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Yuejun Chen
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Cell Therapy
Adult Brain
Neurodegenerative Diseases
Stem Cells
Neural Differentiation
Synaptic Connections
Axon Guidance
Crispr/Cas9
Gene Editing
Functional Integration
Areas of Focus
- Mechanisms of Cell Therapy in the Adult Brain
- Development of New Strategies for Cell Transplantation Therapy for Neurodegenerative Diseases
Work Experience
- 2016-08 to Present - Chinese Academy of Sciences, Institute of Neuroscience - Researcher
- 2015-02 to 2016-08 - University of Wisconsin - Assistant Scientist
- 2013-02 to 2015-02 - University of Wisconsin - Postdoctoral Researcher
- 2012-12 to 2016-03 - Fudan University - Associate Professor
- 2008-09 to 2012-12 - Fudan University - Lecturer
Academic Background & Achievements
- 2003-09 to 2008-06 PhD: Fudan University
- 1998-09 to 2003-06 Bachelor's: Fudan University
Publications
- Mapping of clonal lineages across developmental stages in human neural differentiation, Zhiwen You, Luyue Wang, Hui He, Ziyan Wu, Xinyue Zhang, Shuaixiang Xue, Peibo Xu, Yanhong Hong, Man Xiong, Wu Wei, Yuejun Chen, 2023
- Functional reconstruction of the basal ganglia neural circuit by human striatal neurons in hypoxic-ischaemic injured brain, Ji, Xiaoli, Zhou, Yingying, Gao, Qinqin, He, Hui, Wu, Ziyan, Feng, Ban, Mei, Yuting, Cheng, Yan, Zhou, Wenhao, Chen, Yuejun, Xiong, Man, 2022
- Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model, Xu, Peibo, He, Hui, Gao, Qinqin, Zhou, Yingying, Wu, Ziyan, Zhang, Xiao, Sun, Linyu, Hu, Gang, Guan, Qian, You, Zhiwen, Zhang, Xinyue, Zheng, Wenping, Xiong, Man, Chen, Yuejun, 2022
- Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys, Tao, Yunlong, Vermilyea, Scott C, Zammit, Matthew, Lu, Jianfeng, Olsen, Miles, Metzger, Jeanette M, Yao, Lin, Chen, Yuejun, Phillips, Sean, Holden, James E, Bondarenko, Viktoriya, Block, Walter F, Barnhart, Todd E, SchultzDarken, Nancy, Brunner, Kevin, Simmons, Heather, Christian, Bradley T, Emborg, Marina E, Zhang, SuChun, 2021
- Human cerebral organoids establish subcortical projections in the mouse brain after transplantation, Dong, Xin, Xu, ShiBo, Chen, Xin, Tao, Mengdan, Tang, XiaoYan, Fang, KaiHeng, Xu, Min, Pan, Yufeng, Chen, Yuejun, He, Shuijin, Liu, Yan, 2021
- An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development, Zhang, Ran, He, Hui, Yuan, Bo, Wu, Ziyan, Wang, Xiuzhen, Du, Yasong, Chen, Yuejun, Qiu, Zilong, 2021
- Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function, Xiong, Man, Tao, Yezheng, Gao, Qinqin, Feng, Ban, Yan, Wei, Zhou, Yingying, Kotsonis, Thomas A, Yuan, Tingli, You, Zhiwen, Wu, Ziyan, Xi, Jiajie, Haberman, Alexander, Graham, Julia, Block, Jasper, Zhou, Wenhao, Chen, Yuejun, Zhang, SuChun, 2021
- Generation of an induced pluripotent stem cell line from an Alstrom Syndrome patient with ALMS1 mutation (c.3902C > A, c.6436C > T) and a gene correction isogenic iPSC line, Ji, Xiaoli, Tang, Qingyuan, Tang, Chuanqing, Wu, Ziyan, Ma, Ling, Guo, Xiaohong, Cheng, Guoqiang, Chen, Yuejun, Yang, Tong, Xiong, Man, Zhou, Wenhao, 2020
- Generation of an induced pluripotent stem cell line from an Alström Syndrome patient with ALMS1 mutation (c.3902C>A, c.6436C>T) and a gene correction isogenic iPSC line, Xiaoli Ji, Qingyuan Tang, Chuanqing Tang, Ziyan Wu, Ling Ma, Xiaohong Guo, Guoqiang Cheng, Yuejun Chen, Tong Yang, Man Xiong, Wenhao Zhou, 2020
- Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model, Cui, Kangli, Wang, Yaqing, Zhu, Yujuan, Tao, Tingting, Yin, Fangchao, Guo, Yaqiong, Liu, Haitao, Li, Fei, Wang, Peng, Chen, Yuejun, Qin, Jianhua, 2020
- Plasticity of Synaptic Transmission in Human Stem Cell-Derived Neural Networks, Dong, Yi, Xiong, Man, Chen, Yuejun, Tao, Yezheng, Li, Xiang, Bhattacharyya, Anita, Zhang, SuChun, 2020
- Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease, Chen, Yuejun, Xiong, Man, Dong, Yi, Haberman, Alexander, Cao, Jingyuan, Liu, Huisheng, Zhou, Wenhao, Zhang, SuChun, 2016
- Expansion of cardiac progenitors from reprogrammed fibroblasts as potential novel cardiovascular therapy, Nevin Witman, Makoto Sahara, 2016
- Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9, Chen, Yuejun, Cao, Jingyuan, Xiong, Man, Petersen, Andrew J, Dong, Yi, Tao, Yunlong, Huang, Cindy TzuLing, Du, Zhongwei, Zhang, SuChun, 2015
- Illuminating Parkinson's therapy with optogenetics, Chen, Yuejun, Xiong, Man, Zhang, SuChun, 2015
- Myo9b and RICS Modulate Dendritic Morphology of Cortical Neurons, Long, Hui, Zhu, Xinru, Yang, Ping, Gao, Qinqin, Chen, Yuejun, Ma, Lan, 2013
- Targeted Ubiquitination and Degradation of G-Protein-Coupled Receptor Kinase 5 by the DDB1-CUL4 Ubiquitin Ligase Complex, Wu, Ziyan, Chen, Yuejun, Yang, Tong, Gao, Qinqin, Yuan, Man, Ma, Lan, 2012
- Chronic, but not acute morphine treatment, up-regulates alpha-Ca(2+)/calmodulin dependent protein kinase II gene expression in rat brain, Chen, Yuejun, Jiang, Yan, Yue, Wen, Zhou, Yuqing, Lu, Lin, Ma, Lan, 2008
- EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation, Chen, Yuejun, Long, Hui, Wu, Ziyan, Jiang, Xi, Ma, Lan, 2008
- GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesis, Chen Yuejun, Wang Feifei, Long Hui, Chen Ying, Wu Ziyan, Ma Lan, 2011
Awards
- Research on New Mechanisms of Neural Plasticity Regulation (2012): Second Prize, Ministry Level
- Research on New Mechanisms of Opioid Receptor Signal Transduction (2009): First Prize, Ministry Level
