Professor | Jianjun Luo | Asia Growth Partners

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Name	Jianjun Luo
Contact Information	luojianj@ibp.ac.cn
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Jianjun Luo

Contact Information

luojianj@ibp.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2004-08 to 2010-07: Ph.D., Michigan State University 2001-09 to 2004-07: Master's, Institute of Botany, Chinese Academy of Sciences 1997-09 to 2001-07: Bachelor's, China Agricultural University
Work Experience	2020-01 to Present: Researcher, Institute of Biophysics, Chinese Academy of Sciences 2013-09 to 2019-12: Associate Researcher, Institute of Biophysics, Chinese Academy of Sciences 2010-08 to 2013-08: Postdoctoral Fellow, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2004-08 to 2010-07: Ph.D., Michigan State University
2001-09 to 2004-07: Master's, Institute of Botany, Chinese Academy of Sciences
1997-09 to 2001-07: Bachelor's, China Agricultural University

Work Experience

2020-01 to Present: Researcher, Institute of Biophysics, Chinese Academy of Sciences
2013-09 to 2019-12: Associate Researcher, Institute of Biophysics, Chinese Academy of Sciences
2010-08 to 2013-08: Postdoctoral Fellow, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine

Areas of Focus	Systematic discovery and functional mechanism of long non-coding RNA in tumorigenesis, development, and stem cell reprogramming Complexity of non-coding RNA translation New technologies and methods in RNA research Function and regulatory mechanism of non-coding RNA in centromere and constitutive heterochromatin formation Function and regulatory mechanism of non-coding RNA in early mouse embryonic development
Publications	Readon: a novel algorithm to identify read-through transcripts with long-read sequencing data, Chen, S., Wang, H., Zhang, D., Chen, R., and Luo, J., 2024 Genetic variations associated with long noncoding RNAs, Luo, J., and Chen, R., 2020 LRIK interacts with the Ku70-Ku80 heterodimer enhancing its ability to sense DSBs during NHEJ repair, Wang, D., Zhou, Z., Wu, E., Ouyang, C., Wei, G., Wang, Y., He, D., Cui, Y., Zhang, D., Chen, X., Reed, S., Luo, J., and Chen, R., 2020 The long noncoding RNA HAND2-AS1 promotes self-renewal of liver cancer stem cells and serves as a potential target for cancer therapy, Wang, Y., Zhu, P., Luo, J., Wang, J., Liu, Z., Wu, W., Du, Y., He, L., Wu, J., He, L., Ye, B., Wang, D., Chen, R., Tian, Y., and Fan, Z., 2019 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing, Zhang, Z., Jones, A.E., Wu, W., Kim, J., Kang, Y., Bi, X., Gu, Y., Popov, I.K., Renfrow, M.B., Vassylyeva, M.N., Vassylyev, D.G., Giles, K.E., Chen, D., Kumar, A., Fan, Y., Tong, Y., Liu, C.F., An, W., Chang, C., Luo, J., Chow, L.T., and Wang, H., 2017 Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory, Cui, X., Zhang, R., Yang, Y., Wu, E., Tang, Y., Zhao, Z., Li, C., Yang, L., Teng, X., Ye, Y., Cui, Y., Xu, F., Su, Z., Wang, D., Zhang, D., Yang, Y., Sun, J., Luo, J., Zhang, S., Chen, R., and Xi, J.J., 2022 Modulated Ultrasmall γ-Fe2O3 Nanocrystal Assembles for Switchable Magnetic Resonance Imaging and Photothermal-Ferroptotic-Chemical Synergistic Cancer Therapy, Yang, B., Zhang, Y., Sun, L., Wang, J., Zhao, Z., Huang, Z., Mao, W., Xue, R., Chen, R., Luo, J., Wang, T., Jiang, J., and Qin, Y., 2022 Discovery of Plasma Membrane-Associated RNAs through APEX-seq, Wu, E., Guo, X., Teng, X., Zhang, R., Li, F., Cui, Y., Zhang, D., Liu, Q., Luo, J., Wang, J., and Chen, R., 2021 Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs, Zhang, Q., Wu, E., Tang, Y., Cai, T., Zhang, L., Wang, J., Hao, Y., Zhang, B., Zhou, Y., Guo, X., Luo, J., Chen, R., and Yang, F., 2021 LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition, Li, J., Hao, Y., Mao, W., Xue, X., Xu, P., Liu, L., Yuan, J., Zhang, D., Li, N., Chen, H., Zhao, L., Sun, Z., Luo, J., Chen, R., and Zhao, R., 2019 Genetic alterations in juvenile cervical clear cell adenocarcinoma unrelated to human papillomavirus, Su, Y., Zhang, Y., Zhou, M., Zhang, R., Chen, S., Zhang, L., Wang, H., Zhang, D., Zhang, T., Li, X., Zhang, C., Wang, B., Yuan, S., Zhang, M., Zhou, Y., Cao, L., Zhang, M., and Luo, J., 2023 LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation, Liu, L., Liu, Z., Liu, Q., Wu, W., Lin, P., Liu, X., Zhang, Y., Wang, D., Prager, B.C., Gimple, R.C., Yu, J., Zhao, W., Wu, Q., Zhang, W., Wu, E., Chen, X., Luo, J., Rich, J.N., Xie, Q., Jiang, T., and Chen, R., 2023 Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a, Yan, X., Zhang, D., Wu, W., Wu, S., Qian, J., Hao, Y., Yan, F., Zhu, P., Wu, J., Huang, G., Huang, Y., Luo, J., Liu, X., Liu, B., Chen, X., Du, Y., Chen, R., and Fan, Z., 2017 The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling, Wang, Y., He, L., Du, Y., Zhu, P., Huang, G., Luo, J., Yan, X., Ye, B., Li, C., Xia, P., Zhang, G., Tian, Y., Chen, R., and Fan, Z., 2015 LncRNA-encoded microproteins: A new form of cargo in cell culture-derived and circulating extracellular vesicles, Cai, T., Zhang, Q., Wu, B., Wang, J., Li, N., Zhang, T., Wang, Z., Luo, J., Guo, X., Ding, X., Xie, Z., Niu, L., Ning, W., Fan, Z., Chen, X., Guo, X., Chen, R., Zhang, H., and Yang, F., 2021 Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress, Zhang, Y.W., Wang, Z., Xie, W., Cai, Y., Xia, L., Easwaran, H., Luo, J., Yen, R.C., Li, Y., and Baylin, S.B., 2017 TGF-beta changes cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy, Zhang, N., Zhao, Z., Zhao, Y., Yang, L., Xue, Y., Feng, Y., Luo, J., Chen, R., Wei, W., and Qin, Y., 2023 Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene, Wan, L., Hu, P., Zhang, L., Wang, Z.X., Fleming, J., Ni, B., Luo, J., Guan, C.X., Bai, L., Tan, Y., Liu, H., Li, N., Xiao, T., Bai, H., Zhang, Y.A., Zhang, X.E., Wan, K., Bi, L., Ouyang, S., and Zhang, H., 2023 LncRNA HRCEG, regulated by HDAC1, inhibits cells proliferation and epithelial-mesenchymal-transition in gastric cancer, Wu, S., Wu, E., Wang, D., Niu, Y., Yue, H., Zhang, D., Luo, J., and Chen, R., 2020 Knockdown of long non-coding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis, Zhang, C., Wu, W., Zhu, H., Yu, X., Zhang, Y., Ye, X., Cheng, H., Ma, R., Cui, H., Luo, J., Guan, J., and Chang, X., 2018 Long noncoding RNA LINC01186, regulated by TGF-beta/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer, Hao, Y., Yang, X., Zhang, D., Luo, J., and Chen, R., 2017 LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway, Liu, L., Yue, H., Liu, Q., Yuan, J., Li, J., Wei, G., Chen, X., Lu, Y., Guo, M., Luo, J., and Chen, R., 2016 Expression profiling and functional prediction of long noncoding RNAs in nasopharyngeal nonkeratinizing carcinoma, Zhang, B., Wang, D., Wu, J., Tang, J., Chen, W., Chen, X., Zhang, D., Deng, Y., Guo, M., Wang, Y., Luo, J., and Chen, R., 2016 Identification of Tension Sensing Motif of Histone H3 in Saccharomyces cerevisiae and Its Regulation by Histone Modifying Enzymes, Luo, J., Deng, X., Buehl, C., Xu, X., and Kuo, M.H., 2016 Histone h3 exerts a key function in mitotic checkpoint control, Luo, J., Xu, X., Hall, H., Hyland, E.M., Boeke, J.D., Hazbun, T., and Kuo, M.H., 2010 Episo: quantitative estimation of RNA 5-methylcytosine at iso

Areas of Focus

Systematic discovery and functional mechanism of long non-coding RNA in tumorigenesis, development, and stem cell reprogramming
Complexity of non-coding RNA translation
New technologies and methods in RNA research
Function and regulatory mechanism of non-coding RNA in centromere and constitutive heterochromatin formation
Function and regulatory mechanism of non-coding RNA in early mouse embryonic development

Publications

Readon: a novel algorithm to identify read-through transcripts with long-read sequencing data, Chen, S., Wang, H., Zhang, D., Chen, R., and Luo, J., 2024
Genetic variations associated with long noncoding RNAs, Luo, J., and Chen, R., 2020
LRIK interacts with the Ku70-Ku80 heterodimer enhancing its ability to sense DSBs during NHEJ repair, Wang, D., Zhou, Z., Wu, E., Ouyang, C., Wei, G., Wang, Y., He, D., Cui, Y., Zhang, D., Chen, X., Reed, S., Luo, J., and Chen, R., 2020
The long noncoding RNA HAND2-AS1 promotes self-renewal of liver cancer stem cells and serves as a potential target for cancer therapy, Wang, Y., Zhu, P., Luo, J., Wang, J., Liu, Z., Wu, W., Du, Y., He, L., Wu, J., He, L., Ye, B., Wang, D., Chen, R., Tian, Y., and Fan, Z., 2019
Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing, Zhang, Z., Jones, A.E., Wu, W., Kim, J., Kang, Y., Bi, X., Gu, Y., Popov, I.K., Renfrow, M.B., Vassylyeva, M.N., Vassylyev, D.G., Giles, K.E., Chen, D., Kumar, A., Fan, Y., Tong, Y., Liu, C.F., An, W., Chang, C., Luo, J., Chow, L.T., and Wang, H., 2017
Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory, Cui, X., Zhang, R., Yang, Y., Wu, E., Tang, Y., Zhao, Z., Li, C., Yang, L., Teng, X., Ye, Y., Cui, Y., Xu, F., Su, Z., Wang, D., Zhang, D., Yang, Y., Sun, J., Luo, J., Zhang, S., Chen, R., and Xi, J.J., 2022
Modulated Ultrasmall γ-Fe2O3 Nanocrystal Assembles for Switchable Magnetic Resonance Imaging and Photothermal-Ferroptotic-Chemical Synergistic Cancer Therapy, Yang, B., Zhang, Y., Sun, L., Wang, J., Zhao, Z., Huang, Z., Mao, W., Xue, R., Chen, R., Luo, J., Wang, T., Jiang, J., and Qin, Y., 2022
Discovery of Plasma Membrane-Associated RNAs through APEX-seq, Wu, E., Guo, X., Teng, X., Zhang, R., Li, F., Cui, Y., Zhang, D., Liu, Q., Luo, J., Wang, J., and Chen, R., 2021
Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs, Zhang, Q., Wu, E., Tang, Y., Cai, T., Zhang, L., Wang, J., Hao, Y., Zhang, B., Zhou, Y., Guo, X., Luo, J., Chen, R., and Yang, F., 2021
LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition, Li, J., Hao, Y., Mao, W., Xue, X., Xu, P., Liu, L., Yuan, J., Zhang, D., Li, N., Chen, H., Zhao, L., Sun, Z., Luo, J., Chen, R., and Zhao, R., 2019
Genetic alterations in juvenile cervical clear cell adenocarcinoma unrelated to human papillomavirus, Su, Y., Zhang, Y., Zhou, M., Zhang, R., Chen, S., Zhang, L., Wang, H., Zhang, D., Zhang, T., Li, X., Zhang, C., Wang, B., Yuan, S., Zhang, M., Zhou, Y., Cao, L., Zhang, M., and Luo, J., 2023
LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation, Liu, L., Liu, Z., Liu, Q., Wu, W., Lin, P., Liu, X., Zhang, Y., Wang, D., Prager, B.C., Gimple, R.C., Yu, J., Zhao, W., Wu, Q., Zhang, W., Wu, E., Chen, X., Luo, J., Rich, J.N., Xie, Q., Jiang, T., and Chen, R., 2023
Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a, Yan, X., Zhang, D., Wu, W., Wu, S., Qian, J., Hao, Y., Yan, F., Zhu, P., Wu, J., Huang, G., Huang, Y., Luo, J., Liu, X., Liu, B., Chen, X., Du, Y., Chen, R., and Fan, Z., 2017
The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling, Wang, Y., He, L., Du, Y., Zhu, P., Huang, G., Luo, J., Yan, X., Ye, B., Li, C., Xia, P., Zhang, G., Tian, Y., Chen, R., and Fan, Z., 2015
LncRNA-encoded microproteins: A new form of cargo in cell culture-derived and circulating extracellular vesicles, Cai, T., Zhang, Q., Wu, B., Wang, J., Li, N., Zhang, T., Wang, Z., Luo, J., Guo, X., Ding, X., Xie, Z., Niu, L., Ning, W., Fan, Z., Chen, X., Guo, X., Chen, R., Zhang, H., and Yang, F., 2021
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress, Zhang, Y.W., Wang, Z., Xie, W., Cai, Y., Xia, L., Easwaran, H., Luo, J., Yen, R.C., Li, Y., and Baylin, S.B., 2017
TGF-beta changes cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy, Zhang, N., Zhao, Z., Zhao, Y., Yang, L., Xue, Y., Feng, Y., Luo, J., Chen, R., Wei, W., and Qin, Y., 2023
Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene, Wan, L., Hu, P., Zhang, L., Wang, Z.X., Fleming, J., Ni, B., Luo, J., Guan, C.X., Bai, L., Tan, Y., Liu, H., Li, N., Xiao, T., Bai, H., Zhang, Y.A., Zhang, X.E., Wan, K., Bi, L., Ouyang, S., and Zhang, H., 2023
LncRNA HRCEG, regulated by HDAC1, inhibits cells proliferation and epithelial-mesenchymal-transition in gastric cancer, Wu, S., Wu, E., Wang, D., Niu, Y., Yue, H., Zhang, D., Luo, J., and Chen, R., 2020
Knockdown of long non-coding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis, Zhang, C., Wu, W., Zhu, H., Yu, X., Zhang, Y., Ye, X., Cheng, H., Ma, R., Cui, H., Luo, J., Guan, J., and Chang, X., 2018
Long noncoding RNA LINC01186, regulated by TGF-beta/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer, Hao, Y., Yang, X., Zhang, D., Luo, J., and Chen, R., 2017
LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway, Liu, L., Yue, H., Liu, Q., Yuan, J., Li, J., Wei, G., Chen, X., Lu, Y., Guo, M., Luo, J., and Chen, R., 2016
Expression profiling and functional prediction of long noncoding RNAs in nasopharyngeal nonkeratinizing carcinoma, Zhang, B., Wang, D., Wu, J., Tang, J., Chen, W., Chen, X., Zhang, D., Deng, Y., Guo, M., Wang, Y., Luo, J., and Chen, R., 2016
Identification of Tension Sensing Motif of Histone H3 in Saccharomyces cerevisiae and Its Regulation by Histone Modifying Enzymes, Luo, J., Deng, X., Buehl, C., Xu, X., and Kuo, M.H., 2016
Histone h3 exerts a key function in mitotic checkpoint control, Luo, J., Xu, X., Hall, H., Hyland, E.M., Boeke, J.D., Hazbun, T., and Kuo, M.H., 2010
Episo: quantitative estimation of RNA 5-methylcytosine at iso

Long Non-Coding Rna Tumorigenesis Stem Cell Reprogramming Rna Translation Rna Research Centromere Heterochromatin Embryonic Development Regulatory Mechanism Rna Function

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