2005-09--2010-06 PhD: Nanjing Agricultural University
2001-09--2005-06 Bachelor: Nanjing Agricultural University
2020-07~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
2020-02~2021-01 - Greifswald University (Germany) - Visiting Scholar
2014-04~2020-06 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Associate Researcher
2010-07~2014-04 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Assistant Researcher
2019: Application of Structural Biology in Enzyme Function Research, Second Prize, Provincial Level
Research
Protein Crystallography Protein Engineering Microbiology Biocatalysis
Exploring new galaxies: Perspectives on the discovery of novel PET-degrading enzymes, Third Author, 2024
Structural and Functional Characterization of a New Bacterial Dipeptidyl Peptidase III Involved in Fruiting Body Formation in Myxobacteria, Sixth Author, 2023
Structure of an Alkaline Pectate Lyase and Rational Engineering with Improved Thermo-Alkaline Stability for Efficient Ramie Degumming, Fourth Author, 2023
Characterization of a PBAT Degradation Carboxylesterase from Thermobacillus composti KWC4, Eleventh Author, 2023
Coenzyme Engineering of Glucose-6-phosphate Dehydrogenase on a Nicotinamide-Based Biomimic and Its Application as a Glucose Biosensor, Ninth Author, 2023
Enhanced Thermostability of an l -Rhamnose Isomerase for d -Allose Synthesis by Computation-Based Rational Redesign of Flexible Regions, Seventh Author, 2023
来源于海洋宏基因组塑料降解酶Ple629的耐热性提升改造, 第七作者, 2023
Sequence- and Structure-Based Mining of Thermostable D-Allulose 3-Epimerase and Computer-Guided Protein Engineering To Improve Enzyme Activity, Sixth Author, 2023
Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer, Fifth Author, 2023
聚对苯二甲酸乙二醇酯（PET）塑料水解酶结构、功能及改造, 第五作者, 2022
A Combined Computational-Experimental Study on the Substrate Binding and Reaction Mechanism of Salicylic Acid Decarboxylase, Ninth Author, 2022
Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase, Eleventh Author, 2022
Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization, Eleventh Author, 2022
Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation, Seventh Author, 2022
Structural insight and engineering of a plastic degrading hydrolase Ple629, Eleventh Author, 2022
Molecular Insights into the Regioselectivity of the Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Catalyzed C-H Hydroxylation of Amino Acids, Eleventh Author, 2022
Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy, Sixth Author, 2022
Protein Engineering of Glucosylglycerol Phosphorylase Facilitating Efficient and Highly Regio- and Stereoselective Glycosylation of Polyols in a Synthetic System, Eleventh Author, 2022
Mechanism-Based Design of Efficient PET Hydrolases, Sixth Author, 2022
Unlocking the stereoselectivity and substrate acceptance of enzymes: Proline induced loop engineering test, Sixth Author, 2022
A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins, Third Author, 2022
A growth selection system for the directed evolution of amine-forming or converting enzymes, Fifth Author, 2022
Molecular and Biochemical Differences of the Tandem and Cold-Adapted PET Hydrolases Ple628 and Ple629, Isolated From a Marine Microbial Consortium, Fourth Author, 2022
Engineered Imine Reductase for Larotrectinib Intermediate Manufacture, Zero Author, 2022
工业应用导向的蛋白质结构与功能研究进展, 第九作者, 2022
Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy, Zero Author, 2021
Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action, Fourth Author, 2021
General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis, Seventh Author, 2021
Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids, Eighth Author, 2021
Unlocking the Stereoselectivity and Substrate Acceptance of Enzymes: Proline-Induced Loop Engineering Test, Sixth Author, 2021
Structural Basis of Salicylic Acid Decarboxylase Reveals a Unique Substrate Recognition Mode and Access Channel, Seventh Author, 2021
Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases, Sixth Author, 2021
Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediates, Ninth Author, 2020
Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1, Eleventh Author, 2020
Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate, Fourth Author, 2020
来源于麦氏喙枝孢霉的玉米赤霉烯酮水解酶在毕赤酵母中的高效表达及活性分析, 第三作者, 2020
Structure of a gut microbial diltiazem-metabolizing enzyme suggests possible substrate binding mode, Fourth Author, 2020
Structure basis of non-structural protein pA151R from African Swine Fever Virus, Eighth Author, 2020
Biochemical characterization and structural analysis of ulvan lyase from marine Alteromonas sp . reveals the basis for its salt tolerance, Eleventh Author, 2020
Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase, Sixth Author, 2020
Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism, Fourth Author, 2019
Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei, Fourth Author, 2019
Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1, Eighth Author, 2019
Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase, Fourth Author, 2019
Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis, Seventh Author, 2019
Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium
Keywords
Protein Crystallography: StructureFunctionEnzymeCrystallizationX-RayDiffractionMolecularBiologyBiochemistryAnalysisProtein Engineering: DesignModificationStabilityActivityApplicationMicrobiology: BacteriaFungiVirusCultureIdentificationGeneticsBiocatalysis: EnzymeReactionSynthesisDegradationBiotransformationIndustry
