Areas of Focus
- Drug discovery and mechanism research for emotional disorders such as depression and mania
- High-throughput screening and single-channel functional research of high-efficiency inhibitors targeting potassium channels
- Research on the crystal structure and regulatory mechanisms of potassium channels
Work Experience
- 2009-09 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2002-07 to 2009-09 - University of Texas Southwestern Medical Center - Postdoctoral Researcher
Academic Background & Achievements
- 1999-09 to 2002-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1996-09 to 1999-07 Master's: East China Normal University, Department of Biology
- 1988-09 to 1992-07 Bachelor's: Shandong University, Department of Biology
Publications
- Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating, Ma, Yuqin, Luo, Qichao, Fu, Jie, Che, Yanxin, Guo, Fei, Mei, Lianghe, Zhang, Qiansen, Li, Yang, Yang, Huaiyu, 2020
- Molecular insights into the human CLC-7/Ostm1 transporter, Zhang, Sensen, Liu, Yang, Zhang, Bing, Zhou, Jun, Li, Tianyu, Liu, Zhiqiang, Li, Yang, Yang, Maojun, 2020
- Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC, Li, Qian, Zhang, Bing, Cao, Hang, Liu, Wei, Guo, Fei, Shen, Fuyi, Ye, Binglu, Liu, Huan, Li, Yang, Liu, Zhiqiang, 2020
- Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling, Ali, Tahir, Hao, Qiang, Ullah, Najeeb, Rahman, Shafiq Ur, Shah, Fawad Ali, He, Kaiwu, Zheng, Chengyou, Li, Weifen, Murtaza, Iram, Li, Yang, Jiang, Yuhua, Tan, Zhen, Li, Shupeng, 2020
- 抗抑郁的新靶点与新机制研究, 李扬, 2019
- A binding-block ion selective mechanism revealed by a Na/K selective channel (vol 9, pg 629, 2018), Yu, Jie, Zhang, Bing, Zhang, Yixiao, Xu, Congqiao, Zhuo, Wei, Ge, Jingpeng, Li, Jun, Gao, Ning, Li, Yang, Yang, Maojun, 2019
- Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel, Chai, Hao, Cheng, Xi, Zhou, Bin, Zhao, Lifen, Lin, Xianhua, Huang, Dongping, Lu, Weiqiang, Lv, Hao, Tang, Feng, Zhang, Qiansen, Huang, Wei, Li, Yang, Yang, Huaiyu, 2019
- A binding-block ion selective mechanism revealed by a Na/K selective channel, Yu, Jie, Zhang, Bing, Zhang, Yixiao, Xu, Congqiao, Zhuo, Wei, Ge, Jingpeng, Li, Jun, Gao, Ning, Li, Yang, Yang, Maojun, 2018
- 新型化合物YY-21快速抗抑郁机制研究, 郭飞, 张兵, 李扬, 2018
- K2P channels and NMDA receptor as new targets of fast onset antidepressants, LI Yang, GUO Fei, MA Yuqin, 2018
- Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats, Shen, FuYi, Song, YingCai, Guo, Fei, Xu, ZhenDong, Li, Qian, Zhang, Bing, Ma, YuQin, Zhang, YueQi, Lin, Rong, Li, Yang, Liu, ZhiQiang, 2018
- A binding-block ion selective mechanism revealed by a Na/K selective channel, Jie Yu, Bing Zhang, Yixiao Zhang, Congqiao Xu, Wei Zhuo, Jingpeng Ge, Jun Li, Ning Gao, Yang Li, Maojun Yang, 2017
- Identification of Intracellular beta-Barrel Residues Involved in Ion Selectivity in the Mechanosensitive Channel of Thermoanaerobacter tengcongensis, Song, Yingcai, Zhang, Bing, Guo, Fei, Yang, Maojun, Li, Yang, Liu, ZhiQiang, 2017
- An allosteric ligand-binding site in the extracellular cap of K2P channels, Qichao Luo, Liping Chen, Xi Cheng, Yuqin Ma, Xiaona Li, Bing Zhang, Li Li, Shilei Zhang, Fei Guo, Yang Li, Huaiyu Yang, 2017
- Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD, Zhang, Bing, Guo, Fei, Ma, Yuqin, Song, Yingcai, Lin, Rong, Shen, FuYi, Jin, GuoZhang, Li, Yang, Liu, ZhiQiang, 2017
- TMCO1 Is an ER Ca2+ Load-Activated Ca2+ Channel, Wang, QiaoChu, Zheng, Qiaoxia, Tan, Haiyan, Zhang, Bing, Li, Xiaoling, Yang, Yuxiu, Yu, Jie, Liu, Yang, Chai, Hao, Wang, Xi, Sun, Zhongshuai, Wang, JiuQiang, Zhu, Shu, Wang, Fengli, Yang, Maojun, Guo, Caixia, Wang, Heng, Zheng, Qingyin, Li, Yang, Chen, Quan, Zhou, Aimin, Tang, TieShan, 2016
- KCNQ potassium channels in sensory system and neural circuits, Wang, Jingjing, Li, Yang, 2016
- The rapid antidepressant and anxiolytic-like effects of YY-21 involve enhancement of excitatory synaptic transmission via activation of mTOR signaling in the mPFC, Guo, Fei, Zhang, Bing, Fu, Zhiwen, Ma, Yuqin, Gao, Yu, Shen, Fuyi, Huang, Chenggang, Li, Yang, 2016
- Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice, Zhang, Qi, Guo, Fei, Fu, Zhiwen, Zhang, Bing, Huang, Chenggang, Li, Yang, 2016
- SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways, Zhou, Tingting, Quan, Lingling, Chen, Liping, Du, Te, Sun, KX, Zhang, JC, Yu, Liang, Li, Yang, Wan, Ping, Chen, Lili, Jiang, BH, Hu, Lihong, Chen, Jing, Shen, Xu, 2016
- Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice, QiZHANG, Fei GUO, Zhi-wen FU, Bing ZHANG, Cheng-gang HUANG, Yang LI, 2016
- Timosaponin derivative YY-23 acts as a n8on-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice, Li Yang, 2016
- TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling, Ye, Dongqing, Li, Yang, Zhang, Xiangrong, Guo, Fei, Geng, Leiyu, Zhang, Qi, Zhang, Zhijun, 2015
- Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation, Chen, Liping, Zhang, Qiansen, Qiu, Yunguang, Li, Zanyuan, Chen, Zhuxi, Jiang, Hualiang, Li, Yang, Yang, Huaiyu, 2015
- Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells, Zhong, Fuqing, Li, Yang, Mi, Xianqiang, 2014
- Influence of Genetic Polymorphisms Involved in the Hypothalamic-Pituitary-Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response, Geng, LeiYu, Ye, DongQing, Shi, YanYan, Xu, Zhi, Pu, MengJia, Li, ZanYuan, Li, XiaoLi, Li, Yang, Zhang, ZhiJun, 2014
- Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants, Guo, Fei, Zhang, Qi, Zhang, Bing, Fu, Zhiwen, Wu, Bin, Huang, Chenggang, Li, Yang, 2014
- 针对谷氨酸能系统的抗抑郁药物的研究进展, 张兵, 李扬, 2014
- An antidepressant from Chinese herbs improves the burst firing of medial prefrontal cortex induced by chronic mild stress, Guo, Fei, Zhang, Qi, Li, Yang, 2013
- Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance, Zhang, Xiaozhe, Wang, Jingjing, Feng, Yue, Ge, Jingpeng, Li, Wenfei, Sun, Wending, Iscla, Irene, Yu, Jie, Blount, Paul, Li, Yang, Yang, Maojun, 2012
- trek1钾通道与抑郁症, 李扬, 叶冬青, 张志珺, 2012
- 针对早老性痴呆等神经系统疾病的高通量筛选, 李扬, 2011
- Crucial Points within the Pore as Determinants of K+ Channel Conductance and Gating, Shi, Ning, Zeng, Weizhong, Ye, Sheng, Li, Yang, Jiang, Youxing, 2011
- Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore, Derebe, Mehabaw G, Zeng, Weizhong, Li, Yang, Alam, Amer, Jiang, Youxing, 0201
