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Mingkai Xu
Life Science
University of Chinese Academy of Sciences
Liaoning
Language: Chinese, English
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Microbial Ecology: Microorganisms Environment Interactions Ecosystems Biodiversity Biogeochemical Cycles Microbial Communities Soil Microbiology Aquatic Microbiology Microbial Evolution Microbial Resource Development And Utilization: Bioprospecting Biotechnology Industrial Microbiology Bioresources Bioproducts Microbial Diversity Bioconversion Fermentation Microbial Enzymes Microbial Metabolites Microbial Engineering: Genetic Engineering Metabolic Engineering Synthetic Biology Bioprocessing Bioreactors Microbial Production Bioengineering Microbial Genetics Microbial Physiology Microbial Biotechnology Biopharmaceutical Development: Drug Discovery Biotherapeutics Monoclonal Antibodies Vaccines Biomanufacturing Clinical Trials Regulatory Affairs Pharmacokinetics Pharmacodynamics Biopharmaceuticals Pollutant Toxicological Effects: Toxicology Environmental Pollutants Health Effects Risk Assessment Exposure Assessment Ecotoxicology Biomarkers Environmental Health Pollution Control Toxicological Mechanisms Protein Structure-Function Relationship: Protein Structure Protein Function Structural Biology Molecular Dynamics Protein Folding Protein Engineering Protein Interactions Bioinformatics Proteomics Protein Modeling Tumor Immunology: Cancer Immunotherapy Immune Checkpoints Tumor Microenvironment Immuno-Oncology T Cells Immune Response Cancer Vaccines Tumor Antigens Immunomodulation Adoptive Cell Therapy Cellular Immunology: Immune Cells Immune Signaling Cytokines Immunoregulation Immune Receptors Cell-Mediated Immunity Immunological Memory Immune Tolerance Immunopathology Immunogenetics Vaccine Immunology: Vaccine Development Immunogenicity Adjuvants Vaccine Efficacy Vaccine Safety Immunization Vaccine Delivery Vaccine Formulations Vaccine Technology
Areas of Focus
  • Microbial Ecology
  • Microbial Resource Development and Utilization
  • Microbial Engineering
  • Biopharmaceutical Development
  • Pollutant Toxicological Effects
  • Protein Structure-Function Relationship
  • Tumor Immunology
  • Cellular Immunology
  • Vaccine Immunology
Work Experience
  • 2014-10~Present - Institute of Applied Ecology, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Deputy Director
  • 2013-03~2015-03 - Chinese University of Hong Kong - Hong Kong Scholar
  • 2007-08~2014-09 - Institute of Applied Ecology, Chinese Academy of Sciences - Associate Researcher, Master's Supervisor
  • 2005-07~2007-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral, Assistant Researcher
Academic Background & Achievements
  • 2000-07--2005-06 PhD: Institute of Applied Ecology, Chinese Academy of Sciences
  • 1996-07--2000-06 Bachelor's: Shenyang Pharmaceutical University
Publications
  • Overview of Recombinant Skin Models and Progress in Their Application in Vitro Assessment of Toxicity and Efficacy, Mingkai Xu, 2023
  • Continuous oral exposure to micro- and nanoplastics induced gut microbiota dysbiosis, intestinal barrier and immune dysfunction in adult mice, Mingkai Xu, 2023
  • Staphylococcal Enterotoxin C2 Mutant-Induced Antitumor Immune Response Is Controlled by CDC42/MLC2-Mediated Tumor Cell Stiffness, Mingkai Xu, 2023
  • A Novel Pathway of Chlorimuron-Ethyl Biodegradation by Chenggangzhangella methanolivorans Strain CHL1 and Its Molecular Mechanisms, Mingkai Xu, 2022
  • 重组皮肤模型在日化产品毒性和皮肤病体外评估中的应用进展, Mingkai Xu, 2022
  • In vitro study on the toxicity of nanoplastics with different charges to murine splenic lymphocytes, Mingkai Xu, 2022
  • Whole-Genome Sequencing of a Chlorimuron-Ethyl-Degrading Strain: Chenggangzhangella methanolivorans CHL1 and Its Degrading Enzymes, Mingkai Xu, 2022
  • 一株高效广谱莠去津降解菌SB5的生长和降解特性, Mingkai Xu, 2022
  • Characterizing the Microbial Consortium L1 Capable of Efficiently Degrading Chlorimuron-Ethyl via Metagenome Combining 16S rDNA Sequencing, Mingkai Xu, 2022
  • Toxic effects of nanoplastics with different sizes and surface charges on epithelial-to-mesenchymal transition in A549 cells and the potential toxicological mechanism, Mingkai Xu, 2022
  • TRAIL produced by SAM-1-activated CD4+ and CD8+ subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors, Mingkai Xu, 2021
  • The Improved Expression and Stability of Zearalenone Lactonohydrolase from Escherichia coli BL21 (DE3), Mingkai Xu, 2021
  • Induction of CD4(+) regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways, Mingkai Xu, 2021
  • Staphylococcal Enterotoxin C2 Mutant-Directed Fatty Acid and Mitochondrial Energy Metabolic Programs Regulate CD8(+) T Cell Activation, Mingkai Xu, 2020
  • 超级抗原在肿瘤免疫治疗中的应用, Mingkai Xu, 2020
  • An iRGD peptide fused superantigen mutant induced tumor-targeting and T lymphocyte infiltrating in cancer immunotherapy, Mingkai Xu, 2020
  • Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell, Mingkai Xu, 2019
Awards
  • Chinese Academy of Sciences 'Regional Development Youth Scholar Talent' (2022): Institute Level
  • Liaoning Province Xingliao Talent Plan 'Youth Top Talent' (2018): Provincial Level
  • Liaoning Province Hundred Thousand Talents Project 'Hundred Level' Talent (2018): Provincial Level
  • Shenyang First Batch of High-Level Talents 'Leading Talent' (2018): City Level
  • Hong Kong Scholar (2012): Ministry Level
  • Liaoning Province Excellent Postdoctoral (2011): Provincial Level
  • Chinese Academy of Sciences Di'ao Scholarship First Prize (2005): Institute Level
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