Professor | Lei Zhang | Asia Growth Partners

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Name	Lei Zhang
Contact Information	rayzhang@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Lei Zhang

Contact Information

rayzhang@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2001-12 to 2009-01: Postdoctoral and Assistant Lecturer at Southwestern Medical Center, USA 1998-09 to 2001-06: PhD from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences 1995-09 to 1998-06: Master's degree from Jilin University, State Key Laboratory of Enzyme Engineering 1991-09 to 1995-06: Bachelor's degree from Jilin University, Department of Molecular Biology, Biochemistry major
Work Experience	2009-01 to Present: Researcher at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 2015-03-01 to 2020-02-29: Distinguished Professor at ShanghaiTech University

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2001-12 to 2009-01: Postdoctoral and Assistant Lecturer at Southwestern Medical Center, USA
1998-09 to 2001-06: PhD from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
1995-09 to 1998-06: Master's degree from Jilin University, State Key Laboratory of Enzyme Engineering
1991-09 to 1995-06: Bachelor's degree from Jilin University, Department of Molecular Biology, Biochemistry major

Work Experience

2009-01 to Present: Researcher at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2015-03-01 to 2020-02-29: Distinguished Professor at ShanghaiTech University

Areas of Focus	Regulation of organ size and tissue homeostasis
Publications	A protocol for in vivo analysis of liver tumorigenesis using sleeping beauty transposon system., Lei Zhang, 2021 An optimized two-step chromatin immunoprecipitation protocol to quantify the associations of two separate proteins and their common target DNA., Lingli He, Wentao Yu, Wenxiang Zhang, Lei Zhang, 2021 The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice., Feng, Xue, Lu, Tiantian, Li, Jinhui, Yang, Ruizeng, Hu, Liqiao, Ye, Yi, Mao, Feifei, He, Lingli, Xu, Jinjin, Wang, Zuoyun, Liu, Yingbin, Zhang, Yonglong, Ji, Hongbin, Zhao, Yun, Cheng, Shuqun, Tian, Wei, Zhang, Lei, 2020 Mechanical force regulation of YAP by F-actin and GPCR revealed by super-resolution imaging., Gao, Jing, He, Lingli, Zhou, Lulu, Jing, Yingying, Wang, Feng, Shi, Yan, Cai, Mingjun, Sun, Jiayin, Xu, Haijiao, Jiang, Junguang, Zhang, Lei, Wang, Hongda, 2020 A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis., He, Lingli, Yuan, Liang, Yu, Wentao, Sun, Yang, Jiang, Dan, Wang, Xiaodong, Feng, Xue, Wang, Zuoyun, Xu, Jinjin, Yang, Ruizeng, Zhang, Wenxiang, Feng, Hua, Chen, Hangzi, Zeng, Yi Arial, Hui, Lijian, Wu, Qiao, Zhang, Yonglong, Zhang, Lei, 2020 VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription., Suo, Jinlong, Feng, Xue, Li, Jiayi, Wang, Jinghui, Wang, Zuoyun, Zhang, Lei, Zou, Weiguo, 2020 SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling., Liang Xu, Peixue Li, Xue Hao, Yi Lu, Mingxian Liu, Wenqian Song, Lin Shan, Jiao Yu, Hongyu Ding, Shishuang Chen, Ailing Yang, Yi Arial Zeng, Lei Zhang, Hai Jiang, 2020 VGLL4 plays a critical role in heart valve development and homeostasis., Yu, Wei, Ma, Xueyan, Xu, Jinjin, Heumueller, Andreas Wilhelm, Fei, Zhaoliang, Feng, Xue, Wang, Xiaodong, Liu, Kuo, Li, Jinhui, Cui, Guizhong, Peng, Guangdun, Ji, Hongbin, Li, Jinsong, Jing, Naihe, Song, Hai, Lin, Zhiqiang, Zhao, Yun, Wang, Zuoyun, Zhou, Bin, Zhang, Lei, 2019 Dual function of VGLL4 in muscle regeneration., Feng, Xue, Wang, Zuoyun, Wang, Fei, Lu, Tiantian, Xu, Jinjin, Ma, Xueyan, Li, Jinhui, He, Lingli, Zhang, Wenxiang, Li, Sheng, Yang, Wenjun, Zhang, Shu, Ge, Gaoxiang, Zhao, Yun, Hu, Ping, Zhang, Lei, 2019 Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila., Li, Mengjie, Hu, Xiaolong, Zhang, Shu, Ho, Margaret S, Wu, Geng, Zhang, Lei, 2019 Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression., He, Lingli, Yuan, Liang, Sun, Yang, Wang, Pingyang, Zhang, Hailin, Feng, Xue, Wang, Zuoyun, Zhang, Wenxiang, Yang, Chuanyu, Zeng, Yi Arial, Zhao, Yun, Chen, Ceshi, Zhang, Lei, 2019 Staurosporine targets the Hippo pathway to inhibit cell growth., Ma, Xueyan, Li, Peixue, Chen, Peihao, Li, Jinhui, Huang, Hongling, Wang, Chao, Li, Wenjing, Ding, Jianping, Zhao, Yun, Yu, FaXing, Qi, Xiangbing, Zhang, Lei, 2018 The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting cofactors VGLL4 and CtBP2 into a transcriptional complex., Zhang Lei, 2018 Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila., Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu, Yun Zhao, 2018 Smurf Downregulates Echinoid in the Amnioserosa To Regulate Drosophila Dorsal Closure., ChiaoMing Lin, JuiChou Hsu, LienChieh Cheng, YuChiao Li, WenTing Yang, Chao Wang, Jiajun Xu, Lei Zhang, 2017 Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity., Xu, Jiajun, Hao, Xue, Yin, MengXin, Lu, Yi, Jin, Yunyun, Xu, Jinjin, Ge, Ling, Wu, Wenqing, Ho, Margaret, Yang, Yingzi, Zhao, Yun, Zhang, Lei, 2017 Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration., Wang, Chao, Yin, MengXin, Wu, Wei, Dong, Liang, Wang, Shimin, Lu, Yi, Xu, Jinjin, Wu, Wenqing, Li, Sheng, Zhao, Yun, Zhang, Lei, 2016 Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal., Zhang Lei, 2016 Involvement of the Hippo Pathway in Regeneration and Fibrogenesis after Ischemic Acute Kidney Injury: YAP is the Key Effector., Zhang Lei, 2016 Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded., Hu, Lianxin, Xu, Jiajun, Yin, MengXin, Zhang, Liguo, Lu, Yi, Wu, Wenqing, Xue, Zhaoyu, Ho, Margaret S, Gao, Guanjun, Zhao, Yun, Zhang, Lei, 2016 Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis., Wang, Chao, Zhang, Wenxiang, Yin, MengXin, Hu, Lianxin, Li, Peixue, Xu, Jiajun, Huang, Hongling, Wang, Shimin, Lu, Yi, Wu, Wenqing, Ho, Margaret S, Li, Lin, Zhao, Yun, Zhang, Lei, 2015 Growth suppressor lingerer regulates bantam microRNA to restrict organ size., Dong, Liang, Li, Jinhui, Huang, Hongling, Yin, MengXin, Xu, Jinjin, Li, Peixue, Lu, Yi, Wu, Wenqing, Yang, Hang, Zhao, Yun, Zhang, Lei, 2015 Hippo signaling in epithelial stem cells., Yin MengXin, Zhang Lei, 2015 Control of growth and beyond: a special issue on Hippo signaling., Lei Zhang, 2015 A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer., Jiao, Shi, Wang, Huizhen, Shi, Zhubing, Dong, Aimei, Zhang, Wenjing, Song, Xiaomin, He, Feng, Wang, Yicui, Zhang, Zhenzhen, Wang, Wenjia, Wang, Xin, Guo, Tong, Li, Peixue, Zhao, Yun, Ji, Hongbin, Zhang, Lei, Zhou, Zhaocai, 2014 VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEADs transcriptional complex., Zhang Lei, 2014 Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo., Zhang Lei, 2014 YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression., Gao, Yijun, Zhang, Wenjing, Han, Xiangkun, Li, Fuming, Wang, Xujun, Wang, Rui, Fang, Zhaoyuan, Tong, Xinyuan, Yao, Shun, Li, Fei, Feng, Yan, Sun, Yihua, Hou, Yingyong, Yang, Zhongzhou, Guan, Kunliang, Chen, Haiquan, Zhang, Lei, Ji, Hongbin, 2014 Atrophin/Rpd3 complex represses Hedgehog signaling by interacting with Ci., Zhang Lei, 2013 Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling., Yunyun Jin, 2013 Drosophila Vps36 is involved in Hh signaling by regulating Smo trafficking., Zhang Lei, 2013 Drosophila Ste-20 Family Protein Kinase, Hippo, Modulates Fat Cell Proliferation., Huang, Hongling, Wu, Wenqing, Zhang, Lei, Liu, XinYuan, 2013 Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis., Zhang, Zhao, Lv, Xiangdong, Jiang, Jin, Zhang, Lei, Zhao, Yun, 2013 Structural Mechanism of CCM3 Heterod

Areas of Focus

Regulation of organ size and tissue homeostasis

Publications

A protocol for in vivo analysis of liver tumorigenesis using sleeping beauty transposon system., Lei Zhang, 2021
An optimized two-step chromatin immunoprecipitation protocol to quantify the associations of two separate proteins and their common target DNA., Lingli He, Wentao Yu, Wenxiang Zhang, Lei Zhang, 2021
The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice., Feng, Xue, Lu, Tiantian, Li, Jinhui, Yang, Ruizeng, Hu, Liqiao, Ye, Yi, Mao, Feifei, He, Lingli, Xu, Jinjin, Wang, Zuoyun, Liu, Yingbin, Zhang, Yonglong, Ji, Hongbin, Zhao, Yun, Cheng, Shuqun, Tian, Wei, Zhang, Lei, 2020
Mechanical force regulation of YAP by F-actin and GPCR revealed by super-resolution imaging., Gao, Jing, He, Lingli, Zhou, Lulu, Jing, Yingying, Wang, Feng, Shi, Yan, Cai, Mingjun, Sun, Jiayin, Xu, Haijiao, Jiang, Junguang, Zhang, Lei, Wang, Hongda, 2020
A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis., He, Lingli, Yuan, Liang, Yu, Wentao, Sun, Yang, Jiang, Dan, Wang, Xiaodong, Feng, Xue, Wang, Zuoyun, Xu, Jinjin, Yang, Ruizeng, Zhang, Wenxiang, Feng, Hua, Chen, Hangzi, Zeng, Yi Arial, Hui, Lijian, Wu, Qiao, Zhang, Yonglong, Zhang, Lei, 2020
VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription., Suo, Jinlong, Feng, Xue, Li, Jiayi, Wang, Jinghui, Wang, Zuoyun, Zhang, Lei, Zou, Weiguo, 2020
SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling., Liang Xu, Peixue Li, Xue Hao, Yi Lu, Mingxian Liu, Wenqian Song, Lin Shan, Jiao Yu, Hongyu Ding, Shishuang Chen, Ailing Yang, Yi Arial Zeng, Lei Zhang, Hai Jiang, 2020
VGLL4 plays a critical role in heart valve development and homeostasis., Yu, Wei, Ma, Xueyan, Xu, Jinjin, Heumueller, Andreas Wilhelm, Fei, Zhaoliang, Feng, Xue, Wang, Xiaodong, Liu, Kuo, Li, Jinhui, Cui, Guizhong, Peng, Guangdun, Ji, Hongbin, Li, Jinsong, Jing, Naihe, Song, Hai, Lin, Zhiqiang, Zhao, Yun, Wang, Zuoyun, Zhou, Bin, Zhang, Lei, 2019
Dual function of VGLL4 in muscle regeneration., Feng, Xue, Wang, Zuoyun, Wang, Fei, Lu, Tiantian, Xu, Jinjin, Ma, Xueyan, Li, Jinhui, He, Lingli, Zhang, Wenxiang, Li, Sheng, Yang, Wenjun, Zhang, Shu, Ge, Gaoxiang, Zhao, Yun, Hu, Ping, Zhang, Lei, 2019
Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila., Li, Mengjie, Hu, Xiaolong, Zhang, Shu, Ho, Margaret S, Wu, Geng, Zhang, Lei, 2019
Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression., He, Lingli, Yuan, Liang, Sun, Yang, Wang, Pingyang, Zhang, Hailin, Feng, Xue, Wang, Zuoyun, Zhang, Wenxiang, Yang, Chuanyu, Zeng, Yi Arial, Zhao, Yun, Chen, Ceshi, Zhang, Lei, 2019
Staurosporine targets the Hippo pathway to inhibit cell growth., Ma, Xueyan, Li, Peixue, Chen, Peihao, Li, Jinhui, Huang, Hongling, Wang, Chao, Li, Wenjing, Ding, Jianping, Zhao, Yun, Yu, FaXing, Qi, Xiangbing, Zhang, Lei, 2018
The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting cofactors VGLL4 and CtBP2 into a transcriptional complex., Zhang Lei, 2018
Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila., Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu, Yun Zhao, 2018
Smurf Downregulates Echinoid in the Amnioserosa To Regulate Drosophila Dorsal Closure., ChiaoMing Lin, JuiChou Hsu, LienChieh Cheng, YuChiao Li, WenTing Yang, Chao Wang, Jiajun Xu, Lei Zhang, 2017
Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity., Xu, Jiajun, Hao, Xue, Yin, MengXin, Lu, Yi, Jin, Yunyun, Xu, Jinjin, Ge, Ling, Wu, Wenqing, Ho, Margaret, Yang, Yingzi, Zhao, Yun, Zhang, Lei, 2017
Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration., Wang, Chao, Yin, MengXin, Wu, Wei, Dong, Liang, Wang, Shimin, Lu, Yi, Xu, Jinjin, Wu, Wenqing, Li, Sheng, Zhao, Yun, Zhang, Lei, 2016
Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal., Zhang Lei, 2016
Involvement of the Hippo Pathway in Regeneration and Fibrogenesis after Ischemic Acute Kidney Injury: YAP is the Key Effector., Zhang Lei, 2016
Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded., Hu, Lianxin, Xu, Jiajun, Yin, MengXin, Zhang, Liguo, Lu, Yi, Wu, Wenqing, Xue, Zhaoyu, Ho, Margaret S, Gao, Guanjun, Zhao, Yun, Zhang, Lei, 2016
Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis., Wang, Chao, Zhang, Wenxiang, Yin, MengXin, Hu, Lianxin, Li, Peixue, Xu, Jiajun, Huang, Hongling, Wang, Shimin, Lu, Yi, Wu, Wenqing, Ho, Margaret S, Li, Lin, Zhao, Yun, Zhang, Lei, 2015
Growth suppressor lingerer regulates bantam microRNA to restrict organ size., Dong, Liang, Li, Jinhui, Huang, Hongling, Yin, MengXin, Xu, Jinjin, Li, Peixue, Lu, Yi, Wu, Wenqing, Yang, Hang, Zhao, Yun, Zhang, Lei, 2015
Hippo signaling in epithelial stem cells., Yin MengXin, Zhang Lei, 2015
Control of growth and beyond: a special issue on Hippo signaling., Lei Zhang, 2015
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer., Jiao, Shi, Wang, Huizhen, Shi, Zhubing, Dong, Aimei, Zhang, Wenjing, Song, Xiaomin, He, Feng, Wang, Yicui, Zhang, Zhenzhen, Wang, Wenjia, Wang, Xin, Guo, Tong, Li, Peixue, Zhao, Yun, Ji, Hongbin, Zhang, Lei, Zhou, Zhaocai, 2014
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEADs transcriptional complex., Zhang Lei, 2014
Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo., Zhang Lei, 2014
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression., Gao, Yijun, Zhang, Wenjing, Han, Xiangkun, Li, Fuming, Wang, Xujun, Wang, Rui, Fang, Zhaoyuan, Tong, Xinyuan, Yao, Shun, Li, Fei, Feng, Yan, Sun, Yihua, Hou, Yingyong, Yang, Zhongzhou, Guan, Kunliang, Chen, Haiquan, Zhang, Lei, Ji, Hongbin, 2014
Atrophin/Rpd3 complex represses Hedgehog signaling by interacting with Ci., Zhang Lei, 2013
Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling., Yunyun Jin, 2013
Drosophila Vps36 is involved in Hh signaling by regulating Smo trafficking., Zhang Lei, 2013
Drosophila Ste-20 Family Protein Kinase, Hippo, Modulates Fat Cell Proliferation., Huang, Hongling, Wu, Wenqing, Zhang, Lei, Liu, XinYuan, 2013
Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis., Zhang, Zhao, Lv, Xiangdong, Jiang, Jin, Zhang, Lei, Zhao, Yun, 2013
Structural Mechanism of CCM3 Heterod

Organ Size Tissue Homeostasis Cell Number Cell Size Cell Arrangement Hippo Signaling Pathway Tumor Suppression Cell Growth Cell Proliferation Cell Apoptosis

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