Professor | Jian Zhang | Asia Growth Partners

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Name	Jian Zhang
Contact Information	jian.zhang@siat.ac.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Jian Zhang

Contact Information

jian.zhang@siat.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1999-07--2003-06 PhD: Institute of Zoology, Chinese Academy of Sciences Achievement: Applied for 90 patents, 40 granted
Work Experience	2010-12 to present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher 2008-2010 - Stanford University/ELIXIR/PAIRE - Research Scientist 2003-2008 - Stanford University/Department of Obstetrics and Gynecology - Postdoctoral
Awards	Shenzhen Science and Technology Progress Award Second Prize (2022): First Completer Shenzhen National Leading Talent (2021) Chinese Academy of Sciences 'Preferential Support' (2011) Shenzhen Outstanding Youth (2012) Shenzhen 'Peacock Plan' Overseas High-Level Talent Category C (2014)/Category B (2016) Chinese Academy of Sciences President's Award for Excellence (2003) Chinese Academy of Sciences Graduate Innovation Scholarship (2002) Best Poster Award at Weimar Conference, Germany (2002)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1999-07--2003-06 PhD: Institute of Zoology, Chinese Academy of Sciences
Achievement: Applied for 90 patents, 40 granted

Work Experience

2010-12 to present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher
2008-2010 - Stanford University/ELIXIR/PAIRE - Research Scientist
2003-2008 - Stanford University/Department of Obstetrics and Gynecology - Postdoctoral

Awards

Shenzhen Science and Technology Progress Award Second Prize (2022): First Completer
Shenzhen National Leading Talent (2021)
Chinese Academy of Sciences 'Preferential Support' (2011)
Shenzhen Outstanding Youth (2012)
Shenzhen 'Peacock Plan' Overseas High-Level Talent Category C (2014)/Category B (2016)
Chinese Academy of Sciences President's Award for Excellence (2003)
Chinese Academy of Sciences Graduate Innovation Scholarship (2002)
Best Poster Award at Weimar Conference, Germany (2002)

Areas of Focus	Role and mechanism of active peptides in the metabolic regulation of the hypothalamic effector organ axis (adipose tissue, bone, muscle, etc.) and ovaries Role and mechanism of active peptides in the metabolic interaction between the hypothalamic effector organ axis (adipose tissue, bone, muscle, etc.) and maternal-fetal metabolism and the regulation of metabolic risk in two generations
Publications	Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia, TAN L B, OUYANG Z j, CHEN Z L, SUN F, GUO H C, WANG F, MULDER M, SUN Y, LU XF, ZHANG JV, DANSER AHJ, VERDONK K, FAN X J, YANG Q, 2023 Role of small RNAs harbored by sperm in embryonic development and offspring phenotype, YANG C, ZENG QX, LIU JC, YEUNG WS, ZHANG JV, DUAN YG, 2022 Chondroitin sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-guided Chemotherapy Against Triple Negative Breast Primary and Lung Metastatic Cancer, HUANG C, BIN C, CAI J X, CHEN J, WANG B B, LI MX, ZHOU WEI, WANG J G, ZHANG P F, ZHANG J V, 2022 Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression, YU M, YANG Y L, ZHAO H, LI M X, CHEN J, WANG B B, XIAO T X, HUANG C, ZHAO HS, ZHOU W, ZHANG J V, 2022 Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/beta-catenin signaling in preeclampsia, GUAN X N, YU M, WU LL, CHEN J, TONG J N, WU X X, YIN A Q, XIAO T X, WANG B B, ZHANG J V, NIU J M, 2022 Chemerin: a functional adipokine in reproductive health and diseases, YU M, YANG YL, HUANG C, GE L, XUE L, XIAO ZL, XIAO TX, ZHAO HS, REN PG, ZHANG JV, 2022 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia, YIN A Q, GUAN X N, ZHANG JV, NIU J M, 2022 Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old, SONG Q Y, XIAO B, HUANG H L, MA L Y, ZHANG JV, ZHU Y F, 2022 The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy, ZHANG QQ, XIAO Z L, LEE C K, DUAN Y G, FAN X J, YEUNG W S B, CHIU P C N, ZHANG J V, 2022 Simulated microgravity potentiates hematopoietic differention of human pluripotent stem cells and supports formation of 3D hematopoietic cluster, MA CY, XIONG Y, HAN P, ZHANG X Y, CAO Y J, WANG B B, ZHAO H S, DUAN E K, ZHANG J V, LEI X H, 2022 Extended endocrine therapy in breastcancer:A basket of length-constraint feature selection metaheuristics to balance Type I againstType II errors, LIU H P, ZHANG J V, WANG DW, ALBRECHT A, STEINHÖFEL K, LAI HM, 2022 Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia, LEE CL, CHEN ZL, ZHANG Q Q, GUO Y, NG VWY, ZHANG B Z, BAI KF, RUAN DG, KAN ASY, CHEUNG KW, MAK ASL, YEUNG WSB, SU R, YANG Q, CHEN M, DU MR, ZHANG J, FAN XJ, CHIU PCN, 2022 Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms, TAN L B, CHEN Z L, SUN F, ZHOU Z Q, Zhang B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN RI, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J, 2022 Placenta-Specific miR-125b Overexpression Leads to Increased Rates of Pregnancy Loss in Mice, SUN F, CAI H, TAN L B, QIN D Z, ZHANG J, HUA J L, FAN X J, PENG S, 2022 SLC4A10表达水平对肝癌患者预后的影响, 黄容，张键，车旭, 2022 Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models, ZHOU X S, ZHAO J, ZHANG J V, WU Y L, WANG L, CHEN X Q, JI D M, ZHOU G G Y, 2021 An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic -Pituitary- Ovarian Axis, LI R R, MA C Y, XIONG Y, ZHAO H S, YANG Y L, XUE L, WANG B B, XIAO T X, CHEN J, LEI X H, MA B H, ZHANG J V, 2021 Inhibition of Col6a5 improve lipid metabolism disorder in Dihydrotestosterone-induced hyperandrogenic mice, SUN LF, YANG Y L, WANG M Y, ZHAO H S, XIAO T X, LI M X, WANG B B, HUANG C, REN P G, ZHANG JV, 2021 High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway, WANG H F, HUANG B B, HOU A L, XUE L, WANG B B, CHEN J, LI M X, ZHANG J V, 2021 Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells, ZHANG J Z, CHEN Z L, WANG B B, CHEN J, XIAO TX, ZHANG J V, CHEN S L, FAN XJ, 2021 Upregulation of OATP1A2 in Human Esophageal Squamous Cell Carcinoma Cells via the HDAC6-GCN5/PCAF-H3K9Ac Axis, ZHENG X L, ZHANG J V, BAI Y F, WANG J Q, JIANG M F, ZENG S, WANG L H, 2021 Placental Trophoblast Specific Overexpression of Chemerin Induces Preeclampsia-like Symptoms, TAN L B, CHEN Z L, SUN F, ZHOU Z Q, ZHANG B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN R I, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J, 2021 DYF-4 regulates patched-related/ DAF-6-mediated sensory compartment formation in C. elegans, HONG H, CHEN H C, ZHANG Y X, WU Z M, ZHANG Y Y, ZHANG Y Y, HU Z, ZHANG J V, LING K, HU J H, WEI Q, 2021 Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles, ZHAO Y, FENG H W, ZHANG Y H, ZHANG J V, WANG X H, LIU D T, WANG T R, LI R H W, NG E H Y, YEUNG W S B, RODRIGUEZ-WALLBERG K A, LIU K, 2021 A novel photocrosslinked phosphate functionalized Chitosan-Sr5(PO4)2SiO4 composite hydrogels and in vitro biomineralization, osteogenesis, angiogenesis for bone regeneration application, CHEN Y Q,

Areas of Focus

Role and mechanism of active peptides in the metabolic regulation of the hypothalamic effector organ axis (adipose tissue, bone, muscle, etc.) and ovaries
Role and mechanism of active peptides in the metabolic interaction between the hypothalamic effector organ axis (adipose tissue, bone, muscle, etc.) and maternal-fetal metabolism and the regulation of metabolic risk in two generations

Publications

Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia, TAN L B, OUYANG Z j, CHEN Z L, SUN F, GUO H C, WANG F, MULDER M, SUN Y, LU XF, ZHANG JV, DANSER AHJ, VERDONK K, FAN X J, YANG Q, 2023
Role of small RNAs harbored by sperm in embryonic development and offspring phenotype, YANG C, ZENG QX, LIU JC, YEUNG WS, ZHANG JV, DUAN YG, 2022
Chondroitin sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-guided Chemotherapy Against Triple Negative Breast Primary and Lung Metastatic Cancer, HUANG C, BIN C, CAI J X, CHEN J, WANG B B, LI MX, ZHOU WEI, WANG J G, ZHANG P F, ZHANG J V, 2022
Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression, YU M, YANG Y L, ZHAO H, LI M X, CHEN J, WANG B B, XIAO T X, HUANG C, ZHAO HS, ZHOU W, ZHANG J V, 2022
Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/beta-catenin signaling in preeclampsia, GUAN X N, YU M, WU LL, CHEN J, TONG J N, WU X X, YIN A Q, XIAO T X, WANG B B, ZHANG J V, NIU J M, 2022
Chemerin: a functional adipokine in reproductive health and diseases, YU M, YANG YL, HUANG C, GE L, XUE L, XIAO ZL, XIAO TX, ZHAO HS, REN PG, ZHANG JV, 2022
Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia, YIN A Q, GUAN X N, ZHANG JV, NIU J M, 2022
Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old, SONG Q Y, XIAO B, HUANG H L, MA L Y, ZHANG JV, ZHU Y F, 2022
The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy, ZHANG QQ, XIAO Z L, LEE C K, DUAN Y G, FAN X J, YEUNG W S B, CHIU P C N, ZHANG J V, 2022
Simulated microgravity potentiates hematopoietic differention of human pluripotent stem cells and supports formation of 3D hematopoietic cluster, MA CY, XIONG Y, HAN P, ZHANG X Y, CAO Y J, WANG B B, ZHAO H S, DUAN E K, ZHANG J V, LEI X H, 2022
Extended endocrine therapy in breastcancer:A basket of length-constraint feature selection metaheuristics to balance Type I againstType II errors, LIU H P, ZHANG J V, WANG DW, ALBRECHT A, STEINHÖFEL K, LAI HM, 2022
Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia, LEE CL, CHEN ZL, ZHANG Q Q, GUO Y, NG VWY, ZHANG B Z, BAI KF, RUAN DG, KAN ASY, CHEUNG KW, MAK ASL, YEUNG WSB, SU R, YANG Q, CHEN M, DU MR, ZHANG J, FAN XJ, CHIU PCN, 2022
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms, TAN L B, CHEN Z L, SUN F, ZHOU Z Q, Zhang B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN RI, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J, 2022
Placenta-Specific miR-125b Overexpression Leads to Increased Rates of Pregnancy Loss in Mice, SUN F, CAI H, TAN L B, QIN D Z, ZHANG J, HUA J L, FAN X J, PENG S, 2022
SLC4A10表达水平对肝癌患者预后的影响, 黄容，张键，车旭, 2022
Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models, ZHOU X S, ZHAO J, ZHANG J V, WU Y L, WANG L, CHEN X Q, JI D M, ZHOU G G Y, 2021
An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic -Pituitary- Ovarian Axis, LI R R, MA C Y, XIONG Y, ZHAO H S, YANG Y L, XUE L, WANG B B, XIAO T X, CHEN J, LEI X H, MA B H, ZHANG J V, 2021
Inhibition of Col6a5 improve lipid metabolism disorder in Dihydrotestosterone-induced hyperandrogenic mice, SUN LF, YANG Y L, WANG M Y, ZHAO H S, XIAO T X, LI M X, WANG B B, HUANG C, REN P G, ZHANG JV, 2021
High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway, WANG H F, HUANG B B, HOU A L, XUE L, WANG B B, CHEN J, LI M X, ZHANG J V, 2021
Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells, ZHANG J Z, CHEN Z L, WANG B B, CHEN J, XIAO TX, ZHANG J V, CHEN S L, FAN XJ, 2021
Upregulation of OATP1A2 in Human Esophageal Squamous Cell Carcinoma Cells via the HDAC6-GCN5/PCAF-H3K9Ac Axis, ZHENG X L, ZHANG J V, BAI Y F, WANG J Q, JIANG M F, ZENG S, WANG L H, 2021
Placental Trophoblast Specific Overexpression of Chemerin Induces Preeclampsia-like Symptoms, TAN L B, CHEN Z L, SUN F, ZHOU Z Q, ZHANG B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN R I, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J, 2021
DYF-4 regulates patched-related/ DAF-6-mediated sensory compartment formation in C. elegans, HONG H, CHEN H C, ZHANG Y X, WU Z M, ZHANG Y Y, ZHANG Y Y, HU Z, ZHANG J V, LING K, HU J H, WEI Q, 2021
Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles, ZHAO Y, FENG H W, ZHANG Y H, ZHANG J V, WANG X H, LIU D T, WANG T R, LI R H W, NG E H Y, YEUNG W S B, RODRIGUEZ-WALLBERG K A, LIU K, 2021
A novel photocrosslinked phosphate functionalized Chitosan-Sr5(PO4)2SiO4 composite hydrogels and in vitro biomineralization, osteogenesis, angiogenesis for bone regeneration application, CHEN Y Q,

Active Peptides Hypothalamus Effector Organ Axis Metabolic Regulation Adipose Tissue Bone Muscle Ovaries Maternal-Fetal Metabolism Metabolic Risk

Xinran Ma - East China Normal University

Xinran Ma - East China Normal University

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