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Lin Li
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Cell Signaling
Molecular Mechanisms
Regulation
Biochemistry
Molecular Biology
Signal Transduction
Cell Biology
Wnt Signaling
Dna Repair
Tumor Sensitivity
Areas of Focus
- Molecular Mechanisms and Functions of Cell Signal Transduction and Regulation
Work Experience
- 2000-01 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
- 1993-12 to 2000-01 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Researcher
- 1992-01 to 1993-12 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Associate Researcher
- 1990-06 to 1992-05 - Department of Physiology and Biophysics, State University of New York at Stony Brook - Postdoctoral Researcher
- 1983-09 to 1989-06 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - PhD in Biochemistry and Molecular Biology
- 1979-09 to 1983-06 - Department of Biology, Nanjing University - Bachelor's in Biochemistry
Academic Background & Achievements
- 1983-09 to 1989-06 PhD in Biochemistry and Molecular Biology: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 1979-09 to 1983-06 Bachelor's in Biochemistry: Department of Biology, Nanjing University
Publications
- CXorf67 in PFA Ependymomas: Mechanisms and Functions, 11th Author, 2022
- Improving the genome assembly of rabbits with long-read sequencing, 7th Author, 2021
- CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway, 11th Author, 2020
- Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors, 11th Author, 2020
- DKK2 imparts tumor immunity evasion through beta-catenin-independent suppression of cytotoxic immune-cell activation, 11th Author, 2018
- Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity, 11th Author, 2017
- Axin PPI Networks: New Interacting Proteins and New Targets?, 11th Author, 2016
- Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists, 11th Author, 2016
- Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation, 11th Author, 2016
- A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy, 11th Author, 2016
- J Biol Chem, 1st Author, 2014
- New insights into the regulation of Axin function in canonical Wnt signaling pathway, 1st Author, 2014
- Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP, 1st Author, 2014
- Nature Chem Biol, 1st Author, 2013
- Mol Cell Biol, 1st Author, 2013
- Mol Cell Biol, 1st Author, 2012
- Proc Natl Acad Sci USA, 1st Author, 2011
- J Biol Chem, 1st Author, 2011
- Cell Res, 1st Author, 2011
- Dishevelled interacts with p65 and acts as a repressor of NF-κB mediated transcription, 11th Author, 2010
- Regulation of Immature Dendritic Cell Migration by RhoA Guanine Nucleotide Exchange Factor Arhgef5, 11th Author, 2009
- Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/β-Catenin Signaling, 9th Author, 2009
- Cell Res, 1st Author, 2009
- J Cell Biol, 1st Author, 2008
- Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabilization of β-catenin/TCF interaction, 6th Author, 2008
- Smurf1-mediated Axin Ubiquitination Requires Smurf1 C2 Domain and Is Cell Cycle-dependent, 6th Author, 2008
- TAB2 Scaffolds TAK1 and NLK in Repressing Canonical Wnt Signaling, 8th Author, 2008
- Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl, 2nd Author, 2008
