Areas of Focus
- Regenerative Medicine
Work Experience
- 2024-01~Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
- 2018-01~2024-01 - Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
- 2014-07~2018-01 - Institute of Zoology, Chinese Academy of Sciences - Postdoctoral Researcher
Academic Background & Achievements
- 2010-09--2014-06 PhD: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- 2007-09--2010-06 Master's Degree: Academy of Military Medical Sciences
- 2003-09--2007-06 Bachelor's Degree: Shandong University (Weihai)
Publications
- mRNA isoform switches during mouse zygotic genome activation, Guanghai Feng, 2024
- Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution, Guanghai Feng, 2023
- Live-cell imaging reveals redox metabolic reprogramming during zygotic genome activation, Guanghai Feng, 2023
- High-efficiency targeted transgene integration via primed micro-homologues, Guanghai Feng, 2023
- Influence of feeder cells on transcriptomic analysis of pluripotent stem cells, Guanghai Feng, 2022
- Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCs in vivo and in vitro, Guanghai Feng, 2021
- TRANSCRIPTOME AND DNA METHYLATION PROFILES OF MOUSE FETUS AND PLACENTA GENERATED BY ROUND SPERMATID INJECTION, Guanghai Feng, 2021
- Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation, Guanghai Feng, 2020
- Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging, Guanghai Feng, 2020
- Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer, Guanghai Feng, 2020
- Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells, Guanghai Feng, 2020
- Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs, Guanghai Feng, 2020
- Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis, Guanghai Feng, 2020
- Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, Guanghai Feng, 2020
- Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing, Guanghai Feng, 2020
- Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, Guanghai Feng, 2019
- Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, Guanghai Feng, 2019
- Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds, Guanghai Feng, 2019
- Derivation of Mouse Haploid Trophoblast Stem Cells, Guanghai Feng, 2019
- Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Guanghai Feng, 2018
- MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation, Guanghai Feng, 2018
- SIRT6 deficiency results in developmental retardation cynomolgus monkeys, Guanghai Feng, 2018
- RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells, Guanghai Feng, 2018
- MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer, Guanghai Feng, 2018
- Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions, Guanghai Feng, 2018
- Repurposing CRISPR-Cas12b for mammalian genome engineering, Guanghai Feng, 2018
- Mitochondrially produced ATP affects stem cell pluripotency via ActI6a-mediated histone acetylation, Guanghai Feng, 2018
- Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis, Guanghai Feng, 2018
- Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-Wide Genetic Screening, Guanghai Feng, 2017
- Mettl3-Mediated m6A Regulates Spermatogonial Differentiation and Meiosis Initiation, Guanghai Feng, 2017
- Rat Embryonic Stem Cells Produce Fertile Offspring Through Tetraploid Complementation, Guanghai Feng, 2017
- Birth of Fertile Bimaternal Offspring Following Intracytoplasmic Injection of Parthenogenetic Haploid Embryonic Stem Cells, Guanghai Feng, 2016
- Ubiquitously Expressed Genes Participate in Cell-Specific Functions via Alternative Promoter Usage, Guanghai Feng, 2016
Awards
- Outstanding Scientific Achievement Award of the Chinese Academy of Sciences (2020): Collective Award
- National Maternal and Child Health Science and Technology Award (2019): First Prize in Natural Science
