Professor | Xiaohua Lei | Asia Growth Partners

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Name	Xiaohua Lei
Contact Information	xh.lei@siat.ac.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Xiaohua Lei

Contact Information

xh.lei@siat.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2014-09 to 2018-06 Ph.D. in Science: China Agricultural University 2005-09 to 2008-06 Master's in Agriculture: Northwest A&F University
Work Experience	2020-09 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher 2008-07 to 2020-09 - Institute of Zoology, Chinese Academy of Sciences - Research Assistant, Engineer, Senior Engineer
Awards	CAS Special Research Position (2022): Ministry Level Shenzhen High-Level Talent (2021): City Level, Third Prize Key Technical Talent of Chinese Academy of Sciences (2018): Ministry Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2014-09 to 2018-06 Ph.D. in Science: China Agricultural University
2005-09 to 2008-06 Master's in Agriculture: Northwest A&F University

Work Experience

2020-09 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher
2008-07 to 2020-09 - Institute of Zoology, Chinese Academy of Sciences - Research Assistant, Engineer, Senior Engineer

Awards

CAS Special Research Position (2022): Ministry Level
Shenzhen High-Level Talent (2021): City Level, Third Prize
Key Technical Talent of Chinese Academy of Sciences (2018): Ministry Level

Areas of Focus	Space Life Science Early Embryonic Development in Mammals Stem Cell Proliferation, Differentiation, and Metabolism Application of Stem Cells and Biomaterials
Publications	Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells, Cheng, Kaixin, Feng, Xiean, Yang, Chen, Ma, Chiyuan, Niu, Shudong, Jia, Longzhong, Yang, Xuebing, Liang, Jing, Bo, Yingnan, Geng, Kaiying, Li, Qin, Zhang, Hua, Lei, Xiaohua, Zhang, Yan, 2023 3D cell culture model: From ground experiment to microgravity study, Chiyuan Ma, Xianglong Duan, Xiaohua Lei, 2023 Melatonin ameliorates simulated-microgravity-induced mitochondrial dysfunction and lipid metabolism dysregulation in hepatocytes, Xiong, Yue, Ma, Chiyuan, Li, Qin, Zhang, Wenya, Zhao, Huashan, Ren, Peigen, Zhang, Ke, Lei, Xiaohua, 2023 mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo, Ma, Chiyuan, Li, Qin, Yang, Yuxin, Ge, Lei, Cai, Jiaxuan, Wang, Juan, Zhu, Maoxian, Xiong, Yue, Zhang, Wenya, Xie, Jingtong, Cao, Yujing, Zhao, Huashan, Wei, Qing, Huang, Chen, Shi, Junchao, Zhang, Jian V, Duan, Enkui, Lei, Xiaohua, 2023 Stem Cells and Exosome Applications for Cutaneous Wound Healing: From Ground to Microgravity Environment, Zhang, Wenya, Zhang, Jinhua, Cui, Yan, Zhao, Yongxiang, Lei, Xiaohua, 2023 Editorial: The Regulating Mechanisms of Development, Growth, and Metabolism: From Ground to Space, Xiaohua Lei, Wensheng Zhang, Yan Zhang, Lei Zhao, 2022 Radiotherapy Side Effects: Comprehensive Proteomic Study Unraveled Neural Stem Cell Degenerative Differentiation upon Ionizing Radiation, Liang, Dong, Ning, Meng, Xie, Hang, He, Xiaoyan, Ren, Peigen, Lei, Xiaohua, Zhang, Xuepei, 2022 Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster, Ma, Chiyuan, Xiong, Yue, Han, Pei, Zhang, Xueying, Cao, Yujing, Wang, Baobei, Zhao, Huashan, Duan, Enkui, Zhang, Jian V, Lei, Xiaohua, 2022 Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation, Xiumin Chen, Yanzhu Ji, Yalin Cheng, Yan Hao, Xiaohua Lei, Gang Song, Yanhua Qu, Fumin Lei, 2022 Synthetic Extracellular Matrices for 3D Culture of Schwann Cells, Hepatocytes, and HUVECs, Chiyuan Ma, Kaizheng Liu, Qin Li, Yue Xiong, Cuixiang Xu, Wenya Zhang, Changshun Ruan, Xin Li, Xiaohua Lei, Jan Roanc, Chengfei Zhang, Botjan Vihar, Uro Maver, 2022 The emerging roles of GPR158 in the regulation of the endocrine system, Lin, Jinju, Li, Qin, Lei, Xiaohua, Zhao, Huashan, 2022 中国空间生命科学40年回顾与展望, 李莹辉, 孙野青, 郑慧琼, 商澎, 曲丽娜, 雷晓华, 刘红, 刘敏, 赫荣乔, 龙勉, 孙喜庆, 王俊峰, 周光明, 孙联文, 2021 Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer, Cuixiang Xu, Xiaoyan Huang, Xiaohua Lei, Zhankui Jin, Min Wu, Xiao Liu, Yubin Huang, Xiangrong Zhao, Yue Xiong, Jingying Sun, Xianglong Duan, Jianhua Wang, 2021 Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization, Yongcun Qu, Qi Chen, Shanshan Guo, Chiyuan Ma, Yonggang Lu, Junchao Shi, Shichao Liu, Tong Zhou, Taichi Noda, Jingjing Qian, Liwen Zhang, Xili Zhu, Xiaohua Lei, Yujing Cao, Wei Li, Wei Li, Nicolas Plachta, Martin MMatzuk, Masahito Ikawa, Enkui Duan, Ying Zhang, Hongmei Wang, 2021 太空环境下哺乳动物胚胎发育和生殖研究进展及展望, 马驰原, 曹宇静, 段恩奎, 雷晓华, 2021 An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis, Li, Rongrong, Ma, Chiyuan, Xiong, Yue, Zhao, Huashan, Yang, Yali, Xue, Li, Wang, Baobei, Xiao, Tianxia, Chen, Jie, Lei, Xiaohua, Ma, Baohua, Zhang, Jian, 2021 中国空间生命科学40周年回顾与展望, 雷晓华, 2021 Effects of Microgravity on Early Embryonic Development and Embryonic Stem Cell Differentiation: Phenotypic Characterization and Potential Mechanisms, Li, Feng, Ye, Ying, Lei, Xiaohua, Zhang, Wensheng, 2021 The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks, Lei Zhao, Chengyu Bao, Yuxuan Shang, Xinye He, Chiyuan Ma, Xiaohua Lei, Dong Mi, Yeqing Sun, 2020 Development of mouse preimplantation embryos in space, Lei, Xiaohua, Cao, Yujing, Ma, Baohua, Zhang, Yunfang, Ning, Lina, Qian, Jingjing, Zhang, Liwen, Qu, Yongcun, Zhang, Tao, Li, Dehong, Chen, Qi, Shi, Junchao, Zhang, Xudong, Ma, Chiyuan, Zhang, Ying, Duan, Enkui, 2020 Identification of potential radiation-responsive biomarkers based on human orthologous genes with possible roles in DNA repair pathways by comparison between Arabidopsis thaliana and homo sapiens, Zhao, Lei, He, Xinye, Shang, Yuxuan, Bao, Chengyu, Peng, Ailin, Lei, Xiaohua, Han, Pei, Mi, Dong, Sun, Yeqing, 2020 Chemically induced transformation of human dermal fibroblasts to hair-inducing dermal papilla-like cells, Zhao, Qian, Li, Na, Zhang, Huishan, Lei, Xiaohua, Cao, Yujing, Xia, Guoliang, Duan, Enkui, Liu, Shuang, 2019 Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production, Lei, XiaoHua, Yang, YiQing, Ma, ChiYuan, Duan, EnKui, 2019 Systematic biomedical research of the NASA Twins Study facilitates the hazard risk assessment of long-term spaceflight missions, Dai, Zhongquan, Lei, Xiaohua, Yang, Chao, Zhao, Lei, Lu, Liang, Li, Yinghui, 2019 Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells, Shaopeng Zhang, Tianzhi Chen, Naixin Chen, Dengfeng Gao, Bingbo Shi, Shuangbo Kong, Rachel Claire West, Ye Yuan, Minglei Zhi, Qingqing Wei, Jinzhu Xiang, Haiyuan Mu, Liang Yue, Xiaohua Lei, Xuepeng Wang, Liang Zhong, Hui Liang, Suying Cao, Juan Carlos Izpisua Belmonte, Haibin Wang, Jianyong Han, 2019 Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang, Yunfang, Zhang, Xudong, Shi, Junchao, Tuorto, Francesca, Li, Xin, Liu, Yusheng, Liebers, Reinhard, Zhang, Liwen, Qu, Yongcun, Qian, Jingjing, Pahima, Maya, Liu, Ying, Yan, Menghong, Cao, Zhonghong, Lei, Xiaohua, Cao, Yujing, Peng, Hongying, Liu, Shichao, Wang, Yue, Zheng, Huili, Woolsey, Rebekah, Quilici, David, Zhai, Qiwei, Li, Lei, Zhou, Tong, Yan, Wei, Lyko, Frank, Zhang, Ying, Zhou, Qi, Duan, Enkui, Chen, Qi, 2018 Effect of microgravity on proliferation and differentiation of embryonic stem cells in an automated culturing system during the TZ-1 space mission, Lei, Xiaohua, Cao, Yujing, Zhang, Ying, Qian, Jingjing, Zhao, Qian, Liu, Fangwu, Zhang, Tao, Zhou, Jiaxi, Gu, Ying, Xia, Guoliang, Duan, Enkui, 2018

Areas of Focus

Space Life Science
Early Embryonic Development in Mammals
Stem Cell Proliferation, Differentiation, and Metabolism
Application of Stem Cells and Biomaterials

Publications

Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells, Cheng, Kaixin, Feng, Xiean, Yang, Chen, Ma, Chiyuan, Niu, Shudong, Jia, Longzhong, Yang, Xuebing, Liang, Jing, Bo, Yingnan, Geng, Kaiying, Li, Qin, Zhang, Hua, Lei, Xiaohua, Zhang, Yan, 2023
3D cell culture model: From ground experiment to microgravity study, Chiyuan Ma, Xianglong Duan, Xiaohua Lei, 2023
Melatonin ameliorates simulated-microgravity-induced mitochondrial dysfunction and lipid metabolism dysregulation in hepatocytes, Xiong, Yue, Ma, Chiyuan, Li, Qin, Zhang, Wenya, Zhao, Huashan, Ren, Peigen, Zhang, Ke, Lei, Xiaohua, 2023
mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo, Ma, Chiyuan, Li, Qin, Yang, Yuxin, Ge, Lei, Cai, Jiaxuan, Wang, Juan, Zhu, Maoxian, Xiong, Yue, Zhang, Wenya, Xie, Jingtong, Cao, Yujing, Zhao, Huashan, Wei, Qing, Huang, Chen, Shi, Junchao, Zhang, Jian V, Duan, Enkui, Lei, Xiaohua, 2023
Stem Cells and Exosome Applications for Cutaneous Wound Healing: From Ground to Microgravity Environment, Zhang, Wenya, Zhang, Jinhua, Cui, Yan, Zhao, Yongxiang, Lei, Xiaohua, 2023
Editorial: The Regulating Mechanisms of Development, Growth, and Metabolism: From Ground to Space, Xiaohua Lei, Wensheng Zhang, Yan Zhang, Lei Zhao, 2022
Radiotherapy Side Effects: Comprehensive Proteomic Study Unraveled Neural Stem Cell Degenerative Differentiation upon Ionizing Radiation, Liang, Dong, Ning, Meng, Xie, Hang, He, Xiaoyan, Ren, Peigen, Lei, Xiaohua, Zhang, Xuepei, 2022
Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster, Ma, Chiyuan, Xiong, Yue, Han, Pei, Zhang, Xueying, Cao, Yujing, Wang, Baobei, Zhao, Huashan, Duan, Enkui, Zhang, Jian V, Lei, Xiaohua, 2022
Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation, Xiumin Chen, Yanzhu Ji, Yalin Cheng, Yan Hao, Xiaohua Lei, Gang Song, Yanhua Qu, Fumin Lei, 2022
Synthetic Extracellular Matrices for 3D Culture of Schwann Cells, Hepatocytes, and HUVECs, Chiyuan Ma, Kaizheng Liu, Qin Li, Yue Xiong, Cuixiang Xu, Wenya Zhang, Changshun Ruan, Xin Li, Xiaohua Lei, Jan Roanc, Chengfei Zhang, Botjan Vihar, Uro Maver, 2022
The emerging roles of GPR158 in the regulation of the endocrine system, Lin, Jinju, Li, Qin, Lei, Xiaohua, Zhao, Huashan, 2022
中国空间生命科学40年回顾与展望, 李莹辉, 孙野青, 郑慧琼, 商澎, 曲丽娜, 雷晓华, 刘红, 刘敏, 赫荣乔, 龙勉, 孙喜庆, 王俊峰, 周光明, 孙联文, 2021
Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer, Cuixiang Xu, Xiaoyan Huang, Xiaohua Lei, Zhankui Jin, Min Wu, Xiao Liu, Yubin Huang, Xiangrong Zhao, Yue Xiong, Jingying Sun, Xianglong Duan, Jianhua Wang, 2021
Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization, Yongcun Qu, Qi Chen, Shanshan Guo, Chiyuan Ma, Yonggang Lu, Junchao Shi, Shichao Liu, Tong Zhou, Taichi Noda, Jingjing Qian, Liwen Zhang, Xili Zhu, Xiaohua Lei, Yujing Cao, Wei Li, Wei Li, Nicolas Plachta, Martin MMatzuk, Masahito Ikawa, Enkui Duan, Ying Zhang, Hongmei Wang, 2021
太空环境下哺乳动物胚胎发育和生殖研究进展及展望, 马驰原, 曹宇静, 段恩奎, 雷晓华, 2021
An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis, Li, Rongrong, Ma, Chiyuan, Xiong, Yue, Zhao, Huashan, Yang, Yali, Xue, Li, Wang, Baobei, Xiao, Tianxia, Chen, Jie, Lei, Xiaohua, Ma, Baohua, Zhang, Jian, 2021
中国空间生命科学40周年回顾与展望, 雷晓华, 2021
Effects of Microgravity on Early Embryonic Development and Embryonic Stem Cell Differentiation: Phenotypic Characterization and Potential Mechanisms, Li, Feng, Ye, Ying, Lei, Xiaohua, Zhang, Wensheng, 2021
The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks, Lei Zhao, Chengyu Bao, Yuxuan Shang, Xinye He, Chiyuan Ma, Xiaohua Lei, Dong Mi, Yeqing Sun, 2020
Development of mouse preimplantation embryos in space, Lei, Xiaohua, Cao, Yujing, Ma, Baohua, Zhang, Yunfang, Ning, Lina, Qian, Jingjing, Zhang, Liwen, Qu, Yongcun, Zhang, Tao, Li, Dehong, Chen, Qi, Shi, Junchao, Zhang, Xudong, Ma, Chiyuan, Zhang, Ying, Duan, Enkui, 2020
Identification of potential radiation-responsive biomarkers based on human orthologous genes with possible roles in DNA repair pathways by comparison between Arabidopsis thaliana and homo sapiens, Zhao, Lei, He, Xinye, Shang, Yuxuan, Bao, Chengyu, Peng, Ailin, Lei, Xiaohua, Han, Pei, Mi, Dong, Sun, Yeqing, 2020
Chemically induced transformation of human dermal fibroblasts to hair-inducing dermal papilla-like cells, Zhao, Qian, Li, Na, Zhang, Huishan, Lei, Xiaohua, Cao, Yujing, Xia, Guoliang, Duan, Enkui, Liu, Shuang, 2019
Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production, Lei, XiaoHua, Yang, YiQing, Ma, ChiYuan, Duan, EnKui, 2019
Systematic biomedical research of the NASA Twins Study facilitates the hazard risk assessment of long-term spaceflight missions, Dai, Zhongquan, Lei, Xiaohua, Yang, Chao, Zhao, Lei, Lu, Liang, Li, Yinghui, 2019
Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells, Shaopeng Zhang, Tianzhi Chen, Naixin Chen, Dengfeng Gao, Bingbo Shi, Shuangbo Kong, Rachel Claire West, Ye Yuan, Minglei Zhi, Qingqing Wei, Jinzhu Xiang, Haiyuan Mu, Liang Yue, Xiaohua Lei, Xuepeng Wang, Liang Zhong, Hui Liang, Suying Cao, Juan Carlos Izpisua Belmonte, Haibin Wang, Jianyong Han, 2019
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang, Yunfang, Zhang, Xudong, Shi, Junchao, Tuorto, Francesca, Li, Xin, Liu, Yusheng, Liebers, Reinhard, Zhang, Liwen, Qu, Yongcun, Qian, Jingjing, Pahima, Maya, Liu, Ying, Yan, Menghong, Cao, Zhonghong, Lei, Xiaohua, Cao, Yujing, Peng, Hongying, Liu, Shichao, Wang, Yue, Zheng, Huili, Woolsey, Rebekah, Quilici, David, Zhai, Qiwei, Li, Lei, Zhou, Tong, Yan, Wei, Lyko, Frank, Zhang, Ying, Zhou, Qi, Duan, Enkui, Chen, Qi, 2018
Effect of microgravity on proliferation and differentiation of embryonic stem cells in an automated culturing system during the TZ-1 space mission, Lei, Xiaohua, Cao, Yujing, Zhang, Ying, Qian, Jingjing, Zhao, Qian, Liu, Fangwu, Zhang, Tao, Zhou, Jiaxi, Gu, Ying, Xia, Guoliang, Duan, Enkui, 2018

Space Life Science Microgravity Embryonic Development Stem Cells Biomaterials Proliferation Differentiation Metabolism Mammals Research

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