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Lixin Zhan
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Tumor Metabolism
Cell Polarity
Molecular Mechanisms
Cell Biology
Pathology
Pathophysiology
Cancer
Metabolic Regulation
Cell Signaling
Molecular Biology
Areas of Focus
- Cell Biology - Molecular Mechanisms of Tumor Metabolism and Cell Polarity
- Pathology and Pathophysiology - Molecular Mechanisms of Tumor Metabolism and Cell Polarity
Work Experience
- 2010-02~Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher
- 2004-11~2010-02 - Cold Spring Harbor Laboratory, USA - Postdoctoral Researcher
- 1998-08~2003-07 - Second Military Medical University - PhD
- 1991-08~1996-07 - Zhejiang Medical University - Bachelor
Academic Background & Achievements
- 1998-08--2003-07 PhD: Second Military Medical University
- 1991-08--1996-07 Bachelor: Zhejiang Medical University
Publications
- Scribble defciency mediates colon infammation by inhibiting autophagydependent oxidative stress elimination, Lixin Zhan, 2023
- Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases, Lixin Zhan, 2023
- Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis, Lixin Zhan, 2023
- Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression, Lixin Zhan, 2022
- miR-224-5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting PTEN, Lixin Zhan, 2021
- Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/beta-catenin signaling in mice, Lixin Zhan, 2021
- Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer, Lixin Zhan, 2019
- Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling, Lixin Zhan, 2019
- Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner, Lixin Zhan, 2019
- Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways, Lixin Zhan, 2018
- Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, Lixin Zhan, 2018
- Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis, Lixin Zhan, 2018
- Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance, Lixin Zhan, 2016
- Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies, Lixin Zhan, 2015
- Effects of exposure to benzoapyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling, Lixin Zhan, 2015
- Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression, Lixin Zhan, 2015
- Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition, Lixin Zhan, 2014
- Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma, Lixin Zhan, 2008
- Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: Implications for progression of ErbB2-overexpressing tumors, Lixin Zhan, 2006
