1983-09--1988-07 Bachelor of Medicine: Shandong Medical University
2014-06~2016-10 - Shanghai Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine - Deputy Director
2007-01~2007-07 - Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, UK - Visiting Scholar
2004-01~2004-04 - University of Bath, Bath, United Kingdom - Visiting Scholar
2002-04~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
2001-01~2001-04 - The Forsyth Institute and Harvard School of Dental Medicine - Visiting Scholar
1997-09~2002-06 - Shanghai Institute of Biological Engineering, Chinese Academy of Sciences - Associate Researcher, Researcher
1995-07~1997-09 - Max-Planck Institute for Molecular Genetics, Germany - Visiting Scholar
1988-09~1995-06 - Institute of Hematology, Chinese Academy of Medical Sciences - Research Intern, Assistant Researcher
WuXi AppTec Life Chemistry Research Award, Second Prize, 2010
Tan Jiazhen Life Science Award Innovation Award, Third Prize, 2009
China Youth Science and Technology Award, National Level, 2004
Shanghai Natural Science Peony Award, Municipal Level, 2004
Heat Shock Protein Transcription Factor HSF4 Mutation Leading to Cataract, First Prize, Municipal Level, 2003
DSPP Mutation Causing Hereditary Dentinogenesis Imperfecta Type I with or without Progressive High-Frequency Hearing Loss, Second Prize, Municipal Level, 2002
Research on the Pathogenic Gene of Hereditary Dentinogenesis Imperfecta, Second Prize, National Level, 2002
Research
Cell Biology - Identification and Functional Study of Disease Susceptibility Genes Pathology and Pathophysiology - Identification and Functional Study of Disease Susceptibility Genes
Global analysis of T-cell groups reveals immunological features and common antigen targets of digestive tract tumors, Not mentioned, 2024
Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop., Not mentioned, 2024
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation., Not mentioned, 2024
Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis., Not mentioned, 2023
A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3., Not mentioned, 2023
Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity., Not mentioned, 2023
Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases., Not mentioned, 2023
Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition., Not mentioned, 2023
Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex., Not mentioned, 2023
Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors., Not mentioned, 2023
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals., Not mentioned, 2022
Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma., Not mentioned, 2022
SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes., Not mentioned, 2022
Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR., Not mentioned, 2022
Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation., Not mentioned, 2021
PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism., Not mentioned, 2021
Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells., Not mentioned, 2021
CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis., Not mentioned, 2021
Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer., Not mentioned, 2021
Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma., Not mentioned, 2021
Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C., Not mentioned, 2020
Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression., Not mentioned, 2020
Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer., Not mentioned, 2020
Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II., Not mentioned, 2020
Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach, Not mentioned, 2015
Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations, Not mentioned, 2015
Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma, Not mentioned, 2015
Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network, Not mentioned, 2015
Alternative splicing at GYNNGY 5’ splice sites: more noise, less regulation, Not mentioned, 2014
COL4A3 mutations cause focal segmental glomerulosclerosis, Not mentioned, 2014
Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients, Not mentioned, 2014
Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving, Not mentioned, 2013
Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study, Not mentioned, 2013
Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases, Not mentioned, 2011
SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell, Not mentioned, 2011
Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation, Not mentioned, 2010
Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features, Not mentioned, 2010
Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, Not mentioned, 2010
Loss-of-Function Mutations in the PRPS1 Gene Cause a Type of Nonsyndromic X-linked Sensorineural Deafness, DFN2, Not mentioned, 2010
Area of Focus
Osteoporosis | Fracture | Mouse Models | Stem Cells | Therapy | Biomedical Research | Cell Biology | Regenerative Medicine | Bone Health | Clinical Applications
