Upload Avatar (500 x 500)
Xiangyin Kong
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English, German
Gene Identification
Functional Study
Disease Susceptibility
Cell Biology
Pathology
Pathophysiology
Genetics
Molecular Biology
Biomedical Research
Health Sciences
Areas of Focus
- Cell Biology - Identification and Functional Study of Disease Susceptibility Genes
- Pathology and Pathophysiology - Identification and Functional Study of Disease Susceptibility Genes
Work Experience
- 2014-06~2016-10 - Shanghai Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine - Deputy Director
- 2007-01~2007-07 - Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, UK - Visiting Scholar
- 2004-01~2004-04 - University of Bath, Bath, United Kingdom - Visiting Scholar
- 2002-04~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
- 2001-01~2001-04 - The Forsyth Institute and Harvard School of Dental Medicine - Visiting Scholar
- 1997-09~2002-06 - Shanghai Institute of Biological Engineering, Chinese Academy of Sciences - Associate Researcher, Researcher
- 1995-07~1997-09 - Max-Planck Institute for Molecular Genetics, Germany - Visiting Scholar
- 1988-09~1995-06 - Institute of Hematology, Chinese Academy of Medical Sciences - Research Intern, Assistant Researcher
Academic Background & Achievements
- 1983-09--1988-07 Bachelor of Medicine: Shandong Medical University
Publications
- Global analysis of T-cell groups reveals immunological features and common antigen targets of digestive tract tumors, Not mentioned, 2024
- Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop., Not mentioned, 2024
- Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation., Not mentioned, 2024
- Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis., Not mentioned, 2023
- A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3., Not mentioned, 2023
- Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity., Not mentioned, 2023
- Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases., Not mentioned, 2023
- Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition., Not mentioned, 2023
- Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex., Not mentioned, 2023
- Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors., Not mentioned, 2023
- Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals., Not mentioned, 2022
- Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma., Not mentioned, 2022
- SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes., Not mentioned, 2022
- Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR., Not mentioned, 2022
- Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation., Not mentioned, 2021
- PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism., Not mentioned, 2021
- Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells., Not mentioned, 2021
- CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis., Not mentioned, 2021
- Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer., Not mentioned, 2021
- Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma., Not mentioned, 2021
- Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C., Not mentioned, 2020
- Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression., Not mentioned, 2020
- Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer., Not mentioned, 2020
- Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II., Not mentioned, 2020
- Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach, Not mentioned, 2015
- Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations, Not mentioned, 2015
- Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma, Not mentioned, 2015
- Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network, Not mentioned, 2015
- Alternative splicing at GYNNGY 5’ splice sites: more noise, less regulation, Not mentioned, 2014
- COL4A3 mutations cause focal segmental glomerulosclerosis, Not mentioned, 2014
- Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients, Not mentioned, 2014
- Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving, Not mentioned, 2013
- Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study, Not mentioned, 2013
- Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases, Not mentioned, 2011
- SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell, Not mentioned, 2011
- Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation, Not mentioned, 2010
- Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features, Not mentioned, 2010
- Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, Not mentioned, 2010
- Loss-of-Function Mutations in the PRPS1 Gene Cause a Type of Nonsyndromic X-linked Sensorineural Deafness, DFN2, Not mentioned, 2010
- Identification of vimentin as a novel target of h
Awards
- WuXi AppTec Life Chemistry Research Award, Second Prize, 2010
- Tan Jiazhen Life Science Award Innovation Award, Third Prize, 2009
- China Youth Science and Technology Award, National Level, 2004
- Shanghai Natural Science Peony Award, Municipal Level, 2004
- Heat Shock Protein Transcription Factor HSF4 Mutation Leading to Cataract, First Prize, Municipal Level, 2003
- DSPP Mutation Causing Hereditary Dentinogenesis Imperfecta Type I with or without Progressive High-Frequency Hearing Loss, Second Prize, Municipal Level, 2002
- Research on the Pathogenic Gene of Hereditary Dentinogenesis Imperfecta, Second Prize, National Level, 2002
