Areas of Focus
- Decoding genetic and epigenetic information of human aging
- Research on human disease mechanisms and precision treatment based on stem cell technology
- Development and application of new gene editing methods and gene therapy technologies
Work Experience
- 2007-2012 - The Scripps Research Institute and Salk Institute for Biological Studies - Research Associate
- 2012-2019 - Institute of Biophysics, Chinese Academy of Sciences - Researcher (PI)
- 2019-present - Institute of Zoology, Chinese Academy of Sciences - Researcher (PI)
Academic Background & Achievements
- 2002 Bachelor of Science: Peking University Health Science Center
- 2007 Doctor of Science: Institute of Biophysics, Chinese Academy of Sciences
- Member of the Chinese Academy of Medical Sciences
- Fellow of the International Union of Physiological Sciences
- Deputy Director of the Academic Committee of the Institute of Zoology, Chinese Academy of Sciences
- Deputy Director of the State Key Laboratory of Membrane Biology
- Director of the Stem Cell and Regenerative Medicine Science Data Center, Chinese Academy of Sciences
- Vice President and Academic Committee Director of the Beijing Institute of Stem Cell and Regenerative Medicine
- Leader of the National Natural Science Foundation of China Innovation Research Group Project
- Recipient of the Outstanding Youth Fund Project
Publications
- Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland, Wang Q, Wang X, Liu B, Ma S, Zhang F, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Belmonte JCI, Qu J, Liu GH, Zhang W, 2024
- The Sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA, Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun Q, Wu Z, Diao Z, Li J, Sun L, Belmonte JCI, Zhang W, Liu GH, Qu J, 2024
- CHIT1-positive microglia drive motor neuron aging in the primate spinal cord, Sun S, Li J, Wang S, Li J, Ren J, Bao Z, Sun L, Ma X, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J, Zhang W, Liu GH, 2023
- Resurrection of endogenous retroviruses during aging reinforces senescence, Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH, 2023
- Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation, Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Eseban CR, Ready P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J, Zhang W, Qu J, Liu GH, 2023
- Decoding aging-dependent regenerative decline across tissues at single-cell resolution, Cai Y, Xiong M, Xin Z, Liu C, Jie R, Yang X, Lei J, Li W, Liu F, Chu Q, Yin J, Ye Y, Liu D, Fan Y, Sun S, Zhao Q, Zhao L, Che S, Zheng Y, Yan H, Ma S, Wang S, Belmonte JCI, Qu J, Zhang W, Liu GH, 2023
- SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B, Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J, Zhang W, Liu GH, 2023
- M6A epitranscriptomic regulation of tissue homeostasis during primate aging, Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang Y, Xiao J, Belmonte JCI, Qu J, Zhang W, Ci W, Liu GH, 2023
- Determining a Multimodal Aging Clock in a Cohort of Chinese Women, Li J, Xiong M, Fu XH, Fan Y, Dong C, Sun X, Zheng F, Wang SW, Liu L, Xu M, Wang C, Ping J, Che S, Wang Q, Yang K, Zuo Y, Lu X, Zheng Z, Lan T, Wang S, Ma S, Sun S, Zhang B, Chen CS, Cheng KY, Ye J, Qu J, Xue Y, Yang YG, Zhang F, Zhang W, Liu GH, 2023
- Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging, Zhang H, Li J, Yu Y, Ren J, Liu Q, Bao Z, Sun S, Liu X, Ma S, Liu Z, Yan K, Wu Z, Fan Y, Sun X, Zhang Y, Ji Q, Cheng F, Wei PH, Ma X, Zhang S, Xie Z, Niu Y, Wang WY, Han JD, Jiang T, Zhao G, Ji W, Belmonte JCI, Wang S, Qu J, Zhang W, Liu GH, 2023
- A Single-cell Transcriptomic Atlas of Exercise-induced Anti-inflammatory and Geroprotective Effects across the Body, Sun S, Ma S, Cai Y, Wang S, Ren J, Yang Y, Ping J, Wang X, Zhang Y, Yan H, Li W, Esteban CR, Yu Y, Liu F, Belmonte JCI, Zhang W, Qu J, Liu GH, 2023
- SGF29 nuclear condensates reinforce cellular aging, Yan K, Ji Q, Zhao D, Li M, Sun X, Wang Z, Liu X, Liu Z, Li H, Ding Y, Wang S, Belmonte JCI, Qu J, Zhang W, Liu GH, 2023
- Single-Cell Transcriptomic Atlas of Mouse Cochlear Aging, Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q,
Awards
- China's Top Ten Scientific Advances (2023)
- Top Ten Advances in Life Sciences in China (2023)
- Fellow of the International Union of Physiological Sciences (2023)
- National Innovation Award Medal (2023)
- Beijing Outstanding Contribution Talent in Science, Technology, and Management (2023)
- Elsevier Highly Cited Chinese Scholar (2020-2023)
- Member of the Chinese Academy of Medical Sciences (2022)
- First Prize of the Overseas Chinese Contribution Award (2022)
- Major Achievements in Basic Research of the National '13th Five-Year Plan' Science and Technology Innovation Achievement Exhibition (2021)
- Science Exploration Award (2021)
- Chinese Medical Science and Technology Award (2021)
- Beijing Outstanding Youth Zhongguancun Award (2021)
- China's Top Ten Scientific Advances (2020)
- Top Ten Advances in Life Sciences in China (2020)
- Outstanding Scientific Achievement Award of the Chinese Academy of Sciences (2020)
- State Council Special Government Allowance (2020)
- Gu Xiaocheng Lecture Award (2019)
- WuXi AppTec Life Chemistry Research Award (2019)
- Zhongyuan Concord Life Medicine Innovation Breakthrough Award (2019)
- Special Award of the China Youth Science and Technology Award (2018)
- Tan Jiazhen Life Science Innovation Award (2018)
- Top Ten Advances in Life Sciences in China (2018)
- Shulan Medical Youth Award (2017)
- First Outstanding Contribution Award in Geriatric Medicine (2017)
