Professor | Youming Zhang | Asia Growth Partners

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Name	Youming Zhang
Contact Information	ym.zhang1@siat.ac.cn
Language ability	English, Chinese, German
Province	Guangdong

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Name

Youming Zhang

Contact Information

ym.zhang1@siat.ac.cn

Language ability

English, Chinese, German

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1990-05--1994-12 PhD: Heidelberg University 1985-09--1988-07 Master's: Peking Union Medical College 1981-09--1985-07 Bachelor's: Xiamen University
Work Experience	2021-04~Present - Chinese Academy of Sciences Shenzhen Institute of Advanced Technology - Head of Department of Engineering Biology 2013-04~Present - Shandong University - Director of State Key Laboratory of Microbial Technology 2000-07~2013-03 - Gene Bridges GmbH - Chief Technology Officer 1998-07~2000-06 - European Molecular Biology Laboratory (EMBL) - Long-term fellowship 1997-01~1998-06 - European Molecular Biology Laboratory (EMBL) - Postdoctoral Researcher 1995-01~1996-12 - Heidelberg University Medical School - Postdoctoral Researcher 1988-09~1990-04 - Chinese Academy of Medical Sciences - Assistant Researcher
Awards	German National Academy of Engineering (acatech) (2020): Member Elsevier China Highly Cited Scholar (2020): Recognition Natural Science Award (2019): Second Prize Baosteel Excellent Teacher Award (2019): Recognition Shandong University Excellent Teacher Award (2019): Recognition Elsevier China Highly Cited Scholar (2019): Recognition Academia Europaea (2019): Member Elsevier China Highly Cited Scholar (2018): Recognition

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1990-05--1994-12 PhD: Heidelberg University
1985-09--1988-07 Master's: Peking Union Medical College
1981-09--1985-07 Bachelor's: Xiamen University

Work Experience

2021-04~Present - Chinese Academy of Sciences Shenzhen Institute of Advanced Technology - Head of Department of Engineering Biology
2013-04~Present - Shandong University - Director of State Key Laboratory of Microbial Technology
2000-07~2013-03 - Gene Bridges GmbH - Chief Technology Officer
1998-07~2000-06 - European Molecular Biology Laboratory (EMBL) - Long-term fellowship
1997-01~1998-06 - European Molecular Biology Laboratory (EMBL) - Postdoctoral Researcher
1995-01~1996-12 - Heidelberg University Medical School - Postdoctoral Researcher
1988-09~1990-04 - Chinese Academy of Medical Sciences - Assistant Researcher

Awards

German National Academy of Engineering (acatech) (2020): Member
Elsevier China Highly Cited Scholar (2020): Recognition
Natural Science Award (2019): Second Prize
Baosteel Excellent Teacher Award (2019): Recognition
Shandong University Excellent Teacher Award (2019): Recognition
Elsevier China Highly Cited Scholar (2019): Recognition
Academia Europaea (2019): Member
Elsevier China Highly Cited Scholar (2018): Recognition

Areas of Focus	Synthetic Biology Molecular and Cellular Biology Biochemistry and Molecular Biology Biochemistry Molecular Biology Microbiology
Publications	Genomics-Driven Activation of Silent Biosynthetic Gene Clusters in Burkholderia gladioli by Screening Recombineering System, Youming Zhang, 2021 Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis, Youming Zhang, 2021 Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria, Youming Zhang, 2021 Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters, Youming Zhang, 2020 RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters, Youming Zhang, 2020 Natural Products from Mammalian Gut Microbiota, Youming Zhang, 2019 Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation, Youming Zhang, 2018 Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species, Youming Zhang, 2018 ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes, Youming Zhang, 2018 An Engineered Virus Library as a Resource for the Spectrum-wide Exploration of Virus and Vector Diversity, Youming Zhang, 2017 RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression, Youming Zhang, 2016 A new recombineering system for Photorhabdus and Xenorhabdus, Youming Zhang, 2015 Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety, Youming Zhang, 2015 Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene transfer, Youming Zhang, 2014 Improved seamless mutagenesis by recombineering using ccdB for counterselection, Youming Zhang, 2014 Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting, Youming Zhang, 2012 High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes, Youming Zhang, 2011 Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition, Youming Zhang, 2008 TransgeneOmics: a high-throughput method for exploration of protein function in mammals, Youming Zhang, 2008 A recombineering pipeline for functional genomics applied to Caenorhabditis elegans, Youming Zhang, 2006 Engineering of mouse genome with bacterial artificial chromosomes to create multipurpose alleles, Youming Zhang, 2003 RecE/RecT and Red/Red initiate double stranded break repair by specifically interacting with their respective partners, Youming Zhang, 2000 DNA cloning by homologous recombination in Escherichia coli, Youming Zhang, 2000 Rapid modification of bacterial artificial chromosomes by ET-recombination, Youming Zhang, 1999 A new logic for DNA engineering using recombination in Escherichia coli, Youming Zhang, 1998 Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity, Youming Zhang, 1998 Intravenous somatic gene transfer with antisense-tissue factor reduces tumor necrosis factor induced tissue factor expression and fibrin formation on the endothelial cells of mouse Meth-A sarcomas, Youming Zhang, 1996 Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice, Youming Zhang, 1994 The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth, Youming Zhang, 1994

Areas of Focus

Synthetic Biology
Molecular and Cellular Biology
Biochemistry and Molecular Biology
Biochemistry
Molecular Biology
Microbiology

Publications

Genomics-Driven Activation of Silent Biosynthetic Gene Clusters in Burkholderia gladioli by Screening Recombineering System, Youming Zhang, 2021
Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis, Youming Zhang, 2021
Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria, Youming Zhang, 2021
Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters, Youming Zhang, 2020
RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters, Youming Zhang, 2020
Natural Products from Mammalian Gut Microbiota, Youming Zhang, 2019
Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation, Youming Zhang, 2018
Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species, Youming Zhang, 2018
ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes, Youming Zhang, 2018
An Engineered Virus Library as a Resource for the Spectrum-wide Exploration of Virus and Vector Diversity, Youming Zhang, 2017
RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression, Youming Zhang, 2016
A new recombineering system for Photorhabdus and Xenorhabdus, Youming Zhang, 2015
Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety, Youming Zhang, 2015
Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene transfer, Youming Zhang, 2014
Improved seamless mutagenesis by recombineering using ccdB for counterselection, Youming Zhang, 2014
Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting, Youming Zhang, 2012
High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes, Youming Zhang, 2011
Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition, Youming Zhang, 2008
TransgeneOmics: a high-throughput method for exploration of protein function in mammals, Youming Zhang, 2008
A recombineering pipeline for functional genomics applied to Caenorhabditis elegans, Youming Zhang, 2006
Engineering of mouse genome with bacterial artificial chromosomes to create multipurpose alleles, Youming Zhang, 2003
RecE/RecT and Red/Red initiate double stranded break repair by specifically interacting with their respective partners, Youming Zhang, 2000
DNA cloning by homologous recombination in Escherichia coli, Youming Zhang, 2000
Rapid modification of bacterial artificial chromosomes by ET-recombination, Youming Zhang, 1999
A new logic for DNA engineering using recombination in Escherichia coli, Youming Zhang, 1998
Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity, Youming Zhang, 1998
Intravenous somatic gene transfer with antisense-tissue factor reduces tumor necrosis factor induced tissue factor expression and fibrin formation on the endothelial cells of mouse Meth-A sarcomas, Youming Zhang, 1996
Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice, Youming Zhang, 1994
The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth, Youming Zhang, 1994

Genomics Biosynthesis Gene Clusters Recombineering Microbial Technology Synthetic Biology Molecular Biology Biochemistry Cell Biology Microbiology

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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