2001-09 to 2006-06 Ph.D. in Science: Institute of Biophysics, Chinese Academy of Sciences
1997-09 to 2001-07 Bachelor's in Science: Wuhan University
2018-02 to Present - Institute of Microbiology, Chinese Academy of Sciences - Project Researcher
2006-07 to 2018-01 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher/Associate Researcher/Project Researcher
Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2014)
Research
Microbial degradation of pollutants and adaptation mechanisms Structural biology
Paraflavitalea pollutisoli sp. nov., Pollutibacter soli gen. nov. sp. nov., Polluticoccus soli gen. nov. sp. nov., and Terrimonas pollutisoli sp. nov., four new members of the family Chitinophagaceae from polluted soil., Defeng Li, 2024
The ligand binding domain of a type IV pilus chemoreceptor PilJ has a different fold from that of another PilJ-type receptor McpN., Defeng Li, 2024
A hydrogel-modified electrochemical biosensor for the rapid detection of ammonia-nitrogen-resistant bacteria, Defeng Li, 2024
Attractant and repellent induce opposing changes in the four-helix bundle ligand-binding domain of a bacterial chemoreceptor., Defeng Li, 2023
Flagellar brake protein YcgR interacts with motor proteins MotA and FliG to regulate the flagellar rotation speed and direction., Defeng Li, 2023
Agromyces chromiiresistens sp. nov., Novosphingobium album sp. nov., Sphingobium arseniciresistens sp. nov., Sphingomonas pollutisoli sp. nov., and Salinibacterium metalliresistens sp. nov.: five new members of Microbacteriaceae and Sphingomonadaceae from polluted soil., Defeng Li, 2023
Identification and characterization of a novel hydroxylamine oxidase, DnfA, that catalyzes the oxidation of hydroxylamine to N2, Defeng Li, 2022
Crystal structure of the chromosome partition protein MukE homodimer, Defeng Li, 2022
Desymmetric hydrolysis of prochiral imide for S-pregabalin synthesis by rationally designed d-hydantoinase, Defeng Li, 2022
Structural insights into the substrate specificity of 5-chloro-2-hydroxymuconate tautomerase CnbG, Defeng Li, 2022
Mutations in surface-sensing receptor WspA lock the Wsp signal transduction system into a constitutively active state, Defeng Li, 2022
The Response Regulator FlmD Regulates Biofilm Formation in Comamonas testosteroni through the Transcriptional Activator SoxR, Defeng Li, 2022
Genetic Foundations of Direct Ammonia Oxidation (Dirammox) to N-2 and MocR-Like Transcriptional Regulator DnfR in Alcaligenes faecalis Strain JQ135, Defeng Li, 2022
Crystal Structure of the Core Module of the Yeast Paf1 Complex, Defeng Li, 2022
Soil microbiomes divergently respond to heavy metals and polycyclic aromatic hydrocarbons in contaminated industrial sites, Defeng Li, 2022
PapA, a peptidoglycan-associated protein, interacts with OmpC and maintains cell envelope integrity, Defeng Li, 2021
Structural and Biochemical Analysis Reveals a Distinct Catalytic Site of Salicylate 5-Monooxygenase NagGH from Rieske Dioxygenases, Defeng Li, 2021
Single-Component and Two-Component para-Nitrophenol Monooxygenases: Structural Basis for Their Catalytic Difference, Defeng Li, 2021
Novel Alcaligenes ammonioxydans sp. nov. from wastewater treatment sludge oxidizes ammonia to N-2 with a previously unknown pathway, Defeng Li, 2021
Hexachlorobenzene Monooxygenase Substrate Selectivity and Catalysis: Structural and Biochemical Insights, Defeng Li, 2021
Biochemical insights into Paf1 complex-induced stimulation of Rad6/Bre1-mediated H2B monoubiquitination, Defeng Li, 2021
Characterization of the Methanomicrobial Archaeal RNase Zs for Processing the CCA-Containing tRNA Precursors, Defeng Li, 2020
A New State I-plus Observed for the L, D- transpeptidase LdtMt2-ertapenem Adduct, Defeng Li, 2020
Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli, Defeng Li, 2020
A newly identified duplex RNA unwinding activity of archaeal RNase J depends on processive exoribonucleolysis coupled steric occlusion by its structural archaeal loops, Defeng Li, 2020
Crystal structure of the glycoside hydrolase PssZ from Listeria monocytogenes, Defeng Li, 2019
The 1-beta-methyl group confers a lower affinity of L,D-transpeptidase Ldt(Mt2) for ertapenem than for imipenem, Defeng Li, 2019
The ligand-binding domain of a chemoreceptor from Comamonas testosteroni has a previously unknown homotrimeric structure, Defeng Li, 2019
Huang Z, Wang YH, Zhu HZ, Andrianova EP, Jiang CY, Li D, Ma L, Feng J, Liu ZP, Xiang H, Zhulin IB, Liu SJ.Cross Talk between Chemosensory Pathways That Modulate Chemotaxis and Biofilm Formation., Defeng Li, 2019
Cross Talk between Chemosensory Pathways That Modulate Chemotaxis and Biofilm Formation, Defeng Li, 2019
Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids, Defeng Li, 2019
Study on Itching Substance and Mechanism in Chinese Yam (Dioscoreae Rhizoma), Defeng Li, 2019
The C2′- and C3′-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain, Defeng Li, 2018
A potential substrate binding pocket of BdcA plays a critical role in NADPH recognition and biofilm dispersal, Defeng Li, 2018
Structural and Functional Characterization of the FadR Regulatory Protein from Vibrio alginolyticus, Defeng Li, 2017
Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis, Defeng Li, 2017
Mycobacterium tuberculosis proteasomal ATPase Mpa has a β-grasp domain that hinders docking with the proteasome core protease, Defeng Li, 2017
New molecular insights into an archaeal rnase j reveal a conserved processive exoribonucleolysis mechanism of the rnase j family, Defeng Li, 2017
Dissemination and Mechanism for the MCR-1 Colistin Resistance, Defeng Li, 2016
Origin, dissemination and entry of the pandemic Zika viruses, Defeng Li, 2016
Molecular Structural Basis for the Cold Adaptedness of the Psychrophilic β-Glucosidase BglU in Micrococcus antarcticus, Defeng Li, 2016
Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention, Defeng Li, 2016
Molecular Structural Basis for the Cold Adaptedness of the Psychrophilic beta-Glucosidase BglU in Micrococcus antarcticus, Defeng Li, 2016
Crystal structure of Rv3899c 184–410 , a hypothetical protein from Mycobacterium tuberculosis, Defeng Li, 2016
Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis, Defeng Li, 2016
Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis, Defeng Li, 2015
Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase, Defeng Li, 2015
Structural Basis of Specific Recognition of Non-Reducing Terminal N-Acetylglucosamine by an Agrocybe aegerita Lectin, Defeng Li, 2015
Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties, Defeng Li, 2015
Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATP
Area of Focus
Peptides | Biochemistry | Pharmaceuticals | Drug Development | Pdt | Cancer Research | Molecular Biology | Chemical Synthesis | Protein Engineering | Therapeutics
