Professor | Yanfen Fang | Asia Growth Partners

Name	Yanfen Fang
Contact Information	yffang@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yanfen Fang

Contact Information

yffang@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2006-09--2011-06 PhD: Zhejiang University 2002-09--2006-06 Bachelor's Degree: Zhejiang University
Work Experience	2017-11~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher 2017-04~2017-10 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher 2013-07~2017-03 - East China Normal University - Assistant Researcher 2011-10~2013-06 - University of Michigan - Postdoctoral Researcher 2006-09~2011-06 - Zhejiang University - PhD Student 2002-09~2006-06 - Zhejiang University - Bachelor's Degree
Awards	Patent (2018): A new branched linker for targeted drug delivery systems, 4th author, Patent No: ZL201510005869.X Patent (2017): A glucose-conjugated near-infrared dye and its preparation method and application, 3rd author, Patent No: ZL201610111482.7

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2006-09--2011-06 PhD: Zhejiang University
2002-09--2006-06 Bachelor's Degree: Zhejiang University

Work Experience

2017-11~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
2017-04~2017-10 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher
2013-07~2017-03 - East China Normal University - Assistant Researcher
2011-10~2013-06 - University of Michigan - Postdoctoral Researcher
2006-09~2011-06 - Zhejiang University - PhD Student
2002-09~2006-06 - Zhejiang University - Bachelor's Degree

Awards

Patent (2018): A new branched linker for targeted drug delivery systems, 4th author, Patent No: ZL201510005869.X
Patent (2017): A glucose-conjugated near-infrared dye and its preparation method and application, 3rd author, Patent No: ZL201610111482.7

Areas of Focus	Tumor Pharmacology
Publications	Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition, 9th author, 2023 PI3K inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma, 3rd author, 2021 Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation, 5th author, 2020 AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition, 3rd author, 2019 NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3, 6th author, 2019 Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression, 5th author, 2019 ES2 enhances the efficacy of chemotherapeutic agents in ABCB1-overexpressing cancer cells in vitro and in vivo, 1st author, 2018 Characterization of a near-infrared fluorescent DCPO-tagged glucose analogue for cancer cell imaging, 1st author, 2017 Structure-based design and synthesis of imidazo1,2-apyridine derivatives as novel and potent Nek2 inhibitors with invitro and invivo antitumor activities, 2nd author, 2017 Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis, 6th author, 2017 Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity, 1st author, 2016 Targeting NEK2 as a promising therapeutic approach for cancer treatment, 1st author, 2016 Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases, 7th author, 2016 NIR fluorescent DCPO glucose analogues and their application in cancer cell imaging, 2nd author, 2016

Areas of Focus

Tumor Pharmacology

Publications

Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition, 9th author, 2023
PI3K inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma, 3rd author, 2021
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation, 5th author, 2020
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition, 3rd author, 2019
NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3, 6th author, 2019
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression, 5th author, 2019
ES2 enhances the efficacy of chemotherapeutic agents in ABCB1-overexpressing cancer cells in vitro and in vivo, 1st author, 2018
Characterization of a near-infrared fluorescent DCPO-tagged glucose analogue for cancer cell imaging, 1st author, 2017
Structure-based design and synthesis of imidazo1,2-apyridine derivatives as novel and potent Nek2 inhibitors with invitro and invivo antitumor activities, 2nd author, 2017
Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis, 6th author, 2017
Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity, 1st author, 2016
Targeting NEK2 as a promising therapeutic approach for cancer treatment, 1st author, 2016
Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases, 7th author, 2016
NIR fluorescent DCPO glucose analogues and their application in cancer cell imaging, 2nd author, 2016

Cancer Pharmacology Tumor Drug Delivery Chemotherapy Targeted Therapy Oncology Molecular Biology Cell Biology Biomedical Research

Guoan Chen - Southern University of Science and Technology

Songmei Liu - Wuhan University

Yan Liu - Wuhan University

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