Professor | Qiang Sun | Asia Growth Partners

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Name	Qiang Sun
Contact Information	qsun@ion.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Qiang Sun

Contact Information

qsun@ion.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2002-09--2005-06 PhD: Shanghai Institute of Pharmaceutical Industry 1996-09--1999-06 Master's: Yangzhou University College of Veterinary Medicine 1992-09--1996-06 Bachelor's: Inner Mongolia Zhelimu Animal Husbandry College
Work Experience	2018-02~Present - Institute of Neuroscience, Chinese Academy of Sciences - Researcher 2009-06~2018-01 - Institute of Neuroscience, Chinese Academy of Sciences - Senior Engineer 2005-09~2009-05 - East China Normal University - Associate Researcher 2002-09~2005-06 - Shanghai Institute of Pharmaceutical Industry - PhD 1999-07~2005-08 - Yangzhou University College of Veterinary Medicine - Lecturer
Awards	Shanghai Science and Technology Award (2022): First Prize WuXi AppTec Life Chemistry Research Award (2020): First Prize Tan Jiazhen Life Science Innovation Award (2018): First Prize Top Ten Scientific Advances in China (2018): First Prize Young and Middle-aged Leading Talents in Science and Technology Innovation by Ministry of Science and Technology (2018): First Prize Top Ten Scientific Advances in China (2016): First Prize Top Ten Advances in Life Sciences in China (2016): First Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2002-09--2005-06 PhD: Shanghai Institute of Pharmaceutical Industry
1996-09--1999-06 Master's: Yangzhou University College of Veterinary Medicine
1992-09--1996-06 Bachelor's: Inner Mongolia Zhelimu Animal Husbandry College

Work Experience

2018-02~Present - Institute of Neuroscience, Chinese Academy of Sciences - Researcher
2009-06~2018-01 - Institute of Neuroscience, Chinese Academy of Sciences - Senior Engineer
2005-09~2009-05 - East China Normal University - Associate Researcher
2002-09~2005-06 - Shanghai Institute of Pharmaceutical Industry - PhD
1999-07~2005-08 - Yangzhou University College of Veterinary Medicine - Lecturer

Awards

Shanghai Science and Technology Award (2022): First Prize
WuXi AppTec Life Chemistry Research Award (2020): First Prize
Tan Jiazhen Life Science Innovation Award (2018): First Prize
Top Ten Scientific Advances in China (2018): First Prize
Young and Middle-aged Leading Talents in Science and Technology Innovation by Ministry of Science and Technology (2018): First Prize
Top Ten Scientific Advances in China (2016): First Prize
Top Ten Advances in Life Sciences in China (2016): First Prize

Areas of Focus	Non-human primate model construction and related technologies Reproductive endocrine regulation and related animal model development Somatic cell reprogramming in non-human primates Transgenic and gene editing technologies in mammals
Publications	Disturbed rhythmicity of intestinal hydrogen peroxide alters gut microbial oscillations in BMAL1-deficient monkeys, 5th Author, 2023 Cynomolgus monkey embryo model captures gastrulation and early pregnancy, 23rd Author, 2023 Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy, 11th Author, 2022 Epigenetic manipulation to improve mouse SCNT embryonic development, 11th Author, 2022 Characterization of gut microbial alterations in cynomolgus macaques during growth and maturation, 11th Author, 2022 Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty, 11th Author, 2021 Mitochondrial replacement in macaque monkey offspring by first polar body transfer, 13th Author, 2021 Modeling a cataract disorder in mice with prime editing, 11th Author, 2021 Mitochondrial replacement in macaque monkey offspring by first polar body transfer, 11th Author, 2021 Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin, 7th Author, 2020 Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species, 11th Author, 2020 Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice, 11th Author, 2020 Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis), 11th Author, 2020 A pannexin 1 channelopathy causes human oocyte death, 18th Author, 2019 Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer, 16th Author, 2019 BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders, 14th Author, 2019 Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, 6th Author, 2019 Age-related nomograms of serum anti-Mullerian hormone levels in female monkeys: Comparison of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys, 11th Author, 2018 Serum anti-Mullerian hormone predicts ovarian response in (Macaca fascicularis) monkeys, 11th Author, 2018 Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer, 11th Author, 2018 Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats, 11th Author, 2018 Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing, 11th Author, 2018 Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models, 13th Author, 2018 Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing, 11th Author, 2018 Homology-mediated end joining-based targeted integration using crispr/cas9, 11th Author, 2017 One-step generation of complete gene knockout mice and monkeys by crispr/cas9-mediated gene editing with multiple sgrnas, 11th Author, 2017 Generation of macaques with sperm derived from juvenile monkey testicular xenografts, 11th Author, 2016 Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2, 11th Author, 2016 Generation of a monkey with MECP2 mutations by TALEN-based gene targeting, 14th Author, 2014 Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes, 17th Author, 2013 Efficient reproduction of cynomolgus monkey using pronuclear embryo transfer technique, 11th Author, 2008

Areas of Focus

Non-human primate model construction and related technologies
Reproductive endocrine regulation and related animal model development
Somatic cell reprogramming in non-human primates
Transgenic and gene editing technologies in mammals

Publications

Disturbed rhythmicity of intestinal hydrogen peroxide alters gut microbial oscillations in BMAL1-deficient monkeys, 5th Author, 2023
Cynomolgus monkey embryo model captures gastrulation and early pregnancy, 23rd Author, 2023
Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy, 11th Author, 2022
Epigenetic manipulation to improve mouse SCNT embryonic development, 11th Author, 2022
Characterization of gut microbial alterations in cynomolgus macaques during growth and maturation, 11th Author, 2022
Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty, 11th Author, 2021
Mitochondrial replacement in macaque monkey offspring by first polar body transfer, 13th Author, 2021
Modeling a cataract disorder in mice with prime editing, 11th Author, 2021
Mitochondrial replacement in macaque monkey offspring by first polar body transfer, 11th Author, 2021
Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin, 7th Author, 2020
Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species, 11th Author, 2020
Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice, 11th Author, 2020
Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis), 11th Author, 2020
A pannexin 1 channelopathy causes human oocyte death, 18th Author, 2019
Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer, 16th Author, 2019
BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders, 14th Author, 2019
Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, 6th Author, 2019
Age-related nomograms of serum anti-Mullerian hormone levels in female monkeys: Comparison of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys, 11th Author, 2018
Serum anti-Mullerian hormone predicts ovarian response in (Macaca fascicularis) monkeys, 11th Author, 2018
Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer, 11th Author, 2018
Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats, 11th Author, 2018
Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing, 11th Author, 2018
Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models, 13th Author, 2018
Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing, 11th Author, 2018
Homology-mediated end joining-based targeted integration using crispr/cas9, 11th Author, 2017
One-step generation of complete gene knockout mice and monkeys by crispr/cas9-mediated gene editing with multiple sgrnas, 11th Author, 2017
Generation of macaques with sperm derived from juvenile monkey testicular xenografts, 11th Author, 2016
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2, 11th Author, 2016
Generation of a monkey with MECP2 mutations by TALEN-based gene targeting, 14th Author, 2014
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes, 17th Author, 2013
Efficient reproduction of cynomolgus monkey using pronuclear embryo transfer technique, 11th Author, 2008

Non-Human Primate Model Construction Reproductive Endocrine Animal Model Somatic Cell Reprogramming Transgenic Gene Editing Mammals Neuroscience Biotechnology

Jun Zheng - China Medical University

Zhang Hui - Shanghai Normal University

Chong Wang - Shanghai Normal University

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