Professor | Nengyin Sheng | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Nengyin Sheng
Contact Information	shengnengyin@mail.kiz.ac.cn
Language ability	Chinese, English
Province	Yunnan

Upload Avatar (500 x 500)

Name

Nengyin Sheng

Contact Information

shengnengyin@mail.kiz.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2003-09--2011-01 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 1999-09--2003-07 Bachelor's Degree: School of Life Sciences, Nankai University
Work Experience	2017-08~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher 2011-08~2017-07 - Department of Molecular and Cellular Pharmacology, University of California, San Francisco - Postdoctoral Researcher 2003-09~2011-01 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - PhD 1999-09~2003-07 - School of Life Sciences, Nankai University - Bachelor's Degree

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2003-09--2011-01 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
1999-09--2003-07 Bachelor's Degree: School of Life Sciences, Nankai University

Work Experience

2017-08~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher
2011-08~2017-07 - Department of Molecular and Cellular Pharmacology, University of California, San Francisco - Postdoctoral Researcher
2003-09~2011-01 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - PhD
1999-09~2003-07 - School of Life Sciences, Nankai University - Bachelor's Degree

Areas of Focus	Brain Evolution and Development Synaptic Development and Functional Regulation
Publications	RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination, Science Advances, 2024 Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules, CELL, 2023 Integrative omics reveals rapidly evolving regulatory sequences driving primate brain evolution, Molecular Biology and Evolution, 2023 Correlative Assembly of Subsynaptic Nanoscale Organizations During Development, Frontiers in Synaptic Neuroscience, 2022 Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human, Molecular Psychiatry, 2022 Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory, Molecular Psychiatry, 2022 The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, TRANSLATIONAL PSYCHIATRY, 2022 KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor, MOLECULAR PSYCHIATRY, 2022 RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission, SCIENCE ADVANCES, 2022 A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021 Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci, EBIOMEDICINE, 2019 Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, NATIONAL SCIENCE REVIEW, 2019 Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain, NATURE COMMUNICATIONS, 2018 LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018 Postsynaptic delta 1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018 A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons, NEUROPHARMACOLOGY, 2017 Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017 Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017 Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1, ELIFE, 2015 ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models, STEM CELL REPORTS, 2015 The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways, ELIFE, 2014 A Cortical Circuit for Gain Control by Behavioral State, CELL, 2014 BMP signaling pathway and spinal cord development, 生物学前沿：英文版, 2012 AP2 gamma regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning, CELL RESEARCH, 2012 Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010 The function of BMP signaling pathway during the central nervous system development, Chinese Journal of Cell Biology, 2009 NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development, JOURNAL OF CELL SCIENCE, 2009 Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1, DEVELOPMENTAL CELL, 2007

Areas of Focus

Brain Evolution and Development
Synaptic Development and Functional Regulation

Publications

RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination, Science Advances, 2024
Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules, CELL, 2023
Integrative omics reveals rapidly evolving regulatory sequences driving primate brain evolution, Molecular Biology and Evolution, 2023
Correlative Assembly of Subsynaptic Nanoscale Organizations During Development, Frontiers in Synaptic Neuroscience, 2022
Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human, Molecular Psychiatry, 2022
Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory, Molecular Psychiatry, 2022
The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, TRANSLATIONAL PSYCHIATRY, 2022
KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor, MOLECULAR PSYCHIATRY, 2022
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission, SCIENCE ADVANCES, 2022
A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021
Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci, EBIOMEDICINE, 2019
Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, NATIONAL SCIENCE REVIEW, 2019
Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain, NATURE COMMUNICATIONS, 2018
LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018
Postsynaptic delta 1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018
A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons, NEUROPHARMACOLOGY, 2017
Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017
Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1, ELIFE, 2015
ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models, STEM CELL REPORTS, 2015
The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways, ELIFE, 2014
A Cortical Circuit for Gain Control by Behavioral State, CELL, 2014
BMP signaling pathway and spinal cord development, 生物学前沿：英文版, 2012
AP2 gamma regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning, CELL RESEARCH, 2012
Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010
The function of BMP signaling pathway during the central nervous system development, Chinese Journal of Cell Biology, 2009
NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development, JOURNAL OF CELL SCIENCE, 2009
Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1, DEVELOPMENTAL CELL, 2007

Brain Evolution Development Synaptic Function Neurobiology Molecular Biology Cell Biology Neuroscience Genetics Biochemistry Research

Yixuan Wang - Tongji University

Lei Xue - Tongji University

Jing Xie - Tongji University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us