2004-09 to 2009-06 PhD: Institute of Biophysics, Chinese Academy of Sciences
2000-09 to 2004-06 Bachelor: Biology, Wuhan University
2020-01 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2012-01 to 2019-12 - Institute of Biophysics, Chinese Academy of Sciences - Associate Researcher
2009-07 to 2011-12 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
Research
Endoplasmic Reticulum Stress and Homeostasis Redox Regulation Folding Enzymes and Molecular Chaperones
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic, Ping Liu, Junjie Hu, Lei Wang, 2023
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum, Lei Wang, Chihchen Wang, 2023
V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation, Yiwei Sun, Xie Wang, Xiaotong Yang, Lei Wang, Jingjin Ding, Chihchen Wang, Hong Zhang, Xi Wang, 2023
Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H2O2 release, Fang Cheng, Qianzhao Ji, Lu Wang, Chihchen Wang, GuangHui Liu, Lei Wang, 2023
“后AlphaFold时代”的蛋白质折叠问题, 胡昕炜, 王志珍, 王磊
Flavonoids from Lycium barbarum Leaves Exhibit Anti-Aging Effects through the Redox-Modulation, Yinhong Niu, Jiale Liao, Haitao Zhou, Chihchen Wang, Lei Wang, Yanli Fan, 2022
SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases, Ping Liu, Xi Wang, Yiwei Sun, Hongyu Zhao, Fang Cheng, Jifeng Wang, Fuquan Yang, Junjie Hu, Hong Zhang, Chihchen Wang, Lei Wang, 2022
Lycium barbarum Extracts Extend Lifespan and Alleviate Proteotoxicity in Caenorhabditis elegans, Haitao Zhou, Shanshan Ding, Chuanxin Sun, Jiahui Fu, Dong Yang, Xie Wang, Chihchen Wang, Lei Wang, 2022
ER reductive stress caused by Ero1 alpha S-nitrosation accelerates senescence, Xinhua Qiao, Yingmin Zhang, Aojun Ye, Yini Zhang, Ting Xie, Zhenyu Lv, Chang Shi, Dongli Wu, Boyu Chu, Xun Wu, Weiqi Zhang, Ping Wang, GuangHui Liu, Chihchen Wang, Lei Wang, Chang Chen, 2022
The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential, Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-chen Wang, Lei Wang, 2022
Two Arabidopsis Protein Disulfide Isomerase Subgroups Work Synergistically in Catalyzing Oxidative Protein Folding, Fan Fenggui, Zhang Qiao, Zhang Yini, Huang Guozhong, Liang Xuelian, Wang Chih-chen, Wang Lei, Lu Dongping, 2022
A Solvatochromic Fluorescent Probe Reveals Polarity Heterogeneity upon Protein Aggregation in Cells, Wang Wan, Lianggang Zeng, Wenhan Jin, Xinxin Chen, Di Shen, Yanan Huang, Mengdie Wang, Yulong Bai, Haochen Lyu, Xuepeng Dong, Zhenming Gao, Lei Wang, Xiaojing Liu, Yu Liu, 2021
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions, Lei Wang, Jiaojiao Yu, Chihchen Wang, 2021
Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization, Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xie Wang, Junyu Xiao, Chihchen Wang, Lei Wang, 2021
Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner, Yu Yan, Xun Wu, Pengcheng Wang, Songyang Zhang, Lulu Sun, Yang Zhao, GuangYi Zeng, Bo Liu, Guoheng Xu, Huiying Liu, Lei Wang, Xian Wang, Changtao Jiang, 2020
S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal ?-helical lid, Jie Yang, Hong Zhang, Weibin Gong, Zhenyan Liu, Huiwen Wu, Wanhui Hu, Xinxin Chen, Lei Wang, Si Wu, Chang Chen, Sarah Perrett, 2020
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, Jiaojiao Yu, Tao Li, Yu Liu, Xi Wang, Jianchao Zhang, Xie Wang, Guizhi Shi, Jizhong Lou, Likun Wang, Chihchen Wang, Lei Wang, 2020
AtERO1 and AtERO2 exhibit differences in catalyzing oxidative protein folding in the ER, Fan Fenggui, Zhang Yini, Huang Guozhong, Zhang Qiao, Wang Chihchen, Wang Lei, Lu Dongping, 2019
The b ' domain of protein disulfide isomerase cooperates with the a and a ' domains to functionally interact with platelets, Lu Wang, Junsong Zhou, Lei Wang, Chihchen Wang, David W. Essex, 2019
Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis, Xun Wu, Lihui Zhang, Yutong Miao, Juan Yang, Xian Wang, Chihchen Wang, Juan Feng, Lei Wang, 2019
Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer, Yini Zhang, Tao Li, Lihui Zhang, Fugen Shangguan, Guizhi Shi, Xun Wu, Ya Cui, Xie Wang, Xi Wang, Yongzhang Liu, Bin Lu, Taotao Wei, Chihchen Wang, Lei Wang, 2019
Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111, WenChang Xu, JinZhao Liang, Cheng Li, ZhiXin He, HanYe Yuan, BenYan Huang, XiaoLing Liu, Bo Tang, DaiWen Pang, HaiNing Du, Yi Yang, Jie Chen, Lei Wang, Min Zhang, Yi Liang, 2018
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7, Jingqi Fang, Jiping Yang, Xun Wu, Gangming Zhang, Tao Li, Xie Wang, Hong Zhang, Chihchen Wang, GuangHui Liu, Lei Wang, 2018
Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity, Huanhuan Li, Kai Yang, Wenjia Wang, Yingbo Niu, Jun Li, Yuhui Dong, Yingfang Liu, Chihchen Wang, Lei Wang, Huanhuan Liang, 2018
Characterization of the oxidative protein folding activity of a unique plant oxidoreductase, Arabidopsis protein disulfide isomerase-11, Fan Fenggui, Zhang Yini, Wang Shen, Yongfeng Han, Lei Wang, Dongping Lu, 2018
Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1 alpha, Jianchao Zhang, Qinyu Zhu, Xie Wang, Jiaojiao Yu, Xinxin Chen, Jifeng Wang, Xi Wang, Junyu Xiao, Chihchen Wang, Lei Wang, 2018
Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia, Yazi Li, Yuying Zhang, Lei Wang, Ping Wang, Yanhong Xue, Xiaopeng Li, Xinhua Qiao, Xu Zhang, Tao Xu, Guanghui Liu, Peng Li, Chang Chen, 2017
Novel Roles of the Non-catalytic Elements of Yeast Protein-disulfide Isomerase in Its Interplay with Endoplasmic Reticulum Oxidoreductin 1, Yingbo Niu, Lihui Zhang, Jiaojiao Yu, Chihchen Wang, Lei Wang, 2016
Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone, Lei Wang, Xi Wang, Chihchen Wang, 2015
未折叠蛋白响应：2014年拉斯克基础医学研究奖解读, 王曦, 王磊, 陈畅, 王志珍
Different Interaction Modes for Protein-disulfide Isomerase (PDI) as an Efficient Regulator and a Specific Substrate of Endoplasmic Reticulum Oxidoreductin-1 alpha (Ero1 alpha), Lihui Zhang, Yingbo Niu, Li Zhu, Jingqi Fang, Xie Wang, Lei Wang, Chihchen Wang, 2014
Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1 alpha to Promote Oxidative Protein Folding, Lei Wang, Lihui Zhang, Yingbo Niu, Roberto Sitia, Chihchen Wang, 2014
Different Interaction Modes for Protein-disulfide Isomerase (PDI) as an Efficient Regulator and a Specific Substrate of Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) *, Lihui Zhang, Yingbo Niu, Li Zhu, Jingqi Fang, Xie Wang, Lei Wang, Chihchen Wang, 2014
Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a ', Chao Wang, Jiang Yu, Lin Huo, Lei Wang, Wei Feng, Chihchen Wang, 2012
The endoplasmic reticulum sulfhydryl oxidase Ero1 beta drives efficient oxidative protein folding with loose regulation, Lei Wang, Li Zhu, Chihchen Wang, 2011
