Professor | Weiwei Yang | Asia Growth Partners

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Name	Weiwei Yang
Contact Information	weiweiyang@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Weiwei Yang

Contact Information

weiweiyang@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2001-09 to 2007-07 PhD: Chinese Academy of Sciences, Shanghai Institute of Life Sciences 1997-09 to 2001-07 Bachelor's: Wuhan University
Work Experience	2013-06 to Present - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher 2008-06 to 2013-06 - MD Anderson Cancer Center, USA - Postdoctoral Fellow

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2001-09 to 2007-07 PhD: Chinese Academy of Sciences, Shanghai Institute of Life Sciences
1997-09 to 2001-07 Bachelor's: Wuhan University

Work Experience

2013-06 to Present - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher
2008-06 to 2013-06 - MD Anderson Cancer Center, USA - Postdoctoral Fellow

Areas of Focus	Metabolic reprogramming mechanisms in major diseases like cancer New functions of metabolic small molecules Interactive regulation of tumor microenvironment and tumor cell metabolism
Publications	MAPK signaling-induced Phosphorylation and Subcellular Translocation of PDHE1α Promotes Tumor Immune Evasion, Zhang Y, Zhao M, Gao H, Yu G, Zhao Y, Yao F, Yang W, 2022 Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma, Wu S, Cao R, Tao B, Wu P, Peng C, Gao H, Liang J, Yang W, 2022 Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine, Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, Wei P, Liang J, Yu G, Wang X, Li X, Li D, Yang W, 2021 α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development, Wang X, Liu R, Zhu W, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G, Yang W, 2019 UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis, Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G, Yang W, 2019 Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance, Liu R, Li W, Tao B, Wang X, Yang Z, Zhang Y, Wang C, Liu R, Gao H, Liang J, Yang W, 2019 Phosphoglucomutase 1 Inhibits Hepatocellular Carcinoma Progression by Regulating Glucose Trafficking, Jin G, Zhang Y, Cong W, Wu X, Wang X, Wu S, Wang S, Zhou W, Yuan S, Gao H, Yu G, Yang W, 2018 Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis, Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G, Liang J, Yang W, 2018 Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2, Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Yang W, 2017 PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis, Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W, Lu Z, 2016 ERK1/2-dependent nuclear translocation of PKM2 promotes the Warburg effect, Yang W, Zheng Y, Xia Y, Ji H, Cote G, Aldape K, Chen X, Lu Z, 2013 EGFR-induced NF-κB activation upregulates PKM2 expression and promotes the Warburg effect, Yang W, Xia Y, Zheng Y, Bu W, Yung W, Cote G, Aldape K, Li Y, Verma I, Chiao P, Lu Z, 2012 PKM2 phosphorylates Histone H3 and promotes gene transcription and tumorigenesis, Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Yung W, Lu Z, 2012 Nuclear PKM2 regulates beta-catenin transactivation upon EGF stimulation, Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z, 2011

Areas of Focus

Metabolic reprogramming mechanisms in major diseases like cancer
New functions of metabolic small molecules
Interactive regulation of tumor microenvironment and tumor cell metabolism

Publications

MAPK signaling-induced Phosphorylation and Subcellular Translocation of PDHE1α Promotes Tumor Immune Evasion, Zhang Y, Zhao M, Gao H, Yu G, Zhao Y, Yao F, Yang W, 2022
Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma, Wu S, Cao R, Tao B, Wu P, Peng C, Gao H, Liang J, Yang W, 2022
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine, Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, Wei P, Liang J, Yu G, Wang X, Li X, Li D, Yang W, 2021
α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development, Wang X, Liu R, Zhu W, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G, Yang W, 2019
UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis, Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G, Yang W, 2019
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance, Liu R, Li W, Tao B, Wang X, Yang Z, Zhang Y, Wang C, Liu R, Gao H, Liang J, Yang W, 2019
Phosphoglucomutase 1 Inhibits Hepatocellular Carcinoma Progression by Regulating Glucose Trafficking, Jin G, Zhang Y, Cong W, Wu X, Wang X, Wu S, Wang S, Zhou W, Yuan S, Gao H, Yu G, Yang W, 2018
Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis, Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G, Liang J, Yang W, 2018
Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2, Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Yang W, 2017
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis, Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W, Lu Z, 2016
ERK1/2-dependent nuclear translocation of PKM2 promotes the Warburg effect, Yang W, Zheng Y, Xia Y, Ji H, Cote G, Aldape K, Chen X, Lu Z, 2013
EGFR-induced NF-κB activation upregulates PKM2 expression and promotes the Warburg effect, Yang W, Xia Y, Zheng Y, Bu W, Yung W, Cote G, Aldape K, Li Y, Verma I, Chiao P, Lu Z, 2012
PKM2 phosphorylates Histone H3 and promotes gene transcription and tumorigenesis, Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Yung W, Lu Z, 2012
Nuclear PKM2 regulates beta-catenin transactivation upon EGF stimulation, Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z, 2011

Cancer Metabolism Tumor Microenvironment Biomarker Diagnosis Therapy Signal Pathways Cell Survival Growth

Yi Shi - Shanghai Jiao Tong University

Shi Yi - Shanghai Jiao Tong University

Wei Chen - Huazhong University of Science and Technology

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