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Jun Liu
Life Science
University of Chinese Academy of Sciences
Tianjin
Language: Chinese, English
Microbial Physiology
Metabolic Engineering
Corynebacterium Glutamicum
L-Cysteine Production
Sulfur Recycling
Crispr
Genome Evolution
Redox Homeostasis
Biosensors
High-Throughput Screening
Areas of Focus
- Microbial Physiology
- Metabolic Engineering
Work Experience
- 2014-02~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
- 2010-07~2013-12 - Mount Sinai School of Medicine, USA - Research Assistant Professor
- 2006-03~2010-06 - Mount Sinai School of Medicine, USA - Postdoctoral Researcher
Academic Background & Achievements
- 2002-09--2006-03 PhD: Institute of Microbiology, Chinese Academy of Sciences
- 1999-09--2002-06 Master's Degree: Nankai University
- 1994-09--1998-06 Bachelor's Degree: Nankai University
Publications
- Reprogramming the sulfur recycling network to improve l-cysteine production in Corynebacterium glutamicum., Jun Liu, 2023
- Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in Corynebacterium glutamicum, Jun Liu, 2023
- Identification and engineering efflux transporters for improved L-homoserine production in Escherichia coli, Jun Liu, 2023
- Developing a PAM-Flexible CRISPR-Mediated Dual-Deaminase Base Editor to Regulate Extracellular Electron Transport in Shewanella oneidensis, Jun Liu, 2023
- DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum, Jun Liu, 2023
- Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum., Jun Liu, 2023
- Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control, Jun Liu, 2022
- Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction, Jun Liu, 2022
- Transcriptome profiles of high-lysine adaptation reveal insights into osmotic stress response in Corynebacterium glutamicum, Jun Liu, 2022
- Tuning Redox Potential of Anthraquinone-2-Sulfonate (AQS) by Chemical Modification to Facilitate Electron Transfer From Electrodes in Shewanella oneidensis., Jun Liu, 2021
- Combining protein and metabolic engineering to construct efficient microbial cell factories, Jun Liu, 2020
- Expression,purification and characterization of catalase from Corynebacterium glutamicum, Jun Liu, 2020
- Engineering of L-glutamate oxidase as the whole-cell biocatalyst for the improvement of α-ketoglutarate production, Jun Liu, 2020
- Engineering an electroactive Escherichia coli for the microbial electrosynthesis of succinate from glucose and CO2, Jun Liu, 2019
- Combining Protein and Metabolic Engineering Strategies for High-Level Production of O-Acetylhomoserine in Escherichia coli, Jun Liu, 2019
- Recent advances of pH homeostasis mechanisms in Corynebacterium glutamicum, Jun Liu, 2019
- Recent advances in the applications of promoter engineering for the optimization of metabolite biosynthesis, Jun Liu, 2019
- Deletion of cg1360 Affects ATP Synthase Function and Enhances Production of L-Valine in Corynebacterium glutamicum, Jun Liu, 2019
- Impaired oxidative stress and sulfur assimilation contribute to acid tolerance of Corynebacterium glutamicum, Jun Liu, 2019
- Metabolic engineering of Corynebacterium glutamicum for l-cysteine production, Jun Liu, 2019
- Construction and application of a single-cell biosensor for detection of cysteine, Jun Liu, 2018
- Roles of Staphylococcus aureus Mnh1 and Mnh2 Antiporters in Salt Tolerance, Alkali Tolerance, and Pathogenesis, Jun Liu, 2018
- Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum, Jun Liu, 2018
- The Lysine 299 Residue Endows the Multisubunit Mrp1 Antiporter with Dominant Roles in Na+ Resistance and pH Homeostasis in Corynebacterium glutamicum, Jun Liu, 2018
- The expression of glutamate decarboxylase from bacillus megaterium and its enzymatic activity, Jun Liu, 2017
- Effects of exogenous arginine on the growth and fermentation performance of Corynebacterium glutamicum under high glucose stress, Jun Liu, 2017
- Biotechnological advances and perspectives of gamma-aminobutyric acid production, Jun Liu, 2017
- Co-expression of (L)-glutamate oxidase and catalase in Escherichia coli to produce alpha-ketoglutaric acid by whole-cell biocatalyst, Jun Liu, 2017
- Expression, characterization and mutagenesis of a novel glutamate decarboxylase from Bacillus megaterium, Jun Liu, 2016
- In vitro functional characterization of the Na+/H+ antiporters in Corynebacterium glutamicum, Jun Liu, 2016
- Synthetic Life and Biosecurity, Jun Liu, 2016
- Research progress of the Na+/H+ antiporters in bacteria, Jun Liu, 2015
- Cardiolipin Is Dispensable for Oxidative Phosphorylation and Non-fermentative Growth of Alkaliphilic Bacillus pseudofirmus OF4, Jun Liu, 2014
- The c-ring ion-binding site of the ATP synthase from Bacillus pseudofirmus OF4 is adapted to alkaliphilic lifestyle, Jun Liu, 2014
- The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4, Jun Liu, 2013
- Roles of AtpI and Two YidC-Type Proteins from Alkaliphilic Bacillus pseudofirmus OF4 in ATP Synthase Assembly and Nonfermentative Growth, Jun Liu, 2013
- Mutations in a Helix-1 Motif of the ATP Synthase c-Subunit of Bacillus pseudofirmus OF4 Cause Functional Deficits and Changes in the c-Ring Stability and Mobility on Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis, Jun Liu, 2011
- The genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4, Jun Liu, 2011
- The ATP Synthase a-subunit of Extreme Alkaliphiles Is a Distinct Variant: MUTATIONS IN THE CRITICAL ALKALIPHILE-SPECIFIC RESIDUE LYS-180 AND OTHER RESIDUES THAT SUPPORT ALKALIPHILE OXIDATIVE PHOSPHORYLATION, Jun Liu, 2010
- F1F0-ATP synthases of alkaliphilic bacteria: Lessons from their adaptations, Jun Liu, 2010
- Characterization of the Functionally Critical AXAXAXA and PXXEXXP Motifs of the ATP Synthase c-Subunit from an Alkaliphilic Bacillus, Jun Liu, 2009
- Purification of two putative type II NADH dehydrogenases with different substrate specificities from alkaliphilic Bacillus pseudofirmus OF4, Jun Liu, 2008
- Three putative cation/proton antiporters from the soda lake alkaliphile Alkalimonas amylolytica N10 complement an alkali-sensitive Escherichia coli mutant, Jun Liu, 2007
- Activity profile of the nhad-type na+(li+)/h+ antiporter from the soda lake haloalkaliphile alkalimonas amylolytica is adaptive for the extreme environment, Jun Liu, 2005
