Professor | Changan Geng | Asia Growth Partners

Name	Changan Geng
Contact Information	gengchangan@mail.kib.ac.cn
Language ability	Chinese, English
Province	Yunnan

Name

Changan Geng

Contact Information

gengchangan@mail.kib.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2008-09 to 2011-06 Ph.D. in Science: Kunming Institute of Botany, Chinese Academy of Sciences 2005-09 to 2008-06 M.Sc. in Science: Kunming Institute of Botany, Chinese Academy of Sciences 2001-09 to 2005-06 B.Sc. in Medicine: Ocean University of China
Work Experience	2021-04 to Present - Kunming Institute of Botany, Chinese Academy of Sciences - Doctoral Supervisor 2020-11 to Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher 2017-04 to Present - Kunming Institute of Botany, Chinese Academy of Sciences - Master's Supervisor 2016-10 to 2017-09 - University of Warwick - Visiting Scholar 2014-01 to 2020-11 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher 2011-09 to 2013-12 - Kunming Institute of Botany, Chinese Academy of Sciences - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2008-09 to 2011-06 Ph.D. in Science: Kunming Institute of Botany, Chinese Academy of Sciences
2005-09 to 2008-06 M.Sc. in Science: Kunming Institute of Botany, Chinese Academy of Sciences
2001-09 to 2005-06 B.Sc. in Medicine: Ocean University of China

Work Experience

2021-04 to Present - Kunming Institute of Botany, Chinese Academy of Sciences - Doctoral Supervisor
2020-11 to Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher
2017-04 to Present - Kunming Institute of Botany, Chinese Academy of Sciences - Master's Supervisor
2016-10 to 2017-09 - University of Warwick - Visiting Scholar
2014-01 to 2020-11 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher
2011-09 to 2013-12 - Kunming Institute of Botany, Chinese Academy of Sciences - Assistant Researcher

Areas of Focus	Discovery and development of hypoglycemic active ingredients based on multiple targets Comprehensive development and utilization of traditional medicinal plants
Publications	Four new phenolic compounds from the fruits of Alpinia galanga, Liu, Pei, Wu, ShengLi, Wang, Tian, Zhang, XueMei, Geng, ChangAn, 2023 Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga, Wang, Tian, Wu, ShengLi, Liu, Pei, Chen, JiJun, Zhang, XueMei, Geng, ChangAn, 2023 Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway, He, Xiaofeng, Ma, Wenjing, Hu, Jing, Li, Tianze, Geng, Changan, Ma, Yunbao, Wang, Mengfei, Yang, Kexin, Zhang, Xuemei, Chen, JiJun, 2023 Artematrovirenolides A-D and Artematrolides S-Z, Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens, Su, LiHua, Li, TianZe, Ma, YunBao, Geng, ChangAn, Huang, XiaoYan, Zhang, Xin, Gao, Zhen, Chen, JiJun, 2022 Norlignans as potent GLP-1 secretagogues from the fruits of Amomum villosum, Ding, Min, Wu, ShengLi, Hu, Jing, He, XiaoFeng, Huang, XiaoYan, Li, TianZe, Ma, YunBao, Zhang, XueMei, Geng, ChangAn, 2022 Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity, Luo, Shuaibin, Zhang, Xuemei, He, Kang, Zou, Juan, Geng, ChangAn, 2022 Oligostilbenes from the seeds of Paeonia lactiflora as potent GLP-1 secretagogues targeting TGR5 receptor, Wu, ShengLi, Zhang, ChenChen, Chen, JiJun, Zhang, XueMei, Guan, Min, Geng, ChangAn, 2022 Artemidubolides A−T, cytotoxic unreported guaiane-type sesquiterpenoid dimers against three hepatoma cell lines from Artemisia dubia, Zhen Gao, WenJing Ma, TianZe Li, YunBao Ma, Jing Hu, XiaoYan Huang, ChangAn Geng, XiaoFeng He, XueMei Zhang, JiJun Chen, 2022 New diarylheptanoid dimers as GLP-1 secretagogues and multiple-enzyme inhibitors from Alpinia katsumadai, He, XiaoFeng, Wu, ShengLi, Chen, JiJun, Hu, Jing, Huang, XiaoYan, Li, TianZe, Zhang, XueMei, Guo, YuanQiang, Geng, ChangAn, 2022 Antidiabetic triterpenoids from the leaves of Paeonia suffruticosa and Paeonia delavayi, Huang, Qian, Pan, Yang, Wu, ShengLi, Huang, XiaoYan, Hu, Jing, Ma, YunBao, Zhang, XueMei, Geng, ChangAn, 2022 砂仁中的萜类成分及其降血糖活性, 丁敏, 吴圣丽, 何小凤, 张雪梅, 耿长安, 2022 Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities, Li, TianZe, Hu, Jing, Sun, JinJin, Huang, XiaoYan, Geng, ChangAn, Liu, ShuBai, Zhang, XueMei, Chen, JiJun, 2022 Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis, Dong, Wei, Li, TianZe, Huang, XiaoYan, He, XiaoFeng, Geng, ChangAn, Zhang, XueMei, Chen, JiJun, 2022 Distepharinamide, a novel dimeric proaporphine alkaloid from Diploclisia glaucescens, inhibits the differentiation and proliferative expansion of CD4(+)Foxp3(+) regulatory T cells, Chen, FengYang, Geng, ChangAn, Chou, ChonKit, Zheng, JingBin, Yang, Yang, Wang, YiFei, Li, TianZe, Li, Ping, Chen, JiJun, Chen, Xin, 2022 Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha, Xin Zhang, YunBao Ma, XiaoFeng He, TianZe Li, ChangAn Geng, LiHua Su, Shuang Tang, Zhen Gao, JiJun Chen, 2022 Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants, Li, Tian-Ze, Huang,Xiao-Yan, Sun, Jin-Jin, Geng,Chang-An, Zhang,Xue-Mei, Chen,Ji-Jun, 2022 Artemicapillasins A-N, cytotoxic coumaric acid analogues against hepatic stellate cell LX2 from Artemisia capillaris (Yin-Chen), Gao, Zhen, Huang, XiaoYan, Geng, ChangAn, Li, TianZe, Chen, JiJun, 2021 Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities, Su, LiHua, Li, TianZe, Geng, ChangAn, Ma, YunBao, Huang, XiaoYan, Wang, JinPing, Zhang, XueMei, Chen, JiJun, 2021 Artematrolide A inhibited cervical cancer cell proliferation via ROS/ERK/mTOR pathway and metabolic shift, Zhang, XinTian, Hu, Jing, Su, LiHua, Geng, ChangAn, Chen, JiJun, 2021 Diarylheptanoid-chalcone hybrids with PTP1B and α-glucosidase dual inhibition from Alpinia katsumadai, XiaoFeng He, JiJun Chen, TianZe Li, Jing Hu, XueMei Zhang, ChangAn Geng, 2021 Chemical profiling and antidiabetic potency of Paeonia delavayi: Comparison between different parts and constituents, Huang, Qian, Chen, JiJun, Pan, Yang, He, XiaoFeng, Wang, Yuan, Zhang, XueMei, Geng, ChangAn, 2021 Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai, He, XiaoFeng, Chen, JiJun, Li, TianZe, Hu, Jing, Huang, XiaoYan, Zhang, XuKe, Guo, YuanQiang, Geng, ChangAn, 2021 The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors, He, XiaoFeng, Chen, JiJun, Huang, XiaoYan, Hu, Jing, Zhang, XuKe, Guo, YuanQiang, Zhang, XueMei, Geng, ChangAn, 2021 Tsaokols A and B,unusual flavanol-monoterpenoid hybrids asα-glucosidase inhibitors from Amomum tsao-ko, XiaoFeng He, JiJun Chen, TianZe Li, Jing Hu, XuKe Zhang, YuanQiang Guo, XueMei Zhang, ChangAn Geng, 2021 Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction, Li, TianZe, Yang, XiaoTong, Wang, JinPing, Geng, ChangAn, Ma, YunBao, Su, LiHua, Zhang, XueMei, Chen, JiJun, 2021 Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens, Su, LiHua, Ma, YunBao, Geng, ChangAn, Li, TianZe, Huang, XiaoYan, Hu, Jing, Zhang, Xin, Tang, Shuang, Shen, Cheng, Gao, Zhen, Zhang, XueMei, Chen, JiJun, 2021 Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2, Wang, JinPing, Li, TianZe, Huang, XiaoYan, Geng, ChangAn, Shen, Cheng, Sun, JinJin, Xue, Dong, Chen, JiJun, 2021

Areas of Focus

Discovery and development of hypoglycemic active ingredients based on multiple targets
Comprehensive development and utilization of traditional medicinal plants

Publications

Four new phenolic compounds from the fruits of Alpinia galanga, Liu, Pei, Wu, ShengLi, Wang, Tian, Zhang, XueMei, Geng, ChangAn, 2023
Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga, Wang, Tian, Wu, ShengLi, Liu, Pei, Chen, JiJun, Zhang, XueMei, Geng, ChangAn, 2023
Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway, He, Xiaofeng, Ma, Wenjing, Hu, Jing, Li, Tianze, Geng, Changan, Ma, Yunbao, Wang, Mengfei, Yang, Kexin, Zhang, Xuemei, Chen, JiJun, 2023
Artematrovirenolides A-D and Artematrolides S-Z, Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens, Su, LiHua, Li, TianZe, Ma, YunBao, Geng, ChangAn, Huang, XiaoYan, Zhang, Xin, Gao, Zhen, Chen, JiJun, 2022
Norlignans as potent GLP-1 secretagogues from the fruits of Amomum villosum, Ding, Min, Wu, ShengLi, Hu, Jing, He, XiaoFeng, Huang, XiaoYan, Li, TianZe, Ma, YunBao, Zhang, XueMei, Geng, ChangAn, 2022
Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity, Luo, Shuaibin, Zhang, Xuemei, He, Kang, Zou, Juan, Geng, ChangAn, 2022
Oligostilbenes from the seeds of Paeonia lactiflora as potent GLP-1 secretagogues targeting TGR5 receptor, Wu, ShengLi, Zhang, ChenChen, Chen, JiJun, Zhang, XueMei, Guan, Min, Geng, ChangAn, 2022
Artemidubolides A−T, cytotoxic unreported guaiane-type sesquiterpenoid dimers against three hepatoma cell lines from Artemisia dubia, Zhen Gao, WenJing Ma, TianZe Li, YunBao Ma, Jing Hu, XiaoYan Huang, ChangAn Geng, XiaoFeng He, XueMei Zhang, JiJun Chen, 2022
New diarylheptanoid dimers as GLP-1 secretagogues and multiple-enzyme inhibitors from Alpinia katsumadai, He, XiaoFeng, Wu, ShengLi, Chen, JiJun, Hu, Jing, Huang, XiaoYan, Li, TianZe, Zhang, XueMei, Guo, YuanQiang, Geng, ChangAn, 2022
Antidiabetic triterpenoids from the leaves of Paeonia suffruticosa and Paeonia delavayi, Huang, Qian, Pan, Yang, Wu, ShengLi, Huang, XiaoYan, Hu, Jing, Ma, YunBao, Zhang, XueMei, Geng, ChangAn, 2022
砂仁中的萜类成分及其降血糖活性, 丁敏, 吴圣丽, 何小凤, 张雪梅, 耿长安, 2022
Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities, Li, TianZe, Hu, Jing, Sun, JinJin, Huang, XiaoYan, Geng, ChangAn, Liu, ShuBai, Zhang, XueMei, Chen, JiJun, 2022
Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis, Dong, Wei, Li, TianZe, Huang, XiaoYan, He, XiaoFeng, Geng, ChangAn, Zhang, XueMei, Chen, JiJun, 2022
Distepharinamide, a novel dimeric proaporphine alkaloid from Diploclisia glaucescens, inhibits the differentiation and proliferative expansion of CD4(+)Foxp3(+) regulatory T cells, Chen, FengYang, Geng, ChangAn, Chou, ChonKit, Zheng, JingBin, Yang, Yang, Wang, YiFei, Li, TianZe, Li, Ping, Chen, JiJun, Chen, Xin, 2022
Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha, Xin Zhang, YunBao Ma, XiaoFeng He, TianZe Li, ChangAn Geng, LiHua Su, Shuang Tang, Zhen Gao, JiJun Chen, 2022
Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants, Li, Tian-Ze, Huang,Xiao-Yan, Sun, Jin-Jin, Geng,Chang-An, Zhang,Xue-Mei, Chen,Ji-Jun, 2022
Artemicapillasins A-N, cytotoxic coumaric acid analogues against hepatic stellate cell LX2 from Artemisia capillaris (Yin-Chen), Gao, Zhen, Huang, XiaoYan, Geng, ChangAn, Li, TianZe, Chen, JiJun, 2021
Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities, Su, LiHua, Li, TianZe, Geng, ChangAn, Ma, YunBao, Huang, XiaoYan, Wang, JinPing, Zhang, XueMei, Chen, JiJun, 2021
Artematrolide A inhibited cervical cancer cell proliferation via ROS/ERK/mTOR pathway and metabolic shift, Zhang, XinTian, Hu, Jing, Su, LiHua, Geng, ChangAn, Chen, JiJun, 2021
Diarylheptanoid-chalcone hybrids with PTP1B and α-glucosidase dual inhibition from Alpinia katsumadai, XiaoFeng He, JiJun Chen, TianZe Li, Jing Hu, XueMei Zhang, ChangAn Geng, 2021
Chemical profiling and antidiabetic potency of Paeonia delavayi: Comparison between different parts and constituents, Huang, Qian, Chen, JiJun, Pan, Yang, He, XiaoFeng, Wang, Yuan, Zhang, XueMei, Geng, ChangAn, 2021
Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai, He, XiaoFeng, Chen, JiJun, Li, TianZe, Hu, Jing, Huang, XiaoYan, Zhang, XuKe, Guo, YuanQiang, Geng, ChangAn, 2021
The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors, He, XiaoFeng, Chen, JiJun, Huang, XiaoYan, Hu, Jing, Zhang, XuKe, Guo, YuanQiang, Zhang, XueMei, Geng, ChangAn, 2021
Tsaokols A and B,unusual flavanol-monoterpenoid hybrids asα-glucosidase inhibitors from Amomum tsao-ko, XiaoFeng He, JiJun Chen, TianZe Li, Jing Hu, XuKe Zhang, YuanQiang Guo, XueMei Zhang, ChangAn Geng, 2021
Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction, Li, TianZe, Yang, XiaoTong, Wang, JinPing, Geng, ChangAn, Ma, YunBao, Su, LiHua, Zhang, XueMei, Chen, JiJun, 2021
Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens, Su, LiHua, Ma, YunBao, Geng, ChangAn, Li, TianZe, Huang, XiaoYan, Hu, Jing, Zhang, Xin, Tang, Shuang, Shen, Cheng, Gao, Zhen, Zhang, XueMei, Chen, JiJun, 2021
Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2, Wang, JinPing, Li, TianZe, Huang, XiaoYan, Geng, ChangAn, Shen, Cheng, Sun, JinJin, Xue, Dong, Chen, JiJun, 2021

Hypoglycemic Active Ingredients Multiple Targets Traditional Medicine Diabetes Clinical Efficacy Medicinal Plants Structure Optimization Mechanism Of Action Drug Development Traditional Medicinal Plants Lcms Multi-Target Screening Systematic Analysis Comparative Analysis Medicinal Resources Utilization Natural Products Phytochemistry

Benhong Zhou - Wuhan University

Linsen Qing - University of Chinese Academy of Sciences

Tong Jing - Wuhan University

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