1990-09 to 1994-06 Bachelor's Degree: China Agricultural University
2009-05 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
2003-10 to 2009-05 - National Institutes of Health, USA - Visiting/Research Fellow
2002-04 to 2003-10 - Gunma University, Japan - Foreign Researcher
1998-05 to 1999-03 - Gunma University, Japan - Trainee
1994-07 to 1997-08 - Jiangxi Mingxing Enterprise Group - Engineer
NIH Fellow Award for Research Excellence (2008)
NIDDK Nancy Nossal Fellowship Award (2007)
NIH Fellow Award for Research Excellence (2005)
Research
Basic Medicine
Structural basis of the subcortical maternal complex and its implications in reproductive disorders., Chi P, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L, Deng D., 2024
Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation., Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, Wang R, Gao Z, Lu X, Yang X, Wu Y, Gu C, Xie W, Li L., 2023
Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition., Quan Y, Wang M, Xu C, Wang X, Qin D, Lin Y, Lu X, Lu F, Li L., 2022
Ultrasensitive Ribo-seq reveals translational landscapes during oocyte-to-embryo transition and pre-implantation development., Xiong Z, Xu K, Lin Z, Kong F, Wang Q, Quan Y, Sha Q, Li F, Zou Z, Liu L, Ji S, Chen Y, Zhang H, Fang J, Yu G, Liu B, Wang L, Wang H, Deng H, Yang X, Fan H, Li L, Xie W., 2022
In vitro investigation of mammalian early embryonic development (in Chinese)., Wang Z, Zhang J, Li L., 2022
In vitro investigation of mammalian peri-implantation embryogenesis., Quan Y, Wang X, Li L., 2022
BCAS2 is involved in alternative splicing and mouse oocyte development., Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, Wang Q, Lu X, Liu J, Li L., 2022
Ash2l-1 is essential for mouse early hematopoietic development of yolk sac (in Chinese)., Wang X, Lu X, Xiang Y, Li L., 2021
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation., Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao Z, Jiang X, Wang X, Lu X, Qin D, Quan Y, Zhang J, Shyh-Chang N, Wang H, Jing N, Xie W, Li L., 2021
Stabilizing formative pluripotent states with germ cell competency., Shyn-Chang N and Li L., 2021
Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation'., Ma H, Wang H, Zheng P, Li L., 2020
Epigenomic analysis of gastrulation reveals a unique chromatin state for primed pluripotency., Xiang Y, Zhang Y, Xu Q, Zhou C, Liu B, Du Z, Zhang K, Zhang B, Wang X, Gayen S, Liu L, Wang Y, Li Y, Wang Q, Kalantry S, Li L, Xie W., 2020
In vitro culture of cynomolgus monkey embryos beyond early gastrulation., Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao Z, Zhao B, Zheng P, Li L, Wang H., 2019
The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution., Qin D, Gao Z, Xiao Y, Zhang X, Ma H, Yu X, Nie X, Fan N, Wang X, OuYang Y, Sun QY, Yi Z, Li L., 2019
Compression generated by a 3D supracellular actomyosin cortex promotes embryonic stem cell colony growth and expression of Nanog and Oct4., Du J, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Wu C, Weitz D, Feng X., 2019
Putting stem cells on a low-fat diet switches their pluripotent state., Jiang Z, Guang L, Li L, Shyh-Chang N., 2019
Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation., Meng T, Lu X, Guo L, Hou G, Ma X, Li Q, Huang L, Fan L, Zhao Z, Ou X, OuYang Y, Schatten H, Li L, Wang Z, Sun QY., 2019
An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese)., Wang X, Qin D, Lu X, Li L., 2018
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs., Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q., 2018
Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis., Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z, Li L., 2018
Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles., Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L., 2018
ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast., Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z, Li L., 2018
Dynamic epigenomic landscapes during early lineage specification., Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W., 2018
A maternal functional module in the mammalian oocyte-to-embryo transition., Lu X, Gao Z, Qin D, Li L., 2017
MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production., Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S., 2017
First cell lineage specification in mammalian early development (in Chinese)., Nie X, Lu X, Li L., 2017
BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis., Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S, Yi Z, Li L., 2017
Trp-Asp (WD) repeat domain 1 is essential for mouse peri-implantation development and regulates Cofilin phosphorylation., Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, Xiang Y, Liu W, Chen J, Yi Z, Li L., 2017
BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis., Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L., 2016
MicroRNA-127 promotes primitive streak formation by targeting left-right determination factor 2., Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q, Li L., 2016
Maternal BCAS2 protects genomic integrity in mouse early embryonic development., Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H, Huang J, Yi Z, Gao S, Li L., 2015
The roles of ERAS during cell lineage specification of mouse early embryonic development., Zhao Z, Yu Y, Ma H, Wang X, Lu X, Zhai Y, Zhang X, Wang H, Li L., 2015
Filia is an ESC-specific regulator of DNA damage response and safeguards genomic stability., Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P., 2015
Identification of a human subcortical maternal complex., Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J, Li L., 2015
The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics., Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J, Li L., 2014
Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms., Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang Y, Li B, Chen Q, Duan E, Wang
Area of Focus
Proteomics | Method Development | Technology Innovation | Biological Problems | Human Diseases | Treatment | Application | Research | Science | Medicine
