Areas of Focus
- Pathology and Pathophysiology - Tumor Metastasis and Microenvironment Regulation
- Cell Biology - Tumor Metastasis and Microenvironment Regulation
Work Experience
- 2017-10 to Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Deputy Director/Researcher/Research Group Leader
- 2009-08 to 2017-09 - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher/Research Group Leader
- 2005-08 to 2009-08 - Princeton University - Postdoctoral/Associate Research Scholar
Academic Background & Achievements
- 2000-09 to 2005-05 PhD in Molecular Genetics: Rutgers University
- 1996-09 to 2000-07 Bachelor's in Biological Sciences and Technology: Tsinghua University
Publications
- MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation, Guohong Hu, 2023
- SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches, Guohong Hu, 2023
- lncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma, Guohong Hu, 2022
- miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression, Guohong Hu, 2022
- ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression, Guohong Hu, 2022
- Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation, Guohong Hu, 2021
- Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis, Guohong Hu, 2020
- MTSS1 suppresses expansion and activity of mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination, Guohong Hu, 2020
- SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation, Guohong Hu, 2020
- ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression, Guohong Hu, 2019
- Epigenetic Regulation of NAMPT by NAMPT-AS Drives Metastatic Progression in Triple-Negative Breast Cancer, Guohong Hu, 2019
- Cancer and microenvironment plasticity: double-edged swords in metastasis, Guohong Hu, 2019
- In vitro Osteoclastogenesis Assays Using Primary Mouse Bone Marrow Cells, Guohong Hu, 2018
- Biomarker Studies in Early Detection and Prognosis of Breast Cancer, Guohong Hu, 2017
- YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation, Guohong Hu, 2017
- Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1, Guohong Hu, 2017
- The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis, Guohong Hu, 2017
- AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis, Guohong Hu, 2017
- A CD44v + subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity, Guohong Hu, 2017
- MicroRNA-182 targets SMAD7 to potentiate TGF beta-induced epithelial-mesenchymal transition and metastasis of cancer cells, Guohong Hu, 2016
- Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer, Guohong Hu, 2015
- Roles of miR-182 in sensory organ development and cancer, Guohong Hu, 2015
- Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis, Guohong Hu, 2014
- DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis, Guohong Hu, 2014
- Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis, Guohong Hu, 2014
- Uncovering the Rare Variants of DLC1 Isoform 1 and Their Functional Effects in a Chinese Sporadic Congenital Heart Disease Cohort, Guohong Hu, 2014
- Transcriptional Network Analysis Identifies BACH1 as a Master Regulator of Breast Cancer Bone Metastasis, Guohong Hu, 2012
- Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis, Guohong Hu, 2012
- Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region, Guohong Hu, 2011
- Pegylated Composite Nanoparticles Containing Upconverting Phosphors and meso-Tetraphenyl porphine (TPP) for Photodynamic Therapy, Guohong Hu, 2011
- Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization, Guohong Hu, 2011
- MTDH: An emerging key regulator of malignant progression in multiple cancers, Guohong Hu, 2011
- In Vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer, Guohong Hu, 2010
- ADAMTS1 and MMP1 proteolytically engage EGF-like growth factors in an osteolytic paracrine signaling cascade to promote breast cancer bone metastasis., Guohong Hu, 2009
- MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer, Guohong Hu, 2009
- From Breast to the Brain: Unraveling the Puzzle of Metastasis Organotropism, Guohong Hu, 2009
- The Multifaceted Role of MTDH/AEG-1 in Cancer Progression, Guohong Hu, 2009
- Metadherin as a link between metastasis and chemoresistance, Guohong Hu, 2009
- A highly sensitive and specific system for large-scale gene expression profiling, Guohong Hu, 2008
- Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression, Guohong Hu, 2008
- AccuTyping: new algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays, Guohong Hu, 2006
- Determination of haplotype organization of human IGHV region on single chromosomes by multiplex PCR and microarray analysis of single sperm., Guohong Hu, 2005
- Production of poly-3-hydroxybutyrate by Bacillus sp JMa5 cultivated in molasses media, Guohong Hu, 2001
- The Oncogene Metadherin Modulates the Apoptotic Pathway Based on the Tumor Necrosis Factor Superfamily Member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in Breast Cancer, Guohong Hu, 2001
- The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2, Guohong Hu, 2001
Awards
- Chinese Academy of Sciences Excellent Mentor Award (2022)
- Chinese Academy of Sciences Excellent Mentor Award (2019)
- Shanghai Youth Science and Technology Talent (2018)
- Innovation Talent Contribution Award of the Chinese Overseas Chinese Community (2014)
- Meiji Life Science Award (2013)
