Professor | Xuyu Zhou | Asia Growth Partners

Name	Xuyu Zhou
Contact Information	zhouxy@im.ac.cn
Language ability	Chinese, English, Japanese
Province	Beijing

Name

Xuyu Zhou

Contact Information

zhouxy@im.ac.cn

Language ability

Chinese, English, Japanese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1997-04 to 2001-03 Doctor of Medicine: Osaka University 1993-09 to 1996-07 Master of Science: Shandong Agricultural University 1989-09 to 1993-07 Bachelor of Science: Shandong University
Work Experience	2003-10 to 2009-09 - University of California, San Francisco (UCSF) - Postdoctoral Researcher 2001-04 to 2003-09 - Osaka University - Exchange Scholar and Research Assistant

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1997-04 to 2001-03 Doctor of Medicine: Osaka University
1993-09 to 1996-07 Master of Science: Shandong Agricultural University
1989-09 to 1993-07 Bachelor of Science: Shandong University

Work Experience

2003-10 to 2009-09 - University of California, San Francisco (UCSF) - Postdoctoral Researcher
2001-04 to 2003-09 - Osaka University - Exchange Scholar and Research Assistant

Areas of Focus	T-cell immune regulation Mechanisms of regulatory T cell (Treg) suppression and stability Molecular signaling networks of Treg cell function Dynamic changes of Treg cells in vivo Relationship between Treg cells and autoimmune diseases, tumors, infectious diseases CD4+ T cell differentiation Tumor TCR-T therapy development
Publications	The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory Tcells., Ting Wang, Jie Guo, Liping Li, Qiuzhu Jin, Fuping Zhang, Baidong Hou, Yan Zhang, Xuyu Zhou, 2024 The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis., Qianchong Gu, Xiufeng Zhao, Jie Guo, Qiuzhu Jin, Ting Wang, Wei Xu, Liping Li, Jianhua Zhang, Wei Zhang, Sheng Hong, Fuping Zhang, Baidong Hou, Xuyu Zhou, 2023 The Crohn Disease-associated ATG16L1(T300A) polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling., Gao, Ping, Liu, Hongtao, Huang, Huarong, Sun, Yu, Jia, Baoqian, Hou, Baidong, Zhou, Xuyu, Strober, Warren, Zhang, Fuping, 2022 Editorial: Revisit the roles of regulatory T cells in infection., Xuyu Zhou, Jingxian Zhao, Bin Li, Xuguang Tai, 2022 Apolipoprotein E mediates cell resistance to influenza virus infection., Ping Gao, Miao Ji, Xinyuan Liu, Xiaotong Chen, Hongtao Liu, Shihua Li, Baoqian Jia, Chao Li, Lili Ren, Xin Zhao, Qihui Wang, Yuhai Bi, Xu Tan, Baidong Hou, Xuyu Zhou, Wenjie Tan, Tao Deng, Jianwei Wang, George Fu Gao, Fuping Zhang, 2022 A Split-Cre system designed to detect simultaneous expression of two genes based on SpyTag/SpyCatcher conjugation and Split-GFP dimerization., Wei, Xundong, Zhang, Jianhua, Cui, Jian, Xu, Wei, Zhou, Xuyu, Ma, Jie, 2021 Editorial: Regulators of a Regulator: Post-Transcriptional Regulation in Tregs., Zhou, Xuyu, Lu, LiFan, 2021 Ex-TFRs: A Missing Piece of the SLE Puzzle?., Wei, Xundong, Zhang, Jianhua, Zhou, Xuyu, 2021 A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity., Zhao, Ruozhu, Chen, Xin, Ma, Weiwei, Zhang, Jinyu, Guo, Jie, Zhong, Xiu, Yao, Jiacheng, Sun, Jiahui, Rubinfien, Julian, Zhou, Xuyu, Wang, Jianbin, Qi, Hai, 2020 A wave of Foxp3(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance., Li, Mingyang, Zhao, Weijia, Wang, Yifan, Jin, Lixue, Jin, Gaowen, Sun, Xiuyuan, Wang, Wei, Wang, Ke, Xu, Xi, Hao, Jie, Jin, Rong, Fu, Wenxian, Sun, Ying, Chang, Yingjun, Huang, Xiaojun, Zhou, Xuyu, Wu, Hounan, Zhang, Kunshan, Ge, Qing, 2020 Down-regulated Treg cells in exacerbated periodontal disease during pregnancy., Hays, Aislinn, Duan, Xingyu, Zhu, Jianxin, Zhou, Wei, Upadhyayula, Satya, Shivde, Juili, Song, Li, Wang, Huizhi, Su, Li, Zhou, Xuyu, Liang, Shuang, 2019 Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells., Zhu, Xueping, Zhang, Wei, Guo, Jie, Zhang, Xuejie, Li, Liping, Wang, Ting, Yan, Jinghua, Zhang, Fuping, Hou, Baidong, Gao, Ning, Gao, George F, Zhou, Xuyu, 2019 Foxp3 Instability Helps tTregs Distinguish Self and Non-self., Zhang, Zhongmei, Zhou, Xuyu, 2019 B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4(+) T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen., Hong, Sheng, Zhang, Zhimin, Liu, Hongtao, Tian, Meijie, Zhu, Xiping, Zhang, Zhuqiang, Wang, Weihong, Zhou, Xuyu, Zhang, Fuping, Ge, Qing, Zhu, Bing, Tang, Hong, Hua, Zhaolin, Hou, Baidong, 2018 B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle., Tian, Meijie, Hua, Zhaolin, Hong, Sheng, Zhang, Zhimin, Liu, Can, Lin, Lin, Chen, Jiaorong, Zhang, Wei, Zhou, Xuyu, Zhang, Fuping, DeFranco, Anthony L, Hou, Baidong, 2018 Noc4L dictates Treg activation in vivo., Zhou, Xuyu, 2018 MicroRNAs in regulatory T cells., Phiwpan, Krung, Zhou, Xuyu, 2018 Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability Article., Zhou Xuyu, 2017 Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance., Wei, Xundong, Zhang, Jianhua, Gu, Qianchong, Huang, Man, Zhang, Wei, Guo, Jie, Zhou, Xuyu, 2017 Interaction of factor H-binding protein of Streptococcus suis with globotriaosylceramide promotes the development of meningitis., Kong, Decong, Chen, Zhe, Wang, Junping, Lv, Qingyu, Jiang, Hua, Zheng, Yuling, Xu, Maokai, Zhou, Xuyu, Hao, Huaijie, Jiang, Yongqiang, 2017 Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability., Zhang, Zhongmei, Zhang, Wei, Guo, Jie, Gu, Qianchong, Zhu, Xueping, Zhou, Xuyu, 2017 MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway., Hu, Tanyu, Phiwpan, Krung, Guo, Jitao, Zhang, Wei, Guo, Jie, Zhang, Zhongmei, Zou, Mangge, Zhang, Xuejie, Zhang, Jianhua, Zhou, Xuyu, 2016 Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation., Huang, Man, Zhang, Wei, Guo, Jie, Wei, Xundong, Phiwpan, Krung, Zhang, Jianhua, Zhou, Xuyu, 2016 Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters., Tong, Yaojun, Liu, Mei, Zhang, Yu, Liu, Xueting, Huang, Ren, Song, Fuhang, Dai, Huanqin, Ren, Biao, Sun, Nuo, Pei, Gang, Bian, Jiang, Jia, XinMing, Huang, Guanghua, Zhou, Xuyu, Li, Shaojie, Zhang, Buchang, Fukuda, Takashi, Tomoda, Hiroshi, Omura, Satoshi, Cannon, Richard D, Calderone, Richard, Zhang, Lixin, 2016 Regulatory T cells turn pathogenic., Jitao Guo, Xuyu Zhou, 2015 Regulatory T cells turn pathogenic., Guo, Jitao, Zhou, Xuyu, 2015 A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo., Phiwpan, Krung, Guo, Jie, Zhang, Wei, Hu, Tanyu, Boruah, Bhargavi M, Zhang, Jianhua, Zhou, Xuyu, 2015 Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*33:03 in peripheral blood mononuclear cells from patients and transgenic mice., Pan, Xuwen, Ding, Huiguo, Zhou, Xuyu, Tien, Po, 2014 小鼠T-bet逆转录病毒载体的构建与功能验证., 周旭宇, 张建华, 张伟, 郭洁, 周旭宇, 2014 Sustained PI3K activation destabilized tTreg., Zhou, Xuyu, 2014 Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activation RhoA and Rac1 GTPase., Zhou Xuyu, 2014 Constitutive Activation of MEK1 Promotes Treg Cell Instability in Vivo., Guo, Jitao, Zhang, Jianhua, Zhang, Xuejie, Zhang, Zhongmei, Wei, Xundong, Zhou, Xuyu, 2014 Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains., Peipei Liu, Di Liu, Xi Yang, Jing Gao, Yan Chen, Xue Xiao, Fei Liu, Jing Zou, Jun Wu, Juncai Ma, Fangqing Zhao, Xuyu Zhou, George F Gao, Baoli Zhu, 2014 Characterization of human alpha beta TCR repertoire and discovery of

Areas of Focus

T-cell immune regulation
Mechanisms of regulatory T cell (Treg) suppression and stability
Molecular signaling networks of Treg cell function
Dynamic changes of Treg cells in vivo
Relationship between Treg cells and autoimmune diseases, tumors, infectious diseases
CD4+ T cell differentiation
Tumor TCR-T therapy development

Publications

The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory Tcells., Ting Wang, Jie Guo, Liping Li, Qiuzhu Jin, Fuping Zhang, Baidong Hou, Yan Zhang, Xuyu Zhou, 2024
The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis., Qianchong Gu, Xiufeng Zhao, Jie Guo, Qiuzhu Jin, Ting Wang, Wei Xu, Liping Li, Jianhua Zhang, Wei Zhang, Sheng Hong, Fuping Zhang, Baidong Hou, Xuyu Zhou, 2023
The Crohn Disease-associated ATG16L1(T300A) polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling., Gao, Ping, Liu, Hongtao, Huang, Huarong, Sun, Yu, Jia, Baoqian, Hou, Baidong, Zhou, Xuyu, Strober, Warren, Zhang, Fuping, 2022
Editorial: Revisit the roles of regulatory T cells in infection., Xuyu Zhou, Jingxian Zhao, Bin Li, Xuguang Tai, 2022
Apolipoprotein E mediates cell resistance to influenza virus infection., Ping Gao, Miao Ji, Xinyuan Liu, Xiaotong Chen, Hongtao Liu, Shihua Li, Baoqian Jia, Chao Li, Lili Ren, Xin Zhao, Qihui Wang, Yuhai Bi, Xu Tan, Baidong Hou, Xuyu Zhou, Wenjie Tan, Tao Deng, Jianwei Wang, George Fu Gao, Fuping Zhang, 2022
A Split-Cre system designed to detect simultaneous expression of two genes based on SpyTag/SpyCatcher conjugation and Split-GFP dimerization., Wei, Xundong, Zhang, Jianhua, Cui, Jian, Xu, Wei, Zhou, Xuyu, Ma, Jie, 2021
Editorial: Regulators of a Regulator: Post-Transcriptional Regulation in Tregs., Zhou, Xuyu, Lu, LiFan, 2021
Ex-TFRs: A Missing Piece of the SLE Puzzle?., Wei, Xundong, Zhang, Jianhua, Zhou, Xuyu, 2021
A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity., Zhao, Ruozhu, Chen, Xin, Ma, Weiwei, Zhang, Jinyu, Guo, Jie, Zhong, Xiu, Yao, Jiacheng, Sun, Jiahui, Rubinfien, Julian, Zhou, Xuyu, Wang, Jianbin, Qi, Hai, 2020
A wave of Foxp3(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance., Li, Mingyang, Zhao, Weijia, Wang, Yifan, Jin, Lixue, Jin, Gaowen, Sun, Xiuyuan, Wang, Wei, Wang, Ke, Xu, Xi, Hao, Jie, Jin, Rong, Fu, Wenxian, Sun, Ying, Chang, Yingjun, Huang, Xiaojun, Zhou, Xuyu, Wu, Hounan, Zhang, Kunshan, Ge, Qing, 2020
Down-regulated Treg cells in exacerbated periodontal disease during pregnancy., Hays, Aislinn, Duan, Xingyu, Zhu, Jianxin, Zhou, Wei, Upadhyayula, Satya, Shivde, Juili, Song, Li, Wang, Huizhi, Su, Li, Zhou, Xuyu, Liang, Shuang, 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells., Zhu, Xueping, Zhang, Wei, Guo, Jie, Zhang, Xuejie, Li, Liping, Wang, Ting, Yan, Jinghua, Zhang, Fuping, Hou, Baidong, Gao, Ning, Gao, George F, Zhou, Xuyu, 2019
Foxp3 Instability Helps tTregs Distinguish Self and Non-self., Zhang, Zhongmei, Zhou, Xuyu, 2019
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4(+) T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen., Hong, Sheng, Zhang, Zhimin, Liu, Hongtao, Tian, Meijie, Zhu, Xiping, Zhang, Zhuqiang, Wang, Weihong, Zhou, Xuyu, Zhang, Fuping, Ge, Qing, Zhu, Bing, Tang, Hong, Hua, Zhaolin, Hou, Baidong, 2018
B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle., Tian, Meijie, Hua, Zhaolin, Hong, Sheng, Zhang, Zhimin, Liu, Can, Lin, Lin, Chen, Jiaorong, Zhang, Wei, Zhou, Xuyu, Zhang, Fuping, DeFranco, Anthony L, Hou, Baidong, 2018
Noc4L dictates Treg activation in vivo., Zhou, Xuyu, 2018
MicroRNAs in regulatory T cells., Phiwpan, Krung, Zhou, Xuyu, 2018
Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability Article., Zhou Xuyu, 2017
Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance., Wei, Xundong, Zhang, Jianhua, Gu, Qianchong, Huang, Man, Zhang, Wei, Guo, Jie, Zhou, Xuyu, 2017
Interaction of factor H-binding protein of Streptococcus suis with globotriaosylceramide promotes the development of meningitis., Kong, Decong, Chen, Zhe, Wang, Junping, Lv, Qingyu, Jiang, Hua, Zheng, Yuling, Xu, Maokai, Zhou, Xuyu, Hao, Huaijie, Jiang, Yongqiang, 2017
Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability., Zhang, Zhongmei, Zhang, Wei, Guo, Jie, Gu, Qianchong, Zhu, Xueping, Zhou, Xuyu, 2017
MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway., Hu, Tanyu, Phiwpan, Krung, Guo, Jitao, Zhang, Wei, Guo, Jie, Zhang, Zhongmei, Zou, Mangge, Zhang, Xuejie, Zhang, Jianhua, Zhou, Xuyu, 2016
Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation., Huang, Man, Zhang, Wei, Guo, Jie, Wei, Xundong, Phiwpan, Krung, Zhang, Jianhua, Zhou, Xuyu, 2016
Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters., Tong, Yaojun, Liu, Mei, Zhang, Yu, Liu, Xueting, Huang, Ren, Song, Fuhang, Dai, Huanqin, Ren, Biao, Sun, Nuo, Pei, Gang, Bian, Jiang, Jia, XinMing, Huang, Guanghua, Zhou, Xuyu, Li, Shaojie, Zhang, Buchang, Fukuda, Takashi, Tomoda, Hiroshi, Omura, Satoshi, Cannon, Richard D, Calderone, Richard, Zhang, Lixin, 2016
Regulatory T cells turn pathogenic., Jitao Guo, Xuyu Zhou, 2015
Regulatory T cells turn pathogenic., Guo, Jitao, Zhou, Xuyu, 2015
A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo., Phiwpan, Krung, Guo, Jie, Zhang, Wei, Hu, Tanyu, Boruah, Bhargavi M, Zhang, Jianhua, Zhou, Xuyu, 2015
Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*33:03 in peripheral blood mononuclear cells from patients and transgenic mice., Pan, Xuwen, Ding, Huiguo, Zhou, Xuyu, Tien, Po, 2014
小鼠T-bet逆转录病毒载体的构建与功能验证., 周旭宇, 张建华, 张伟, 郭洁, 周旭宇, 2014
Sustained PI3K activation destabilized tTreg., Zhou, Xuyu, 2014
Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activation RhoA and Rac1 GTPase., Zhou Xuyu, 2014
Constitutive Activation of MEK1 Promotes Treg Cell Instability in Vivo., Guo, Jitao, Zhang, Jianhua, Zhang, Xuejie, Zhang, Zhongmei, Wei, Xundong, Zhou, Xuyu, 2014
Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains., Peipei Liu, Di Liu, Xi Yang, Jing Gao, Yan Chen, Xue Xiao, Fei Liu, Jing Zou, Jun Wu, Juncai Ma, Fangqing Zhao, Xuyu Zhou, George F Gao, Baoli Zhu, 2014
Characterization of human alpha beta TCR repertoire and discovery of

T-Cell Immune Regulation Treg Suppression Stability Molecular Signaling Dynamic Changes Autoimmune Diseases Tumors Infectious Diseases

Xiaoming Zhang - University of Chinese Academy of Sciences

Lin Zhaoyu - Nanjing University

Zhou Zhengyang - Nanjing University

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