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Guoliang Xu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, German, English
Epigenetics
Cancer
Regulation
Dna Methylation
Gene Expression
Chromatin
Histones
Non-Coding Rna
Cell Differentiation
Disease Mechanisms
Areas of Focus
- Epigenetic regulation and its relationship with major diseases such as cancer
Work Experience
- 2001-08~Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher, Group Leader
- 2000-04~2001-07 - Columbia University Medical Center - Associate Research Scientist
- 1995-10~2000-03 - Department of Genetics and Development, Columbia University - Postdoctoral Researcher
- 1994-08~1995-09 - National University of Singapore, Life Sciences Center - Laboratory Director
- 1993-03~1994-07 - Max Planck Institute for Molecular Genetics - Postdoctoral Researcher
Academic Background & Achievements
- 1989-09--1993-03 PhD: Max Planck Institute for Molecular Genetics
- 1985-09--1988-08 Master's: Institute of Genetics, Chinese Academy of Sciences, Beijing
- 1981-09--1985-06 Bachelor's: Zhejiang University (formerly Hangzhou University)
Publications
- Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development, 11th Author, 2022
- Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency, 11th Author, 2022
- A vitamin-C-derived DNA modification catalysed by an algal TET homologue, 11th Author, 2019
- TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling, 11th Author, 2016
- Gadd45a promotes DNA demethylation through TDG, 11th Author, 2015
- Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote, 11th Author, 2014
- Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming, 11th Author, 2014
- Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition, 1st Author, 2013
- Vitamin C modulates TET1 function during somatic cell reprogramming, 1st Author, 2013
- Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells, 1st Author, 2012
- Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA, 11th Author, 2011
- The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes, 11th Author, 2011
Awards
- Third National Innovation Award (2023): National Level
- Shanghai Natural Science Award, First Prize (2016): Provincial Level
- 14th Shanghai Science and Technology Elite (2015): Provincial Level
- Chen Jiageng Life Science Award (2014): Other
- TWAS Biology Award (2013): Other
