Areas of Focus
- Reproductive Cells
- Fertilization
- Embryonic Development
- Cell Reprogramming
- Stem Cells
Work Experience
- 2005-06~2010-04 - Temple University - Associate Scientist
- 2002-12~2005-06 - Temple University - Postdoctoral Researcher
- 1996-07~1997-07 - Institute of Zoology, Chinese Academy of Sciences - Research Assistant
Academic Background & Achievements
- 1997-09--2002-07 PhD in Science: Beijing Normal University
- 1992-09--1996-07 Bachelor's in Science: Beijing Normal University
Publications
- Overexpression of let-7a mitigates diploidization in mouse androgenetic haploid embryonic stem cells., iScience, 2024
- NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition., Advanced Science, 2023
- Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes., Cell Proliferation, 2023
- SRSF2 is required for mRNA splicing during spermatogenesis., BMC Biology, 2023
- SRSF1-mediated alternative splicing is required for spermatogenesis., International Journal of Biological Sciences, 2023
- A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human., iScience, 2023
- Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation., JCI Insight, 2023
- MAPRE2 regulates the first meiotic progression in mouse oocytes., Experimental Cell Research, 2022
- Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling., Cellular and Molecular Gastroenterology and Hepatology, 2022
- SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing., eLife, 2022
- Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation., Zoological Research, 2022
- Cerebral cavernous malformation development in chronic mouse models driven by dual recombinases induced gene deletion in brain endothelial cells., Journal of Cerebral Blood Flow and Metabolism, 2022
- PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4, Journal of Cellular Physiology, 2021
- Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting, JCI Insight, 2021
- NEK家族在细胞周期调控中的作用, 遗传, 2021
- NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development, Molecular Reproduction and Development, 2019
- Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b, Stem Cell Reports, 2018
- Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations, Science Advances, 2018
- High Throughput Sequencing Identifies an Imprinted Gene, Grb10, Associated with the Pluripotency State in Nuclear Transfer Embryonic Stem Cells, Oncotarget, 2017
- Sperm-Carried RNAs Play Critical Roles in Mouse Embryonic Development, Oncotarget, 2017
- Is Embryonic Hypothermia Tolerance Common in Birds?, Biology Letters, 2017
- 小鼠孤雄单倍体胚胎干细胞增殖的研究, 中国细胞生物学学报, 2016
- 小鼠受精卵雌雄原核重编程能力的不对称性, 科学新闻, 2015
- 甲状旁腺激素样激素在胚胎发育中的作用, 遗传, 2014
- Roles of Sphingosine-I-Phosphate in Reproduction, Reproductive Sciences, 2014
- DNA Methylation in Oocytes and Liver of Female Mice and Their Offspring: Effects of High-Fat-Diet-Induced Obesity, Environmental Health Perspectives, 2014
- Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygotes, Cell Reports, 2014
- Maternal Obesity and Diabetes may Cause DNA Methylation Alteration in the Spermatozoa of Offspring in Mice, Reproductive Biology and Endocrinology, 2014
- Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice, Reproductive Biology and Endocrinology, 2013
- Maternal Diabetes Causes Alterations of DNA Methylation Statuses of Some Imprinted Genes in Murine Oocytes, Biology of Reproduction, 2013
- The Outcome of Different Post-Thawed Culture Period in Frozen-Thawed Embryo Transfer Cycle, Journal of Assisted Reproduction and Genetics, 2013
- Cyclin O Regulates Germinal Vesicle Breakdown in Mouse Oocytes, Biology of Reproduction, 2013
- The Roles of Parathyroid Hormone-Like Hormone during Mouse Preimplantation Embryonic Development, PLOS ONE, 2012
- The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation, Molecular Human Reproduction, 2011
- Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes, Fertility and Sterility, 2011
- DNA甲基化和组蛋白修饰在克隆动物发育过程中的作用, 遗传, 2010
- The histone demethylase jmjd2c is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development, Biology of Reproduction, 2010
- Oocyte spindle proteomics analysis leading to rescue of chromosome congression defects in cloned embryos, Journal of Proteome Research, 2010
- Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos, American Journal of Physiology-Cell Physiology, 2010
- Chapter 10 - Nuclear Transfer in Mouse Oocytes and Embryos, Methods in Enzymology, 2010
- 哺乳动物的受精, 生物学通报, 2010
- Effects of ooplasm transfer on paternal genome function in mice, Human Reproduction, 2009
- Effects of Ooplasm Manipulation on DNA Methylation and Growth of Progeny in Mice, Biology of Reproduction, 2009
- The Unfolded Protein Response Contributes to Preimplantation Mouse Embryo Death in the DDK Syndrome, Biology of Reproduction, 2009
- Role of glucose in cloned mouse embryo development, American Journal of Physiology-Endocrinology and Metabolism, 2008
- Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype, Biology of Reproduction, 2008
- The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues, Gene Expression Patterns, 2008
- Trichostatin a and nuclear reprogramming of cloned rabbit embryos, Journal of Animal Science, 2008
- Trichostatin a (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos, Developmental Dynamics, 2008
- Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos, Molecular Reproduction and Development, 2007
- Tough beginnings: Alterations in the transcriptome of cloned embryos during the first two cell cycles, Developmental Biology, 2007
- Therapeutic cloning: Status and prospects, Current Opinion in Molecular Therapeutics, 2007
- Somatic cell nuclei in cloning: Strangers traveling in a foreign land, Advances in Experimental Medicine and Biology, 2007
- Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones, Developmental Biology, 2006
- Maternal factors controlling blastomere fragmentation in early mouse embryos, Biology of Reproduction, 2005
- X chromosome reactivation and regulation in cloned embryos, Developmental Biology, 2005
- Differential In Vivo Binding
Awards
- National Population and Family Planning Science and Technology Achievement Award, First Prize, National Level, 2006
