Avon Foundation – AACR International Scholar Award (2006)
9th National Servier Young Pharmacologist Award (2005)
Research
Tumor Pharmacology
Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3K inhibitors, Chen Yi, 2023
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression, Chen Yi, 2023
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines, Chen Yi, 2023
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKK and overcomes gefitinib resistance in non-small cell lung cancer, Chen Yi, 2022
Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer, Chen Yi, 2022
PI3K inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma, Chen Yi, 2021
SN38-based albumin-binding prodrug for efficient targeted cancer chemotherapy, Chen Yi, 2021
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation, Chen Yi, 2021
Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment, Chen Yi, 2021
Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors, Chen Yi, 2020
EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma, Chen Yi, 2020
G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1, Chen Yi, 2018
Iron Metabolism in Cancer, Chen Yi, 2018
Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer, Chen Yi, 2017
G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin, Chen Yi, 2017
Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation, Chen Yi, 2015
Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents, Chen Yi, 2015
G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro, Chen Yi, 2014
Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs, Chen Yi, 2014
Design, synthesis and biological evaluation of 4'-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors, Chen Yi, 2014
G226, a new ETP derivative, triggers DNA damage, and apoptosis via ROS generation, Chen Yi, 2014
JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1, Chen Yi, 2013
The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase, Chen Yi, 2013
Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro, Chen Yi, 2013
The discovery of colchicine-SAHA hybrids as a new class of antitumor agents, Chen Yi, 2013
AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and antitumor activity via targeting VEGFR, FGFR, PDGFR, Chen Yi, 2012
Synthesis and biological evaluation of new homocamptothecin analogues, Chen Yi, 2012
Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo, Chen Yi, 2011
Design, synthesis and biological evaluation of substituted 11 H-benzo acarbazole-5-carboxamides as novel antitumor agents, Chen Yi, 2011
Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles, Chen Yi, 2011
Increased accumulation of hypoxia-inducible factor-1 alpha with reduced transcriptional activity mediates the antitumor effect of triptolide, Chen Yi, 2010
Oligomannurarate sulfate, a novel antimitotic agent, exerts anti-cancer activity by binding to tubulin on novel site, Chen Yi, 2010
The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model, Chen Yi, 2010
Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors, Chen Yi, 2009
Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling, Chen Yi, 2008
SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor, Chen Yi, 2006
The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11-dideoxyverticillin-induced G2/M arrest, Chen Yi, 2005
Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus shiraia bambusicola, Chen Yi, 2005
Area of Focus
Oncology | Lung Cancer | Esophageal Cancer | Mediastinal Tumors | Gastrointestinal Cancer | Breast Cancer | Thyroid Cancer | Diagnosis | Treatment | Clinical Experience
Area of Focus
Oncology | Geriatrics | Traditional Chinese Medicine | Western Medicine | Clinical Research | Breast Cancer | Lung Cancer | Nasopharyngeal Carcinoma | Colorectal Cancer | Gynecological Tumors
