zhuo, Chen, Xueyuan, 2020
Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistant Acinetobacter baumannii based on lanthanide nanoparticles, Liu, Wenzhen, Zhang, Yuxiang, You, Wenwu, Su, Jianqiang, Yu, Shaohua, Dai, Tao, Huang, Yunmei, Chen, Xueyuan, Song, Xiaorong, Chen, Zhuo, 2020
Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis, Wang, Dong, Yang, Yongshuai, Wang, Yu, Proulle, Valerie, Andreasen, Peter A, Hong, Wanjin, Chen, Zhuo, Huang, Mingdong, Xu, Peng, 2020
Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating photodynamic therapy, photothermal therapy, and enzyme inhibition, Wang, Dong, Liu, Wenzhen, Wang, Le, Wang, Yu, Liao, Christopher Kai, Chen, Jincan, Hu, Ping, Hong, Wanjin, Huang, Mingdong, Chen, Zhuo, Xu, Peng, 2020
Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells, Liu, Jihao, Chen, Zhuo, Huang, Mingdong, Tang, Shuzhi, Wang, Qianchao, Hu, Ping, Gupta, Pranav, Ashby, Charles R, Chen, ZheSheng, Zhang, Lei, 2020
The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer, Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, ZheSheng Chen, 2020
Research Progress of Structure Based Antitumor Drug Design, Zhang Lei, Chen Zhuo, 2020
Broadband excitable NIR-II luminescent nano-bioprobes based on CuInSe2 quantum dots for the detection of circulating tumor cells, Lian, Wei, Tu, Datao, Hu, Ping, Song, Xiaorong, Gong, Zhongliang, Chen, Tao, Song, Jibin, Chen, Zhuo, Chen, Xueyuan, 2020
Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression, Sun, Jing, Zhang, Yuxiang, Su, Jianqiang, Dai, Tao, Chen, Jincan, Zhang, Lei, Wang, Huanhuan, Liu, Wenzhen, Huang, Mingdong, Chen, Zhuo, 2020
Specific inhibition of plasminogen activator inhibitor 1 reduces blood glucose level by lowering TNF-a, Tang, Shuzhi, Liu, Wenzhen, Pan, Xiaohong, Liu, Libin, Yang, Yongshuai, Wang, Dong, Xu, Peng, Huang, Mingdong, Chen, Zhuo, 2020
Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions, Li, Xiuxiu

Tumor Screening Targeted Therapy Photodynamic Pathogenic Microorganisms Cardiovascular Cerebrovascular Drug Development Metabolic Diseases Molecular Pharmacology Therapeutics

Tao Huang - Peking University

Yuanjie Pang - Peking University

Gao Liangcai - East China Normal University

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