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Lingling Chen
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: English, Chinese
Rna
Metabolism
Function
Biochemistry
Molecular Biology
Gene Expression
Rna Processing
Rna Regulation
Rna Structure
Rna Dynamics
Areas of Focus
- RNA Metabolism and Function
Work Experience
- 2023-11~Present - Key Laboratory of RNA Function and Application - Director
- 2017-05~2023-10 - State Key Laboratory of Molecular Biology - Deputy Director
- 2011-01~Present - Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences - Senior Researcher
- 2010-05~2011-01 - University of Connecticut Health Center - Assistant Professor
- 2009-04~2010-04 - University of Connecticut Health Center - Postdoctoral Researcher
- 2003-07~2004-06 - National Center for Drug Screening, Shanghai Institute of Materia Medica - Research Assistant
Academic Background & Achievements
- 2007-09--2009-05 MBA: University of Connecticut
- 2004-09--2009-02 PhD: University of Connecticut
- 2000-09--2003-06 Master's: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1996-09--2000-06 Bachelor's: Lanzhou University
Publications
- Unveiling the mystery of nuclear RNA homeostasis, Lingling Chen, 2024
- Altered nucleocytoplasmic export of adenosine (A)-rich circRNAs by PABPC1 contributes to neuronal function, Lingling Chen, 2024
- A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development, Lingling Chen, 2024
- Therapeutic application of circular RNA aptamers in a mouse model of psoriasis, Lingling Chen, 2024
- CRISPR array-mediated imaging of non-repetitive and multiplex genomic loci in living cells, Lingling Chen, 2024
- Emerging roles of nuclear bodies in genome spatial organization, Lingling Chen, 2023
- A guide to naming eukaryotic circular RNAs, Lingling Chen, 2023
- Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome-surveillance., Lingling Chen, 2023
- Long non-coding RNAs: definitions, functions, challenges and recommendations, Lingling Chen, 2023
- CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos, Lingling Chen, 2023
- Using sno-lncRNAs as potential markers for Prader-Willi syndrome diagnosis., Lingling Chen, 2023
- Multi-color RNA imaging with CRISPR-Cas13b systems in living cells, Lingling Chen, 2022
- Circular RNAs: characterization, cellular roles, and applications, Lingling Chen, 2022
- Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function, Lingling Chen, 2022
- RNA circles with minimized immunogenicity as potent PKR inhibitors, Lingling Chen, 2022
- Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system, Lingling Chen, 2022
- Biogenesis and regulatory roles of circular RNAs, Lingling Chen, 2022
- 7S RNA is surveilling mitochondrial DNA transcription, Lingling Chen, 2022
- Understanding lncRNA-protein assemblies with imaging and single-molecule approaches, Lingling Chen, 2022
- LETN and NPM1 tango in human nucleoli, Lingling Chen, 2021
- Long noncoding RNA and protein abundance in lncRNPs, Lingling Chen, 2021
- lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription
Awards
- FAOBMB Award for Excellence in Research (2024): Other
- First Shanghai Outstanding Talent (2023): Provincial
- National Innovation Award (2023): Ministerial
- First New Cornerstone Researcher (2022): Other
- Shanghai Natural Science Award First Prize (2022): Provincial
- Chinese Academy of Sciences Excellent Mentor Award (2022): Ministerial
- National March 8th Red Banner Holder (2022): National
- Chinese Academy of Sciences Excellent Mentor Award (2021): Ministerial
- Shanghai March 8th Red Banner Holder Nomination Award (2021): Provincial
- International RNA Society Mid-Career Research Award (2021): Other
- 16th China Youth Science and Technology Award (2020): Ministerial
- Science Exploration Award (2020): Other
- Chinese Academy of Sciences Excellent Mentor Award (2019): Ministerial
- Shanghai March 8th Red Banner Holder (2019): Provincial
- National Leading Talent in Science and Technology Innovation (2018): National
- Chinese Academy of Sciences Youth Scientist Award (2018): Ministerial
- Tan Jiazhen Life Science Innovation Award (2017): Other
- Chinese Academy of Sciences Excellent Mentor Award (2017): Ministerial
- Promega Innovation Award (2017): Other
- HHMI International Research Scholar (2017): Other
- Shanghai Science and Technology System March 8th Red Banner Holder (2017): Provincial
- Ministry of Science and Technology Innovation Talent Promotion Plan (2017): Ministerial
- 13th China Young Female Scientist Award (2017): National
- CBIS Young Investigator Award (2016): Other
- A-IMBN Research Young Investigator/Ken-ichi Arai Award (2016): Other
- Chinese Society for Cell Biology Stem Cell Young Investigator Award (2016): Other
- 8th Shanghai Youth Science and Technology Talent Award (2016): Provincial
- 15th Li Ruqi Animal Genetics Award (2015): Other
- National Outstanding Youth Fund (2013): National
- Shanghai Institute of Life Sciences Special Talent (2012): Institute
- National Youth Top Talent Support Program (2012): National
- Connecticut Stem Cell Seed Award (2009): Provincial
- Gordon Research Conference Best Poster Presentation Award (2009): National
- Best Oral Presentation Award (2009): National
- Jinzheng Scholarship (1999): National
