1997-09--2002-07 PhD in Science: Beijing Normal University
1992-09--1996-07 Bachelor's in Science: Beijing Normal University
2005-06~2010-04 - Temple University - Associate Scientist
2002-12~2005-06 - Temple University - Postdoctoral Researcher
1996-07~1997-07 - Institute of Zoology, Chinese Academy of Sciences - Research Assistant
National Population and Family Planning Science and Technology Achievement Award, First Prize, National Level, 2006
Research
Reproductive Cells Fertilization Embryonic Development Cell Reprogramming Stem Cells
Overexpression of let-7a mitigates diploidization in mouse androgenetic haploid embryonic stem cells., iScience, 2024
NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition., Advanced Science, 2023
Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes., Cell Proliferation, 2023
SRSF2 is required for mRNA splicing during spermatogenesis., BMC Biology, 2023
SRSF1-mediated alternative splicing is required for spermatogenesis., International Journal of Biological Sciences, 2023
A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human., iScience, 2023
Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation., JCI Insight, 2023
MAPRE2 regulates the first meiotic progression in mouse oocytes., Experimental Cell Research, 2022
Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling., Cellular and Molecular Gastroenterology and Hepatology, 2022
SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing., eLife, 2022
Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation., Zoological Research, 2022
Cerebral cavernous malformation development in chronic mouse models driven by dual recombinases induced gene deletion in brain endothelial cells., Journal of Cerebral Blood Flow and Metabolism, 2022
PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4, Journal of Cellular Physiology, 2021
Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting, JCI Insight, 2021
NEK家族在细胞周期调控中的作用, 遗传, 2021
NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development, Molecular Reproduction and Development, 2019
Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b, Stem Cell Reports, 2018
Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations, Science Advances, 2018
High Throughput Sequencing Identifies an Imprinted Gene, Grb10, Associated with the Pluripotency State in Nuclear Transfer Embryonic Stem Cells, Oncotarget, 2017
Sperm-Carried RNAs Play Critical Roles in Mouse Embryonic Development, Oncotarget, 2017
Is Embryonic Hypothermia Tolerance Common in Birds?, Biology Letters, 2017
小鼠孤雄单倍体胚胎干细胞增殖的研究, 中国细胞生物学学报, 2016
小鼠受精卵雌雄原核重编程能力的不对称性, 科学新闻, 2015
甲状旁腺激素样激素在胚胎发育中的作用, 遗传, 2014
Roles of Sphingosine-I-Phosphate in Reproduction, Reproductive Sciences, 2014
DNA Methylation in Oocytes and Liver of Female Mice and Their Offspring: Effects of High-Fat-Diet-Induced Obesity, Environmental Health Perspectives, 2014
Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygotes, Cell Reports, 2014
Maternal Obesity and Diabetes may Cause DNA Methylation Alteration in the Spermatozoa of Offspring in Mice, Reproductive Biology and Endocrinology, 2014
Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice, Reproductive Biology and Endocrinology, 2013
Maternal Diabetes Causes Alterations of DNA Methylation Statuses of Some Imprinted Genes in Murine Oocytes, Biology of Reproduction, 2013
The Outcome of Different Post-Thawed Culture Period in Frozen-Thawed Embryo Transfer Cycle, Journal of Assisted Reproduction and Genetics, 2013
Cyclin O Regulates Germinal Vesicle Breakdown in Mouse Oocytes, Biology of Reproduction, 2013
The Roles of Parathyroid Hormone-Like Hormone during Mouse Preimplantation Embryonic Development, PLOS ONE, 2012
The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation, Molecular Human Reproduction, 2011
Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes, Fertility and Sterility, 2011
DNA甲基化和组蛋白修饰在克隆动物发育过程中的作用, 遗传, 2010
The histone demethylase jmjd2c is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development, Biology of Reproduction, 2010
Oocyte spindle proteomics analysis leading to rescue of chromosome congression defects in cloned embryos, Journal of Proteome Research, 2010
Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos, American Journal of Physiology-Cell Physiology, 2010
Chapter 10 - Nuclear Transfer in Mouse Oocytes and Embryos, Methods in Enzymology, 2010
哺乳动物的受精, 生物学通报, 2010
Effects of ooplasm transfer on paternal genome function in mice, Human Reproduction, 2009
Effects of Ooplasm Manipulation on DNA Methylation and Growth of Progeny in Mice, Biology of Reproduction, 2009
The Unfolded Protein Response Contributes to Preimplantation Mouse Embryo Death in the DDK Syndrome, Biology of Reproduction, 2009
Role of glucose in cloned mouse embryo development, American Journal of Physiology-Endocrinology and Metabolism, 2008
Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype, Biology of Reproduction, 2008
The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues, Gene Expression Patterns, 2008
Trichostatin a and nuclear reprogramming of cloned rabbit embryos, Journal of Animal Science, 2008
Trichostatin a (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos, Developmental Dynamics, 2008
Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos, Molecular Reproduction and Development, 2007
Tough beginnings: Alterations in the transcriptome of cloned embryos during the first two cell cycles, Developmental Biology, 2007
Therapeutic cloning: Status and prospects, Current Opinion in Molecular Therapeutics, 2007
Somatic cell nuclei in cloning: Strangers traveling in a foreign land, Advances in Experimental Medicine and Biology, 2007
Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones, Developmental Biology, 2006
Maternal factors controlling blastomere fragmentation in early mouse embryos, Biology of Reproduction, 2005
X chromosome reactivation and regulation in cloned embryos, Developmental Biology, 2005
Differential In Vivo Binding
Keywords
Reproductive CellsFertilizationEmbryonic DevelopmentCell ReprogrammingStem CellsDevelopmental BiologyGeneticsMolecular BiologyCell BiologyBiomedical Research
Area of Focus
Critical Care | Intensive Care | Sepsis | Clinical Research | Emergency Medicine | Inflammation | Organ Protection | Medical Education | Molecular Biology | Biomedical Research
