Professor | En-Duo Wang | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	En-Duo Wang
Contact Information	edwang@sibs.ac.cn
Language ability	Chinese, English, French
Province	Shanghai

Upload Avatar (500 x 500)

Name

En-Duo Wang

Contact Information

edwang@sibs.ac.cn

Language ability

Chinese, English, French

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1978-07 to 1981-07: Master's Degree, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1965-07 to 1969-07: Master's Degree, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 2005: Elected as Academician of the Chinese Academy of Sciences 2006: Elected as Academician of the Third World Academy of Sciences
Work Experience	1986: Associate Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1993: Researcher and Doctoral Supervisor, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1984-1987: Visiting Scholar, School of Medicine, University of California, Davis 1992-10 to 1992-12, 1994-10 to 1994-12, 1998-01 to 1998-04: Collaborative Research, Institute of Molecular and Cellular Research, CNRS, Strasbourg, France 1996-09 to 1997-02: Research Work, Department of Biochemistry, Hong Kong University of Science and Technology 2000-06 to 2000-08, 2003-09 to 2003-10, 2006-07 to 2006-09: Collaborative Research, Department of Biochemistry, Laval University, Canada
Awards	2000: First Prize of Shanghai Natural Science Award 2001: Second Prize of National Natural Science Award 1998-2001: Shanghai Model Worker 2001: Shanghai 'March 8th' Red Banner Pacesetter 2002: Second Shanghai Women's Innovation Award 2003: Procter & Gamble Excellent Graduate Supervisor Award, Chinese Academy of Sciences 2005: Excellent Graduate Supervisor Award, Chinese Academy of Sciences 2006: Shanghai 'March 8th' Red Banner Honor Medal 2006: Excellent Supervisor, Graduate School of the Chinese Academy of Sciences 2006: Excellent Doctoral Dissertation Supervisor Award, Chinese Academy of Sciences 2006: Ho Leung Ho Lee Science and Technology Progress Award 2007: National May 1st Labor Medal 2008: Outstanding Contribution Teacher, Chinese Academy of Sciences 2008: Second Prize of Shanghai Natural Science Award 2009: Advanced Individual of Returned Overseas Chinese and Their Relatives 2010: Top Ten of Shanghai Overseas Chinese Community 2010-04: National Advanced Worker 2013: BHP Billiton Supervisor Research Award, University of Chinese Academy of Sciences 2016: Shanghai Science Popularization Education Innovation Award, Outstanding Popular Science Figure Award 2017: 2016 Shanghai 'Model Worker of the Year' Honorary Title

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1978-07 to 1981-07: Master's Degree, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1965-07 to 1969-07: Master's Degree, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
2005: Elected as Academician of the Chinese Academy of Sciences
2006: Elected as Academician of the Third World Academy of Sciences

Work Experience

1986: Associate Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1993: Researcher and Doctoral Supervisor, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1984-1987: Visiting Scholar, School of Medicine, University of California, Davis
1992-10 to 1992-12, 1994-10 to 1994-12, 1998-01 to 1998-04: Collaborative Research, Institute of Molecular and Cellular Research, CNRS, Strasbourg, France
1996-09 to 1997-02: Research Work, Department of Biochemistry, Hong Kong University of Science and Technology
2000-06 to 2000-08, 2003-09 to 2003-10, 2006-07 to 2006-09: Collaborative Research, Department of Biochemistry, Laval University, Canada

Awards

2000: First Prize of Shanghai Natural Science Award
2001: Second Prize of National Natural Science Award
1998-2001: Shanghai Model Worker
2001: Shanghai 'March 8th' Red Banner Pacesetter
2002: Second Shanghai Women's Innovation Award
2003: Procter & Gamble Excellent Graduate Supervisor Award, Chinese Academy of Sciences
2005: Excellent Graduate Supervisor Award, Chinese Academy of Sciences
2006: Shanghai 'March 8th' Red Banner Honor Medal
2006: Excellent Supervisor, Graduate School of the Chinese Academy of Sciences
2006: Excellent Doctoral Dissertation Supervisor Award, Chinese Academy of Sciences
2006: Ho Leung Ho Lee Science and Technology Progress Award
2007: National May 1st Labor Medal
2008: Outstanding Contribution Teacher, Chinese Academy of Sciences
2008: Second Prize of Shanghai Natural Science Award
2009: Advanced Individual of Returned Overseas Chinese and Their Relatives
2010: Top Ten of Shanghai Overseas Chinese Community
2010-04: National Advanced Worker
2013: BHP Billiton Supervisor Research Award, University of Chinese Academy of Sciences
2016: Shanghai Science Popularization Education Innovation Award, Outstanding Popular Science Figure Award
2017: 2016 Shanghai 'Model Worker of the Year' Honorary Title

Areas of Focus	Nucleic Acid and Protein Interactions
Publications	Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, Taru Hilander, Xiao-Long Zhou, Svetlana Konovalova, Fu-Ping Zhang, Liliya Euro, Dmitri Chilov, Matti Poutanen, Joseph Chihade, En-Duo Wang, 2018 A natural non-Watson-Crick base pair in human mitochondrial tRNAThr causes structural and functional susceptibility to local mutations, Yong Wang, Qi-Yu Zeng, Wen-Qiang Zheng, Quan-Quan Ji, Xiao-Long Zhou, En-Duo Wang, 2018 A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, Yun Chen, Zhi-Rong Ruan, Yong Wang, Qian Huang, Mei-Qin Xue, Xiao-Long Zhou, En-Duo Wang, 2018 Acetylation of lysine ε-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli, Qing Ye, Quan-Quan Ji, Wei Yan, Fang Yang, En-Duo Wang, 2017 Structural basis for substrate binding and catalytic mechanism of a human RNA: m5C methyltransferase NSun6, Ru-Juan Liu, Tao Long, Jing Li, Hao Li, En-Duo Wang, 2017 Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain, Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Cheng-Wu Chi, En-Duo Wang, 2017 Translational quality control by bacterial threonyl-tRNA synthetases, Xiao-Long Zhou, Yong Wang, Ru-Juan Liu, Mei-Qin Xue, En-Duo Wang, 2016 A human disease-causing point mutation in mitochondrial threonyl-tRNA synthetase induces both structural and functional defects, Yong Wang, Xiao-Long Zhou, Zhi-Rong Ruan, Ru-Juan Liu, Gilbert Eriani, En-Duo Wang, 2016 C-terminal domain of leucyl-tRNA synthetase from pathogenic Candida albicans recognizes both tRNASer and tRNALeu, Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Zhi-Rong Ruan, Xiao-Long Zhou, En-Duo Wang, 2016 A Newly Identified Missense Mutation in FARS2 Causes Autosomal-Recessive Spastic Paraplegia, Ying Yang, Wei Liu, Zhi-Peng Fang, Juan Shi, Feng-Yu Che, Chun-Xia He, Li-Bo Yao, En-Duo Wang, Yuan-Ming Wu, 2016 Identification of lethal mutations in yeast threonyl-tRNA synthetase which reveals critical residues in its human homolog, Zhi-Rong Ruan, Zhi-Peng Fang, Qing Ye, Hui-Yan Lei, Gilbert Eriani, Xiao-Long Zhou, En-Duo Wang, 2015 Modulation of aminoacylation and editing properties of leucyl-tRNA synthetase by a conserved structural module, Wei Yan, Qing Ye, Min Tan, Xin Chen, Gilbert Eriani, En-Duo Wang, 2015 Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase, Mi Zhou, Tao Long, Zhi-Peng Fang, Xiao-Long Zhou, Ru-Juan Liu, En-Duo Wang, 2015 tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily, Ru-Juan Liu, Tao Long, Mi Zhou, Xiao-Long Zhou, En-Duo Wang, 2015 Degenerate CP1 domain From Human Mitochondrial Leucyl-tRNA Synthetase, Qing Ye, Meng Wang, Zhi-Peng Fang, Zhi-Rong Ruan, Quan-Quan Ji, Xiao-Long Zhou, En-Duo Wang, 2015 Calpain cleaves most components in the multiple aminoacyl-tRNA synthetase complex and affects their functions, Hui-Yan Lei, Xiao-Long Zhou, Zhi-Rong Ruan, Wei-Chen Sun, Gilbert Eriani, En-Duo Wang, 2015 A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity, Qian Huang, Xiao-Long Zhou, Zhi-Peng Fang, Lei HY, Qing-Hua Hu, Peng Yao, En-Duo Wang, 2015 Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis, Lan-Tao Gou, Peng Dai, Jian-Hua Yang, Yuanchao Xue, Yun-Ping Hu, Yu Zhou, Jun-Y

Areas of Focus

Nucleic Acid and Protein Interactions

Publications

Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, Taru Hilander, Xiao-Long Zhou, Svetlana Konovalova, Fu-Ping Zhang, Liliya Euro, Dmitri Chilov, Matti Poutanen, Joseph Chihade, En-Duo Wang, 2018
A natural non-Watson-Crick base pair in human mitochondrial tRNAThr causes structural and functional susceptibility to local mutations, Yong Wang, Qi-Yu Zeng, Wen-Qiang Zheng, Quan-Quan Ji, Xiao-Long Zhou, En-Duo Wang, 2018
A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, Yun Chen, Zhi-Rong Ruan, Yong Wang, Qian Huang, Mei-Qin Xue, Xiao-Long Zhou, En-Duo Wang, 2018
Acetylation of lysine ε-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli, Qing Ye, Quan-Quan Ji, Wei Yan, Fang Yang, En-Duo Wang, 2017
Structural basis for substrate binding and catalytic mechanism of a human RNA: m5C methyltransferase NSun6, Ru-Juan Liu, Tao Long, Jing Li, Hao Li, En-Duo Wang, 2017
Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain, Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Cheng-Wu Chi, En-Duo Wang, 2017
Translational quality control by bacterial threonyl-tRNA synthetases, Xiao-Long Zhou, Yong Wang, Ru-Juan Liu, Mei-Qin Xue, En-Duo Wang, 2016
A human disease-causing point mutation in mitochondrial threonyl-tRNA synthetase induces both structural and functional defects, Yong Wang, Xiao-Long Zhou, Zhi-Rong Ruan, Ru-Juan Liu, Gilbert Eriani, En-Duo Wang, 2016
C-terminal domain of leucyl-tRNA synthetase from pathogenic Candida albicans recognizes both tRNASer and tRNALeu, Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Zhi-Rong Ruan, Xiao-Long Zhou, En-Duo Wang, 2016
A Newly Identified Missense Mutation in FARS2 Causes Autosomal-Recessive Spastic Paraplegia, Ying Yang, Wei Liu, Zhi-Peng Fang, Juan Shi, Feng-Yu Che, Chun-Xia He, Li-Bo Yao, En-Duo Wang, Yuan-Ming Wu, 2016
Identification of lethal mutations in yeast threonyl-tRNA synthetase which reveals critical residues in its human homolog, Zhi-Rong Ruan, Zhi-Peng Fang, Qing Ye, Hui-Yan Lei, Gilbert Eriani, Xiao-Long Zhou, En-Duo Wang, 2015
Modulation of aminoacylation and editing properties of leucyl-tRNA synthetase by a conserved structural module, Wei Yan, Qing Ye, Min Tan, Xin Chen, Gilbert Eriani, En-Duo Wang, 2015
Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase, Mi Zhou, Tao Long, Zhi-Peng Fang, Xiao-Long Zhou, Ru-Juan Liu, En-Duo Wang, 2015
tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily, Ru-Juan Liu, Tao Long, Mi Zhou, Xiao-Long Zhou, En-Duo Wang, 2015
Degenerate CP1 domain From Human Mitochondrial Leucyl-tRNA Synthetase, Qing Ye, Meng Wang, Zhi-Peng Fang, Zhi-Rong Ruan, Quan-Quan Ji, Xiao-Long Zhou, En-Duo Wang, 2015
Calpain cleaves most components in the multiple aminoacyl-tRNA synthetase complex and affects their functions, Hui-Yan Lei, Xiao-Long Zhou, Zhi-Rong Ruan, Wei-Chen Sun, Gilbert Eriani, En-Duo Wang, 2015
A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity, Qian Huang, Xiao-Long Zhou, Zhi-Peng Fang, Lei HY, Qing-Hua Hu, Peng Yao, En-Duo Wang, 2015
Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis, Lan-Tao Gou, Peng Dai, Jian-Hua Yang, Yuanchao Xue, Yun-Ping Hu, Yu Zhou, Jun-Y

Nucleic Acid Protein Interaction Biochemistry Cell Biology Molecular Biology Trna Aminoacylation Editing Quality Control

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us