Areas of Focus
- Microbial Ecology
- Microbial Resource Development and Utilization
- Microbial Engineering
- Biopharmaceutical Development
- Pollutant Toxicological Effects
- Protein Structure-Function Relationship
- Tumor Immunology
- Cellular Immunology
- Vaccine Immunology
Work Experience
- 2014-10~Present - Institute of Applied Ecology, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Deputy Director
- 2013-03~2015-03 - Chinese University of Hong Kong - Hong Kong Scholar
- 2007-08~2014-09 - Institute of Applied Ecology, Chinese Academy of Sciences - Associate Researcher, Master's Supervisor
- 2005-07~2007-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral, Assistant Researcher
Academic Background & Achievements
- 2000-07--2005-06 PhD: Institute of Applied Ecology, Chinese Academy of Sciences
- 1996-07--2000-06 Bachelor's: Shenyang Pharmaceutical University
Publications
- Overview of Recombinant Skin Models and Progress in Their Application in Vitro Assessment of Toxicity and Efficacy, Mingkai Xu, 2023
- Continuous oral exposure to micro- and nanoplastics induced gut microbiota dysbiosis, intestinal barrier and immune dysfunction in adult mice, Mingkai Xu, 2023
- Staphylococcal Enterotoxin C2 Mutant-Induced Antitumor Immune Response Is Controlled by CDC42/MLC2-Mediated Tumor Cell Stiffness, Mingkai Xu, 2023
- A Novel Pathway of Chlorimuron-Ethyl Biodegradation by Chenggangzhangella methanolivorans Strain CHL1 and Its Molecular Mechanisms, Mingkai Xu, 2022
- 重组皮肤模型在日化产品毒性和皮肤病体外评估中的应用进展, Mingkai Xu, 2022
- In vitro study on the toxicity of nanoplastics with different charges to murine splenic lymphocytes, Mingkai Xu, 2022
- Whole-Genome Sequencing of a Chlorimuron-Ethyl-Degrading Strain: Chenggangzhangella methanolivorans CHL1 and Its Degrading Enzymes, Mingkai Xu, 2022
- 一株高效广谱莠去津降解菌SB5的生长和降解特性, Mingkai Xu, 2022
- Characterizing the Microbial Consortium L1 Capable of Efficiently Degrading Chlorimuron-Ethyl via Metagenome Combining 16S rDNA Sequencing, Mingkai Xu, 2022
- Toxic effects of nanoplastics with different sizes and surface charges on epithelial-to-mesenchymal transition in A549 cells and the potential toxicological mechanism, Mingkai Xu, 2022
- TRAIL produced by SAM-1-activated CD4+ and CD8+ subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors, Mingkai Xu, 2021
- The Improved Expression and Stability of Zearalenone Lactonohydrolase from Escherichia coli BL21 (DE3), Mingkai Xu, 2021
- Induction of CD4(+) regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways, Mingkai Xu, 2021
- Staphylococcal Enterotoxin C2 Mutant-Directed Fatty Acid and Mitochondrial Energy Metabolic Programs Regulate CD8(+) T Cell Activation, Mingkai Xu, 2020
- 超级抗原在肿瘤免疫治疗中的应用, Mingkai Xu, 2020
- An iRGD peptide fused superantigen mutant induced tumor-targeting and T lymphocyte infiltrating in cancer immunotherapy, Mingkai Xu, 2020
- Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell, Mingkai Xu, 2019
Awards
- Chinese Academy of Sciences 'Regional Development Youth Scholar Talent' (2022): Institute Level
- Liaoning Province Xingliao Talent Plan 'Youth Top Talent' (2018): Provincial Level
- Liaoning Province Hundred Thousand Talents Project 'Hundred Level' Talent (2018): Provincial Level
- Shenyang First Batch of High-Level Talents 'Leading Talent' (2018): City Level
- Hong Kong Scholar (2012): Ministry Level
- Liaoning Province Excellent Postdoctoral (2011): Provincial Level
- Chinese Academy of Sciences Di'ao Scholarship First Prize (2005): Institute Level