Professor | Song Xiangfei | Asia Growth Partners

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Name	Song Xiangfei
Contact Information	songxf@qibebt.ac.cn
Language ability	Chinese, English
Province	Shandong

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Name

Song Xiangfei

Contact Information

songxf@qibebt.ac.cn

Language ability

Chinese, English

Province

Shandong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2017-09 to 2020-12 PhD: University of Chinese Academy of Sciences 2007-09 to 2010-06 Master's: Nanjing Normal University 2003-09 to 2007-06 Bachelor's: Hunan University of Arts and Science
Work Experience	2023-05 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Deputy Head of Protein Design Research Group 2018-12 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Associate Researcher 2013-12 to 2018-12 - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Assistant Researcher 2011-03 to 2013-12 - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Research Intern

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2017-09 to 2020-12 PhD: University of Chinese Academy of Sciences
2007-09 to 2010-06 Master's: Nanjing Normal University
2003-09 to 2007-06 Bachelor's: Hunan University of Arts and Science

Work Experience

2023-05 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Deputy Head of Protein Design Research Group
2018-12 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Associate Researcher
2013-12 to 2018-12 - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Assistant Researcher
2011-03 to 2013-12 - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Research Intern

Areas of Focus	Protein structure and dynamics Enzyme catalytic mechanism analysis and rational design
Publications	Improving the Enzymatic Activity and Stability of a Lytic Polysaccharide Monooxygenase, Second Author, 2023 Intracellular environment can change protein conformational dynamics in cells through weak interactions, Second Author, 2023 Quantifying Protein Electrostatic Interactions in Cells by Nuclear Magnetic Resonance Spectroscopy, First Author, 2021 Osmolytes Can Destabilize Proteins in Cells by Modulating Electrostatics and Quinary Interactions, First Author, 2021 Characterization of Residue Specific Protein Folding and Unfolding Dynamics in Cells, First Author, 2019 Entropy drives the formation of salt bridges in the protein GB3, Fourth Author, 2017 Corrigendum to ‘A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis’ Enzyme Microb. Technol. 87–88 (2016) 9–16, First Author, 2016 Cellulose Chain Binding Free Energy Drives the Processive Move of Cellulases on the Cellulose Surface, Third Author, 2016 A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis, First Author, 2016 Improving the activity of Trichoderma reesei cel7B through stabilizing the transition state, Second Author, 2016 Integration of bacterial expansin-like proteins into cellulosome promotes the cellulose degradation, Third Author, 2016 A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis (vol 87, pg 9, 2016), First Author, 2016 Characterization of the Dielectric Constant in the Trichoderma reesei Cel7B Active Site, First Author, 2015 Improving Trichoderma reesei Cel7B Thermostability by Targeting the Weak Spots, Third Author, 2014 Engineering a More Thermostable Blue Light Photo Receptor Bacillus subtilis YtvA LOV Domain by a Computer Aided Rational Design Method, Corresponding Author, 2013 Efficiency and Stability Enhancement of Cis-epoxysuccinic Acid Hydrolase by Fusion with a Carbohydrate Binding Module and Immobilization onto Cellulose, Third Author, 2012 Comparison of Three Thermostable beta-Glucosidases for Application in the Hydrolysis of Soybean Isoflavone Glycosides, First Author, 2011 Overexpression of beta-glucosidase from Thermotoga maritima for the production of highly purified aglycone isoflavones from soy flour, Second Author, 2009 Over-expression of xylanolytic alpha-glucuronidase from Thermotoga maritima in the pHsh system of Escherichia coli for the production of xylobiose from xylan, Third Author, 2008

Areas of Focus

Protein structure and dynamics
Enzyme catalytic mechanism analysis and rational design

Publications

Improving the Enzymatic Activity and Stability of a Lytic Polysaccharide Monooxygenase, Second Author, 2023
Intracellular environment can change protein conformational dynamics in cells through weak interactions, Second Author, 2023
Quantifying Protein Electrostatic Interactions in Cells by Nuclear Magnetic Resonance Spectroscopy, First Author, 2021
Osmolytes Can Destabilize Proteins in Cells by Modulating Electrostatics and Quinary Interactions, First Author, 2021
Characterization of Residue Specific Protein Folding and Unfolding Dynamics in Cells, First Author, 2019
Entropy drives the formation of salt bridges in the protein GB3, Fourth Author, 2017
Corrigendum to ‘A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis’ Enzyme Microb. Technol. 87–88 (2016) 9–16, First Author, 2016
Cellulose Chain Binding Free Energy Drives the Processive Move of Cellulases on the Cellulose Surface, Third Author, 2016
A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis, First Author, 2016
Improving the activity of Trichoderma reesei cel7B through stabilizing the transition state, Second Author, 2016
Integration of bacterial expansin-like proteins into cellulosome promotes the cellulose degradation, Third Author, 2016
A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis (vol 87, pg 9, 2016), First Author, 2016
Characterization of the Dielectric Constant in the Trichoderma reesei Cel7B Active Site, First Author, 2015
Improving Trichoderma reesei Cel7B Thermostability by Targeting the Weak Spots, Third Author, 2014
Engineering a More Thermostable Blue Light Photo Receptor Bacillus subtilis YtvA LOV Domain by a Computer Aided Rational Design Method, Corresponding Author, 2013
Efficiency and Stability Enhancement of Cis-epoxysuccinic Acid Hydrolase by Fusion with a Carbohydrate Binding Module and Immobilization onto Cellulose, Third Author, 2012
Comparison of Three Thermostable beta-Glucosidases for Application in the Hydrolysis of Soybean Isoflavone Glycosides, First Author, 2011
Overexpression of beta-glucosidase from Thermotoga maritima for the production of highly purified aglycone isoflavones from soy flour, Second Author, 2009
Over-expression of xylanolytic alpha-glucuronidase from Thermotoga maritima in the pHsh system of Escherichia coli for the production of xylobiose from xylan, Third Author, 2008

Protein Structure Protein Dynamics Enzyme Catalysis Mechanism Analysis Rational Design Biochemistry Molecular Biology Catalytic Activity Enzyme Stability Protein Engineering

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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