Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies., Cell., 2024
Cryoablation triggers type I interferon-dependent antitumor immunity and potentiates immunotherapy efficacy in lung cancer., J Immunother Cancer., 2024
Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer., Cancer Cell., 2024
Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023
KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition, CANCER CELL, 2023
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer, NATURE CANCER, 2022
Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis, 国家科学评论:英文版, 2022
Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis, NATIONAL SCIENCE REVIEW, 2022
Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022
A mesenchymal-like subpopulation in non-neuroendocrine SCLC contributes to metastasis, JOURNAL OF GENETICS AND GENOMICS, 2021
Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation (vol 13, e12627, 2021), EMBO MOLECULAR MEDICINE, 2021
Functional and mechanistic studies on the transition from adenocarcinoma to squamous cell carcinoma in lung cancer drug resistance, 生物医学转化, 2021
Targeting HSPA1A in ARID2-deficient lung adenocarcinoma, NATIONAL SCIENCE REVIEW, 2021
A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks, GENOME BIOLOGY, 2021
Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway, NEOPLASIA, 2021
Integrative analysis of multi-omics data reveals the heterogeneity and signatures of immune therapy for small cell lung cancer, CLINICAL AND TRANSLATIONAL MEDICINE, 2021
Lung stem cells in regeneration and tumorigenesis, JOURNAL OF GENETICS AND GENOMICS, 2021
Phase separation of EML4-ALK in firing downstream signaling and promoting lung tumorigenesis, CELL DISCOVERY, 2021
Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11, CANCER RESEARCH, 2021
PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer, JOURNAL OF GENETICS AND GENOMICS, 2021
In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor, PLOS GENETICS, 2020
肺癌耐药的新机制——肺癌的病理转化, 癌症, 2020
Specific gut microbiome signature predicts the early-stage lung cancer, GUT MICROBES, 2020
Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation, ONCOGENE, 2019
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition, NATURE COMMUNICATIONS, 2019
Pathological transition as the arising mechanism for drug resistance in lung cancer, CANCER COMMUNICATIONS, 2019
Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction (vol 51, pg 728, 2019), NATURE GENETICS, 2019
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors, CELL REPORTS, 2019
Kdm1a promotes SCLC progression by transcriptionally silencing the tumor suppressor Rest, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019
HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib, ANNALS OF ONCOLOGY, 2019
Smart and dual-targeted BSA nanomedicine with controllable release by high autolysosome levels, COLLOIDS AND SURFACES B-BIOINTERFACES, 2019
Landscape of transcriptional deregulation in lung cancer, BMC GENOMICS, 2018
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018
Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance, PROTEIN & CELL, 2017
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis, SCIENTIFIC REPORTS, 2017
YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation, CANCER RESEARCH, 2017
Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma, THE AMERICAN JOURNAL OF PATHOLOGY, 2017
A novel BMX variant promotes tumor cell growth and migration in lung adenocarcinoma, ONCOTARGET, 2017
Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma, CELL RESEARCH, 2016
Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance, SCIENTIFIC REPORTS, 2016
Squamous Transition of Lung Adenocarcinoma and Drug Resistance, TRENDS IN CANCER, 2016
LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response, CANCER CELL, 2015
YAP Promotes Malignant Progression of Lkb1-Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin, CANCER RESEARCH, 2015
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression, Nat Commun, 2014
Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma, NATURE COMMUNICATIONS, 2014
Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, CANCER LETTERS, 2014
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex., CELL RESEARCH, 2014
Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014
NEDD9 promotes lung cancer metastasis through epithelial- mesenchymal transition
