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Shunyi Zhu
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Peptide
Biology
Evolution
Molecular
Design
New Molecules
Biochemistry
Molecular Biology
Research
Innovation
Areas of Focus
- Peptide Biology and Evolution
- Design of New Peptide Molecules
Work Experience
- 2001-10 to 2004-04 - Leuven University - Postdoctoral Researcher
- 2017-01-01 to Present - Scientific Reports - Editorial Board Member
- 2015-10-01 to Present - Acta Entomologica Sinica - Editorial Board Member
Academic Background & Achievements
- 1997-09 to 2001-04 PhD: Wuhan University
Publications
- Molecular Diversity and Evolution of Antimicrobial Peptides in Musca domestica, Shunyi Zhu, 2021
- How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: The Molecular and Evolutionary Basis Uncovered, Shunyi Zhu, 2020
- Scorpion Toxins: Positive Selection at a Distal Site Modulates Functional Evolution at a Bioactive Site, Shunyi Zhu, 2019
- The research progress of three finger toxin family in snakes, Shunyi Zhu, 2019
- Did cis- and trans-defensins derive from a common ancestor?, Shunyi Zhu, 2019
- Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Shunyi Zhu, 2018
- Receptor variability-driven evolution of snake toxins, Shunyi Zhu, 2018
- Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin, Shunyi Zhu, 2018
- Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins, Shunyi Zhu, 2018
- Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs, Shunyi Zhu, 2018
- Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Shunyi Zhu, 2018
- Antimicrobial and insecticidal activities and evolution of inhibitor cystine knot peptides, Shunyi Zhu, 2018
- Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion, Shunyi Zhu, 2018
- Molecular Dynamics Simulation Reveals Specific Interaction Sites between Scorpion Toxins and Kv1.2 Channel: Implications for Design of Highly Selective Drugs, Shunyi Zhu, 2017
- New Fungal Defensin-Like Peptides Provide Evidence for Fold Change of Proteins in Evolution, Shunyi Zhu, 2017
- Expanding the Pharmacological Profile of α-Hefutoxin 1 and Analogues: A Focus on the Inhibitory Effect on the Oncogenic Channel Kv10.1, Shunyi Zhu, 2017
- Expanding the pharmacological profile of kappa-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1, Shunyi Zhu, 2017
- Evaluating the Potential of a Loop-Extended Scorpion Toxin-Like Peptide as a Protein Scaffold, Shunyi Zhu, 2016
- Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides, Shunyi Zhu, 2016
- A Single-Point Mutation Enhances Dual Functionality of a Scorpion Toxin, Shunyi Zhu, 2016
- Single-Point Mutation-Mediated Local Amphipathic Adjustment Dramatically Enhances Antibacterial Activity of a Fungal Defensin, Shunyi Zhu, 2016
- The Drosomycin Multigene Family: Three-Disulfide Variants from Drosophila takahashii Possess Antibacterial Activity, Shunyi Zhu, 2016
- Origin of neurotoxins from defensins, Shunyi Zhu, 2015
- Mesomartoxin, a New Kv1.2-Selective Scorpion Toxin Interacting with the Channel Selectivity Filter, Shunyi Zhu, 2015
- 靶向离子通道的神经毒素起源于抗微生物防御肽, Shunyi Zhu, 2015
- Target-Driven Evolution of Scorpion Toxins, Shunyi Zhu, 2015
- An Insect Defensin-Derived beta-Hairpin Peptide with Enhanced Antibacterial Activity, Shunyi Zhu, 2014
- Nrf2/Maf-Binding-Site-Containing Functional Cyp6a2 Allele Is Associated with DDT Resistance in Drosophila melanogaster, Shunyi Zhu, 2014
- Characterization of NADPH-Cytochrome P450 Reductase Gene from the Cotton Bollworm, Helicoverpa armigera, Shunyi Zhu, 2014
- Experimental Conversion of a Defensin into a Neurotoxin: Implications for Origin of Toxic Function, Shunyi Zhu, 2014
- Fungal Defensins, an Emerging Source of Anti-Infective Drugs, Shunyi Zhu, 2014
- Nematode-Derived Drosomycin-Type Antifungal Peptides Provide Evidence for Plant-to-Ecdysozoan Horizontal Transfer of a Disease Resistance Gene, Shunyi Zhu, 2014
- Evolutionary origin of beta-defensins, Shunyi Zhu, 2013
- Two recombinant alpha-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na+ channels, Shunyi Zhu, 2013
- Functional Evolution of Scorpion Venom Peptides with an Inhibitor Cystine Knot Fold, Shunyi Zhu, 2013
- Characterization of a chimeric antimicrobial peptide uncovers evolutionary significance of exon-shuffling, Shunyi Zhu, 2012
- Dermatophytic defensin with antiinfective potential, Shunyi Zhu, 2012
- Comparative genomics analysis of five families of antimicrobial peptide-like genes in seven ant species, Shunyi Zhu, 2012
- Alteration of the mode of antibacterial action of a defensin by the amino-terminal loop substitution, Shunyi Zhu, 2012
- Evolutionary Diversification of Mesobuthus alpha-Scorpion Toxins Affecting Sodium Channels, Shunyi Zhu, 2012
- Accelerated evolution and functional divergence of scorpion short-chain K+ channel toxins after speciation, Shunyi Zhu, 2012
- Evolution of a Neurotoxin from a Defensin, Shunyi Zhu, 2012
- Two dyad-free Shaker-type K+ channel blockers from scorpion venom, Shunyi Zhu, 2012
- Mutational Analysis of the Analgesic Peptide DrTx(1-42) Revealing a Functional Role of the Amino-Terminal Turn, Shunyi Zhu, 2012
- Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K+ channel toxins, Shunyi Zhu, 2012
- Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, Shunyi Zhu, 2011
- A naturally-occurring carboxyl-terminally truncated alpha-scorpion toxin is a blocker of sodium channels, Shunyi Zhu, 2011
- Molecular divergence of two orthologous scorpion toxins affecting potassium channels, Shunyi Zhu, 2011
- The defensin gene family expansion in the tick Ixodes scapularis, Shunyi Zhu, 2011
- Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins, Shunyi Zhu, 2011
- DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, Shunyi Zhu, 2011
- Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, Shunyi Zhu, 2011
- Molecular design of new sodium channel blockers, Shunyi Zhu, 2011
- DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, Shunyi Zhu, 2011
- Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels, Shunyi Zhu, 2010
- Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, Shunyi Zhu, 2010
- Functional role of charged residues in drosomycin, a Drosophila antifungal peptide, Shunyi Zhu, 2010
- Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, Shunyi Zhu, 2010
- Characterization of a hymenoptaecin-like antimicrobial peptide in the parasitic wasp Nasonia vitripennis, Shunyi
Awards
- East Asian Scorpion Toxinomics Research (2005): First Prize, Provincial Level
