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Youming Zhang
Life Science
University of Chinese Academy of Sciences
Guangdong
Language: English, Chinese, German
Genomics
Biosynthesis
Gene Clusters
Recombineering
Microbial Technology
Synthetic Biology
Molecular Biology
Biochemistry
Cell Biology
Microbiology
Areas of Focus
- Synthetic Biology
- Molecular and Cellular Biology
- Biochemistry and Molecular Biology
- Biochemistry
- Molecular Biology
- Microbiology
Work Experience
- 2021-04~Present - Chinese Academy of Sciences Shenzhen Institute of Advanced Technology - Head of Department of Engineering Biology
- 2013-04~Present - Shandong University - Director of State Key Laboratory of Microbial Technology
- 2000-07~2013-03 - Gene Bridges GmbH - Chief Technology Officer
- 1998-07~2000-06 - European Molecular Biology Laboratory (EMBL) - Long-term fellowship
- 1997-01~1998-06 - European Molecular Biology Laboratory (EMBL) - Postdoctoral Researcher
- 1995-01~1996-12 - Heidelberg University Medical School - Postdoctoral Researcher
- 1988-09~1990-04 - Chinese Academy of Medical Sciences - Assistant Researcher
Academic Background & Achievements
- 1990-05--1994-12 PhD: Heidelberg University
- 1985-09--1988-07 Master's: Peking Union Medical College
- 1981-09--1985-07 Bachelor's: Xiamen University
Publications
- Genomics-Driven Activation of Silent Biosynthetic Gene Clusters in Burkholderia gladioli by Screening Recombineering System, Youming Zhang, 2021
- Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis, Youming Zhang, 2021
- Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria, Youming Zhang, 2021
- Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters, Youming Zhang, 2020
- RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters, Youming Zhang, 2020
- Natural Products from Mammalian Gut Microbiota, Youming Zhang, 2019
- Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation, Youming Zhang, 2018
- Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species, Youming Zhang, 2018
- ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes, Youming Zhang, 2018
- An Engineered Virus Library as a Resource for the Spectrum-wide Exploration of Virus and Vector Diversity, Youming Zhang, 2017
- RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression, Youming Zhang, 2016
- A new recombineering system for Photorhabdus and Xenorhabdus, Youming Zhang, 2015
- Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety, Youming Zhang, 2015
- Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene transfer, Youming Zhang, 2014
- Improved seamless mutagenesis by recombineering using ccdB for counterselection, Youming Zhang, 2014
- Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting, Youming Zhang, 2012
- High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes, Youming Zhang, 2011
- Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition, Youming Zhang, 2008
- TransgeneOmics: a high-throughput method for exploration of protein function in mammals, Youming Zhang, 2008
- A recombineering pipeline for functional genomics applied to Caenorhabditis elegans, Youming Zhang, 2006
- Engineering of mouse genome with bacterial artificial chromosomes to create multipurpose alleles, Youming Zhang, 2003
- RecE/RecT and Red/Red initiate double stranded break repair by specifically interacting with their respective partners, Youming Zhang, 2000
- DNA cloning by homologous recombination in Escherichia coli, Youming Zhang, 2000
- Rapid modification of bacterial artificial chromosomes by ET-recombination, Youming Zhang, 1999
- A new logic for DNA engineering using recombination in Escherichia coli, Youming Zhang, 1998
- Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity, Youming Zhang, 1998
- Intravenous somatic gene transfer with antisense-tissue factor reduces tumor necrosis factor induced tissue factor expression and fibrin formation on the endothelial cells of mouse Meth-A sarcomas, Youming Zhang, 1996
- Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice, Youming Zhang, 1994
- The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth, Youming Zhang, 1994
Awards
- German National Academy of Engineering (acatech) (2020): Member
- Elsevier China Highly Cited Scholar (2020): Recognition
- Natural Science Award (2019): Second Prize
- Baosteel Excellent Teacher Award (2019): Recognition
- Shandong University Excellent Teacher Award (2019): Recognition
- Elsevier China Highly Cited Scholar (2019): Recognition
- Academia Europaea (2019): Member
- Elsevier China Highly Cited Scholar (2018): Recognition
