Professor | Weijun Pan | Asia Growth Partners

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Name	Weijun Pan
Contact Information	weijunpan@sibs.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Weijun Pan

Contact Information

weijunpan@sibs.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1999-09--2005-01 PhD in Science: Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences 1995-09--1999-07 Bachelor of Science: Department of Biochemistry, East China University of Science and Technology
Work Experience	2020-04 to present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher 2011-12 to 2020-04 - Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Researcher 2009-04 to 2012-04 - National Institute of Child Health and Human Development, National Institutes of Health, USA - Postdoctoral Fellow 2005-02 to 2009-03 - Department of Pharmacology, Yale University School of Medicine - Postdoctoral Fellow
Awards	Huaxia Medical Science and Technology Award First Prize (2022): National Level Outstanding Mentor Award, Chinese Academy of Sciences (2020): Ministerial Level First Zeiss-Zebrafish Science Research 'Outstanding Young Scholar Award' by the Chinese Animal Association (2015): National Level Second Batch of 'Youth****' by the Central Organization Department (2012): National Level FARE Research Excellence Award, National Institutes of Health (2010): National Level 10th East Asia Biomedical Research Forum Young Investigator Award (2003): National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1999-09--2005-01 PhD in Science: Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
1995-09--1999-07 Bachelor of Science: Department of Biochemistry, East China University of Science and Technology

Work Experience

2020-04 to present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
2011-12 to 2020-04 - Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Researcher
2009-04 to 2012-04 - National Institute of Child Health and Human Development, National Institutes of Health, USA - Postdoctoral Fellow
2005-02 to 2009-03 - Department of Pharmacology, Yale University School of Medicine - Postdoctoral Fellow

Awards

Huaxia Medical Science and Technology Award First Prize (2022): National Level
Outstanding Mentor Award, Chinese Academy of Sciences (2020): Ministerial Level
First Zeiss-Zebrafish Science Research 'Outstanding Young Scholar Award' by the Chinese Animal Association (2015): National Level
Second Batch of 'Youth****' by the Central Organization Department (2012): National Level
FARE Research Excellence Award, National Institutes of Health (2010): National Level
10th East Asia Biomedical Research Forum Young Investigator Award (2003): National Level

Areas of Focus	Hematopoietic Stem Cell Homing and Proliferation Microenvironment Research
Publications	Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry, 12th Author, 2022 Mutation of Gemin5 Causes Defective Hematopoietic Stem/Progenitor Cells Proliferation in Zebrafish Embryonic Hematopoiesis, 11th Author, 2021 Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B, 20th Author, 2020 The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, 11th Author, 2020 Leukocyte cytoskeleton polarization is initiated by plasma membrane curvature from cell attachment, 10th Author, 2019 Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition, 11th Author, 2019 VCAM-1~+ macrophages guide the homing of HSPCs to a vascular niche, 5th Author, 2019 VCAM-1 + macrophages guide the homing of HSPCs to a vascular niche, 11th Author, 2018 Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity, 11th Author, 2017 TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis, 19th Author, 2015 Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction, 11th Author, 2015 Activated N-Ras signaling regulates arterial-venous specification in zebrafish, 2nd Author, 2013 CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis, 1st Author, 2012 GSK3: a multifaceted kinase in Wnt signaling, 2nd Author, 2010 Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity, 8th Author, 2009 beta-catenin relieves I-mfa-mediated suppression of LEF1 in mammalian cells, 1st Author, 2006 beta-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells, 1st Author, 2005 CELL RES, Not mentioned, 2004 GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs, Not mentioned, 2003 Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway, Not mentioned, 2001 Clathrin and AP2 are required for PtdIns(4,5)P 2 -mediated formation of LRP6 signalosomes, 2nd Author Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl *, 3rd Author Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation, 1st Author

Areas of Focus

Hematopoietic Stem Cell Homing and Proliferation Microenvironment Research

Publications

Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry, 12th Author, 2022
Mutation of Gemin5 Causes Defective Hematopoietic Stem/Progenitor Cells Proliferation in Zebrafish Embryonic Hematopoiesis, 11th Author, 2021
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B, 20th Author, 2020
The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, 11th Author, 2020
Leukocyte cytoskeleton polarization is initiated by plasma membrane curvature from cell attachment, 10th Author, 2019
Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition, 11th Author, 2019
VCAM-1~+ macrophages guide the homing of HSPCs to a vascular niche, 5th Author, 2019
VCAM-1 + macrophages guide the homing of HSPCs to a vascular niche, 11th Author, 2018
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity, 11th Author, 2017
TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis, 19th Author, 2015
Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction, 11th Author, 2015
Activated N-Ras signaling regulates arterial-venous specification in zebrafish, 2nd Author, 2013
CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis, 1st Author, 2012
GSK3: a multifaceted kinase in Wnt signaling, 2nd Author, 2010
Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity, 8th Author, 2009
beta-catenin relieves I-mfa-mediated suppression of LEF1 in mammalian cells, 1st Author, 2006
beta-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells, 1st Author, 2005
CELL RES, Not mentioned, 2004
GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs, Not mentioned, 2003
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway, Not mentioned, 2001
Clathrin and AP2 are required for PtdIns(4,5)P 2 -mediated formation of LRP6 signalosomes, 2nd Author
Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl *, 3rd Author
Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation, 1st Author

Hematopoietic Stem Cells Homing Proliferation Microenvironment Research Cell Biology Pathology Physiology Stem Cell Niche Zebrafish

Xiling Du - Tongji University

Jun Zhang - Shanghai Normal University

Caiqin Hao - Shanghai Normal University

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