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Yongfen Xu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Flavivirus
Drug Targets
Lipid Metabolism
Immune Conditions
Innate Immune Response
Escape Mechanism
Virus Infection
Antiviral Research
Immunology
Virology
Areas of Focus
- Discovery of new drug targets for anti-flavivirus
- Lipid metabolism changes caused by flavivirus infection under different immune conditions
- Research on innate immune response and escape mechanism caused by flavivirus
Work Experience
- 2024-03-31 - Present - Review Editor of Microorganisms
- 2023-07-16 - 2023-11-30 - Guest Editor of Life | Special Issue: Arbovirus: Infection, Immunity and Antiviral Research
- 2022-06-27 - Present - Review Editor of Frontiers in Cellular and Infection Microbiology in Virology
- 2022-06-27 - Present - Review Editor of Frontiers in Cellular and Infection Microbiology in Infectious Agents and Disease
- 2022-06-18 - Present - Associate Editor of Frontiers in Cellular and Infection Microbiology in Virus and Host
- 2020-09-09 - 2023-09-08 - Deputy Director of the Youth Committee of the Ninth Committee of the Medical Virology Branch of the Shanghai Medical Association
- 2017-07-06 - 2020-07-06 - Youth Member of the Eighth Committee of the Medical Virology Branch of the Shanghai Medical Association
Publications
- Extracellular vesicles from Zika virus-infected cells display viral E protein that binds ZIKV-neutralizing antibodies to prevent infection enhancement, Second Author, 2023
- Mouse circulating extracellular vesicles contain virus-derived siRNAs active in antiviral immunity, Not mentioned, 2022
- Photo-catalyzed TiO2 inactivates pathogenic viruses by attacking viral genome, Seventh Author, 2021
- Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody, Fourteenth Author, 2021
- TRIM26 is a critical host factor for HCV replication and contributes to host tropism, Twelfth Author, 2021
- A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution, Fourth Author, 2020
- Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections, Second Author, 2020
- A Nanoparticle-Based Hepatitis C Virus Vaccine With Enhanced Potency, Eighth Author, 2020
- Discovery and research of hepatitis C virus-Thoughts from the 2020 Nobel Prize in Physiology or Medicine, First Author, 2020
- The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection, Second Author, 2020
- IL-1 beta Enhances the Antiviral Effect of IFN-alpha on HCV Replication by Negatively Modulating ERK2 Activation, Eleventh Author, 2020
- Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection, Fourth Author, 2020
- Anti-flavivirus activity of polyoxometalate, Eleventh Author, 2020
- Antiviral effects of simeprevir on multiple viruses, Fourth Author, 2019
- Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness, Fifth Author, 2019
- ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice, Sixth Author, 2019
- Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone, Second Author, 2018
- Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral Effector That Inhibits Hepatitis C Virus Assembly by Targeting Viral E1 Glycoprotein, Not mentioned, 2018
- Antiviral effects of ferric ammonium citrate, Fourth Author, 2018
- Genetic Analysis of Serum-Derived Defective Hepatitis C Virus Genomes Revealed Novel Viral cis Elements for Virus Replication and Assembly, Third Author, 2018
- Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika, Second Author, 2017
- Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome, Fourth Author, 2017
- Innate immunity against hepatitis C virus, First Author, 2016
- HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells, Second Author, 2014
- Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells, First Author, 2013
- Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma, Third Author, 2012
- Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor, Third Author, 2012
- HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells, First Author, 2009
- Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients, Third Author, 2008
- 系统性红斑狼疮外周血B 淋巴细胞激活及 TOLL 样受体9 表达, Third Author, 2006
