Professor | Shunyi Zhu | Asia Growth Partners

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Name	Shunyi Zhu
Contact Information	zhusy@ioz.ac.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Shunyi Zhu

Contact Information

zhusy@ioz.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1997-09 to 2001-04 PhD: Wuhan University
Work Experience	2001-10 to 2004-04 - Leuven University - Postdoctoral Researcher 2017-01-01 to Present - Scientific Reports - Editorial Board Member 2015-10-01 to Present - Acta Entomologica Sinica - Editorial Board Member
Awards	East Asian Scorpion Toxinomics Research (2005): First Prize, Provincial Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1997-09 to 2001-04 PhD: Wuhan University

Work Experience

2001-10 to 2004-04 - Leuven University - Postdoctoral Researcher
2017-01-01 to Present - Scientific Reports - Editorial Board Member
2015-10-01 to Present - Acta Entomologica Sinica - Editorial Board Member

Awards

East Asian Scorpion Toxinomics Research (2005): First Prize, Provincial Level

Areas of Focus	Peptide Biology and Evolution Design of New Peptide Molecules
Publications	Molecular Diversity and Evolution of Antimicrobial Peptides in Musca domestica, Shunyi Zhu, 2021 How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: The Molecular and Evolutionary Basis Uncovered, Shunyi Zhu, 2020 Scorpion Toxins: Positive Selection at a Distal Site Modulates Functional Evolution at a Bioactive Site, Shunyi Zhu, 2019 The research progress of three finger toxin family in snakes, Shunyi Zhu, 2019 Did cis- and trans-defensins derive from a common ancestor?, Shunyi Zhu, 2019 Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Shunyi Zhu, 2018 Receptor variability-driven evolution of snake toxins, Shunyi Zhu, 2018 Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin, Shunyi Zhu, 2018 Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins, Shunyi Zhu, 2018 Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs, Shunyi Zhu, 2018 Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Shunyi Zhu, 2018 Antimicrobial and insecticidal activities and evolution of inhibitor cystine knot peptides, Shunyi Zhu, 2018 Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion, Shunyi Zhu, 2018 Molecular Dynamics Simulation Reveals Specific Interaction Sites between Scorpion Toxins and Kv1.2 Channel: Implications for Design of Highly Selective Drugs, Shunyi Zhu, 2017 New Fungal Defensin-Like Peptides Provide Evidence for Fold Change of Proteins in Evolution, Shunyi Zhu, 2017 Expanding the Pharmacological Profile of α-Hefutoxin 1 and Analogues: A Focus on the Inhibitory Effect on the Oncogenic Channel Kv10.1, Shunyi Zhu, 2017 Expanding the pharmacological profile of kappa-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1, Shunyi Zhu, 2017 Evaluating the Potential of a Loop-Extended Scorpion Toxin-Like Peptide as a Protein Scaffold, Shunyi Zhu, 2016 Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides, Shunyi Zhu, 2016 A Single-Point Mutation Enhances Dual Functionality of a Scorpion Toxin, Shunyi Zhu, 2016 Single-Point Mutation-Mediated Local Amphipathic Adjustment Dramatically Enhances Antibacterial Activity of a Fungal Defensin, Shunyi Zhu, 2016 The Drosomycin Multigene Family: Three-Disulfide Variants from Drosophila takahashii Possess Antibacterial Activity, Shunyi Zhu, 2016 Origin of neurotoxins from defensins, Shunyi Zhu, 2015 Mesomartoxin, a New Kv1.2-Selective Scorpion Toxin Interacting with the Channel Selectivity Filter, Shunyi Zhu, 2015 靶向离子通道的神经毒素起源于抗微生物防御肽, Shunyi Zhu, 2015 Target-Driven Evolution of Scorpion Toxins, Shunyi Zhu, 2015 An Insect Defensin-Derived beta-Hairpin Peptide with Enhanced Antibacterial Activity, Shunyi Zhu, 2014 Nrf2/Maf-Binding-Site-Containing Functional Cyp6a2 Allele Is Associated with DDT Resistance in Drosophila melanogaster, Shunyi Zhu, 2014 Characterization of NADPH-Cytochrome P450 Reductase Gene from the Cotton Bollworm, Helicoverpa armigera, Shunyi Zhu, 2014 Experimental Conversion of a Defensin into a Neurotoxin: Implications for Origin of Toxic Function, Shunyi Zhu, 2014 Fungal Defensins, an Emerging Source of Anti-Infective Drugs, Shunyi Zhu, 2014 Nematode-Derived Drosomycin-Type Antifungal Peptides Provide Evidence for Plant-to-Ecdysozoan Horizontal Transfer of a Disease Resistance Gene, Shunyi Zhu, 2014 Evolutionary origin of beta-defensins, Shunyi Zhu, 2013 Two recombinant alpha-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na+ channels, Shunyi Zhu, 2013 Functional Evolution of Scorpion Venom Peptides with an Inhibitor Cystine Knot Fold, Shunyi Zhu, 2013 Characterization of a chimeric antimicrobial peptide uncovers evolutionary significance of exon-shuffling, Shunyi Zhu, 2012 Dermatophytic defensin with antiinfective potential, Shunyi Zhu, 2012 Comparative genomics analysis of five families of antimicrobial peptide-like genes in seven ant species, Shunyi Zhu, 2012 Alteration of the mode of antibacterial action of a defensin by the amino-terminal loop substitution, Shunyi Zhu, 2012 Evolutionary Diversification of Mesobuthus alpha-Scorpion Toxins Affecting Sodium Channels, Shunyi Zhu, 2012 Accelerated evolution and functional divergence of scorpion short-chain K+ channel toxins after speciation, Shunyi Zhu, 2012 Evolution of a Neurotoxin from a Defensin, Shunyi Zhu, 2012 Two dyad-free Shaker-type K+ channel blockers from scorpion venom, Shunyi Zhu, 2012 Mutational Analysis of the Analgesic Peptide DrTx(1-42) Revealing a Functional Role of the Amino-Terminal Turn, Shunyi Zhu, 2012 Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K+ channel toxins, Shunyi Zhu, 2012 Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, Shunyi Zhu, 2011 A naturally-occurring carboxyl-terminally truncated alpha-scorpion toxin is a blocker of sodium channels, Shunyi Zhu, 2011 Molecular divergence of two orthologous scorpion toxins affecting potassium channels, Shunyi Zhu, 2011 The defensin gene family expansion in the tick Ixodes scapularis, Shunyi Zhu, 2011 Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins, Shunyi Zhu, 2011 DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, Shunyi Zhu, 2011 Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, Shunyi Zhu, 2011 Molecular design of new sodium channel blockers, Shunyi Zhu, 2011 DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, Shunyi Zhu, 2011 Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels, Shunyi Zhu, 2010 Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, Shunyi Zhu, 2010 Functional role of charged residues in drosomycin, a Drosophila antifungal peptide, Shunyi Zhu, 2010 Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, Shunyi Zhu, 2010 Characterization of a hymenoptaecin-like antimicrobial peptide in the parasitic wasp Nasonia vitripennis, Shunyi

Areas of Focus

Peptide Biology and Evolution
Design of New Peptide Molecules

Publications

Molecular Diversity and Evolution of Antimicrobial Peptides in Musca domestica, Shunyi Zhu, 2021
How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: The Molecular and Evolutionary Basis Uncovered, Shunyi Zhu, 2020
Scorpion Toxins: Positive Selection at a Distal Site Modulates Functional Evolution at a Bioactive Site, Shunyi Zhu, 2019
The research progress of three finger toxin family in snakes, Shunyi Zhu, 2019
Did cis- and trans-defensins derive from a common ancestor?, Shunyi Zhu, 2019
Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Shunyi Zhu, 2018
Receptor variability-driven evolution of snake toxins, Shunyi Zhu, 2018
Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin, Shunyi Zhu, 2018
Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins, Shunyi Zhu, 2018
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs, Shunyi Zhu, 2018
Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Shunyi Zhu, 2018
Antimicrobial and insecticidal activities and evolution of inhibitor cystine knot peptides, Shunyi Zhu, 2018
Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion, Shunyi Zhu, 2018
Molecular Dynamics Simulation Reveals Specific Interaction Sites between Scorpion Toxins and Kv1.2 Channel: Implications for Design of Highly Selective Drugs, Shunyi Zhu, 2017
New Fungal Defensin-Like Peptides Provide Evidence for Fold Change of Proteins in Evolution, Shunyi Zhu, 2017
Expanding the Pharmacological Profile of α-Hefutoxin 1 and Analogues: A Focus on the Inhibitory Effect on the Oncogenic Channel Kv10.1, Shunyi Zhu, 2017
Expanding the pharmacological profile of kappa-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1, Shunyi Zhu, 2017
Evaluating the Potential of a Loop-Extended Scorpion Toxin-Like Peptide as a Protein Scaffold, Shunyi Zhu, 2016
Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides, Shunyi Zhu, 2016
A Single-Point Mutation Enhances Dual Functionality of a Scorpion Toxin, Shunyi Zhu, 2016
Single-Point Mutation-Mediated Local Amphipathic Adjustment Dramatically Enhances Antibacterial Activity of a Fungal Defensin, Shunyi Zhu, 2016
The Drosomycin Multigene Family: Three-Disulfide Variants from Drosophila takahashii Possess Antibacterial Activity, Shunyi Zhu, 2016
Origin of neurotoxins from defensins, Shunyi Zhu, 2015
Mesomartoxin, a New Kv1.2-Selective Scorpion Toxin Interacting with the Channel Selectivity Filter, Shunyi Zhu, 2015
靶向离子通道的神经毒素起源于抗微生物防御肽, Shunyi Zhu, 2015
Target-Driven Evolution of Scorpion Toxins, Shunyi Zhu, 2015
An Insect Defensin-Derived beta-Hairpin Peptide with Enhanced Antibacterial Activity, Shunyi Zhu, 2014
Nrf2/Maf-Binding-Site-Containing Functional Cyp6a2 Allele Is Associated with DDT Resistance in Drosophila melanogaster, Shunyi Zhu, 2014
Characterization of NADPH-Cytochrome P450 Reductase Gene from the Cotton Bollworm, Helicoverpa armigera, Shunyi Zhu, 2014
Experimental Conversion of a Defensin into a Neurotoxin: Implications for Origin of Toxic Function, Shunyi Zhu, 2014
Fungal Defensins, an Emerging Source of Anti-Infective Drugs, Shunyi Zhu, 2014
Nematode-Derived Drosomycin-Type Antifungal Peptides Provide Evidence for Plant-to-Ecdysozoan Horizontal Transfer of a Disease Resistance Gene, Shunyi Zhu, 2014
Evolutionary origin of beta-defensins, Shunyi Zhu, 2013
Two recombinant alpha-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na+ channels, Shunyi Zhu, 2013
Functional Evolution of Scorpion Venom Peptides with an Inhibitor Cystine Knot Fold, Shunyi Zhu, 2013
Characterization of a chimeric antimicrobial peptide uncovers evolutionary significance of exon-shuffling, Shunyi Zhu, 2012
Dermatophytic defensin with antiinfective potential, Shunyi Zhu, 2012
Comparative genomics analysis of five families of antimicrobial peptide-like genes in seven ant species, Shunyi Zhu, 2012
Alteration of the mode of antibacterial action of a defensin by the amino-terminal loop substitution, Shunyi Zhu, 2012
Evolutionary Diversification of Mesobuthus alpha-Scorpion Toxins Affecting Sodium Channels, Shunyi Zhu, 2012
Accelerated evolution and functional divergence of scorpion short-chain K+ channel toxins after speciation, Shunyi Zhu, 2012
Evolution of a Neurotoxin from a Defensin, Shunyi Zhu, 2012
Two dyad-free Shaker-type K+ channel blockers from scorpion venom, Shunyi Zhu, 2012
Mutational Analysis of the Analgesic Peptide DrTx(1-42) Revealing a Functional Role of the Amino-Terminal Turn, Shunyi Zhu, 2012
Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K+ channel toxins, Shunyi Zhu, 2012
Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, Shunyi Zhu, 2011
A naturally-occurring carboxyl-terminally truncated alpha-scorpion toxin is a blocker of sodium channels, Shunyi Zhu, 2011
Molecular divergence of two orthologous scorpion toxins affecting potassium channels, Shunyi Zhu, 2011
The defensin gene family expansion in the tick Ixodes scapularis, Shunyi Zhu, 2011
Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins, Shunyi Zhu, 2011
DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, Shunyi Zhu, 2011
Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, Shunyi Zhu, 2011
Molecular design of new sodium channel blockers, Shunyi Zhu, 2011
DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, Shunyi Zhu, 2011
Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels, Shunyi Zhu, 2010
Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, Shunyi Zhu, 2010
Functional role of charged residues in drosomycin, a Drosophila antifungal peptide, Shunyi Zhu, 2010
Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, Shunyi Zhu, 2010
Characterization of a hymenoptaecin-like antimicrobial peptide in the parasitic wasp Nasonia vitripennis, Shunyi

Peptide Biology Evolution Molecular Design New Molecules Biochemistry Molecular Biology Research Innovation

Haiyun Wang - Tongji University

Yanfang Wang - Tongji University

Hua Yang - Tongji University

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