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Gaoxiang Ge
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Tumor
Metastasis
Cellular Microenvironment
Regulation
Cancer
Biochemistry
Molecular Biology
Cell Biology
Research
Innovation
Areas of Focus
- Regulation of tumor occurrence and metastasis by the cellular microenvironment
Work Experience
- 2007-12~Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
- 2002-10~2007-11 - University of Wisconsin-Madison, USA - Scientist/Postdoctoral
- 2001-12~2002-09 - University of Tennessee Health Science Center, USA - Postdoctoral
- 2001-09~2001-11 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher
- 1996-09~2001-08 - Institute of Biochemistry, Chinese Academy of Sciences - Ph.D. Student
- 1992-08~1996-08 - Nanjing University - Bachelor's Degree Student
Academic Background & Achievements
- 1996-09--2001-08 Ph.D.: Institute of Biochemistry, Chinese Academy of Sciences
- 1992-08--1996-08 Bachelor's Degree in Science: Nanjing University
Publications
- ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function, Gaoxiang Ge, 2024
- LRP12 is an endogenous transmembrane inactivator of α4 integrins, Gaoxiang Ge, 2023
- Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2, Gaoxiang Ge, 2023
- Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors, Gaoxiang Ge, 2023
- Exploring the underlying biology of cancer and potential therapeutic strategies: a special issue focused on mechanism-based studies, Gaoxiang Ge, 2023
- Type IV collagen α5 chain promotes luminal breast cancer progression through c-Myc-driven glycolysis, Gaoxiang Ge, 2023
- Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3, Gaoxiang Ge, 2022
- Basement membrane promotes tumor development by attenuating T cell activation, Gaoxiang Ge, 2022
- Integrin αEβ7 + T cells direct intestinal stem cell fate decisions via adhesion signaling, Gaoxiang Ge, 2021
- Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries, Gaoxiang Ge, 2021
- Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis, Gaoxiang Ge, 2021
- A mutation that blocks integrin alpha(4)beta(7) activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis, Gaoxiang Ge, 2020
- The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, Gaoxiang Ge, 2020
- Progress of Extracellular Matrix., Gaoxiang Ge, 2019
- Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers, Gaoxiang Ge, 2019
- Dual function of VGLL 4 in muscle regeneration, Gaoxiang Ge, 2019
- Complexity of type IV collagens: from network assembly to function, Gaoxiang Ge, 2019
- Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins., Gaoxiang Ge, 2018
- FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis, Gaoxiang Ge, 2018
- Th-POK regulates mammary gland lactation through mTOR-SREBP pathway, Gaoxiang Ge, 2018
- Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation, Gaoxiang Ge, 2018
- 细胞外基质与肿瘤相关成纤维细, Gaoxiang Ge, 2017
- Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1., Gaoxiang Ge, 2015
- C/EBP Mediates TNF--Induced Cancer Cell Migration by Inducing MMP Expression Dependent on p38 MAPK, Gaoxiang Ge, 2015
- Targeting type I. phosphatidylinositol phosphate kinase inhibits breast cancer metastasis, Gaoxiang Ge, 2015
- Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma, Gaoxiang Ge, 2014
- Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition, Gaoxiang Ge, 2014
- Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation, Gaoxiang Ge, 2014
- Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1, Gaoxiang Ge, 2012
- Lysyl Oxidase, Extracellular Matrix Remodeling and Cancer Metastasis, Gaoxiang Ge, 2012
- LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor, Gaoxiang Ge, 2011
- The CC and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin a4b7., Gaoxiang Ge, 2011
- α3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues, Gaoxiang Ge, 2011
- LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling, Gaoxiang Ge, 2010
- Fibronectin Binds and Enhances the Activity of Bone Morphogenetic Protein 1, Gaoxiang Ge, 2009
- Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction, Gaoxiang Ge, 2009
- ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation, Gaoxiang Ge, 2008
- BIOCHEM BIOPHYS RES COMMUN, Gaoxiang Ge, 2008
- Bone Morphogenetic Protein 1 Processes Prolactin to a 17kDa Anti-Angiogenic Form., Gaoxiang Ge, 2007
- Bone Morphogenetic Protein 1 Prodomain Specifically Binds, Localizes and Regulates Signaling of Bone Morphogenetic Proteins 2 and 4., Gaoxiang Ge, 2007
- CANCER INFORMATICS, Gaoxiang Ge, 2006
- Developmental roles of the BMP1/TLD metalloproteinases., Gaoxiang Ge, 2006
- bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis, Gaoxiang Ge, 2006
- Mammalian Tolloid-like 1 Binds Procollagen C-proteinase Enhancer Protein 1 and Differs from Bone Morphogenetic Protein 1 in the Functional Roles of Homologous Protein Domains, Gaoxiang Ge, 2006
- TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2, Gaoxiang Ge, 2006
- Inhibition of Bone Morphogenetic Protein 1 by Native and Altered Forms of α2-Macroglobulin, Gaoxiang Ge, 2006
- GDF11 Forms a Bone Morphogenetic Protein 1-Activated Latent Complex That Can Modulate Nerve Growth Factor-Induced Differentiation of PC12 Cells, Gaoxiang Ge, 2005
- Bone morphogenetic protein-1/Tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis, Gaoxiang Ge, 2004
- Activation mechanism of solubilized epidermal growth factor tyrosine kinase., Gaoxiang Ge, 2002
- Effect of membrane fluidity on tyrosine kinase activity of reconstituted epidermal growth factor receptor, Gaoxiang Ge, 2001
