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Song Xiangfei
Life Science
University of Chinese Academy of Sciences
Shandong
Language: Chinese, English
Protein Structure
Protein Dynamics
Enzyme Catalysis
Mechanism Analysis
Rational Design
Biochemistry
Molecular Biology
Catalytic Activity
Enzyme Stability
Protein Engineering
Areas of Focus
- Protein structure and dynamics
- Enzyme catalytic mechanism analysis and rational design
Work Experience
- 2023-05 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Deputy Head of Protein Design Research Group
- 2018-12 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Associate Researcher
- 2013-12 to 2018-12 - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Assistant Researcher
- 2011-03 to 2013-12 - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Research Intern
Academic Background & Achievements
- 2017-09 to 2020-12 PhD: University of Chinese Academy of Sciences
- 2007-09 to 2010-06 Master's: Nanjing Normal University
- 2003-09 to 2007-06 Bachelor's: Hunan University of Arts and Science
Publications
- Improving the Enzymatic Activity and Stability of a Lytic Polysaccharide Monooxygenase, Second Author, 2023
- Intracellular environment can change protein conformational dynamics in cells through weak interactions, Second Author, 2023
- Quantifying Protein Electrostatic Interactions in Cells by Nuclear Magnetic Resonance Spectroscopy, First Author, 2021
- Osmolytes Can Destabilize Proteins in Cells by Modulating Electrostatics and Quinary Interactions, First Author, 2021
- Characterization of Residue Specific Protein Folding and Unfolding Dynamics in Cells, First Author, 2019
- Entropy drives the formation of salt bridges in the protein GB3, Fourth Author, 2017
- Corrigendum to ‘A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis’ Enzyme Microb. Technol. 87–88 (2016) 9–16, First Author, 2016
- Cellulose Chain Binding Free Energy Drives the Processive Move of Cellulases on the Cellulose Surface, Third Author, 2016
- A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis, First Author, 2016
- Improving the activity of Trichoderma reesei cel7B through stabilizing the transition state, Second Author, 2016
- Integration of bacterial expansin-like proteins into cellulosome promotes the cellulose degradation, Third Author, 2016
- A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis (vol 87, pg 9, 2016), First Author, 2016
- Characterization of the Dielectric Constant in the Trichoderma reesei Cel7B Active Site, First Author, 2015
- Improving Trichoderma reesei Cel7B Thermostability by Targeting the Weak Spots, Third Author, 2014
- Engineering a More Thermostable Blue Light Photo Receptor Bacillus subtilis YtvA LOV Domain by a Computer Aided Rational Design Method, Corresponding Author, 2013
- Efficiency and Stability Enhancement of Cis-epoxysuccinic Acid Hydrolase by Fusion with a Carbohydrate Binding Module and Immobilization onto Cellulose, Third Author, 2012
- Comparison of Three Thermostable beta-Glucosidases for Application in the Hydrolysis of Soybean Isoflavone Glycosides, First Author, 2011
- Overexpression of beta-glucosidase from Thermotoga maritima for the production of highly purified aglycone isoflavones from soy flour, Second Author, 2009
- Over-expression of xylanolytic alpha-glucuronidase from Thermotoga maritima in the pHsh system of Escherichia coli for the production of xylobiose from xylan, Third Author, 2008
