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Nengyin Sheng
Life Science
University of Chinese Academy of Sciences
Yunnan
Language: Chinese, English
Brain Evolution
Development
Synaptic Function
Neurobiology
Molecular Biology
Cell Biology
Neuroscience
Genetics
Biochemistry
Research
Areas of Focus
- Brain Evolution and Development
- Synaptic Development and Functional Regulation
Work Experience
- 2017-08~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher
- 2011-08~2017-07 - Department of Molecular and Cellular Pharmacology, University of California, San Francisco - Postdoctoral Researcher
- 2003-09~2011-01 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - PhD
- 1999-09~2003-07 - School of Life Sciences, Nankai University - Bachelor's Degree
Academic Background & Achievements
- 2003-09--2011-01 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 1999-09--2003-07 Bachelor's Degree: School of Life Sciences, Nankai University
Publications
- RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination, Science Advances, 2024
- Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules, CELL, 2023
- Integrative omics reveals rapidly evolving regulatory sequences driving primate brain evolution, Molecular Biology and Evolution, 2023
- Correlative Assembly of Subsynaptic Nanoscale Organizations During Development, Frontiers in Synaptic Neuroscience, 2022
- Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human, Molecular Psychiatry, 2022
- Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory, Molecular Psychiatry, 2022
- The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, TRANSLATIONAL PSYCHIATRY, 2022
- KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor, MOLECULAR PSYCHIATRY, 2022
- RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission, SCIENCE ADVANCES, 2022
- A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021
- Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci, EBIOMEDICINE, 2019
- Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, NATIONAL SCIENCE REVIEW, 2019
- Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain, NATURE COMMUNICATIONS, 2018
- LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018
- Postsynaptic delta 1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018
- A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons, NEUROPHARMACOLOGY, 2017
- Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
- Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017
- Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1, ELIFE, 2015
- ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models, STEM CELL REPORTS, 2015
- The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways, ELIFE, 2014
- A Cortical Circuit for Gain Control by Behavioral State, CELL, 2014
- BMP signaling pathway and spinal cord development, 生物学前沿：英文版, 2012
- AP2 gamma regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning, CELL RESEARCH, 2012
- Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010
- The function of BMP signaling pathway during the central nervous system development, Chinese Journal of Cell Biology, 2009
- NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development, JOURNAL OF CELL SCIENCE, 2009
- Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1, DEVELOPMENTAL CELL, 2007
