Professor | Hongchang Li | Asia Growth Partners

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Name	Hongchang Li
Contact Information	hc.li@siat.ac.cn
Language ability	Chinese, English
Province	Guangdong

Upload Avatar (500 x 500)

Name

Hongchang Li

Contact Information

hc.li@siat.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1999-09 to 2006-06 PhD: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences 1995-09 to 1999-07 Bachelor: Department of Biology, Beijing Normal University
Work Experience	2011-11 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher 2006-07 to 2010-08 - Department of Biochemistry, Purdue University - Postdoctoral Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1999-09 to 2006-06 PhD: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
1995-09 to 1999-07 Bachelor: Department of Biology, Beijing Normal University

Work Experience

2011-11 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher
2006-07 to 2010-08 - Department of Biochemistry, Purdue University - Postdoctoral Researcher

Areas of Focus	Cell cycle regulation mechanisms Antitumor mechanisms of natural peptide drugs Antitumor mechanisms of nanomaterials
Publications	Bifunctional Compounds as Molecular Degraders for Integrin-facilitated Targeted Protein Degradation, Jiwei Zheng, Wanyi He, Jing Li, Hongchang Li, Liang Chen, Lijing Fang, 2023 A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination, Guofang Zhang, Hongchang Li, Liming Wang, Yang Li, 2022 Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy, Wu, Chunlei, Hongchang Li, Fang, Lijing, 2022 Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase, Shao, Ximing, Ding, Zhihao, Zhou, Wenhua, Li, Yanyan, Li, Zhibin, Cui, Haodong, Lin, Xian, Cao, Guoli, Cheng, Binghua, Sun, Haiyan, Li, Meiqing, Liu, Ke, Lu, Danyi, Geng, Shengyong, Shi, Wenli, Zhang, Guofang, Song, Qingle, Chen, Liang, Wang, Guocheng, Su, Wu, Cai, Lintao, Fang, Lijing, Leong, David Tai, Li, Yang, Yu, XueFeng, Li, Hongchang, 2021 A Novel N-methylated Cyclodepsipeptide Prodrug for Targeted Cancer Therapy, Wu, Chunlei, Hongchang Li, Lijing Fang, 2021 Coibamide A kills cancer cells through inhibiting autophagy, Shi, Wenli, Lu, Danyi, Wu, Chunlei, Li, Meiqing, Ding, Zhihao, Li, Yanyan, Chen, Binghua, Lin, Xian, Su, Wu, Shao, Ximing, Xia, Zhihui, Fang, Lijing, Liu, Ke, Li, Hongchang, 2021 Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy, Wu, Chunlei, Cheng, Zhehong, Lu, Danyi, Liu, Ke, Cheng, Yulian, Wang, Pengxin, Zhou, Yimin, Li, Meiqing, Shao, Ximing, Li, Hongchang, Su, Wu, Fang, Lijing, 2021 Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2, Liu, Ke, Zou, Rongfeng, Cui, Wenqiang, Li, Meiqing, Wang, Xueying, Dong, Junlin, Li, Hongchun, Li, Hongpei, Wang, Peihui, Shao, Ximing, Su, Wu, Chan, H C Stephen, Li, Hongchang, Yuan, Shuguang, 2020 Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas, Li, Meiqing, Shao, Ximing, Wu, Chunlei, Lu, Danyi, Liu, Ke, Wang, Wei, Liu, Jiakai, Li, Hongchang, Su, Wu, Fang, Lijing, 2020 TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway, Liu, Yanfeng, Tao, Shishi, Liao, Lijuan, Li, Yang, Li, Hongchang, Li, Zhihuan, Lin, Lilong, Wan, Xiaochun, Yang, Xiaolu, Chen, Liang, 2020 A novel machine learning based approach for iPS progenitor cell identification, Haishan Zhang, Ximing Shao, Yin Peng, Yanning Teng, Konda Mani Saravanan, Huiling Zhang, Hongchang Li, Yanjie Wei, 2019 Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues, Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing, 2018 Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo, Liu, Ke, Fang, Lijing, Sun, Haiyan, Pan, Zhengyin, Zhang, Jianchao, Chen, Juntao, Shao, Ximing, Wang, Wei, Tan, Yuanyan, Ding, Zhihao, Ao, Lijiao, Wu, Chunlei, Liu, Xiaoqi, Li, Huashun, Wang, Rui, Su, Wu, Li, Hongchang, 2018 WHITE PANICLE3, a Novel Nucleus-Encoded Mitochondrial Protein, Is Essential for Proper Development and Maintenance of Chloroplasts and Mitochondria in Rice, Li, Hongchang, Ji, Guobiao, Wang, Yun, Qian, Qian, Xu, Jichen, Sodmergen, Liu, Guozhen, Zhao, Xianfeng, Chen, Mingsheng, Zhai, Wenxue, Li, Dayong, Zhu, Lihuang, 2018 Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B, Pan, Zhengyin, Wu, Chunlei, Wang, Wei, Cheng, Zhehong, Yao, Guiyang, Liu, Ke, Li, Hongchang, Fang, Lijing, Su, Wu, 2017 Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4, Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang, 2017 Numb positively regulates autophagic flux via regulating lysosomal function, Sun, Haiyan, Liu, Yi, Zhang, Lei, Shao, Ximing, Liu, Ke, Ding, Zhihao, Liu, Xianming, Jiang, Changan, Li, Huashun, Li, Hongchang, 2017 Aurora蛋白激酶抑制剂研究综述, 陈俊涛, 张建超, 李红昌, 2017 Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation, Wang, Ce, Li, Ping, Liu, Lanlan, Pan, Hong, Li, Hongchang, Cai, Lintao, Ma, Yifan, 2016 Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity, Liu, Ke, Lei, Run, Li, Qiong, Wang, XinXin, Wu, Qian, An, Peng, Zhang, Jianchao, Zhu, Minyan, Xu, Zhiheng, Hong, Yang, Wang, Fudi, Shen, Ying, Li, Hongchang, Li, Huashun, 2016 Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b, Shao, Ximing, Liu, Yi, Yu, Qian, Ding, Zhihao, Qian, Wenyu, Zhang, Lei, Zhang, Jianchao, Jiang, Nan, Gui, Linfei, Xu, Zhiheng, Hong, Yang, Ma, Yifan, Wei, Yanjie, Liu, Xiaoqing, Jiang, Changan, Zhu, Minyan, Li, Hongchang, Li, Huashun, 2016 Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity, Shao Ximing, Liu Ke, Fan Yi, Zhihao Ding, Chen Min, Zhu Minyan, Weinstein Lee S, Li Hongchang, Li Huashun, 2015 EMT的表观遗传调控在癌症进程中的研究进展, 张建超, 李红昌, 2015 Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-kappa B and p38 MAPK signaling pathways, Pan, Hong, Zhang, Yijuan, Luo, Zichao, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Li, Hongchang, Ma, Yifan, 2014

Areas of Focus

Cell cycle regulation mechanisms
Antitumor mechanisms of natural peptide drugs
Antitumor mechanisms of nanomaterials

Publications

Bifunctional Compounds as Molecular Degraders for Integrin-facilitated Targeted Protein Degradation, Jiwei Zheng, Wanyi He, Jing Li, Hongchang Li, Liang Chen, Lijing Fang, 2023
A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination, Guofang Zhang, Hongchang Li, Liming Wang, Yang Li, 2022
Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy, Wu, Chunlei, Hongchang Li, Fang, Lijing, 2022
Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase, Shao, Ximing, Ding, Zhihao, Zhou, Wenhua, Li, Yanyan, Li, Zhibin, Cui, Haodong, Lin, Xian, Cao, Guoli, Cheng, Binghua, Sun, Haiyan, Li, Meiqing, Liu, Ke, Lu, Danyi, Geng, Shengyong, Shi, Wenli, Zhang, Guofang, Song, Qingle, Chen, Liang, Wang, Guocheng, Su, Wu, Cai, Lintao, Fang, Lijing, Leong, David Tai, Li, Yang, Yu, XueFeng, Li, Hongchang, 2021
A Novel N-methylated Cyclodepsipeptide Prodrug for Targeted Cancer Therapy, Wu, Chunlei, Hongchang Li, Lijing Fang, 2021
Coibamide A kills cancer cells through inhibiting autophagy, Shi, Wenli, Lu, Danyi, Wu, Chunlei, Li, Meiqing, Ding, Zhihao, Li, Yanyan, Chen, Binghua, Lin, Xian, Su, Wu, Shao, Ximing, Xia, Zhihui, Fang, Lijing, Liu, Ke, Li, Hongchang, 2021
Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy, Wu, Chunlei, Cheng, Zhehong, Lu, Danyi, Liu, Ke, Cheng, Yulian, Wang, Pengxin, Zhou, Yimin, Li, Meiqing, Shao, Ximing, Li, Hongchang, Su, Wu, Fang, Lijing, 2021
Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2, Liu, Ke, Zou, Rongfeng, Cui, Wenqiang, Li, Meiqing, Wang, Xueying, Dong, Junlin, Li, Hongchun, Li, Hongpei, Wang, Peihui, Shao, Ximing, Su, Wu, Chan, H C Stephen, Li, Hongchang, Yuan, Shuguang, 2020
Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas, Li, Meiqing, Shao, Ximing, Wu, Chunlei, Lu, Danyi, Liu, Ke, Wang, Wei, Liu, Jiakai, Li, Hongchang, Su, Wu, Fang, Lijing, 2020
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway, Liu, Yanfeng, Tao, Shishi, Liao, Lijuan, Li, Yang, Li, Hongchang, Li, Zhihuan, Lin, Lilong, Wan, Xiaochun, Yang, Xiaolu, Chen, Liang, 2020
A novel machine learning based approach for iPS progenitor cell identification, Haishan Zhang, Ximing Shao, Yin Peng, Yanning Teng, Konda Mani Saravanan, Huiling Zhang, Hongchang Li, Yanjie Wei, 2019
Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues, Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing, 2018
Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo, Liu, Ke, Fang, Lijing, Sun, Haiyan, Pan, Zhengyin, Zhang, Jianchao, Chen, Juntao, Shao, Ximing, Wang, Wei, Tan, Yuanyan, Ding, Zhihao, Ao, Lijiao, Wu, Chunlei, Liu, Xiaoqi, Li, Huashun, Wang, Rui, Su, Wu, Li, Hongchang, 2018
WHITE PANICLE3, a Novel Nucleus-Encoded Mitochondrial Protein, Is Essential for Proper Development and Maintenance of Chloroplasts and Mitochondria in Rice, Li, Hongchang, Ji, Guobiao, Wang, Yun, Qian, Qian, Xu, Jichen, Sodmergen, Liu, Guozhen, Zhao, Xianfeng, Chen, Mingsheng, Zhai, Wenxue, Li, Dayong, Zhu, Lihuang, 2018
Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B, Pan, Zhengyin, Wu, Chunlei, Wang, Wei, Cheng, Zhehong, Yao, Guiyang, Liu, Ke, Li, Hongchang, Fang, Lijing, Su, Wu, 2017
Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4, Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang, 2017
Numb positively regulates autophagic flux via regulating lysosomal function, Sun, Haiyan, Liu, Yi, Zhang, Lei, Shao, Ximing, Liu, Ke, Ding, Zhihao, Liu, Xianming, Jiang, Changan, Li, Huashun, Li, Hongchang, 2017
Aurora蛋白激酶抑制剂研究综述, 陈俊涛, 张建超, 李红昌, 2017
Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation, Wang, Ce, Li, Ping, Liu, Lanlan, Pan, Hong, Li, Hongchang, Cai, Lintao, Ma, Yifan, 2016
Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity, Liu, Ke, Lei, Run, Li, Qiong, Wang, XinXin, Wu, Qian, An, Peng, Zhang, Jianchao, Zhu, Minyan, Xu, Zhiheng, Hong, Yang, Wang, Fudi, Shen, Ying, Li, Hongchang, Li, Huashun, 2016
Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b, Shao, Ximing, Liu, Yi, Yu, Qian, Ding, Zhihao, Qian, Wenyu, Zhang, Lei, Zhang, Jianchao, Jiang, Nan, Gui, Linfei, Xu, Zhiheng, Hong, Yang, Ma, Yifan, Wei, Yanjie, Liu, Xiaoqing, Jiang, Changan, Zhu, Minyan, Li, Hongchang, Li, Huashun, 2016
Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity, Shao Ximing, Liu Ke, Fan Yi, Zhihao Ding, Chen Min, Zhu Minyan, Weinstein Lee S, Li Hongchang, Li Huashun, 2015
EMT的表观遗传调控在癌症进程中的研究进展, 张建超, 李红昌, 2015
Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-kappa B and p38 MAPK signaling pathways, Pan, Hong, Zhang, Yijuan, Luo, Zichao, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Li, Hongchang, Ma, Yifan, 2014

Cell Cycle Regulation Mechanisms Antitumor Natural Peptides Drugs Nanomaterials Research Biology Cancer

Fanglin Sun - Tongji University

Chunguang Wang - Tongji University

Haiyun Wang - Tongji University

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