Professor | Zhihua Zhou | Asia Growth Partners

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Name	Zhihua Zhou
Contact Information	zhouzhihua@cemps.ac.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Zhihua Zhou

Contact Information

zhouzhihua@cemps.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Work Experience	2004-12 - 2020-04 - Chinese Academy of Sciences, Shanghai Institute of Plant Physiology and Ecology - Role not specified 2020-05 - Present - Chinese Academy of Sciences, Center for Excellence in Molecular Plant Sciences - Role not specified

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Work Experience

2004-12 - 2020-04 - Chinese Academy of Sciences, Shanghai Institute of Plant Physiology and Ecology - Role not specified
2020-05 - Present - Chinese Academy of Sciences, Center for Excellence in Molecular Plant Sciences - Role not specified

Areas of Focus	Synthesis pathways of natural compounds in plants and fungi Large-scale mining, functional identification, modification, and catalytic mechanism of catalytic elements Regulation mechanisms of protein synthesis and secretion in Trichoderma reesei and its application in high-value protein products Design, construction, and optimization of fungal cell factories for important plant or fungal natural compounds
Publications	Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol, Yang CS, Wang Y, Su Z, Yang X, Ma DW, Zhao GP, Zhou ZH, 2024 Repurposing the cellulase workhorse Trichoderma reesei as a ROBUST chassis for efficient terpene production, Xiao M, Wang YM, Gen Zou, Zhihua Zhou, Pingping Wang, 2023 Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae, Li C, Yan X, Xu Z, Wang Y, Shen X, Zhang L, Zhou Z, Wang P, 2022 Building a Versatile Protein Production Platform Using Engineered Trichoderma reesei, Shunxing Chai, Zhihua Zhu, Ernuo Tian, Meili Xiao, Yan Wang, Gen Zou, Zhihua Zhou, 2022 High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae, Xiaodong Li, Yinmei Wang, Zhenjun Fan, Yan Wang, Pingping Wang, Xing Yan, Zhihua Zhou, 2021 Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli, Pingping Wang, Chaojing Li, Xiaodong Li, Wenjun Huang, Yan Wang, Jiali Wang, Yanjun Zhang, Xiaoman Yang, Xing Yan, Ying Wang, Zhihua Zhou, 2021 Efficient genome editing in filamentous fungi via an improved CRISPR-Cas9 ribonucleoprotein method facilitated by chemical reagents, Gen Zou, Meili Xiao, Shunxing Chai, Zhihua Zhu, Ying Wang, Zhihua Zhou, 2020 Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency, Pingping Wang, Wei Wei, Wei Ye, Xiaodong Li, Wenfang Zhao, Chengshuai Yang, Chaojing Li, Xing Yan, Zhihua Zhou, 2019 Characterizations of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts, Wei W, Wang P, Wei Y, Liu Q, Yang C, G Zhao, Yue J, Yan X, Zhou Z, 2015 Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system, Rui Liu, Ling Chen, Yanping Jiang, Zhihua Zhou, Gen Zou, 2015 Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts, Wang P, Y Wei, Y Fan, Q Liu, W Wei, C Yang, L Zhang, G Zhao, J Yue, X Yan, Z Zhou, 2015 Production of bioactive ginsenoside compound K in metabolically engineered yeast, Yan X, Y Fan, W Wei, P Wang, Q Liu, L Zhang, G Zhao, J Yue, Z Zhou, 2014

Areas of Focus

Synthesis pathways of natural compounds in plants and fungi
Large-scale mining, functional identification, modification, and catalytic mechanism of catalytic elements
Regulation mechanisms of protein synthesis and secretion in Trichoderma reesei and its application in high-value protein products
Design, construction, and optimization of fungal cell factories for important plant or fungal natural compounds

Publications

Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol, Yang CS, Wang Y, Su Z, Yang X, Ma DW, Zhao GP, Zhou ZH, 2024
Repurposing the cellulase workhorse Trichoderma reesei as a ROBUST chassis for efficient terpene production, Xiao M, Wang YM, Gen Zou, Zhihua Zhou, Pingping Wang, 2023
Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae, Li C, Yan X, Xu Z, Wang Y, Shen X, Zhang L, Zhou Z, Wang P, 2022
Building a Versatile Protein Production Platform Using Engineered Trichoderma reesei, Shunxing Chai, Zhihua Zhu, Ernuo Tian, Meili Xiao, Yan Wang, Gen Zou, Zhihua Zhou, 2022
High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae, Xiaodong Li, Yinmei Wang, Zhenjun Fan, Yan Wang, Pingping Wang, Xing Yan, Zhihua Zhou, 2021
Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli, Pingping Wang, Chaojing Li, Xiaodong Li, Wenjun Huang, Yan Wang, Jiali Wang, Yanjun Zhang, Xiaoman Yang, Xing Yan, Ying Wang, Zhihua Zhou, 2021
Efficient genome editing in filamentous fungi via an improved CRISPR-Cas9 ribonucleoprotein method facilitated by chemical reagents, Gen Zou, Meili Xiao, Shunxing Chai, Zhihua Zhu, Ying Wang, Zhihua Zhou, 2020
Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency, Pingping Wang, Wei Wei, Wei Ye, Xiaodong Li, Wenfang Zhao, Chengshuai Yang, Chaojing Li, Xing Yan, Zhihua Zhou, 2019
Characterizations of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts, Wei W, Wang P, Wei Y, Liu Q, Yang C, G Zhao, Yue J, Yan X, Zhou Z, 2015
Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system, Rui Liu, Ling Chen, Yanping Jiang, Zhihua Zhou, Gen Zou, 2015
Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts, Wang P, Y Wei, Y Fan, Q Liu, W Wei, C Yang, L Zhang, G Zhao, J Yue, X Yan, Z Zhou, 2015
Production of bioactive ginsenoside compound K in metabolically engineered yeast, Yan X, Y Fan, W Wei, P Wang, Q Liu, L Zhang, G Zhao, J Yue, Z Zhou, 2014

Natural Compounds Plants Fungi Synthesis Pathways Catalytic Elements Protein Synthesis Secretion Trichoderma Reesei Cell Factories Optimization

Dan Tan - Xi'an Jiaotong University

Xiangyun Zhu - University of Chinese Academy of Sciences

Yanhui Zhao - University of Chinese Academy of Sciences

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