Professor | Lin Li | Asia Growth Partners

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Name	Lin Li
Contact Information	lli@sibs.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Lin Li

Contact Information

lli@sibs.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1983-09 to 1989-06 PhD in Biochemistry and Molecular Biology: Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1979-09 to 1983-06 Bachelor's in Biochemistry: Department of Biology, Nanjing University
Work Experience	2000-01 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher 1993-12 to 2000-01 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Researcher 1992-01 to 1993-12 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Associate Researcher 1990-06 to 1992-05 - Department of Physiology and Biophysics, State University of New York at Stony Brook - Postdoctoral Researcher 1983-09 to 1989-06 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - PhD in Biochemistry and Molecular Biology 1979-09 to 1983-06 - Department of Biology, Nanjing University - Bachelor's in Biochemistry

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1983-09 to 1989-06 PhD in Biochemistry and Molecular Biology: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1979-09 to 1983-06 Bachelor's in Biochemistry: Department of Biology, Nanjing University

Work Experience

2000-01 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
1993-12 to 2000-01 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Researcher
1992-01 to 1993-12 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Associate Researcher
1990-06 to 1992-05 - Department of Physiology and Biophysics, State University of New York at Stony Brook - Postdoctoral Researcher
1983-09 to 1989-06 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - PhD in Biochemistry and Molecular Biology
1979-09 to 1983-06 - Department of Biology, Nanjing University - Bachelor's in Biochemistry

Areas of Focus	Molecular Mechanisms and Functions of Cell Signal Transduction and Regulation
Publications	CXorf67 in PFA Ependymomas: Mechanisms and Functions, 11th Author, 2022 Improving the genome assembly of rabbits with long-read sequencing, 7th Author, 2021 CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway, 11th Author, 2020 Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors, 11th Author, 2020 DKK2 imparts tumor immunity evasion through beta-catenin-independent suppression of cytotoxic immune-cell activation, 11th Author, 2018 Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity, 11th Author, 2017 Axin PPI Networks: New Interacting Proteins and New Targets?, 11th Author, 2016 Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists, 11th Author, 2016 Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation, 11th Author, 2016 A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy, 11th Author, 2016 J Biol Chem, 1st Author, 2014 New insights into the regulation of Axin function in canonical Wnt signaling pathway, 1st Author, 2014 Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP, 1st Author, 2014 Nature Chem Biol, 1st Author, 2013 Mol Cell Biol, 1st Author, 2013 Mol Cell Biol, 1st Author, 2012 Proc Natl Acad Sci USA, 1st Author, 2011 J Biol Chem, 1st Author, 2011 Cell Res, 1st Author, 2011 Dishevelled interacts with p65 and acts as a repressor of NF-κB mediated transcription, 11th Author, 2010 Regulation of Immature Dendritic Cell Migration by RhoA Guanine Nucleotide Exchange Factor Arhgef5, 11th Author, 2009 Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/β-Catenin Signaling, 9th Author, 2009 Cell Res, 1st Author, 2009 J Cell Biol, 1st Author, 2008 Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabilization of β-catenin/TCF interaction, 6th Author, 2008 Smurf1-mediated Axin Ubiquitination Requires Smurf1 C2 Domain and Is Cell Cycle-dependent, 6th Author, 2008 TAB2 Scaffolds TAK1 and NLK in Repressing Canonical Wnt Signaling, 8th Author, 2008 Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl, 2nd Author, 2008

Areas of Focus

Molecular Mechanisms and Functions of Cell Signal Transduction and Regulation

Publications

CXorf67 in PFA Ependymomas: Mechanisms and Functions, 11th Author, 2022
Improving the genome assembly of rabbits with long-read sequencing, 7th Author, 2021
CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway, 11th Author, 2020
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors, 11th Author, 2020
DKK2 imparts tumor immunity evasion through beta-catenin-independent suppression of cytotoxic immune-cell activation, 11th Author, 2018
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity, 11th Author, 2017
Axin PPI Networks: New Interacting Proteins and New Targets?, 11th Author, 2016
Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists, 11th Author, 2016
Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation, 11th Author, 2016
A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy, 11th Author, 2016
J Biol Chem, 1st Author, 2014
New insights into the regulation of Axin function in canonical Wnt signaling pathway, 1st Author, 2014
Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP, 1st Author, 2014
Nature Chem Biol, 1st Author, 2013
Mol Cell Biol, 1st Author, 2013
Mol Cell Biol, 1st Author, 2012
Proc Natl Acad Sci USA, 1st Author, 2011
J Biol Chem, 1st Author, 2011
Cell Res, 1st Author, 2011
Dishevelled interacts with p65 and acts as a repressor of NF-κB mediated transcription, 11th Author, 2010
Regulation of Immature Dendritic Cell Migration by RhoA Guanine Nucleotide Exchange Factor Arhgef5, 11th Author, 2009
Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/β-Catenin Signaling, 9th Author, 2009
Cell Res, 1st Author, 2009
J Cell Biol, 1st Author, 2008
Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabilization of β-catenin/TCF interaction, 6th Author, 2008
Smurf1-mediated Axin Ubiquitination Requires Smurf1 C2 Domain and Is Cell Cycle-dependent, 6th Author, 2008
TAB2 Scaffolds TAK1 and NLK in Repressing Canonical Wnt Signaling, 8th Author, 2008
Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl, 2nd Author, 2008

Cell Signaling Molecular Mechanisms Regulation Biochemistry Molecular Biology Signal Transduction Cell Biology Wnt Signaling Dna Repair Tumor Sensitivity

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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