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Hongbin Ji
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Lung Cancer
Molecular Mechanisms
Cancer Development
Cell Biology
Biochemistry
Tumor Biology
Cancer Resistance
Genomics
Proteomics
Therapeutic Strategies
Areas of Focus
- Molecular Mechanisms of Lung Cancer Development
Work Experience
- 2007-05~Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
- 2000-08~2007-04 - Harvard Medical School - Postdoctoral Fellow, Lecturer
- 1995-09~2000-07 - Shanghai Institute of Life Sciences, Chinese Academy of Sciences - PhD
Academic Background & Achievements
- 1995-09--2000-07 PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
Publications
- Comments on 'Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer'., J Mol Cell Biol., 2024
- EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation., J Exp Med., 2024
- Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies., Cell., 2024
- Cryoablation triggers type I interferon-dependent antitumor immunity and potentiates immunotherapy efficacy in lung cancer., J Immunother Cancer., 2024
- Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer., Cancer Cell., 2024
- Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment., Natl Sci Rev, 2023
- Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023
- KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition, CANCER CELL, 2023
- Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer, NATURE CANCER, 2022
- Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis, 国家科学评论:英文版, 2022
- Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis, NATIONAL SCIENCE REVIEW, 2022
- Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022
- A mesenchymal-like subpopulation in non-neuroendocrine SCLC contributes to metastasis, JOURNAL OF GENETICS AND GENOMICS, 2021
- Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation (vol 13, e12627, 2021), EMBO MOLECULAR MEDICINE, 2021
- Functional and mechanistic studies on the transition from adenocarcinoma to squamous cell carcinoma in lung cancer drug resistance, 生物医学转化, 2021
- Targeting HSPA1A in ARID2-deficient lung adenocarcinoma, NATIONAL SCIENCE REVIEW, 2021
- A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks, GENOME BIOLOGY, 2021
- Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway, NEOPLASIA, 2021
- Integrative analysis of multi-omics data reveals the heterogeneity and signatures of immune therapy for small cell lung cancer, CLINICAL AND TRANSLATIONAL MEDICINE, 2021
- Lung stem cells in regeneration and tumorigenesis, JOURNAL OF GENETICS AND GENOMICS, 2021
- Phase separation of EML4-ALK in firing downstream signaling and promoting lung tumorigenesis, CELL DISCOVERY, 2021
- Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11, CANCER RESEARCH, 2021
- PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer, JOURNAL OF GENETICS AND GENOMICS, 2021
- In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor, PLOS GENETICS, 2020
- 肺癌耐药的新机制——肺癌的病理转化, 癌症, 2020
- Specific gut microbiome signature predicts the early-stage lung cancer, GUT MICROBES, 2020
- Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation, ONCOGENE, 2019
- Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition, NATURE COMMUNICATIONS, 2019
- Pathological transition as the arising mechanism for drug resistance in lung cancer, CANCER COMMUNICATIONS, 2019
- Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction (vol 51, pg 728, 2019), NATURE GENETICS, 2019
- Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors, CELL REPORTS, 2019
- Kdm1a promotes SCLC progression by transcriptionally silencing the tumor suppressor Rest, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019
- HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib, ANNALS OF ONCOLOGY, 2019
- Smart and dual-targeted BSA nanomedicine with controllable release by high autolysosome levels, COLLOIDS AND SURFACES B-BIOINTERFACES, 2019
- Landscape of transcriptional deregulation in lung cancer, BMC GENOMICS, 2018
- In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018
- Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance, PROTEIN & CELL, 2017
- Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis, SCIENTIFIC REPORTS, 2017
- YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation, CANCER RESEARCH, 2017
- Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma, THE AMERICAN JOURNAL OF PATHOLOGY, 2017
- A novel BMX variant promotes tumor cell growth and migration in lung adenocarcinoma, ONCOTARGET, 2017
- Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma, CELL RESEARCH, 2016
- Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance, SCIENTIFIC REPORTS, 2016
- Squamous Transition of Lung Adenocarcinoma and Drug Resistance, TRENDS IN CANCER, 2016
- LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response, CANCER CELL, 2015
- YAP Promotes Malignant Progression of Lkb1-Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin, CANCER RESEARCH, 2015
- YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression, Nat Commun, 2014
- Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma, NATURE COMMUNICATIONS, 2014
- Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, CANCER LETTERS, 2014
- VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex., CELL RESEARCH, 2014
- Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014
- NEDD9 promotes lung cancer metastasis through epithelial- mesenchymal transition
Awards
- Seventh Shanghai Youth Science and Technology Talent (2014): Provincial Level
- Second Prize for Molecular Typing and Clinical Application of Lung Adenocarcinoma (2013): Provincial Level
