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Ronggui Hu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Protein Degradation
Molecular Recognition
Protein Homeostasis
Major Diseases
Ubiquitination
Cellular Stress
Neurodegenerative Diseases
Cancer
Autophagy
Signal Transduction
Areas of Focus
- Protein Degradation Regulation and Molecular Recognition
- Protein Homeostasis and Major Diseases
Work Experience
- 2020-05~Present - Chinese Academy of Sciences Center for Excellence in Molecular Cell Science - Senior Researcher
- 2009-07~2020-04 - Shanghai Institute of Life Sciences, Chinese Academy of Sciences - Researcher
- 2007-04~2009-06 - Division of Biology, California Institute of Technology - Senior Researcher
- 2001-04~2006-12 - Protein Degradation Regulation Research Laboratory, California Institute of Technology - Postdoctoral Researcher
- 2000-08~2001-03 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 1995-09--2000-07 PhD: Graduate School of the Chinese Academy of Sciences
- 1991-09--1995-07 Bachelor's: Department of Biology, Anhui Normal University
Publications
- TRIM25-mediated ubiquitination of G3BP1 regulates the proliferation and migration of human neuroblastoma cells, 11th Author, 2023
- TRAF2 decreases lipid accumulation in hepatocytes under endoplasmic reticulum stress, 5th Author, 2023
- A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission, 11th Author, 2023
- The ubiquitin codes in cellular stress responses, 11th Author, 2023
- Reply to: 'A global survey of alternative splicing of HBV transcriptome using long-read sequencing', 11th Author, 2022
- Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors, 11th Author, 2022
- Retinoic Acid Supplementation Rescues the Social Deficits in Fmr1 Knockout Mice, 11th Author, 2022
- Multiomics interrogation into HBV (Hepatitis B virus)-host interaction reveals novel coding potential in human genome, and identifies canonical and non-canonical proteins as host restriction factors against HBV, 11th Author, 2021
- A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers, 1st Author, 2021
- Translatomic Profiling Reveals Novel Viral Self-Restricting Mechanisms in HBV (Hepatitis B Virus)-Host Interaction., 11th Author, 2021
- TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer, 11th Author, 2021
- MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty, 11th Author, 2021
- Epilepsy-Associated UBE3A Deficiency Downregulates Retinoic Acid Signalling Pathway, 11th Author, 2021
- MTSS1 Suppresses Mammary Tumor-Initiating Cells by Enhancing RBCK1-Mediated P65 Ubiquitination., 11th Author, 2020
- An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling, 11th Author, 2020
- MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3, 11th Author, 2020
- The KBTBD6/7-DRD2 axis regulates pituitary adenomas sensitivity to dopamine agonist treatment., 11th Author, 2020
- Enterohemorrhagic E, coli effector NleL disrupts host NF-kB signaling by targeting multiple host proteins, 0th Author, 2020
- Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders, 11th Author, 2019
- ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection., 11th Author, 2019
- ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death, 11th Author, 2018
- Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders, 1st Author, 2018
- SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination, 11th Author, 2018
- The e3 ligase ring1 targets p53 for degradation and promotes cancer cell proliferation and survival, 11th Author, 2018
- SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling, 11th Author, 2017
- Lrch1 interferes with dock8-cdc42-induced t cell migration and ameliorates experimental autoimmune encephalomyelitis, 0th Author, 2017
- Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium, 14th Author, 2017
- Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress, 11th Author, 2017
- Bacterial effector NleL promotes enterohemorrhagic E. coli -induced attaching and effacing lesions by ubiquitylating and inactivating JNK, 11th Author, 2017
- Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis, 13th Author, 2016
- A CRISPR-based approach for targeted DNA demethylation, 11th Author, 2016
- Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling, 11th Author, 2016
- Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway, 11th Author, 2016
- Identification of Arsenic Direct-Binding Proteins in Acute Promyelocytic Leukaemia Cells, 4th Author, 2015
- Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression, 11th Author, 2014
- The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, 11th Author, 2014
- Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulating localization, stability and function of p53., 11th Author, 2014
- ZIP-seq: genome-wide mapping of trinucleotide repeats at single-base resolution, 10th Author, 2014
- Ubiquitylation of Autophagy Receptor Optineurin by HECT E3 Activates Selective Autophagy for Tumor Suppression, 11th Author, 2014
- Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis, 11th Author, 2014
- Hydrophilic Molybdenum Oxide Nanomaterials with Controlled Morphology and Strong Plasmonic Absorption for Photothermal Ablation of Cancer Cells, 11th Author, 2014
- A simple transformation from silica core-shell-shell to yolk-shell nanostructures: a useful platform for effective cell imaging and drug delivery, 12th Author, 2012
- The N-end rule pathway
Awards
- Zhejiang Provincial Natural Science Award First Prize (2021): Research on New Mechanisms and Targets for Tumor Regulation Based on Protein Homeostasis
- National Leading Talent in the Sixth Batch of the National Ten Thousand Talents Program (2021)
- Young and Middle-aged Leading Talent in Scientific and Technological Innovation in the Innovation Talent Promotion Plan (2019)
- Natural Science Award (2018): New Mechanisms for the Regulation of Iron Metabolism Homeostasis and Imbalance
- National Science Foundation for Distinguished Young Scholars (2015)
- Sanofi-Youth Scientist Award of Shanghai Institute of Life Sciences (2011)
- Shanghai Pujiang Talent Program (A Class) Funding (2010)
- Support from the Chinese Academy of Sciences (2010)
