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Yun Zhao
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Signal Transduction
Molecular Basis
Disease
Intracellular
Pathways
Stem Cells
Self-Renewal
Regulation
Maintenance
Mechanisms
Areas of Focus
- Abnormalities in intracellular signaling pathways and the molecular basis of disease occurrence
- Regulatory mechanisms of stem cell self-renewal and maintenance
Work Experience
- 2008-10~Present - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher
- 2004-03~2008-09 - University of Texas Southwestern Medical Center - Postdoctoral
- 2001-08~2004-02 - Harvard Medical School - Postdoctoral
- 1996-09~2001-07 - Peking University - PhD
Academic Background & Achievements
- 2004-03--2008-09 Postdoctoral: University of Texas Southwestern Medical Center
- 2001-08--2004-02 Postdoctoral: Harvard Medical School
- 1996-09--2001-07 PhD: Peking University
Publications
- Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis., Yun Zhao, 2023
- Identification of a rare Gli1(+) progenitor cell population contributing to liver regeneration during chronic injury, Yun Zhao, 2022
- Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2, Yun Zhao, 2022
- Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression, Yun Zhao, 2022
- Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae, Yun Zhao, 2021
- An MST4–β-CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis, Yun Zhao, 2021
- Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling, Yun Zhao, 2021
- Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2, Yun Zhao, 2021
- Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release, Yun Zhao, 2021
- Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation, Yun Zhao, 2020
- The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice, Yun Zhao, 2020
- Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification, Yun Zhao, 2020
- Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer, Yun Zhao, 2020
- Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics, Yun Zhao, 2020
- Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila, Yun Zhao, 2020
- MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, Yun Zhao, 2020
- PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila, Yun Zhao, 2019
- Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, Yun Zhao, 2019
- Dual function of VGLL 4 in muscle regeneration, Yun Zhao, 2019
- Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci), Yun Zhao, 2018
- Staurosporine targets the Hippo pathway to inhibit cell growth, Yun Zhao, 2018
- The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex, Yun Zhao, 2018
- Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila, Yun Zhao, 2018
- Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system., Yun Zhao, 2017
- Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis, Yun Zhao, 2017
- UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing, Yun Zhao, 2017
- Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity, Yun Zhao, 2017
- Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling, Yun Zhao, 2017
- A positive role for polycomb in transcriptional regulation via H4K20me1, Yun Zhao, 2016
- Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription, Yun Zhao, 2016
- Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals., Yun Zhao, 2016
- SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis, Yun Zhao, 2016
- Gut–neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila, Yun Zhao, 2015
- Sqh is involved in the regulation of Ci stability in Hh signaling pathway, Yun Zhao, 2015
- Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling, Yun Zhao, 2015
- Decoding Ci: From partial degradation to inhibition, Yun Zhao, 2015
- Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET., Yun Zhao, 2015
- Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling, Yun Zhao, 2014
- Haiquan Chen# and Hongbin Ji#. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, Yun Zhao, 2014
- aPKC tau/lambda: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC, Yun Zhao, 2013
- Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism, Yun Zhao, 2013
- Hedgehog in the Drosophila testis niche:what does it do there?, Yun Zhao, 2013
- Atrophin–Rpd3 Complex Represses Hedgehog Signaling by Acting as a Corepressor of CiR, Yun Zhao, 2013
- Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci, Yun Zhao, 2013
- Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling, Yun Zhao, 2013
- Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction*, Yun Zhao, 2013
- Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis, Yun Zhao, 2013
- Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation, Yun Zhao, 2013
- Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling, Yun Zhao, 2013
- A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity, Yun Zhao, 2013
- Activation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover., Yun Zhao, 2013
- Par-1 Regulates Tissue Growth by Influ
Awards
- Cell Apoptosis and NF-kappaB Activation Signal Transduction Research (2006): First Prize, Ministerial Level
- National Excellent Doctoral Dissertation (2003): First Prize, Ministerial Level
- Systematic Study of Non-Cellular System Nuclear Reconstruction (2001): First Prize, Ministerial Level
