Professor | Liangxue Lai | Asia Growth Partners

Name	Liangxue Lai
Contact Information	lai_liangxue@gibh.ac.cn
Language ability	English, Chinese
Province	Guangdong

Name

Liangxue Lai

Contact Information

lai_liangxue@gibh.ac.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1992-09--1995-07 PhD in Science: Northeast Agricultural University
Work Experience	2007-12~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2006-07~2007-12 - Advanced Center for Reproductive Technology, USA - Senior Embryologist 2004-07~2006-07 - National Swine Resource and Research Center, University of Missouri, USA - Research Assistant Professor 2002-07~2004-07 - Animal Research Center, University of Missouri, USA - Research Assistant Professor 1998-07~2002-07 - Animal Research Center, University of Missouri, USA - Postdoctoral Researcher 1995-07~1997-07 - Transgenic Animal Laboratory, Military Veterinary Research Institute, PLA University of Agriculture and Animal Husbandry - Postdoctoral Researcher
Awards	2016: First Prize for Innovation in Pig Gene Mutation Technology and Establishment of Gene-Modified Pig Models, Provincial Level 2013: First Prize for Research on Large Animal Gene Modification Technology and Establishment of Gene-Modified Animal Models, Municipal Level 2011: State Council Special Government Allowance, National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1992-09--1995-07 PhD in Science: Northeast Agricultural University

Work Experience

2007-12~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2006-07~2007-12 - Advanced Center for Reproductive Technology, USA - Senior Embryologist
2004-07~2006-07 - National Swine Resource and Research Center, University of Missouri, USA - Research Assistant Professor
2002-07~2004-07 - Animal Research Center, University of Missouri, USA - Research Assistant Professor
1998-07~2002-07 - Animal Research Center, University of Missouri, USA - Postdoctoral Researcher
1995-07~1997-07 - Transgenic Animal Laboratory, Military Veterinary Research Institute, PLA University of Agriculture and Animal Husbandry - Postdoctoral Researcher

Awards

2016: First Prize for Innovation in Pig Gene Mutation Technology and Establishment of Gene-Modified Pig Models, Provincial Level
2013: First Prize for Research on Large Animal Gene Modification Technology and Establishment of Gene-Modified Animal Models, Municipal Level
2011: State Council Special Government Allowance, National Level

Areas of Focus	Animal Cloning and Embryonic Stem Cells
Publications	Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in, Ting Lan, Yuling Zheng, Yangyang Suo, Yuhui Wei, Hui Shi, Quanmei Yan, Zhenpeng Zhuang, Huangyao Chen, Quanjun Zhang, Nana Fan, Yu Zhao, Zhen Ouyang, Chengdan Lai, Zhaoming Liu, Jizeng Zhou, Chengcheng Tang, NamHyung Kim, Qingjian Zou, Xiaomin Wang, 2023 Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease, Yan, Sen, Zheng, Xiao, Lin, Yingqi, Li, Caijuan, Liu, Zhaoming, Li, Jiawei, Tu, Zhuchi, Zhao, Yu, Huang, Chunhui, Chen, Yizhi, Li, Jun, Song, Xichen, Han, Bofeng, Wang, Wei, Liang, Weien, Lai, Liangxue, Li, XiaoJiang, Li, Shihua, 2023 Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Jin, Qin, Liu, Xiaoyi, Zhuang, Zhenpeng, Huang, Jiayuan, Gou, Shixue, Shi, Hui, Zhao, Yu, Ouyang, Zhen, Liu, Zhaoming, Li, Lei, Mao, Junjie, Ge, Weikai, Chen, Fangbing, Yu, Manya, Guan, Yezhi, Ye, Yinghua, Tang, Chengcheng, Huang, Ren, Wang, Kepin, Lai, Liangxue, 2023 Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus, Wang, Xunlei, Jin, Qin, Xiao, Wenwen, Fang, Puxian, Lai, Liangxue, Xiao, Shaobo, Wang, Kepin, Fang, Liurong, 2022 AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, Liang, Yanhui, Xie, Jingke, Zhang, Quanjun, Wang, Xiaomin, Gou, Shixue, Lin, Lihui, Chen, Tao, Ge, Weikai, Zhuang, Zhenpeng, Lian, Meng, Chen, Fangbing, Li, Nan, Ouyang, Zhen, Lai, Chengdan, Liu, Xiaoyi, Li, Lei, Ye, Yinghua, Wu, Han, Wang, Kepin, Lai, Liangxue, 2022 Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, Jin, Qin, Yang, Xiaoyu, Gou, Shixue, Liu, Xiaoyi, Zhuang, Zhenpeng, Liang, Yanhui, Shi, Hui, Huang, Jiayuan, Wu, Han, Zhao, Yu, Ouyang, Zhen, Zhang, Quanjun, Liu, Zhaoming, Chen, Fangbing, Ge, Weikai, Xie, Jingke, Li, Nan, Lai, Chengdan, Zhao, Xiaozhu, Wang, Jiawei, Lian, Meng, Li, Lei, Quan, Longquan, Ye, Yinghua, Lai, Liangxue, Wang, Kepin, 2022 Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells, Chen, Siyu, Liu, Zhiquan, Yu, Hao, Lai, Liangxue, Li, Zhanjun, 2022 基因编辑猪中条件性基因修饰系统的研究进展, 刘晓艺, 金琴, 王可品, 赖良学, 2022 Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase-nCas9 Fusions, Chen, Siyu, Liu, Zhiquan, Lai, Liangxue, Li, Zhanjun, 2022 Targeted mutagenesis in rabbit using an engineered BhCas12b variant, Yingqi Jia, Tian Wang, Ding Zhao, Zhiquan Liu, Tingting Sui, Siyu Chen, Jinze Li, Liangxue Lai, Zhanjun Li, Jinsong Li, 2022 Highly efficient A-to-G base editing by ABE8.17 in rabbits, Zhao, Ding, Qian, Yuqiang, Li, Jinze, Li, Zhanjun, Lai, Liangxue, 2022 Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9, Liu, Zhiquan, Chen, Siyu, Lai, Liangxue, Li, Zhanjun, 2022 Inhibition of base editors with anti-deaminases derived from viruses, Liu, Zhiquan, Chen, Siyu, Lai, Liangxue, Li, Zhanjun, 2022 PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition, Yating Sun, Dan Li, Hongmei Liu, Yongye Huang, Fanyu Meng, Jiahao Tang, Zhanjun Li, Wanhua Xie, 2022 Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites, Liu, Yang, Zhou, Jizeng, Lan, Ting, Zhou, Xiaoqing, Yang, Yang, Li, Chuan, Zhang, Quanjun, Chen, Min, Wei, Shu, Zheng, Shuwen, Cheng, Lingyin, Zheng, Yuling, Lai, Liangxue, Zou, Qingjian, 2022 Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor, Zheng, Shuwen, Zhong, Haiwen, Zhou, Xiaoqing, Chen, Min, Li, Wansheng, Zi, Yin, Chi, Yue, Wang, Jinling, Zheng, Wei, Zou, Qingjian, Lai, Liangxue, Tang, Chengcheng, 2022 Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors, Chen, Fangbing, Lian, Meng, Ma, Bingxiu, Gou, Shixue, Luo, Xian, Yang, Kaiming, Shi, Hui, Xie, Jingke, Ge, Weika, Ouyang, Zhen, Lai, Chengdan, Li, Nan, Zhang, Quanjun, Jin, Qin, Liang, Yanhui, Chen, Tao, Wang, Jiaowei, Zhao, Xiaozhu, Li, Lei, Yu, Manya, Ye, Yinghua, Wang, Kepin, Wu, Han, Lai, Liangxue, 2022 Versatile and efficient genome editing with Neisseria cinerea Cas9, Liu, Zhiquan, Chen, Siyu, Xie, Wanhua, Yu, Hao, Lai, Liangxue, Li, Zhanjun, 2022 Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy, Liu, Yang, Yang, Yang, Suo, Yangyang, Li, Chuan, Chen, Min, Zheng, Shuwen, Li, Hao, Tang, Chengcheng, Fan, Nana, Lan, Ting, Zhou, Jizeng, Li, Yingying, Wang, Jiaowei, Chen, Huangyao, Zou, Qingjian, Lai, Liangxue, 2022 Development of a rabbit model of Wiskott-Aldrich syndrome, Zhou, Juanjuan, Yan, Quanmei, Tang, Chengcheng, Liao, Yuan, Zhang, Quanjun, Wang, Xiaomin, Zhou, Xiaoqing, Lai, Liangxue, Zou, Qingjian, 2021 CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I, Li, Nan, Gou, Shixue, Wang, Jiaowei, Zhang, Quanjun, Huang, Xingyun, Xie, Jingke, Li, Li, Jin, Qin, Ouyang, Zhen, Chen, Fangbing, Ge, Weikai, Shi, Hui, Liang, Yanhui, Zhuang, Zhenpeng, Zhao, Xiaozhu, Lian, Meng, Ye, Yinghua, Quan, Longquan, Wu, Han, Lai, Liangxue, Wang, Kepin, 2021 Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide, Liu, Zhiquan, Chen, Siyu, Jia, Yingqi, Shan, Huanhuan, Chen, Mao, Song, Yuning, Lai, Liangxue, Li, Zhanjun, 2021 CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia, Yi Yang, Xiangjin Kang, Shiqi Hu, Bangzhu Chen, Yingjun Xie, Bing Song, Quanjun Zhang, Han Wu, Zhanhui Ou, Yexing Xian, Yong Fan, Xiaoping Li, Liangxue Lai, Xiaofang Sun, 2021 A tunable, rapid, and precise drug control of protein expression by combining transcriptional and post-translational regulation systems, Li, Li, Meng, Hongyi, Zhang, Jianmin, Liu, Yang, Zou, Qingjian, Gao, Yi, Yang, Huaqiang, Lai, Liangxue, 2021 Improving Cpf1

Areas of Focus

Animal Cloning and Embryonic Stem Cells

Publications

Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in, Ting Lan, Yuling Zheng, Yangyang Suo, Yuhui Wei, Hui Shi, Quanmei Yan, Zhenpeng Zhuang, Huangyao Chen, Quanjun Zhang, Nana Fan, Yu Zhao, Zhen Ouyang, Chengdan Lai, Zhaoming Liu, Jizeng Zhou, Chengcheng Tang, NamHyung Kim, Qingjian Zou, Xiaomin Wang, 2023
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease, Yan, Sen, Zheng, Xiao, Lin, Yingqi, Li, Caijuan, Liu, Zhaoming, Li, Jiawei, Tu, Zhuchi, Zhao, Yu, Huang, Chunhui, Chen, Yizhi, Li, Jun, Song, Xichen, Han, Bofeng, Wang, Wei, Liang, Weien, Lai, Liangxue, Li, XiaoJiang, Li, Shihua, 2023
Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Jin, Qin, Liu, Xiaoyi, Zhuang, Zhenpeng, Huang, Jiayuan, Gou, Shixue, Shi, Hui, Zhao, Yu, Ouyang, Zhen, Liu, Zhaoming, Li, Lei, Mao, Junjie, Ge, Weikai, Chen, Fangbing, Yu, Manya, Guan, Yezhi, Ye, Yinghua, Tang, Chengcheng, Huang, Ren, Wang, Kepin, Lai, Liangxue, 2023
Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus, Wang, Xunlei, Jin, Qin, Xiao, Wenwen, Fang, Puxian, Lai, Liangxue, Xiao, Shaobo, Wang, Kepin, Fang, Liurong, 2022
AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, Liang, Yanhui, Xie, Jingke, Zhang, Quanjun, Wang, Xiaomin, Gou, Shixue, Lin, Lihui, Chen, Tao, Ge, Weikai, Zhuang, Zhenpeng, Lian, Meng, Chen, Fangbing, Li, Nan, Ouyang, Zhen, Lai, Chengdan, Liu, Xiaoyi, Li, Lei, Ye, Yinghua, Wu, Han, Wang, Kepin, Lai, Liangxue, 2022
Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, Jin, Qin, Yang, Xiaoyu, Gou, Shixue, Liu, Xiaoyi, Zhuang, Zhenpeng, Liang, Yanhui, Shi, Hui, Huang, Jiayuan, Wu, Han, Zhao, Yu, Ouyang, Zhen, Zhang, Quanjun, Liu, Zhaoming, Chen, Fangbing, Ge, Weikai, Xie, Jingke, Li, Nan, Lai, Chengdan, Zhao, Xiaozhu, Wang, Jiawei, Lian, Meng, Li, Lei, Quan, Longquan, Ye, Yinghua, Lai, Liangxue, Wang, Kepin, 2022
Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells, Chen, Siyu, Liu, Zhiquan, Yu, Hao, Lai, Liangxue, Li, Zhanjun, 2022
基因编辑猪中条件性基因修饰系统的研究进展, 刘晓艺, 金琴, 王可品, 赖良学, 2022
Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase-nCas9 Fusions, Chen, Siyu, Liu, Zhiquan, Lai, Liangxue, Li, Zhanjun, 2022
Targeted mutagenesis in rabbit using an engineered BhCas12b variant, Yingqi Jia, Tian Wang, Ding Zhao, Zhiquan Liu, Tingting Sui, Siyu Chen, Jinze Li, Liangxue Lai, Zhanjun Li, Jinsong Li, 2022
Highly efficient A-to-G base editing by ABE8.17 in rabbits, Zhao, Ding, Qian, Yuqiang, Li, Jinze, Li, Zhanjun, Lai, Liangxue, 2022
Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9, Liu, Zhiquan, Chen, Siyu, Lai, Liangxue, Li, Zhanjun, 2022
Inhibition of base editors with anti-deaminases derived from viruses, Liu, Zhiquan, Chen, Siyu, Lai, Liangxue, Li, Zhanjun, 2022
PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition, Yating Sun, Dan Li, Hongmei Liu, Yongye Huang, Fanyu Meng, Jiahao Tang, Zhanjun Li, Wanhua Xie, 2022
Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites, Liu, Yang, Zhou, Jizeng, Lan, Ting, Zhou, Xiaoqing, Yang, Yang, Li, Chuan, Zhang, Quanjun, Chen, Min, Wei, Shu, Zheng, Shuwen, Cheng, Lingyin, Zheng, Yuling, Lai, Liangxue, Zou, Qingjian, 2022
Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor, Zheng, Shuwen, Zhong, Haiwen, Zhou, Xiaoqing, Chen, Min, Li, Wansheng, Zi, Yin, Chi, Yue, Wang, Jinling, Zheng, Wei, Zou, Qingjian, Lai, Liangxue, Tang, Chengcheng, 2022
Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors, Chen, Fangbing, Lian, Meng, Ma, Bingxiu, Gou, Shixue, Luo, Xian, Yang, Kaiming, Shi, Hui, Xie, Jingke, Ge, Weika, Ouyang, Zhen, Lai, Chengdan, Li, Nan, Zhang, Quanjun, Jin, Qin, Liang, Yanhui, Chen, Tao, Wang, Jiaowei, Zhao, Xiaozhu, Li, Lei, Yu, Manya, Ye, Yinghua, Wang, Kepin, Wu, Han, Lai, Liangxue, 2022
Versatile and efficient genome editing with Neisseria cinerea Cas9, Liu, Zhiquan, Chen, Siyu, Xie, Wanhua, Yu, Hao, Lai, Liangxue, Li, Zhanjun, 2022
Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy, Liu, Yang, Yang, Yang, Suo, Yangyang, Li, Chuan, Chen, Min, Zheng, Shuwen, Li, Hao, Tang, Chengcheng, Fan, Nana, Lan, Ting, Zhou, Jizeng, Li, Yingying, Wang, Jiaowei, Chen, Huangyao, Zou, Qingjian, Lai, Liangxue, 2022
Development of a rabbit model of Wiskott-Aldrich syndrome, Zhou, Juanjuan, Yan, Quanmei, Tang, Chengcheng, Liao, Yuan, Zhang, Quanjun, Wang, Xiaomin, Zhou, Xiaoqing, Lai, Liangxue, Zou, Qingjian, 2021
CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I, Li, Nan, Gou, Shixue, Wang, Jiaowei, Zhang, Quanjun, Huang, Xingyun, Xie, Jingke, Li, Li, Jin, Qin, Ouyang, Zhen, Chen, Fangbing, Ge, Weikai, Shi, Hui, Liang, Yanhui, Zhuang, Zhenpeng, Zhao, Xiaozhu, Lian, Meng, Ye, Yinghua, Quan, Longquan, Wu, Han, Lai, Liangxue, Wang, Kepin, 2021
Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide, Liu, Zhiquan, Chen, Siyu, Jia, Yingqi, Shan, Huanhuan, Chen, Mao, Song, Yuning, Lai, Liangxue, Li, Zhanjun, 2021
CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia, Yi Yang, Xiangjin Kang, Shiqi Hu, Bangzhu Chen, Yingjun Xie, Bing Song, Quanjun Zhang, Han Wu, Zhanhui Ou, Yexing Xian, Yong Fan, Xiaoping Li, Liangxue Lai, Xiaofang Sun, 2021
A tunable, rapid, and precise drug control of protein expression by combining transcriptional and post-translational regulation systems, Li, Li, Meng, Hongyi, Zhang, Jianmin, Liu, Yang, Zou, Qingjian, Gao, Yi, Yang, Huaqiang, Lai, Liangxue, 2021
Improving Cpf1

Animal Cloning Embryonic Stem Cells Gene Editing Transgenic Animals Crispr Gene Therapy Regenerative Medicine Biomedical Research Genetic Engineering Stem Cell Therapy

Baoyang Hu - University of Chinese Academy of Sciences

Liu Wang - University of Chinese Academy of Sciences

Jianguo Zhao - University of Chinese Academy of Sciences

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us