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Weijun Pan
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Hematopoietic Stem Cells
Homing
Proliferation
Microenvironment
Research
Cell Biology
Pathology
Physiology
Stem Cell Niche
Zebrafish
Areas of Focus
- Hematopoietic Stem Cell Homing and Proliferation Microenvironment Research
Work Experience
- 2020-04 to present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
- 2011-12 to 2020-04 - Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Researcher
- 2009-04 to 2012-04 - National Institute of Child Health and Human Development, National Institutes of Health, USA - Postdoctoral Fellow
- 2005-02 to 2009-03 - Department of Pharmacology, Yale University School of Medicine - Postdoctoral Fellow
Academic Background & Achievements
- 1999-09--2005-01 PhD in Science: Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
- 1995-09--1999-07 Bachelor of Science: Department of Biochemistry, East China University of Science and Technology
Publications
- Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry, 12th Author, 2022
- Mutation of Gemin5 Causes Defective Hematopoietic Stem/Progenitor Cells Proliferation in Zebrafish Embryonic Hematopoiesis, 11th Author, 2021
- Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B, 20th Author, 2020
- The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, 11th Author, 2020
- Leukocyte cytoskeleton polarization is initiated by plasma membrane curvature from cell attachment, 10th Author, 2019
- Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition, 11th Author, 2019
- VCAM-1~+ macrophages guide the homing of HSPCs to a vascular niche, 5th Author, 2019
- VCAM-1 + macrophages guide the homing of HSPCs to a vascular niche, 11th Author, 2018
- Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity, 11th Author, 2017
- TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis, 19th Author, 2015
- Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction, 11th Author, 2015
- Activated N-Ras signaling regulates arterial-venous specification in zebrafish, 2nd Author, 2013
- CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis, 1st Author, 2012
- GSK3: a multifaceted kinase in Wnt signaling, 2nd Author, 2010
- Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity, 8th Author, 2009
- beta-catenin relieves I-mfa-mediated suppression of LEF1 in mammalian cells, 1st Author, 2006
- beta-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells, 1st Author, 2005
- CELL RES, Not mentioned, 2004
- GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs, Not mentioned, 2003
- Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway, Not mentioned, 2001
- Clathrin and AP2 are required for PtdIns(4,5)P 2 -mediated formation of LRP6 signalosomes, 2nd Author
- Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl *, 3rd Author
- Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation, 1st Author
Awards
- Huaxia Medical Science and Technology Award First Prize (2022): National Level
- Outstanding Mentor Award, Chinese Academy of Sciences (2020): Ministerial Level
- First Zeiss-Zebrafish Science Research 'Outstanding Young Scholar Award' by the Chinese Animal Association (2015): National Level
- Second Batch of 'Youth****' by the Central Organization Department (2012): National Level
- FARE Research Excellence Award, National Institutes of Health (2010): National Level
- 10th East Asia Biomedical Research Forum Young Investigator Award (2003): National Level
