1995-09--2000-07 PhD: Graduate School of the Chinese Academy of Sciences
1991-09--1995-07 Bachelor's: Department of Biology, Anhui Normal University
2020-05~Present - Chinese Academy of Sciences Center for Excellence in Molecular Cell Science - Senior Researcher
2009-07~2020-04 - Shanghai Institute of Life Sciences, Chinese Academy of Sciences - Researcher
2007-04~2009-06 - Division of Biology, California Institute of Technology - Senior Researcher
2001-04~2006-12 - Protein Degradation Regulation Research Laboratory, California Institute of Technology - Postdoctoral Researcher
2000-08~2001-03 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Assistant Researcher
Zhejiang Provincial Natural Science Award First Prize (2021): Research on New Mechanisms and Targets for Tumor Regulation Based on Protein Homeostasis
National Leading Talent in the Sixth Batch of the National Ten Thousand Talents Program (2021)
Young and Middle-aged Leading Talent in Scientific and Technological Innovation in the Innovation Talent Promotion Plan (2019)
Natural Science Award (2018): New Mechanisms for the Regulation of Iron Metabolism Homeostasis and Imbalance
National Science Foundation for Distinguished Young Scholars (2015)
Sanofi-Youth Scientist Award of Shanghai Institute of Life Sciences (2011)
Shanghai Pujiang Talent Program (A Class) Funding (2010)
Support from the Chinese Academy of Sciences (2010)
Research
Protein Degradation Regulation and Molecular Recognition Protein Homeostasis and Major Diseases
TRIM25-mediated ubiquitination of G3BP1 regulates the proliferation and migration of human neuroblastoma cells, 11th Author, 2023
TRAF2 decreases lipid accumulation in hepatocytes under endoplasmic reticulum stress, 5th Author, 2023
A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission, 11th Author, 2023
The ubiquitin codes in cellular stress responses, 11th Author, 2023
Reply to: 'A global survey of alternative splicing of HBV transcriptome using long-read sequencing', 11th Author, 2022
Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors, 11th Author, 2022
Retinoic Acid Supplementation Rescues the Social Deficits in Fmr1 Knockout Mice, 11th Author, 2022
Multiomics interrogation into HBV (Hepatitis B virus)-host interaction reveals novel coding potential in human genome, and identifies canonical and non-canonical proteins as host restriction factors against HBV, 11th Author, 2021
A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers, 1st Author, 2021
Translatomic Profiling Reveals Novel Viral Self-Restricting Mechanisms in HBV (Hepatitis B Virus)-Host Interaction., 11th Author, 2021
TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer, 11th Author, 2021
MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty, 11th Author, 2021
The e3 ligase ring1 targets p53 for degradation and promotes cancer cell proliferation and survival, 11th Author, 2018
SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling, 11th Author, 2017
Lrch1 interferes with dock8-cdc42-induced t cell migration and ameliorates experimental autoimmune encephalomyelitis, 0th Author, 2017
Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium, 14th Author, 2017
Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress, 11th Author, 2017
Bacterial effector NleL promotes enterohemorrhagic E. coli -induced attaching and effacing lesions by ubiquitylating and inactivating JNK, 11th Author, 2017
Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis, 13th Author, 2016
A CRISPR-based approach for targeted DNA demethylation, 11th Author, 2016
Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling, 11th Author, 2016
Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway, 11th Author, 2016
Identification of Arsenic Direct-Binding Proteins in Acute Promyelocytic Leukaemia Cells, 4th Author, 2015
Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression, 11th Author, 2014
The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, 11th Author, 2014
Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulating localization, stability and function of p53., 11th Author, 2014
ZIP-seq: genome-wide mapping of trinucleotide repeats at single-base resolution, 10th Author, 2014
Ubiquitylation of Autophagy Receptor Optineurin by HECT E3 Activates Selective Autophagy for Tumor Suppression, 11th Author, 2014
Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis, 11th Author, 2014
Hydrophilic Molybdenum Oxide Nanomaterials with Controlled Morphology and Strong Plasmonic Absorption for Photothermal Ablation of Cancer Cells, 11th Author, 2014
A simple transformation from silica core-shell-shell to yolk-shell nanostructures: a useful platform for effective cell imaging and drug delivery, 12th Author, 2012
The N-end rule pathway
Keywords
Protein DegradationMolecular RecognitionProtein HomeostasisMajor DiseasesUbiquitinationCellular StressNeurodegenerative DiseasesCancerAutophagySignal Transduction
