Professor | Zihe Rao | Asia Growth Partners

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Name	Zihe Rao
Contact Information	raozh@nankai.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Zihe Rao

Contact Information

raozh@nankai.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1985-07--1989-07 PhD: University of Melbourne 1979-07--1982-07 Master's: Institute of Biophysics, Chinese Academy of Sciences 1973-06--1977-06 Bachelor's: University of Science and Technology of China
Work Experience	2006-05~2011-01 - Nankai University - President 2003-03~2007-03 - Institute of Biophysics, Chinese Academy of Sciences - Director 1996-07~Present - Tsinghua University - Professor 1992-07~1996-07 - University of Oxford - Senior Researcher 1989-07~1992-07 - University of Oxford - Postdoctoral Researcher 1982-07~1985-07 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher 1977-07~1979-07 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
Awards	Outstanding Academic Leader Award (2009): National Level Tan Jiazhen Life Science Achievement Award (2008): National Level Trieste Science Prize (2006): International Ho Leung Ho Lee Prize (2003): National Level Changjiang Scholar Distinguished Professor (2000): Ministerial Level Qiu Shi Outstanding Young Scholar Award (1999): National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1985-07--1989-07 PhD: University of Melbourne
1979-07--1982-07 Master's: Institute of Biophysics, Chinese Academy of Sciences
1973-06--1977-06 Bachelor's: University of Science and Technology of China

Work Experience

2006-05~2011-01 - Nankai University - President
2003-03~2007-03 - Institute of Biophysics, Chinese Academy of Sciences - Director
1996-07~Present - Tsinghua University - Professor
1992-07~1996-07 - University of Oxford - Senior Researcher
1989-07~1992-07 - University of Oxford - Postdoctoral Researcher
1982-07~1985-07 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
1977-07~1979-07 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher

Awards

Outstanding Academic Leader Award (2009): National Level
Tan Jiazhen Life Science Achievement Award (2008): National Level
Trieste Science Prize (2006): International
Ho Leung Ho Lee Prize (2003): National Level
Changjiang Scholar Distinguished Professor (2000): Ministerial Level
Qiu Shi Outstanding Young Scholar Award (1999): National Level

Areas of Focus	Three-dimensional structure of proteins and viruses related to human infection or important physiological functions, and the development of innovative drug therapies Protein structure, function, and innovative drugs
Publications	Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein, Jingyuan Cong, Xiaoying Feng, Huiling Kang, Wangjun Fu, Lei Wang, Chenlong Wang, Xuemei Li, Yutao Chen, Zihe Rao, 2023 Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332, Zhao, Yao, Fang, Chao, Zhang, Qi, Zhang, Ruxue, Zhao, Xiangbo, Duan, Yinkai, Wang, Haofeng, Zhu, Yan, Feng, Lu, Zhao, Jinyi, Shao, Maolin, Yang, Xiuna, Zhang, Leike, Peng, Chao, Yang, Kailin, Ma, Dawei, Rao, Zihe, Yang, Haitao, 2022 Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses, Wang, Chenlong, Kang, Huiling, Tan, Ming, Cong, Jingyuan, Su, Dan, Li, Xuemei, Chen, Yutao, 2022 Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin, Tang, Yanting, Mu, An, Zhang, Yuying, Zhou, Shan, Wang, Weiwei, Lai, Yuezheng, Zhou, Xiaoting, Liu, Fengjiang, Yang, Xiuna, Gong, Hongri, Wang, Quan, Rao, Zihe, 2021 Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels, Weiwei Wang, Yan Gao, Yanting Tang, Xiaoting Zhou, Yuezheng Lai, Shan Zhou, Yuying Zhang, Xiuna Yang, Fengjiang Liu, Luke W Guddat, Quan Wang, Zihe Rao, Hongri Gong, 2021 Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein, Linhua Tai, Guoliang Zhu, Minnan Yang, Lei Cao, Xiaorui Xing, Guoliang Yin, Chun Chan, Chengfeng Qin, Zihe Rao, Xiangxi Wang, Fei Sun, Yun Zhu, 2021 Structural basis for recognition and regulation of arenavirus polymerase L by Z protein, Huiling Kang, Jingyuan Cong, Chenlong Wang, Wenxin Ji, Yuhui Xin, Ying Qian, Xuemei Li, Yutao Chen, Zihe Rao, 2021 Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster, Zhou, Xiaoting, Gao, Yan, Wang, Weiwei, Yang, Xiaolin, Yang, Xiuna, Liu, Fengjiang, Tang, Yanting, Lam, Sin Man, Shui, Guanghou, Yu, Lu, Tian, Changlin, Guddat, Luke W, Wang, Quan, Rao, Zihe, Gong, Hongri, 2021 Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates, Shan Zhou, Weiwei Wang, Xiaoting Zhou, Yuying Zhang, Yuezheng Lai, Yanting Tang, Jinxu Xu, Dongmei Li, Jianping Lin, Xiaolin Yang, Ting Ran, Hongming Chen, Luke W Guddat, Quan Wang, Yan Gao, Zihe Rao, Hongri Gong, David Drew, Volker Dtsch, 2021 Structural biology of SARS-CoV-2 and implications for therapeutic development, Yang, Haitao, Rao, Zihe, 2021 Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2, Zhu, Ling, Deng, YongQiang, Zhang, RongRong, Cui, Zhen, Sun, ChunYun, Fan, ChangFa, Xing, Xiaorui, Huang, Weijin, Chen, Qi, Zhang, NaNa, Ye, Qing, Cao, TianShu, Wang, Nan, Wang, Lei, Cao, Lei, Wang, Huiyu, Kong, Desheng, Ma, Juan, Luo, Chunxia, Zhang, Yanjing, Nie, Jianhui, Sun, Yao, Lv, Zhe, Shaw, Neil, Li, Qianqian, Li, XiaoFeng, Hu, Junjie, Xie, Liangzhi, Rao, Zihe, Wang, Youchun, Wang, Xiangxi, Qin, ChengFeng, 2021 Coupling of N7-methyltransferase and 3 '-5 ' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading, Yan, Liming, Yang, Yunxiang, Li, Mingyu, Zhang, Ying, Zheng, Litao, Ge, Ji, Huang, Yucen C, Liu, Zhenyu, Wang, Tao, Gao, Shan, Zhang, Ran, Huang, Yuanyun Y, Guddat, Luke W, Gao, Yan, Rao, Zihe, Lou, Zhiyong, 2021 Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex, Wu, Jiqin, Wang, Haofeng, Liu, Qiaojie, Li, Rui, Gao, Yan, Fang, Xiang, Zhong, Yao, Wang, Meihua, Wang, Quan, Rao, Zihe, Gong, Peng, 2021 Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes, Fu, Dan, Zhang, Guangshun, Wang, Yuhui, Zhang, Zheng, Hu, Hengrui, Shen, Shu, Wu, Jun, Li, Bo, Li, Xin, Fang, Yaohui, Liu, Jia, Wang, Qiao, Zhou, Yunjiao, Wang, Wei, Li, Yufeng, Lu, Zhonghua, Wang, Xiaoxiao, Nie, Cui, Tian, Yujie, Chen, Da, Wang, Yuan, Zhou, Xingdong, Wang, Qisheng, Yu, Feng, Zhang, Chen, Deng, Changjing, Zhou, Liang, Guan, Guangkuo, Shao, Na, Lou, Zhiyong, Deng, Fei, Zhang, Hongkai, Chen, Xinwen, Wang, Manli, Liu, Louis, Rao, Zihe, Guo, Yu, 2021 Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Wang, Nan, Chen, Wenyuan, Zhu, Ling, Zhu, Dongjie, Feng, Rui, Wang, Jialing, Zhu, Bin, Zhang, Xinzheng, Chen, Xiaoqing, Liu, Xianjie, Yan, Runbin, Ni, Dongyao, Zhou, Grace Guoying, Liu, Hongrong, Rao, Zihe, Wang, Xiangxi, 2020 Structure of the RNA-dependent RNA polymerase from COVID-19 virus, Gao, Yan, Yan, Liming, Huang, Yucen, Liu, Fengjiang, Zhao, Yao, Cao, Lin, Wang, Tao, Sun, Qianqian, Ming, Zhenhua, Zhang, Lianqi, Ge, Ji, Zheng, Litao, Zhang, Ying, Wang, Haofeng, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Hua, Tian, Zhang, Bing, Yang, Xiuna, Li, Jun, Yang, Haitao, Liu, Zhijie, Xu, Wenqing, Guddat, Luke W, Wang, Quan, Lou, Zhiyong, Rao, Zihe, 2020 Host-mediated ubiquitination of a mycobacterial protein suppresses immunity, Wang, Lin, Wu, Juehui, Li, Jun, Yang, Hua, Tang, Tianqi, Liang, Haijiao, Zuo, Mianyong, Wang, Jie, Liu, Haipeng, Liu, Feng, Chen, Jianxia, Liu, Zhonghua, Wang, Yang, Peng, Cheng, Wu, Xiangyang, Zheng, Ruijuan, Huang, Xiaochen, Ran, Yajun, Rao, Zihe, Ge, Baoxue, 2020 Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B, Kang Wang, Binyang Zheng, Li Zhang, Lunbiao Cui, Xuan Su, Qian Zhang, Zhenxi Guo, Yu Guo, Wei Zhang, Ling Zhu, Fengcai Zhu, Zihe Rao, Xiangxi Wang, 2020 Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five beta-Lactam Antibiotics Reveal Mechanism of Inactivation, Lu, Zuokun, Wang, Han, Zhang, Aili, Liu, Xiang, Zhou, Weihong, Yang, Cheng, Guddat, Luke, Yang, Haitao, Schofield, Christopher J, Rao, Zihe, 2020 Structures of fungal and plant acetohydroxyacid synthases, Lonhienne, Thierry, Low, Yu Shang,

Areas of Focus

Three-dimensional structure of proteins and viruses related to human infection or important physiological functions, and the development of innovative drug therapies
Protein structure, function, and innovative drugs

Publications

Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein, Jingyuan Cong, Xiaoying Feng, Huiling Kang, Wangjun Fu, Lei Wang, Chenlong Wang, Xuemei Li, Yutao Chen, Zihe Rao, 2023
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332, Zhao, Yao, Fang, Chao, Zhang, Qi, Zhang, Ruxue, Zhao, Xiangbo, Duan, Yinkai, Wang, Haofeng, Zhu, Yan, Feng, Lu, Zhao, Jinyi, Shao, Maolin, Yang, Xiuna, Zhang, Leike, Peng, Chao, Yang, Kailin, Ma, Dawei, Rao, Zihe, Yang, Haitao, 2022
Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses, Wang, Chenlong, Kang, Huiling, Tan, Ming, Cong, Jingyuan, Su, Dan, Li, Xuemei, Chen, Yutao, 2022
Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin, Tang, Yanting, Mu, An, Zhang, Yuying, Zhou, Shan, Wang, Weiwei, Lai, Yuezheng, Zhou, Xiaoting, Liu, Fengjiang, Yang, Xiuna, Gong, Hongri, Wang, Quan, Rao, Zihe, 2021
Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels, Weiwei Wang, Yan Gao, Yanting Tang, Xiaoting Zhou, Yuezheng Lai, Shan Zhou, Yuying Zhang, Xiuna Yang, Fengjiang Liu, Luke W Guddat, Quan Wang, Zihe Rao, Hongri Gong, 2021
Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein, Linhua Tai, Guoliang Zhu, Minnan Yang, Lei Cao, Xiaorui Xing, Guoliang Yin, Chun Chan, Chengfeng Qin, Zihe Rao, Xiangxi Wang, Fei Sun, Yun Zhu, 2021
Structural basis for recognition and regulation of arenavirus polymerase L by Z protein, Huiling Kang, Jingyuan Cong, Chenlong Wang, Wenxin Ji, Yuhui Xin, Ying Qian, Xuemei Li, Yutao Chen, Zihe Rao, 2021
Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster, Zhou, Xiaoting, Gao, Yan, Wang, Weiwei, Yang, Xiaolin, Yang, Xiuna, Liu, Fengjiang, Tang, Yanting, Lam, Sin Man, Shui, Guanghou, Yu, Lu, Tian, Changlin, Guddat, Luke W, Wang, Quan, Rao, Zihe, Gong, Hongri, 2021
Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates, Shan Zhou, Weiwei Wang, Xiaoting Zhou, Yuying Zhang, Yuezheng Lai, Yanting Tang, Jinxu Xu, Dongmei Li, Jianping Lin, Xiaolin Yang, Ting Ran, Hongming Chen, Luke W Guddat, Quan Wang, Yan Gao, Zihe Rao, Hongri Gong, David Drew, Volker Dtsch, 2021
Structural biology of SARS-CoV-2 and implications for therapeutic development, Yang, Haitao, Rao, Zihe, 2021
Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2, Zhu, Ling, Deng, YongQiang, Zhang, RongRong, Cui, Zhen, Sun, ChunYun, Fan, ChangFa, Xing, Xiaorui, Huang, Weijin, Chen, Qi, Zhang, NaNa, Ye, Qing, Cao, TianShu, Wang, Nan, Wang, Lei, Cao, Lei, Wang, Huiyu, Kong, Desheng, Ma, Juan, Luo, Chunxia, Zhang, Yanjing, Nie, Jianhui, Sun, Yao, Lv, Zhe, Shaw, Neil, Li, Qianqian, Li, XiaoFeng, Hu, Junjie, Xie, Liangzhi, Rao, Zihe, Wang, Youchun, Wang, Xiangxi, Qin, ChengFeng, 2021
Coupling of N7-methyltransferase and 3 '-5 ' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading, Yan, Liming, Yang, Yunxiang, Li, Mingyu, Zhang, Ying, Zheng, Litao, Ge, Ji, Huang, Yucen C, Liu, Zhenyu, Wang, Tao, Gao, Shan, Zhang, Ran, Huang, Yuanyun Y, Guddat, Luke W, Gao, Yan, Rao, Zihe, Lou, Zhiyong, 2021
Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex, Wu, Jiqin, Wang, Haofeng, Liu, Qiaojie, Li, Rui, Gao, Yan, Fang, Xiang, Zhong, Yao, Wang, Meihua, Wang, Quan, Rao, Zihe, Gong, Peng, 2021
Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes, Fu, Dan, Zhang, Guangshun, Wang, Yuhui, Zhang, Zheng, Hu, Hengrui, Shen, Shu, Wu, Jun, Li, Bo, Li, Xin, Fang, Yaohui, Liu, Jia, Wang, Qiao, Zhou, Yunjiao, Wang, Wei, Li, Yufeng, Lu, Zhonghua, Wang, Xiaoxiao, Nie, Cui, Tian, Yujie, Chen, Da, Wang, Yuan, Zhou, Xingdong, Wang, Qisheng, Yu, Feng, Zhang, Chen, Deng, Changjing, Zhou, Liang, Guan, Guangkuo, Shao, Na, Lou, Zhiyong, Deng, Fei, Zhang, Hongkai, Chen, Xinwen, Wang, Manli, Liu, Louis, Rao, Zihe, Guo, Yu, 2021
Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Wang, Nan, Chen, Wenyuan, Zhu, Ling, Zhu, Dongjie, Feng, Rui, Wang, Jialing, Zhu, Bin, Zhang, Xinzheng, Chen, Xiaoqing, Liu, Xianjie, Yan, Runbin, Ni, Dongyao, Zhou, Grace Guoying, Liu, Hongrong, Rao, Zihe, Wang, Xiangxi, 2020
Structure of the RNA-dependent RNA polymerase from COVID-19 virus, Gao, Yan, Yan, Liming, Huang, Yucen, Liu, Fengjiang, Zhao, Yao, Cao, Lin, Wang, Tao, Sun, Qianqian, Ming, Zhenhua, Zhang, Lianqi, Ge, Ji, Zheng, Litao, Zhang, Ying, Wang, Haofeng, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Hua, Tian, Zhang, Bing, Yang, Xiuna, Li, Jun, Yang, Haitao, Liu, Zhijie, Xu, Wenqing, Guddat, Luke W, Wang, Quan, Lou, Zhiyong, Rao, Zihe, 2020
Host-mediated ubiquitination of a mycobacterial protein suppresses immunity, Wang, Lin, Wu, Juehui, Li, Jun, Yang, Hua, Tang, Tianqi, Liang, Haijiao, Zuo, Mianyong, Wang, Jie, Liu, Haipeng, Liu, Feng, Chen, Jianxia, Liu, Zhonghua, Wang, Yang, Peng, Cheng, Wu, Xiangyang, Zheng, Ruijuan, Huang, Xiaochen, Ran, Yajun, Rao, Zihe, Ge, Baoxue, 2020
Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B, Kang Wang, Binyang Zheng, Li Zhang, Lunbiao Cui, Xuan Su, Qian Zhang, Zhenxi Guo, Yu Guo, Wei Zhang, Ling Zhu, Fengcai Zhu, Zihe Rao, Xiangxi Wang, 2020
Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five beta-Lactam Antibiotics Reveal Mechanism of Inactivation, Lu, Zuokun, Wang, Han, Zhang, Aili, Liu, Xiang, Zhou, Weihong, Yang, Cheng, Guddat, Luke, Yang, Haitao, Schofield, Christopher J, Rao, Zihe, 2020
Structures of fungal and plant acetohydroxyacid synthases, Lonhienne, Thierry, Low, Yu Shang,

Protein Structure Virus Structure Human Infection Physiological Functions Three-Dimensional Structure Innovative Drug Therapies Biochemistry Molecular Biology Drug Development Structural Biology

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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