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Gao Daming
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Cancer
Signal Transduction
Metabolism
Tumor
Cell Biology
Biochemistry
Molecular Biology
Therapeutic Strategies
Oncology
Research
Areas of Focus
- Cancer Signal Transduction and Metabolism
Work Experience
- 2012-07 to Present - Shanghai Institute of Life Sciences, Chinese Academy of Sciences - Researcher
- 2010-08 to 2012-07 - Beth Israel Deaconess Medical Center, Harvard Medical School - Lecturer
- 2006-12 to 2010-07 - Beth Israel Deaconess Medical Center, Harvard Medical School - Postdoctoral Fellow
Academic Background & Achievements
- 2001-09 to 2006-07 Ph.D.: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- 1997-09 to 2001-07 Bachelor's: Shandong University
Publications
- Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies, 27th Author, 2024
- Identification of XAF1 as an endogenous AKT inhibitor, 22nd Author, 2023
- Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma, 20th Author, 2023
- Exploring the underlying biology of cancer and potential therapeutic strategies: a special issue focused on mechanism-based studies, 11th Author, 2023
- CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression, 11th Author, 2023
- Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma, 11th Author, 2022
- Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities, 11th Author, 2022
- CUL5-ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy, 2nd Author, 2021
- Osteomodulin positively regulates osteogenesis through interaction with BMP2, 5th Author, 2021
- SCF FBXW7/GSK3β-Mediated GFI1 Degradation Suppresses Proliferation of Gastric Cancer Cells, 11th Author, 2019
- Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma, 11th Author, 2019
- Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin beta 1, 11th Author, 2019
- Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics, 6th Author, 2019
- CUL5-SOCS6 complex regulates mTORC2 function by targeting Sin1 for degradation, 11th Author, 2019
- The mtor-s6k pathway links growth signalling to dna damage response by targeting rnf168, 11th Author, 2018
- A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer., 13th Author, 2018
- Extracellular Signal-regulated Kinases (ERKs) Phosphorylate Lin28aProtein to Modulate P19 Cell Proliferation and Differentiation, 6th Author, 2017
- Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis, 11th Author, 2017
- Acetylation-Dependent Regulation of Skp2 Function, 2nd Author, 2012
- mTOR drives its own activation via SCFb-TRCP-dependent degradation of the mTOR inhibitor DEPTOR, 1st Author, 2011
- Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction, 1st Author, 2010
- Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APC/Cdh1-mediated Skp2 destruction, 1st Author, 2009
- Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2F1 Pathways, 1st Author, 2009
