Professor | Lingling Chen | Asia Growth Partners

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Name	Lingling Chen
Contact Information	linglingchen@sibcb.ac.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Lingling Chen

Contact Information

linglingchen@sibcb.ac.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2007-09--2009-05 MBA: University of Connecticut 2004-09--2009-02 PhD: University of Connecticut 2000-09--2003-06 Master's: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 1996-09--2000-06 Bachelor's: Lanzhou University
Work Experience	2023-11~Present - Key Laboratory of RNA Function and Application - Director 2017-05~2023-10 - State Key Laboratory of Molecular Biology - Deputy Director 2011-01~Present - Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences - Senior Researcher 2010-05~2011-01 - University of Connecticut Health Center - Assistant Professor 2009-04~2010-04 - University of Connecticut Health Center - Postdoctoral Researcher 2003-07~2004-06 - National Center for Drug Screening, Shanghai Institute of Materia Medica - Research Assistant
Awards	FAOBMB Award for Excellence in Research (2024): Other First Shanghai Outstanding Talent (2023): Provincial National Innovation Award (2023): Ministerial First New Cornerstone Researcher (2022): Other Shanghai Natural Science Award First Prize (2022): Provincial Chinese Academy of Sciences Excellent Mentor Award (2022): Ministerial National March 8th Red Banner Holder (2022): National Chinese Academy of Sciences Excellent Mentor Award (2021): Ministerial Shanghai March 8th Red Banner Holder Nomination Award (2021): Provincial International RNA Society Mid-Career Research Award (2021): Other 16th China Youth Science and Technology Award (2020): Ministerial Science Exploration Award (2020): Other Chinese Academy of Sciences Excellent Mentor Award (2019): Ministerial Shanghai March 8th Red Banner Holder (2019): Provincial National Leading Talent in Science and Technology Innovation (2018): National Chinese Academy of Sciences Youth Scientist Award (2018): Ministerial Tan Jiazhen Life Science Innovation Award (2017): Other Chinese Academy of Sciences Excellent Mentor Award (2017): Ministerial Promega Innovation Award (2017): Other HHMI International Research Scholar (2017): Other Shanghai Science and Technology System March 8th Red Banner Holder (2017): Provincial Ministry of Science and Technology Innovation Talent Promotion Plan (2017): Ministerial 13th China Young Female Scientist Award (2017): National CBIS Young Investigator Award (2016): Other A-IMBN Research Young Investigator/Ken-ichi Arai Award (2016): Other Chinese Society for Cell Biology Stem Cell Young Investigator Award (2016): Other 8th Shanghai Youth Science and Technology Talent Award (2016): Provincial 15th Li Ruqi Animal Genetics Award (2015): Other National Outstanding Youth Fund (2013): National Shanghai Institute of Life Sciences Special Talent (2012): Institute National Youth Top Talent Support Program (2012): National Connecticut Stem Cell Seed Award (2009): Provincial Gordon Research Conference Best Poster Presentation Award (2009): National Best Oral Presentation Award (2009): National Jinzheng Scholarship (1999): National

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2007-09--2009-05 MBA: University of Connecticut
2004-09--2009-02 PhD: University of Connecticut
2000-09--2003-06 Master's: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1996-09--2000-06 Bachelor's: Lanzhou University

Work Experience

2023-11~Present - Key Laboratory of RNA Function and Application - Director
2017-05~2023-10 - State Key Laboratory of Molecular Biology - Deputy Director
2011-01~Present - Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences - Senior Researcher
2010-05~2011-01 - University of Connecticut Health Center - Assistant Professor
2009-04~2010-04 - University of Connecticut Health Center - Postdoctoral Researcher
2003-07~2004-06 - National Center for Drug Screening, Shanghai Institute of Materia Medica - Research Assistant

Awards

FAOBMB Award for Excellence in Research (2024): Other
First Shanghai Outstanding Talent (2023): Provincial
National Innovation Award (2023): Ministerial
First New Cornerstone Researcher (2022): Other
Shanghai Natural Science Award First Prize (2022): Provincial
Chinese Academy of Sciences Excellent Mentor Award (2022): Ministerial
National March 8th Red Banner Holder (2022): National
Chinese Academy of Sciences Excellent Mentor Award (2021): Ministerial
Shanghai March 8th Red Banner Holder Nomination Award (2021): Provincial
International RNA Society Mid-Career Research Award (2021): Other
16th China Youth Science and Technology Award (2020): Ministerial
Science Exploration Award (2020): Other
Chinese Academy of Sciences Excellent Mentor Award (2019): Ministerial
Shanghai March 8th Red Banner Holder (2019): Provincial
National Leading Talent in Science and Technology Innovation (2018): National
Chinese Academy of Sciences Youth Scientist Award (2018): Ministerial
Tan Jiazhen Life Science Innovation Award (2017): Other
Chinese Academy of Sciences Excellent Mentor Award (2017): Ministerial
Promega Innovation Award (2017): Other
HHMI International Research Scholar (2017): Other
Shanghai Science and Technology System March 8th Red Banner Holder (2017): Provincial
Ministry of Science and Technology Innovation Talent Promotion Plan (2017): Ministerial
13th China Young Female Scientist Award (2017): National
CBIS Young Investigator Award (2016): Other
A-IMBN Research Young Investigator/Ken-ichi Arai Award (2016): Other
Chinese Society for Cell Biology Stem Cell Young Investigator Award (2016): Other
8th Shanghai Youth Science and Technology Talent Award (2016): Provincial
15th Li Ruqi Animal Genetics Award (2015): Other
National Outstanding Youth Fund (2013): National
Shanghai Institute of Life Sciences Special Talent (2012): Institute
National Youth Top Talent Support Program (2012): National
Connecticut Stem Cell Seed Award (2009): Provincial
Gordon Research Conference Best Poster Presentation Award (2009): National
Best Oral Presentation Award (2009): National
Jinzheng Scholarship (1999): National

Areas of Focus	RNA Metabolism and Function
Publications	Unveiling the mystery of nuclear RNA homeostasis, Lingling Chen, 2024 Altered nucleocytoplasmic export of adenosine (A)-rich circRNAs by PABPC1 contributes to neuronal function, Lingling Chen, 2024 A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development, Lingling Chen, 2024 Therapeutic application of circular RNA aptamers in a mouse model of psoriasis, Lingling Chen, 2024 CRISPR array-mediated imaging of non-repetitive and multiplex genomic loci in living cells, Lingling Chen, 2024 Emerging roles of nuclear bodies in genome spatial organization, Lingling Chen, 2023 A guide to naming eukaryotic circular RNAs, Lingling Chen, 2023 Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome-surveillance., Lingling Chen, 2023 Long non-coding RNAs: definitions, functions, challenges and recommendations, Lingling Chen, 2023 CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos, Lingling Chen, 2023 Using sno-lncRNAs as potential markers for Prader-Willi syndrome diagnosis., Lingling Chen, 2023 Multi-color RNA imaging with CRISPR-Cas13b systems in living cells, Lingling Chen, 2022 Circular RNAs: characterization, cellular roles, and applications, Lingling Chen, 2022 Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function, Lingling Chen, 2022 RNA circles with minimized immunogenicity as potent PKR inhibitors, Lingling Chen, 2022 Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system, Lingling Chen, 2022 Biogenesis and regulatory roles of circular RNAs, Lingling Chen, 2022 7S RNA is surveilling mitochondrial DNA transcription, Lingling Chen, 2022 Understanding lncRNA-protein assemblies with imaging and single-molecule approaches, Lingling Chen, 2022 LETN and NPM1 tango in human nucleoli, Lingling Chen, 2021 Long noncoding RNA and protein abundance in lncRNPs, Lingling Chen, 2021 lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription

Areas of Focus

RNA Metabolism and Function

Publications

Unveiling the mystery of nuclear RNA homeostasis, Lingling Chen, 2024
Altered nucleocytoplasmic export of adenosine (A)-rich circRNAs by PABPC1 contributes to neuronal function, Lingling Chen, 2024
A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development, Lingling Chen, 2024
Therapeutic application of circular RNA aptamers in a mouse model of psoriasis, Lingling Chen, 2024
CRISPR array-mediated imaging of non-repetitive and multiplex genomic loci in living cells, Lingling Chen, 2024
Emerging roles of nuclear bodies in genome spatial organization, Lingling Chen, 2023
A guide to naming eukaryotic circular RNAs, Lingling Chen, 2023
Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome-surveillance., Lingling Chen, 2023
Long non-coding RNAs: definitions, functions, challenges and recommendations, Lingling Chen, 2023
CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos, Lingling Chen, 2023
Using sno-lncRNAs as potential markers for Prader-Willi syndrome diagnosis., Lingling Chen, 2023
Multi-color RNA imaging with CRISPR-Cas13b systems in living cells, Lingling Chen, 2022
Circular RNAs: characterization, cellular roles, and applications, Lingling Chen, 2022
Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function, Lingling Chen, 2022
RNA circles with minimized immunogenicity as potent PKR inhibitors, Lingling Chen, 2022
Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system, Lingling Chen, 2022
Biogenesis and regulatory roles of circular RNAs, Lingling Chen, 2022
7S RNA is surveilling mitochondrial DNA transcription, Lingling Chen, 2022
Understanding lncRNA-protein assemblies with imaging and single-molecule approaches, Lingling Chen, 2022
LETN and NPM1 tango in human nucleoli, Lingling Chen, 2021
Long noncoding RNA and protein abundance in lncRNPs, Lingling Chen, 2021
lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription

Rna Metabolism Function Biochemistry Molecular Biology Gene Expression Rna Processing Rna Regulation Rna Structure Rna Dynamics

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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