2004-03--2008-09 Postdoctoral: University of Texas Southwestern Medical Center
2001-08--2004-02 Postdoctoral: Harvard Medical School
1996-09--2001-07 PhD: Peking University
2008-10~Present - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher
2004-03~2008-09 - University of Texas Southwestern Medical Center - Postdoctoral
2001-08~2004-02 - Harvard Medical School - Postdoctoral
1996-09~2001-07 - Peking University - PhD
Cell Apoptosis and NF-kappaB Activation Signal Transduction Research (2006): First Prize, Ministerial Level
National Excellent Doctoral Dissertation (2003): First Prize, Ministerial Level
Systematic Study of Non-Cellular System Nuclear Reconstruction (2001): First Prize, Ministerial Level
Research
Abnormalities in intracellular signaling pathways and the molecular basis of disease occurrence Regulatory mechanisms of stem cell self-renewal and maintenance
Identification of a rare Gli1(+) progenitor cell population contributing to liver regeneration during chronic injury, Yun Zhao, 2022
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2, Yun Zhao, 2022
Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression, Yun Zhao, 2022
Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae, Yun Zhao, 2021
An MST4–β-CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis, Yun Zhao, 2021
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling, Yun Zhao, 2021
Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2, Yun Zhao, 2021
Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release, Yun Zhao, 2021
Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation, Yun Zhao, 2020
The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice, Yun Zhao, 2020
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer, Yun Zhao, 2020
Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics, Yun Zhao, 2020
Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila, Yun Zhao, 2020
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, Yun Zhao, 2020
PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila, Yun Zhao, 2019
Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, Yun Zhao, 2019
Dual function of VGLL 4 in muscle regeneration, Yun Zhao, 2019
Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci), Yun Zhao, 2018
Staurosporine targets the Hippo pathway to inhibit cell growth, Yun Zhao, 2018
The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex, Yun Zhao, 2018
Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila, Yun Zhao, 2018
Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system., Yun Zhao, 2017
Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis, Yun Zhao, 2017
UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing, Yun Zhao, 2017
Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity, Yun Zhao, 2017
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling, Yun Zhao, 2017
A positive role for polycomb in transcriptional regulation via H4K20me1, Yun Zhao, 2016
Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription, Yun Zhao, 2016
Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals., Yun Zhao, 2016
SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis, Yun Zhao, 2016
Gut–neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila, Yun Zhao, 2015
Sqh is involved in the regulation of Ci stability in Hh signaling pathway, Yun Zhao, 2015
Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling, Yun Zhao, 2015
Decoding Ci: From partial degradation to inhibition, Yun Zhao, 2015
Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET., Yun Zhao, 2015
Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling, Yun Zhao, 2014
Haiquan Chen# and Hongbin Ji#. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, Yun Zhao, 2014
aPKC tau/lambda: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC, Yun Zhao, 2013
Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism, Yun Zhao, 2013
Hedgehog in the Drosophila testis niche:what does it do there?, Yun Zhao, 2013
Atrophin–Rpd3 Complex Represses Hedgehog Signaling by Acting as a Corepressor of CiR, Yun Zhao, 2013
Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci, Yun Zhao, 2013
Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling, Yun Zhao, 2013
Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction*, Yun Zhao, 2013
Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis, Yun Zhao, 2013
Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation, Yun Zhao, 2013
Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling, Yun Zhao, 2013
A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity, Yun Zhao, 2013
Activation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover., Yun Zhao, 2013
Par-1 Regulates Tissue Growth by Influ
Keywords
Signal TransductionMolecular BasisDiseaseIntracellularPathwaysStem CellsSelf-RenewalRegulationMaintenanceMechanisms
