Professor | Yongfen Xu | Asia Growth Partners

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Name	Yongfen Xu
Contact Information	xuyf@siii.cas.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Yongfen Xu

Contact Information

xuyf@siii.cas.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Work Experience	2024-03-31 - Present - Review Editor of Microorganisms 2023-07-16 - 2023-11-30 - Guest Editor of Life \| Special Issue: Arbovirus: Infection, Immunity and Antiviral Research 2022-06-27 - Present - Review Editor of Frontiers in Cellular and Infection Microbiology in Virology 2022-06-27 - Present - Review Editor of Frontiers in Cellular and Infection Microbiology in Infectious Agents and Disease 2022-06-18 - Present - Associate Editor of Frontiers in Cellular and Infection Microbiology in Virus and Host 2020-09-09 - 2023-09-08 - Deputy Director of the Youth Committee of the Ninth Committee of the Medical Virology Branch of the Shanghai Medical Association 2017-07-06 - 2020-07-06 - Youth Member of the Eighth Committee of the Medical Virology Branch of the Shanghai Medical Association

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Work Experience

2024-03-31 - Present - Review Editor of Microorganisms
2023-07-16 - 2023-11-30 - Guest Editor of Life | Special Issue: Arbovirus: Infection, Immunity and Antiviral Research
2022-06-27 - Present - Review Editor of Frontiers in Cellular and Infection Microbiology in Virology
2022-06-27 - Present - Review Editor of Frontiers in Cellular and Infection Microbiology in Infectious Agents and Disease
2022-06-18 - Present - Associate Editor of Frontiers in Cellular and Infection Microbiology in Virus and Host
2020-09-09 - 2023-09-08 - Deputy Director of the Youth Committee of the Ninth Committee of the Medical Virology Branch of the Shanghai Medical Association
2017-07-06 - 2020-07-06 - Youth Member of the Eighth Committee of the Medical Virology Branch of the Shanghai Medical Association

Areas of Focus	Discovery of new drug targets for anti-flavivirus Lipid metabolism changes caused by flavivirus infection under different immune conditions Research on innate immune response and escape mechanism caused by flavivirus
Publications	Extracellular vesicles from Zika virus-infected cells display viral E protein that binds ZIKV-neutralizing antibodies to prevent infection enhancement, Second Author, 2023 Mouse circulating extracellular vesicles contain virus-derived siRNAs active in antiviral immunity, Not mentioned, 2022 Photo-catalyzed TiO2 inactivates pathogenic viruses by attacking viral genome, Seventh Author, 2021 Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody, Fourteenth Author, 2021 TRIM26 is a critical host factor for HCV replication and contributes to host tropism, Twelfth Author, 2021 A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution, Fourth Author, 2020 Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections, Second Author, 2020 A Nanoparticle-Based Hepatitis C Virus Vaccine With Enhanced Potency, Eighth Author, 2020 Discovery and research of hepatitis C virus-Thoughts from the 2020 Nobel Prize in Physiology or Medicine, First Author, 2020 The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection, Second Author, 2020 IL-1 beta Enhances the Antiviral Effect of IFN-alpha on HCV Replication by Negatively Modulating ERK2 Activation, Eleventh Author, 2020 Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection, Fourth Author, 2020 Anti-flavivirus activity of polyoxometalate, Eleventh Author, 2020 Antiviral effects of simeprevir on multiple viruses, Fourth Author, 2019 Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness, Fifth Author, 2019 ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice, Sixth Author, 2019 Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone, Second Author, 2018 Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral Effector That Inhibits Hepatitis C Virus Assembly by Targeting Viral E1 Glycoprotein, Not mentioned, 2018 Antiviral effects of ferric ammonium citrate, Fourth Author, 2018 Genetic Analysis of Serum-Derived Defective Hepatitis C Virus Genomes Revealed Novel Viral cis Elements for Virus Replication and Assembly, Third Author, 2018 Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika, Second Author, 2017 Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome, Fourth Author, 2017 Innate immunity against hepatitis C virus, First Author, 2016 HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells, Second Author, 2014 Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells, First Author, 2013 Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma, Third Author, 2012 Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor, Third Author, 2012 HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells, First Author, 2009 Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients, Third Author, 2008 系统性红斑狼疮外周血B 淋巴细胞激活及 TOLL 样受体9 表达, Third Author, 2006

Areas of Focus

Discovery of new drug targets for anti-flavivirus
Lipid metabolism changes caused by flavivirus infection under different immune conditions
Research on innate immune response and escape mechanism caused by flavivirus

Publications

Extracellular vesicles from Zika virus-infected cells display viral E protein that binds ZIKV-neutralizing antibodies to prevent infection enhancement, Second Author, 2023
Mouse circulating extracellular vesicles contain virus-derived siRNAs active in antiviral immunity, Not mentioned, 2022
Photo-catalyzed TiO2 inactivates pathogenic viruses by attacking viral genome, Seventh Author, 2021
Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody, Fourteenth Author, 2021
TRIM26 is a critical host factor for HCV replication and contributes to host tropism, Twelfth Author, 2021
A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution, Fourth Author, 2020
Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections, Second Author, 2020
A Nanoparticle-Based Hepatitis C Virus Vaccine With Enhanced Potency, Eighth Author, 2020
Discovery and research of hepatitis C virus-Thoughts from the 2020 Nobel Prize in Physiology or Medicine, First Author, 2020
The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection, Second Author, 2020
IL-1 beta Enhances the Antiviral Effect of IFN-alpha on HCV Replication by Negatively Modulating ERK2 Activation, Eleventh Author, 2020
Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection, Fourth Author, 2020
Anti-flavivirus activity of polyoxometalate, Eleventh Author, 2020
Antiviral effects of simeprevir on multiple viruses, Fourth Author, 2019
Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness, Fifth Author, 2019
ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice, Sixth Author, 2019
Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone, Second Author, 2018
Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral Effector That Inhibits Hepatitis C Virus Assembly by Targeting Viral E1 Glycoprotein, Not mentioned, 2018
Antiviral effects of ferric ammonium citrate, Fourth Author, 2018
Genetic Analysis of Serum-Derived Defective Hepatitis C Virus Genomes Revealed Novel Viral cis Elements for Virus Replication and Assembly, Third Author, 2018
Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika, Second Author, 2017
Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome, Fourth Author, 2017
Innate immunity against hepatitis C virus, First Author, 2016
HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells, Second Author, 2014
Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells, First Author, 2013
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma, Third Author, 2012
Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor, Third Author, 2012
HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells, First Author, 2009
Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients, Third Author, 2008
系统性红斑狼疮外周血B 淋巴细胞激活及 TOLL 样受体9 表达, Third Author, 2006

Flavivirus Drug Targets Lipid Metabolism Immune Conditions Innate Immune Response Escape Mechanism Virus Infection Antiviral Research Immunology Virology

Xiaowei Zhang - University of Chinese Academy of Sciences

Fei Deng - University of Chinese Academy of Sciences

Wuxiang Guan - University of Chinese Academy of Sciences

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