Professor | Lixin Zhan | Asia Growth Partners

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Name	Lixin Zhan
Contact Information	lxzhan@sibs.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Lixin Zhan

Contact Information

lxzhan@sibs.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1998-08--2003-07 PhD: Second Military Medical University 1991-08--1996-07 Bachelor: Zhejiang Medical University
Work Experience	2010-02~Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher 2004-11~2010-02 - Cold Spring Harbor Laboratory, USA - Postdoctoral Researcher 1998-08~2003-07 - Second Military Medical University - PhD 1991-08~1996-07 - Zhejiang Medical University - Bachelor

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1998-08--2003-07 PhD: Second Military Medical University
1991-08--1996-07 Bachelor: Zhejiang Medical University

Work Experience

2010-02~Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher
2004-11~2010-02 - Cold Spring Harbor Laboratory, USA - Postdoctoral Researcher
1998-08~2003-07 - Second Military Medical University - PhD
1991-08~1996-07 - Zhejiang Medical University - Bachelor

Areas of Focus	Cell Biology - Molecular Mechanisms of Tumor Metabolism and Cell Polarity Pathology and Pathophysiology - Molecular Mechanisms of Tumor Metabolism and Cell Polarity
Publications	Scribble defciency mediates colon infammation by inhibiting autophagydependent oxidative stress elimination, Lixin Zhan, 2023 Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases, Lixin Zhan, 2023 Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis, Lixin Zhan, 2023 Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression, Lixin Zhan, 2022 miR-224-5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting PTEN, Lixin Zhan, 2021 Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/beta-catenin signaling in mice, Lixin Zhan, 2021 Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer, Lixin Zhan, 2019 Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling, Lixin Zhan, 2019 Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner, Lixin Zhan, 2019 Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways, Lixin Zhan, 2018 Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, Lixin Zhan, 2018 Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis, Lixin Zhan, 2018 Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance, Lixin Zhan, 2016 Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies, Lixin Zhan, 2015 Effects of exposure to benzoapyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling, Lixin Zhan, 2015 Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression, Lixin Zhan, 2015 Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition, Lixin Zhan, 2014 Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma, Lixin Zhan, 2008 Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: Implications for progression of ErbB2-overexpressing tumors, Lixin Zhan, 2006

Areas of Focus

Cell Biology - Molecular Mechanisms of Tumor Metabolism and Cell Polarity
Pathology and Pathophysiology - Molecular Mechanisms of Tumor Metabolism and Cell Polarity

Publications

Scribble defciency mediates colon infammation by inhibiting autophagydependent oxidative stress elimination, Lixin Zhan, 2023
Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases, Lixin Zhan, 2023
Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis, Lixin Zhan, 2023
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression, Lixin Zhan, 2022
miR-224-5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting PTEN, Lixin Zhan, 2021
Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/beta-catenin signaling in mice, Lixin Zhan, 2021
Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer, Lixin Zhan, 2019
Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling, Lixin Zhan, 2019
Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner, Lixin Zhan, 2019
Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways, Lixin Zhan, 2018
Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, Lixin Zhan, 2018
Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis, Lixin Zhan, 2018
Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance, Lixin Zhan, 2016
Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies, Lixin Zhan, 2015
Effects of exposure to benzoapyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling, Lixin Zhan, 2015
Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression, Lixin Zhan, 2015
Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition, Lixin Zhan, 2014
Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma, Lixin Zhan, 2008
Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: Implications for progression of ErbB2-overexpressing tumors, Lixin Zhan, 2006

Tumor Metabolism Cell Polarity Molecular Mechanisms Cell Biology Pathology Pathophysiology Cancer Metabolic Regulation Cell Signaling Molecular Biology

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