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Liu Weidong
Life Science
University of Chinese Academy of Sciences
Tianjin
Language: English, Chinese, German
Protein Crystallography: Structure
Function
Enzyme
Crystallization
X-Ray
Diffraction
Molecular
Biology
Biochemistry
Analysis
Protein Engineering: Design
Modification
Stability
Activity
Application
Microbiology: Bacteria
Fungi
Virus
Culture
Identification
Genetics
Biocatalysis: Enzyme
Reaction
Synthesis
Degradation
Biotransformation
Industry
Areas of Focus
- Protein Crystallography
- Protein Engineering
- Microbiology
- Biocatalysis
Work Experience
- 2020-07~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
- 2020-02~2021-01 - Greifswald University (Germany) - Visiting Scholar
- 2014-04~2020-06 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Associate Researcher
- 2010-07~2014-04 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2005-09--2010-06 PhD: Nanjing Agricultural University
- 2001-09--2005-06 Bachelor: Nanjing Agricultural University
Publications
- Exploring new galaxies: Perspectives on the discovery of novel PET-degrading enzymes, Third Author, 2024
- Structural and Functional Characterization of a New Bacterial Dipeptidyl Peptidase III Involved in Fruiting Body Formation in Myxobacteria, Sixth Author, 2023
- Structure of an Alkaline Pectate Lyase and Rational Engineering with Improved Thermo-Alkaline Stability for Efficient Ramie Degumming, Fourth Author, 2023
- Characterization of a PBAT Degradation Carboxylesterase from Thermobacillus composti KWC4, Eleventh Author, 2023
- Coenzyme Engineering of Glucose-6-phosphate Dehydrogenase on a Nicotinamide-Based Biomimic and Its Application as a Glucose Biosensor, Ninth Author, 2023
- Enhanced Thermostability of an l -Rhamnose Isomerase for d -Allose Synthesis by Computation-Based Rational Redesign of Flexible Regions, Seventh Author, 2023
- 来源于海洋宏基因组塑料降解酶Ple629的耐热性提升改造, 第七作者, 2023
- Sequence- and Structure-Based Mining of Thermostable D-Allulose 3-Epimerase and Computer-Guided Protein Engineering To Improve Enzyme Activity, Sixth Author, 2023
- Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer, Fifth Author, 2023
- 聚对苯二甲酸乙二醇酯（PET）塑料水解酶结构、功能及改造, 第五作者, 2022
- A Combined Computational-Experimental Study on the Substrate Binding and Reaction Mechanism of Salicylic Acid Decarboxylase, Ninth Author, 2022
- Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase, Eleventh Author, 2022
- Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization, Eleventh Author, 2022
- Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation, Seventh Author, 2022
- Structural insight and engineering of a plastic degrading hydrolase Ple629, Eleventh Author, 2022
- Molecular Insights into the Regioselectivity of the Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Catalyzed C-H Hydroxylation of Amino Acids, Eleventh Author, 2022
- Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy, Sixth Author, 2022
- Protein Engineering of Glucosylglycerol Phosphorylase Facilitating Efficient and Highly Regio- and Stereoselective Glycosylation of Polyols in a Synthetic System, Eleventh Author, 2022
- Mechanism-Based Design of Efficient PET Hydrolases, Sixth Author, 2022
- Unlocking the stereoselectivity and substrate acceptance of enzymes: Proline induced loop engineering test, Sixth Author, 2022
- A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins, Third Author, 2022
- A growth selection system for the directed evolution of amine-forming or converting enzymes, Fifth Author, 2022
- Molecular and Biochemical Differences of the Tandem and Cold-Adapted PET Hydrolases Ple628 and Ple629, Isolated From a Marine Microbial Consortium, Fourth Author, 2022
- Engineered Imine Reductase for Larotrectinib Intermediate Manufacture, Zero Author, 2022
- 工业应用导向的蛋白质结构与功能研究进展, 第九作者, 2022
- Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy, Zero Author, 2021
- Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action, Fourth Author, 2021
- General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis, Seventh Author, 2021
- Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids, Eighth Author, 2021
- Unlocking the Stereoselectivity and Substrate Acceptance of Enzymes: Proline-Induced Loop Engineering Test, Sixth Author, 2021
- Structural Basis of Salicylic Acid Decarboxylase Reveals a Unique Substrate Recognition Mode and Access Channel, Seventh Author, 2021
- Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases, Sixth Author, 2021
- 2,3-Dihydroxybenzoic Acid Decarboxylase fromFusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism, Eleventh Author, 2020
- Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediates, Ninth Author, 2020
- Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1, Eleventh Author, 2020
- Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate, Fourth Author, 2020
- 来源于麦氏喙枝孢霉的玉米赤霉烯酮水解酶在毕赤酵母中的高效表达及活性分析, 第三作者, 2020
- Structure of a gut microbial diltiazem-metabolizing enzyme suggests possible substrate binding mode, Fourth Author, 2020
- Structure basis of non-structural protein pA151R from African Swine Fever Virus, Eighth Author, 2020
- Biochemical characterization and structural analysis of ulvan lyase from marine Alteromonas sp . reveals the basis for its salt tolerance, Eleventh Author, 2020
- Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase, Sixth Author, 2020
- Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism, Fourth Author, 2019
- Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei, Fourth Author, 2019
- Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1, Eighth Author, 2019
- Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase, Fourth Author, 2019
- Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis, Seventh Author, 2019
- Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium
Awards
- 2019: Application of Structural Biology in Enzyme Function Research, Second Prize, Provincial Level
