Professor | Zhiyuan Li | Asia Growth Partners

Name	Zhiyuan Li
Contact Information	li_zhiyuan@gibh.ac.cn
Language ability	English, Chinese, Japanese
Province	Guangdong

Name

Zhiyuan Li

Contact Information

li_zhiyuan@gibh.ac.cn

Language ability

English, Chinese, Japanese

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2000-09--2001-12 Postdoctoral: Vanderbilt University, USA 1997-09--2000-07 PhD: Tokushima University, Japan 1994-09--1997-07 PhD: Xiangya School of Medicine, Central South University, China 1991-09--1994-07 Master's: Hunan Medical University, China 1983-09--1988-07 Bachelor's: Hunan Medical University, China
Work Experience	2008-09--Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2002-01--2008-07 - Saint Louis University School of Medicine, USA - Assistant Professor 2000-07--2001-12 - Vanderbilt University School of Medicine, USA - Postdoctoral 1994-07--2000-06 - Hunan Medical University - Lecturer 1988-07--1994-07 - Hunan Medical University - Teaching Assistant
Awards	Hunan Province Natural Science Award, Third Prize, Provincial, 2018 Hunan Province Science and Technology Progress Award, Second Prize, Provincial, 2004 Hunan Medical Science and Technology Award, First Prize, Provincial, 2004 Hunan Province Anatomy Society Excellent Paper Award, First Prize, Provincial, 1998 Hunan Province Natural Science Second Class Excellent Paper, Second Prize, Provincial, 1998

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2000-09--2001-12 Postdoctoral: Vanderbilt University, USA
1997-09--2000-07 PhD: Tokushima University, Japan
1994-09--1997-07 PhD: Xiangya School of Medicine, Central South University, China
1991-09--1994-07 Master's: Hunan Medical University, China
1983-09--1988-07 Bachelor's: Hunan Medical University, China

Work Experience

2008-09--Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2002-01--2008-07 - Saint Louis University School of Medicine, USA - Assistant Professor
2000-07--2001-12 - Vanderbilt University School of Medicine, USA - Postdoctoral
1994-07--2000-06 - Hunan Medical University - Lecturer
1988-07--1994-07 - Hunan Medical University - Teaching Assistant

Awards

Hunan Province Natural Science Award, Third Prize, Provincial, 2018
Hunan Province Science and Technology Progress Award, Second Prize, Provincial, 2004
Hunan Medical Science and Technology Award, First Prize, Provincial, 2004
Hunan Province Anatomy Society Excellent Paper Award, First Prize, Provincial, 1998
Hunan Province Natural Science Second Class Excellent Paper, Second Prize, Provincial, 1998

Areas of Focus	Neurobiology Ion Channel Structure and Function
Publications	Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer, Habimana, Jean de Dieu, Mukama, Omar, Chen, Guiquan, Chen, Mengjun, Amissah, Obed Boadi, Wang, Lin, Liu, Yujie, Sun, Yirong, Li, Amy L, Deng, Sihao, Huang, Jufang, Yan, Xiaoxin, Rutaganda, Theobard, Mutangana, Dieudonne, Wu, LinPing, Huang, Rongqi, Li, Zhiyuan, 2023 Large-scale expansion of human umbilical cord-derived mesenchymal stem cells using PLGA@PLL scaffold, Liu, Yujie, Amissah, Obed Boadi, Huangfang, Xiaoying, Wang, Ling, Dieu Habimana, Jean de, Lv, Linshuang, Ding, Xuanyan, Li, Junyi, Chen, Ming, Zhu, Jinmin, Mukama, Omar, Sun, Yirong, Li, Zhiyuan, Huang, Rongqi, 2023 Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome, Zhao, Huifang, Li, Shuai, He, Lang, Tang, Feng, Han, Xiaobo, Deng, Weiyue, Lin, Zuoxian, Huang, Rongqi, Li, Zhiyuan, 2022 Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma, Huang, Rongqi, Li, Shuai, Tian, Chao, Zhou, Peng, Zhao, Huifang, Xie, Wei, Xiao, Jie, Wang, Ling, Habimana, Jean de Dieu, Lin, Zuoxian, Yang, Yuchen, Cheng, Na, Li, Zhiyuan, 2022 MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice, Zhang, Yuying, Deng, Weiyue, Wang, Wei, Song, Aishi, Mukama, Omar, Deng, Sihao, Han, Xiaobo, Habimana, Jean De Dieu, Peng, Kexin, Ni, Bin, Zhang, Shusheng, Huang, Jufang, Yan, Xiaoxin, Li, Zhiyuan, 2022 Rational Programming of Cas12a for Early-Stage Detection of COVID-19 by Lateral Flow Assay and Portable Real-Time Fluorescence Readout Facilities, Zhijian Yi, Jean de Dieu Habimana, Omar Mukama, Zhiyuan Li, Nelson Odiwuor, Hanzhi Jing, Chengrong Nie, Mei Hu, Zuoxian Lin, Hongping Wei, Lingwen Zeng, 2022 Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model, Han, Xiaobo, Habimana, Jean de Dieu, Li, Amy L, Huang, Rongqi, Mukama, Omar, Deng, Weiyue, Wang, Ling, Zhang, Yuying, Wang, Wei, Deng, Sihao, Peng, Kexin, Ni, Bing, Zhang, Shusheng, Huang, Jufang, Yan, Xiaoxin, Li, Zhiyuan, 2022 Mycotoxins detection: view in the lens of molecularly imprinted polymer and nanoparticles, Mukunzi, Daniel, Habimana, Jean de Dieu, Li, Zhiyuan, Zou, Xiaobo, 2022 Mechanistic insights of CRISPR/Cas nucleases for programmable targeting and early-stage diagnosis: A review, Habimana, Jean de Dieu, Huang, Rongqi, Muhoza, Bertrand, Kalisa, Yvan Ndayambaje, Han, Xiaobo, Deng, Weiyue, Li, Zhiyuan, 2022 Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo, Long, Yan, Hou, Jian, Tang, Feng, Lin, Zuoxian, Huang, Xiaolin, Li, Wei, Chen, Yili, Li, Zhiyuan, Wu, Zhongkai, 2021 Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle, Deng, Weiyue, Zhang, Yuying, Wang, Wei, Song, Aishi, Mukama, Omar, Huang, Jiarong, Han, Xiaobo, Deng, Sihao, Lin, Zuoxian, Habimana, Jean du Dieu, Huang, Rongqi, Peng, Kexin, Ni, Bing, Zhang, Shusheng, Yan, Xiaoxin, Li, Ji, Wu, LinPing, Li, Zhiyuan, 2021 Generation of UCiPSC-derived neurospheres for cell therapy and its application, Li, Shuai, Zhao, Huifang, Han, Xiaobo, Ni, Bin, He, Lang, Mukama, Omar, Habimana, Jean de Dieu, Lin, Zuoxian, Huang, Rongqi, Huang, Hualin, Tian, Chao, Tang, Feng, Li, Zhiyuan, 2021 Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line (CSUXHi005-A) from human urine epithelial cells, He, Lang, Han, Xiaobo, Zhao, Huifang, Li, Shuai, Chen, Zhao, Wang, Chunrong, Wang, Shang, Peng, Linliu, Deng, Weiyue, Li, Zhiyuan, Tang, Beisha, Jiang, Hong, 2021 S100A4 plays a key role in TRPV3 ion channel expression and its electrophysiological function, Deng, Sihao, Zhang, Yuying, Liao, Ziling, Huang, Jufang, Huang, Rongqi, Li, Zhiyuan, 2021 hucMSCs transplantation promotes locomotor function recovery, reduces apoptosis and inhibits demyelination after SCI in rats, Liao, Ziling, Yang, Xiuzhen, Wang, Wei, Deng, Weiyue, Zhang, Yuying, Song, Aishi, Ni, Bin, Zhao, Huifang, Zhang, Shusheng, Li, Zhiyuan, 2021 Human Umbilical Cord Mesenchymal Stem Cells-Secreted TSG-6 Is Anti-Inflammatory and Promote Tissue Repair After Spinal Cord Injury, Liao, Ziling, Wang, Wei, Deng, Weiyue, Zhang, Yuying, Song, Aishi, Deng, Sihao, Zhao, Huifang, Zhang, Shusheng, Li, Zhiyuan, 2021 CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells, He, Lang, Wang, Shang, Peng, Linliu, Zhao, Huifang, Li, Shuai, Han, Xiaobo, Habimana, Jean de Dieu, Chen, Zhao, Wang, Chunrong, Peng, Yun, Peng, Huirong, Xie, Yue, Lei, Lijing, Deng, Qi, Wan, Linlin, Wan, Na, Yuan, Hongyu, Gong, Yiqing, Zou, Guangdong, Li, Zhiyuan, Tang, Beisha, Jiang, Hong, 2021 circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway, Peng Zhou, Wei Xie, HuaLin Huang, RongQi Huang, Chao Tian, HongBo Zhu, YingHuan Dai, ZhiYuan Li, 2020 马王堆古尸蛋白质及蛋白质组学的分析与鉴定, 黄华林, 周鹏, 李志远, 2020 An ultrasensitive and specific point-of-care CRISPR/Cas12 based lateral flow biosensor for the rapid detection of nucleic acids, Mukama, Omar, Wu, Jinghua, Li, Zhiyuan, Liang, Qiongxin, Yi, Zhijian, Lu, Xuewen, Liu, Yujie, Liu, Yumei, Hussain

Areas of Focus

Neurobiology
Ion Channel Structure and Function

Publications

Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer, Habimana, Jean de Dieu, Mukama, Omar, Chen, Guiquan, Chen, Mengjun, Amissah, Obed Boadi, Wang, Lin, Liu, Yujie, Sun, Yirong, Li, Amy L, Deng, Sihao, Huang, Jufang, Yan, Xiaoxin, Rutaganda, Theobard, Mutangana, Dieudonne, Wu, LinPing, Huang, Rongqi, Li, Zhiyuan, 2023
Large-scale expansion of human umbilical cord-derived mesenchymal stem cells using PLGA@PLL scaffold, Liu, Yujie, Amissah, Obed Boadi, Huangfang, Xiaoying, Wang, Ling, Dieu Habimana, Jean de, Lv, Linshuang, Ding, Xuanyan, Li, Junyi, Chen, Ming, Zhu, Jinmin, Mukama, Omar, Sun, Yirong, Li, Zhiyuan, Huang, Rongqi, 2023
Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome, Zhao, Huifang, Li, Shuai, He, Lang, Tang, Feng, Han, Xiaobo, Deng, Weiyue, Lin, Zuoxian, Huang, Rongqi, Li, Zhiyuan, 2022
Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma, Huang, Rongqi, Li, Shuai, Tian, Chao, Zhou, Peng, Zhao, Huifang, Xie, Wei, Xiao, Jie, Wang, Ling, Habimana, Jean de Dieu, Lin, Zuoxian, Yang, Yuchen, Cheng, Na, Li, Zhiyuan, 2022
MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice, Zhang, Yuying, Deng, Weiyue, Wang, Wei, Song, Aishi, Mukama, Omar, Deng, Sihao, Han, Xiaobo, Habimana, Jean De Dieu, Peng, Kexin, Ni, Bin, Zhang, Shusheng, Huang, Jufang, Yan, Xiaoxin, Li, Zhiyuan, 2022
Rational Programming of Cas12a for Early-Stage Detection of COVID-19 by Lateral Flow Assay and Portable Real-Time Fluorescence Readout Facilities, Zhijian Yi, Jean de Dieu Habimana, Omar Mukama, Zhiyuan Li, Nelson Odiwuor, Hanzhi Jing, Chengrong Nie, Mei Hu, Zuoxian Lin, Hongping Wei, Lingwen Zeng, 2022
Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model, Han, Xiaobo, Habimana, Jean de Dieu, Li, Amy L, Huang, Rongqi, Mukama, Omar, Deng, Weiyue, Wang, Ling, Zhang, Yuying, Wang, Wei, Deng, Sihao, Peng, Kexin, Ni, Bing, Zhang, Shusheng, Huang, Jufang, Yan, Xiaoxin, Li, Zhiyuan, 2022
Mycotoxins detection: view in the lens of molecularly imprinted polymer and nanoparticles, Mukunzi, Daniel, Habimana, Jean de Dieu, Li, Zhiyuan, Zou, Xiaobo, 2022
Mechanistic insights of CRISPR/Cas nucleases for programmable targeting and early-stage diagnosis: A review, Habimana, Jean de Dieu, Huang, Rongqi, Muhoza, Bertrand, Kalisa, Yvan Ndayambaje, Han, Xiaobo, Deng, Weiyue, Li, Zhiyuan, 2022
Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo, Long, Yan, Hou, Jian, Tang, Feng, Lin, Zuoxian, Huang, Xiaolin, Li, Wei, Chen, Yili, Li, Zhiyuan, Wu, Zhongkai, 2021
Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle, Deng, Weiyue, Zhang, Yuying, Wang, Wei, Song, Aishi, Mukama, Omar, Huang, Jiarong, Han, Xiaobo, Deng, Sihao, Lin, Zuoxian, Habimana, Jean du Dieu, Huang, Rongqi, Peng, Kexin, Ni, Bing, Zhang, Shusheng, Yan, Xiaoxin, Li, Ji, Wu, LinPing, Li, Zhiyuan, 2021
Generation of UCiPSC-derived neurospheres for cell therapy and its application, Li, Shuai, Zhao, Huifang, Han, Xiaobo, Ni, Bin, He, Lang, Mukama, Omar, Habimana, Jean de Dieu, Lin, Zuoxian, Huang, Rongqi, Huang, Hualin, Tian, Chao, Tang, Feng, Li, Zhiyuan, 2021
Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line (CSUXHi005-A) from human urine epithelial cells, He, Lang, Han, Xiaobo, Zhao, Huifang, Li, Shuai, Chen, Zhao, Wang, Chunrong, Wang, Shang, Peng, Linliu, Deng, Weiyue, Li, Zhiyuan, Tang, Beisha, Jiang, Hong, 2021
S100A4 plays a key role in TRPV3 ion channel expression and its electrophysiological function, Deng, Sihao, Zhang, Yuying, Liao, Ziling, Huang, Jufang, Huang, Rongqi, Li, Zhiyuan, 2021
hucMSCs transplantation promotes locomotor function recovery, reduces apoptosis and inhibits demyelination after SCI in rats, Liao, Ziling, Yang, Xiuzhen, Wang, Wei, Deng, Weiyue, Zhang, Yuying, Song, Aishi, Ni, Bin, Zhao, Huifang, Zhang, Shusheng, Li, Zhiyuan, 2021
Human Umbilical Cord Mesenchymal Stem Cells-Secreted TSG-6 Is Anti-Inflammatory and Promote Tissue Repair After Spinal Cord Injury, Liao, Ziling, Wang, Wei, Deng, Weiyue, Zhang, Yuying, Song, Aishi, Deng, Sihao, Zhao, Huifang, Zhang, Shusheng, Li, Zhiyuan, 2021
CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells, He, Lang, Wang, Shang, Peng, Linliu, Zhao, Huifang, Li, Shuai, Han, Xiaobo, Habimana, Jean de Dieu, Chen, Zhao, Wang, Chunrong, Peng, Yun, Peng, Huirong, Xie, Yue, Lei, Lijing, Deng, Qi, Wan, Linlin, Wan, Na, Yuan, Hongyu, Gong, Yiqing, Zou, Guangdong, Li, Zhiyuan, Tang, Beisha, Jiang, Hong, 2021
circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway, Peng Zhou, Wei Xie, HuaLin Huang, RongQi Huang, Chao Tian, HongBo Zhu, YingHuan Dai, ZhiYuan Li, 2020
马王堆古尸蛋白质及蛋白质组学的分析与鉴定, 黄华林, 周鹏, 李志远, 2020
An ultrasensitive and specific point-of-care CRISPR/Cas12 based lateral flow biosensor for the rapid detection of nucleic acids, Mukama, Omar, Wu, Jinghua, Li, Zhiyuan, Liang, Qiongxin, Yi, Zhijian, Lu, Xuewen, Liu, Yujie, Liu, Yumei, Hussain

Neurobiology Neuroscience Neural Brain Nervous System Neurons Synapses Neurotransmitters Neurogenesis Neuroplasticity Ion Channels Membrane Proteins Electrophysiology Signal Transduction Cell Membrane Channelopathies Calcium Channels Potassium Channels Sodium Channels Channel Modulation

Xiang Li - Wuhan University

Tian Zhixiong - Wuhan University

Zhibiao Chen - Wuhan University

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