Professor | Xichen Bao | Asia Growth Partners

Name	Xichen Bao
Contact Information	bao_xichen@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Xichen Bao

Contact Information

bao_xichen@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2006-09--2011-06 PhD: University of Science and Technology of China 2002-09--2006-06 Bachelor's: Anhui University
Work Experience	2018-01~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2013-01~2017-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher 2011-07~2012-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher
Awards	Outstanding Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2019) Guangdong Outstanding Youth (2019) First Prize for Urine-Induced Pluripotent Stem Cell Technology and Somatic Cell Reprogramming Mechanism (2019) Guangzhou Pearl River Science and Technology New Star (2016) First Prize for Research on Mesenchymal-Epithelial Transition Process in iPS Cell Induction (2015)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2006-09--2011-06 PhD: University of Science and Technology of China
2002-09--2006-06 Bachelor's: Anhui University

Work Experience

2018-01~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2013-01~2017-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
2011-07~2012-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher

Awards

Outstanding Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2019)
Guangdong Outstanding Youth (2019)
First Prize for Urine-Induced Pluripotent Stem Cell Technology and Somatic Cell Reprogramming Mechanism (2019)
Guangzhou Pearl River Science and Technology New Star (2016)
First Prize for Research on Mesenchymal-Epithelial Transition Process in iPS Cell Induction (2015)

Areas of Focus	Systematic separation of RNA-binding proteins and the study of RNA-protein interactions in cell fate, pathology, and physiological regulation
Publications	Transcriptome-wide identification of single-stranded RNA binding proteins, Zhao, Ruiqi, Fang, Xin, Mai, Zhibiao, Chen, Xi, Mo, Jing, Lin, Yingying, Xiao, Rui, Bao, Xichen, Weng, Xiaocheng, Zhou, Xiang, 2023 Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis, Meifeng Zheng, Yingying Lin, Wei Wang, Yu Zhao, Xichen Bao, 2022 Capture of the newly transcribed RNA interactome using click chemistry, Guo, Xiangpeng, Tariq, Muqddas, Lai, Yiwei, Kanwal, Shahzina, Lv, Yuan, Wang, Xiwei, Li, Na, Jiang, Mengling, Meng, Jin, Hu, Jieyi, Yuan, Jianwen, Luo, Zhiwei, Ward, Carl, Volpe, Giacomo, Wang, Dongye, Yin, Menghui, Qin, Baoming, Zhang, Biliang, Bao, Xichen, Esteban, Miguel A., 2021 The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity, Liu, Jiadong, Gao, Mingwei, He, Jiangping, Wu, Kaixin, Lin, Siyuan, Jin, Lingmei, Chen, Yaping, Liu, He, Shi, Junjie, Wang, Xiwei, Chang, Lei, Lin, Yingying, Zhao, YuLi, Zhang, Xiaofei, Zhang, Man, Luo, GuanZheng, Wu, Guangming, Pei, Duanqing, Wang, Jie, Bao, Xichen, Chen, Jiekai, 2021 Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2, Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf, 2020 beta-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus, Zhang, Meng, Lai, Yiwei, Krupalnik, Vladislav, Guo, Pengcheng, Guo, Xiangpeng, Zhou, Jianguo, Xu, Yan, Yu, Zhijun, Liu, Longqi, Jiang, Ao, Li, Wenjuan, Ma, Gang, Li, Na, Fu, Xiuling, Lv, Yuan, Jiang, Mengling, Tariq, Muqddas, Kanwal, Shahzina, Liu, Hao, Xu, Xueting, Zhang, Hui, Huang, Yinghua, Wang, Lulu, Chen, Shuhan, Babarinde, Isaac A, Luo, Zhiwei, Wang, Dongye, Zhou, Tiantian, Ward, Carl, He, Minghui, Ibanez, David P, Li, Yunpan, Zhou, Jiajian, Yuan, Jie, Feng, Yayan, Arumugam, Karthik, Di Vicino, Umberto, Bao, Xichen, Wu, Guangming, Schambach, Axel, Wang, Huating, Sun, Hao, Gao, Fei, Qin, Baoming, Hutchins, Andrew P, Doble, Bradley W, Hartmann, Christine, Cosma, Maria Pia, Qin, Yan, Xu, GuoLiang, Chen, Runsheng, Volpe, Giacomo, Chen, Liang, Hanna, Jacob H, Esteban, Miguel A., 2020 JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency, Yinghua Huang, Hui Zhang, Lulu Wang, Chuanqing Tang, Xiaogan Qin, Xinyu Wu, Meifang Pan, Yujia Tang, Zhongzhou Yang, Isaac A Babarinde, Runxia Lin, Guanyu Ji, Yiwei Lai, Xueting Xu, Jianbin Su, Xue Wen, Takashi Satoh, Tanveer Ahmed, Vikas Malik, Carl Ward, Giacomo Volpe, Lin Guo, Jinlong Chen, Li Sun, Yingying Li, Xiaofen Huang, Xichen Bao, Fei Gao, Baohua Liu, Hui Zheng, Ralf Jauch, Liangxue Lai, Guangjin Pan, Jiekai Chen, Giuseppe Testa, Shizuo Akira, Jifan Hu, Duanqing Pei, Andrew P Hutchins, Miguel A Esteban, Baoming Qin, 2020 Identification of mecciRNAs and their roles in the mitochondrial entry of proteins, Liu, Xu, Wang, Xiaolin, Li, Jingxin, Hu, Shanshan, Deng, Yuqi, Yin, Hao, Bao, Xichen, Zhang, Qiangfeng Cliff, Wang, Geng, Wang, Baolong, Shi, Qinghua, Shan, Ge, 2020 YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways, Liu, Jiadong, Gao, Mingwei, Xu, Shuyang, Chen, Yaping, Wu, Kaixin, Liu, He, Wang, Jie, Yang, Xuejie, Wang, Junwei, Liu, Weiwei, Bao, Xichen, Chen, Jiekai, 2020 Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency, Kanwal, Shahzina, Guo, Xiangpeng, Ward, Carl, Volpe, Giacomo, Qin, Baoming, Esteban, Miguel A, Bao, Xichen, 2020 MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation, Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A Esteban, Hao Sun, Huating Wang, 2019 A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes, Yang, Jiayin, Wong, LaiYung, Tian, XiaoYu, Wei, Rui, Lai, WingHon, Au, KaWing, Luo, Zhiwei, Ward, Carl, Ho, WaiIn, Ibanez, David P, Liu, Hao, Bao, Xichen, Qin, Baoming, Huang, Yu, Esteban, Miguel A, Tse, HungFat, 2018 Capturing the interactome of newly transcribed RNA, Bao, Xichen, Guo, Xiangpeng, Yin, Menghui, Tariq, Muqddas, Lai, Yiwei, Kanwal, Shahzina, Zhou, Jiajian, Li, Na, Lv, Yuan, PulidoQuetglas, Carlos, Wang, Xiwei, Ji, Lu, Khan, Muhammad J, Zhu, Xihua, Luo, Zhiwei, Shao, Changwei, Lim, DoHwan, Liu, Xiao, Li, Nan, Wang, Wei, He, Minghui, Liu, YuLin, Ward, Carl, Wang, Tong, Zhang, Gong, Wang, Dongye, Yang, Jianhua, Chen, Yiwen, Zhang, Chaolin, Jauch, Ralf, Yang, YunGui, Wang, Yangming, Qin, Baoming, Anko, MinnaLiisa, Hutchins, Andrew P, Sun, Hao, Wang, Huating, Fu, XiangDong, Zhang, Biliang, Esteban, Miguel A., 2018 NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming, Zhuang, Qiang, Li, Wenjuan, Benda, Christina, Huang, Zhijian, Ahmed, Tanveer, Liu, Ping, Guo, Xiangpeng, Ibanez, David P, Luo, Zhiwei, Zhang, Meng, Abdul, Mazid Md, Yang, Zhongzhou, Yang, Jiayin, Huang, Yinghua, Zhang, Hui, Huang, Dehao, Zhou, Jianguo, Zhong, Xiaofen, Zhu, Xihua, Fu, Xiuling, Fan, Wenxia, Liu, Yulin, Xu, Yan, Ward, Carl, Khan, Muhammad Jadoon, Kanwal, Shahzina, Mirza, Bushra, Tortorella, Micky D, Tse, HungFat, Chen, Jiayu, Qin, Baoming, Bao, Xichen, Gao, Shaorong, Hutchins, Andrew P, Esteban, Miguel A., 2018 A DGCR8-Independent Stable MicroRNA Expression Strategy Reveals Important Functions of miR-290 and miR-183-182 Families in Mouse Embryonic Stem Cells, Wang, XiWen, Hao, Jing, Guo, WenTing, Liao, LeQi, Huang, SiYue, Guo, Xiangpeng, Bao, Xichen, Esteban, Miguel A, Wang, Yangming, 2017 Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells, Yang, Jiayin, Wang, Yu, Zhou, Ting, Wong, LaiYung, Tian, XiaoYu, Hong, Xueyu, Lai, WingHon, Au, KaWing, Wei, Rui, Liu, Yuqing, Cheng, LaiHung, Liang, Guichan, Huang, Zhijian, Fan, Wenxia, Zhao, Ping, Wang, Xiwei, Ibanez, David P, Luo, Zhiwei, Li, Yingying, Zhong, Xiaofen, Chen, Shuhan, Wang, Dongye, Li, Li, Lai, Liangxue, Qin, Baoming, Bao, Xichen, Hutchins, Andrew P, Siu, ChungWah, Huang, Yu, Esteban, Miguel A, Tse, HungFat, 2017 Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1, Li, Li, Zhang, Quanjun, Yang, Huaqiang, Zou, Qingjian, Lai, Chengdan, Jiang, Fei, Zhao, Ping, Luo, Zhiwei, Yang, Jiayin, Chen, Qian, Wang, Yan, Newsome, Philip N, Frampton, Jon, Maxwell, Patrick H, Li, Wenjuan, Chen, Shuhan, Wang, Dongye, Siu, TakShing, Tam, Sidney, Tse, HungFat, Qin, Baoming, Bao, Xichen, Esteban, Miguel A, Lai, Liangxue

Areas of Focus

Systematic separation of RNA-binding proteins and the study of RNA-protein interactions in cell fate, pathology, and physiological regulation

Publications

Transcriptome-wide identification of single-stranded RNA binding proteins, Zhao, Ruiqi, Fang, Xin, Mai, Zhibiao, Chen, Xi, Mo, Jing, Lin, Yingying, Xiao, Rui, Bao, Xichen, Weng, Xiaocheng, Zhou, Xiang, 2023
Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis, Meifeng Zheng, Yingying Lin, Wei Wang, Yu Zhao, Xichen Bao, 2022
Capture of the newly transcribed RNA interactome using click chemistry, Guo, Xiangpeng, Tariq, Muqddas, Lai, Yiwei, Kanwal, Shahzina, Lv, Yuan, Wang, Xiwei, Li, Na, Jiang, Mengling, Meng, Jin, Hu, Jieyi, Yuan, Jianwen, Luo, Zhiwei, Ward, Carl, Volpe, Giacomo, Wang, Dongye, Yin, Menghui, Qin, Baoming, Zhang, Biliang, Bao, Xichen, Esteban, Miguel A., 2021
The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity, Liu, Jiadong, Gao, Mingwei, He, Jiangping, Wu, Kaixin, Lin, Siyuan, Jin, Lingmei, Chen, Yaping, Liu, He, Shi, Junjie, Wang, Xiwei, Chang, Lei, Lin, Yingying, Zhao, YuLi, Zhang, Xiaofei, Zhang, Man, Luo, GuanZheng, Wu, Guangming, Pei, Duanqing, Wang, Jie, Bao, Xichen, Chen, Jiekai, 2021
Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2, Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf, 2020
beta-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus, Zhang, Meng, Lai, Yiwei, Krupalnik, Vladislav, Guo, Pengcheng, Guo, Xiangpeng, Zhou, Jianguo, Xu, Yan, Yu, Zhijun, Liu, Longqi, Jiang, Ao, Li, Wenjuan, Ma, Gang, Li, Na, Fu, Xiuling, Lv, Yuan, Jiang, Mengling, Tariq, Muqddas, Kanwal, Shahzina, Liu, Hao, Xu, Xueting, Zhang, Hui, Huang, Yinghua, Wang, Lulu, Chen, Shuhan, Babarinde, Isaac A, Luo, Zhiwei, Wang, Dongye, Zhou, Tiantian, Ward, Carl, He, Minghui, Ibanez, David P, Li, Yunpan, Zhou, Jiajian, Yuan, Jie, Feng, Yayan, Arumugam, Karthik, Di Vicino, Umberto, Bao, Xichen, Wu, Guangming, Schambach, Axel, Wang, Huating, Sun, Hao, Gao, Fei, Qin, Baoming, Hutchins, Andrew P, Doble, Bradley W, Hartmann, Christine, Cosma, Maria Pia, Qin, Yan, Xu, GuoLiang, Chen, Runsheng, Volpe, Giacomo, Chen, Liang, Hanna, Jacob H, Esteban, Miguel A., 2020
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency, Yinghua Huang, Hui Zhang, Lulu Wang, Chuanqing Tang, Xiaogan Qin, Xinyu Wu, Meifang Pan, Yujia Tang, Zhongzhou Yang, Isaac A Babarinde, Runxia Lin, Guanyu Ji, Yiwei Lai, Xueting Xu, Jianbin Su, Xue Wen, Takashi Satoh, Tanveer Ahmed, Vikas Malik, Carl Ward, Giacomo Volpe, Lin Guo, Jinlong Chen, Li Sun, Yingying Li, Xiaofen Huang, Xichen Bao, Fei Gao, Baohua Liu, Hui Zheng, Ralf Jauch, Liangxue Lai, Guangjin Pan, Jiekai Chen, Giuseppe Testa, Shizuo Akira, Jifan Hu, Duanqing Pei, Andrew P Hutchins, Miguel A Esteban, Baoming Qin, 2020
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins, Liu, Xu, Wang, Xiaolin, Li, Jingxin, Hu, Shanshan, Deng, Yuqi, Yin, Hao, Bao, Xichen, Zhang, Qiangfeng Cliff, Wang, Geng, Wang, Baolong, Shi, Qinghua, Shan, Ge, 2020
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways, Liu, Jiadong, Gao, Mingwei, Xu, Shuyang, Chen, Yaping, Wu, Kaixin, Liu, He, Wang, Jie, Yang, Xuejie, Wang, Junwei, Liu, Weiwei, Bao, Xichen, Chen, Jiekai, 2020
Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency, Kanwal, Shahzina, Guo, Xiangpeng, Ward, Carl, Volpe, Giacomo, Qin, Baoming, Esteban, Miguel A, Bao, Xichen, 2020
MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation, Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A Esteban, Hao Sun, Huating Wang, 2019
A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes, Yang, Jiayin, Wong, LaiYung, Tian, XiaoYu, Wei, Rui, Lai, WingHon, Au, KaWing, Luo, Zhiwei, Ward, Carl, Ho, WaiIn, Ibanez, David P, Liu, Hao, Bao, Xichen, Qin, Baoming, Huang, Yu, Esteban, Miguel A, Tse, HungFat, 2018
Capturing the interactome of newly transcribed RNA, Bao, Xichen, Guo, Xiangpeng, Yin, Menghui, Tariq, Muqddas, Lai, Yiwei, Kanwal, Shahzina, Zhou, Jiajian, Li, Na, Lv, Yuan, PulidoQuetglas, Carlos, Wang, Xiwei, Ji, Lu, Khan, Muhammad J, Zhu, Xihua, Luo, Zhiwei, Shao, Changwei, Lim, DoHwan, Liu, Xiao, Li, Nan, Wang, Wei, He, Minghui, Liu, YuLin, Ward, Carl, Wang, Tong, Zhang, Gong, Wang, Dongye, Yang, Jianhua, Chen, Yiwen, Zhang, Chaolin, Jauch, Ralf, Yang, YunGui, Wang, Yangming, Qin, Baoming, Anko, MinnaLiisa, Hutchins, Andrew P, Sun, Hao, Wang, Huating, Fu, XiangDong, Zhang, Biliang, Esteban, Miguel A., 2018
NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming, Zhuang, Qiang, Li, Wenjuan, Benda, Christina, Huang, Zhijian, Ahmed, Tanveer, Liu, Ping, Guo, Xiangpeng, Ibanez, David P, Luo, Zhiwei, Zhang, Meng, Abdul, Mazid Md, Yang, Zhongzhou, Yang, Jiayin, Huang, Yinghua, Zhang, Hui, Huang, Dehao, Zhou, Jianguo, Zhong, Xiaofen, Zhu, Xihua, Fu, Xiuling, Fan, Wenxia, Liu, Yulin, Xu, Yan, Ward, Carl, Khan, Muhammad Jadoon, Kanwal, Shahzina, Mirza, Bushra, Tortorella, Micky D, Tse, HungFat, Chen, Jiayu, Qin, Baoming, Bao, Xichen, Gao, Shaorong, Hutchins, Andrew P, Esteban, Miguel A., 2018
A DGCR8-Independent Stable MicroRNA Expression Strategy Reveals Important Functions of miR-290 and miR-183-182 Families in Mouse Embryonic Stem Cells, Wang, XiWen, Hao, Jing, Guo, WenTing, Liao, LeQi, Huang, SiYue, Guo, Xiangpeng, Bao, Xichen, Esteban, Miguel A, Wang, Yangming, 2017
Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells, Yang, Jiayin, Wang, Yu, Zhou, Ting, Wong, LaiYung, Tian, XiaoYu, Hong, Xueyu, Lai, WingHon, Au, KaWing, Wei, Rui, Liu, Yuqing, Cheng, LaiHung, Liang, Guichan, Huang, Zhijian, Fan, Wenxia, Zhao, Ping, Wang, Xiwei, Ibanez, David P, Luo, Zhiwei, Li, Yingying, Zhong, Xiaofen, Chen, Shuhan, Wang, Dongye, Li, Li, Lai, Liangxue, Qin, Baoming, Bao, Xichen, Hutchins, Andrew P, Siu, ChungWah, Huang, Yu, Esteban, Miguel A, Tse, HungFat, 2017
Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1, Li, Li, Zhang, Quanjun, Yang, Huaqiang, Zou, Qingjian, Lai, Chengdan, Jiang, Fei, Zhao, Ping, Luo, Zhiwei, Yang, Jiayin, Chen, Qian, Wang, Yan, Newsome, Philip N, Frampton, Jon, Maxwell, Patrick H, Li, Wenjuan, Chen, Shuhan, Wang, Dongye, Siu, TakShing, Tam, Sidney, Tse, HungFat, Qin, Baoming, Bao, Xichen, Esteban, Miguel A, Lai, Liangxue

Rna-Binding Proteins Rna-Protein Interactions Cell Fate Pathology Physiological Regulation Molecular Mechanisms Non-Coding Rna Cell Differentiation Protein Complexes Biomedical Research

Guoan Chen - Southern University of Science and Technology

Songmei Liu - Wuhan University

Guohua Yang - Wuhan University

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