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Jian Zhang
Life Science
University of Chinese Academy of Sciences
Guangdong
Language: Chinese, English
Active Peptides
Hypothalamus
Effector Organ Axis
Metabolic Regulation
Adipose Tissue
Bone
Muscle
Ovaries
Maternal-Fetal Metabolism
Metabolic Risk
Areas of Focus
- Role and mechanism of active peptides in the metabolic regulation of the hypothalamic effector organ axis (adipose tissue, bone, muscle, etc.) and ovaries
- Role and mechanism of active peptides in the metabolic interaction between the hypothalamic effector organ axis (adipose tissue, bone, muscle, etc.) and maternal-fetal metabolism and the regulation of metabolic risk in two generations
Work Experience
- 2010-12 to present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher
- 2008-2010 - Stanford University/ELIXIR/PAIRE - Research Scientist
- 2003-2008 - Stanford University/Department of Obstetrics and Gynecology - Postdoctoral
Academic Background & Achievements
- 1999-07--2003-06 PhD: Institute of Zoology, Chinese Academy of Sciences
- Achievement: Applied for 90 patents, 40 granted
Publications
- Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia, TAN L B, OUYANG Z j, CHEN Z L, SUN F, GUO H C, WANG F, MULDER M, SUN Y, LU XF, ZHANG JV, DANSER AHJ, VERDONK K, FAN X J, YANG Q, 2023
- Role of small RNAs harbored by sperm in embryonic development and offspring phenotype, YANG C, ZENG QX, LIU JC, YEUNG WS, ZHANG JV, DUAN YG, 2022
- Chondroitin sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-guided Chemotherapy Against Triple Negative Breast Primary and Lung Metastatic Cancer, HUANG C, BIN C, CAI J X, CHEN J, WANG B B, LI MX, ZHOU WEI, WANG J G, ZHANG P F, ZHANG J V, 2022
- Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression, YU M, YANG Y L, ZHAO H, LI M X, CHEN J, WANG B B, XIAO T X, HUANG C, ZHAO HS, ZHOU W, ZHANG J V, 2022
- Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/beta-catenin signaling in preeclampsia, GUAN X N, YU M, WU LL, CHEN J, TONG J N, WU X X, YIN A Q, XIAO T X, WANG B B, ZHANG J V, NIU J M, 2022
- Chemerin: a functional adipokine in reproductive health and diseases, YU M, YANG YL, HUANG C, GE L, XUE L, XIAO ZL, XIAO TX, ZHAO HS, REN PG, ZHANG JV, 2022
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia, YIN A Q, GUAN X N, ZHANG JV, NIU J M, 2022
- Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old, SONG Q Y, XIAO B, HUANG H L, MA L Y, ZHANG JV, ZHU Y F, 2022
- The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy, ZHANG QQ, XIAO Z L, LEE C K, DUAN Y G, FAN X J, YEUNG W S B, CHIU P C N, ZHANG J V, 2022
- Simulated microgravity potentiates hematopoietic differention of human pluripotent stem cells and supports formation of 3D hematopoietic cluster, MA CY, XIONG Y, HAN P, ZHANG X Y, CAO Y J, WANG B B, ZHAO H S, DUAN E K, ZHANG J V, LEI X H, 2022
- Extended endocrine therapy in breastcancer:A basket of length-constraint feature selection metaheuristics to balance Type I againstType II errors, LIU H P, ZHANG J V, WANG DW, ALBRECHT A, STEINHÖFEL K, LAI HM, 2022
- Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia, LEE CL, CHEN ZL, ZHANG Q Q, GUO Y, NG VWY, ZHANG B Z, BAI KF, RUAN DG, KAN ASY, CHEUNG KW, MAK ASL, YEUNG WSB, SU R, YANG Q, CHEN M, DU MR, ZHANG J, FAN XJ, CHIU PCN, 2022
- Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms, TAN L B, CHEN Z L, SUN F, ZHOU Z Q, Zhang B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN RI, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J, 2022
- Placenta-Specific miR-125b Overexpression Leads to Increased Rates of Pregnancy Loss in Mice, SUN F, CAI H, TAN L B, QIN D Z, ZHANG J, HUA J L, FAN X J, PENG S, 2022
- SLC4A10表达水平对肝癌患者预后的影响, 黄容，张键，车旭, 2022
- Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models, ZHOU X S, ZHAO J, ZHANG J V, WU Y L, WANG L, CHEN X Q, JI D M, ZHOU G G Y, 2021
- An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic -Pituitary- Ovarian Axis, LI R R, MA C Y, XIONG Y, ZHAO H S, YANG Y L, XUE L, WANG B B, XIAO T X, CHEN J, LEI X H, MA B H, ZHANG J V, 2021
- Inhibition of Col6a5 improve lipid metabolism disorder in Dihydrotestosterone-induced hyperandrogenic mice, SUN LF, YANG Y L, WANG M Y, ZHAO H S, XIAO T X, LI M X, WANG B B, HUANG C, REN P G, ZHANG JV, 2021
- High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway, WANG H F, HUANG B B, HOU A L, XUE L, WANG B B, CHEN J, LI M X, ZHANG J V, 2021
- Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells, ZHANG J Z, CHEN Z L, WANG B B, CHEN J, XIAO TX, ZHANG J V, CHEN S L, FAN XJ, 2021
- Upregulation of OATP1A2 in Human Esophageal Squamous Cell Carcinoma Cells via the HDAC6-GCN5/PCAF-H3K9Ac Axis, ZHENG X L, ZHANG J V, BAI Y F, WANG J Q, JIANG M F, ZENG S, WANG L H, 2021
- Placental Trophoblast Specific Overexpression of Chemerin Induces Preeclampsia-like Symptoms, TAN L B, CHEN Z L, SUN F, ZHOU Z Q, ZHANG B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN R I, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J, 2021
- DYF-4 regulates patched-related/ DAF-6-mediated sensory compartment formation in C. elegans, HONG H, CHEN H C, ZHANG Y X, WU Z M, ZHANG Y Y, ZHANG Y Y, HU Z, ZHANG J V, LING K, HU J H, WEI Q, 2021
- Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles, ZHAO Y, FENG H W, ZHANG Y H, ZHANG J V, WANG X H, LIU D T, WANG T R, LI R H W, NG E H Y, YEUNG W S B, RODRIGUEZ-WALLBERG K A, LIU K, 2021
- A novel photocrosslinked phosphate functionalized Chitosan-Sr5(PO4)2SiO4 composite hydrogels and in vitro biomineralization, osteogenesis, angiogenesis for bone regeneration application, CHEN Y Q,
Awards
- Shenzhen Science and Technology Progress Award Second Prize (2022): First Completer
- Shenzhen National Leading Talent (2021)
- Chinese Academy of Sciences 'Preferential Support' (2011)
- Shenzhen Outstanding Youth (2012)
- Shenzhen 'Peacock Plan' Overseas High-Level Talent Category C (2014)/Category B (2016)
- Chinese Academy of Sciences President's Award for Excellence (2003)
- Chinese Academy of Sciences Graduate Innovation Scholarship (2002)
- Best Poster Award at Weimar Conference, Germany (2002)
