Areas of Focus
- Pharmacokinetics
- Drug Safety Evaluation
- Cell and Gene Therapy
Work Experience
- 2011-03~Present - Shanghai Institute of Materia Medica - Researcher, Group Leader
- 2008-05~2011-03 - Novartis Institutes for BioMedical Research, USA - Lab Supervisor
- 2007-11~Present - Novartis Institutes for BioMedical Research, USA - Researcher
- 2004-01~2007-10 - Department of Pharmaceutics, College of Pharmacy, University of Minnesota, USA - Postdoctoral Researcher
Academic Background & Achievements
- 2000-09--2003-06 Ph.D.: China Pharmaceutical University
- 1997-09--2000-06 Master's Degree: China Pharmaceutical University
- 1992-09--1997-06 Bachelor's Degree: China Pharmaceutical University
Publications
- FEK self-assembled peptide hydrogels facilitate primary hepatocytes culture and pharmacokinetics screening, 11th Author, 2022
- MSCs cell fates in murine acute liver injury and chronic liver fibrosis induced by carbon tetrachloride., 11th Author, 2022
- Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity, 11th Author, 2021
- Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-beta RI/Smad Signaling, 11th Author, 2021
- Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A-Induced Liver Injury Mice, 12th Author, 2021
- Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy, 11th Author, 2021
- A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters, 11th Author, 2020
- Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway, 11th Author, 2020
- Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells, 21st Author, 2020
- Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2, 11th Author, 2020
- Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia, 19th Author, 2019
- Roles of Hepatic Drug Transporters in Drug Disposition and Liver Toxicity, 11th Author, 2019
- An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests, 8th Author, 2019
- Intestinal Transporter-Associated Drug Absorption and Toxicity, 11th Author, 2019
- Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes, 15th Author, 2019
- Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity, 11th Author, 2019
- Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption, 11th Author, 2019
- The Protective Effect of Magnesium Lithospermate B on Hepatic Ischemia/Reperfusion via Inhibiting the Jak2/Stat3 Signaling Pathway, 11th Author, 2019
- Drug Transporters in Drug Disposition, Effects and Toxicity Preface, 2nd Author, 2019
- 生物人工肝的研究进展, Advances in Bioartificial Liver System, 4th Author, 2019
- Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro, 11th Author, 2019
- Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy, 10th Author, 2018
- Enhanced doxorubicin delivery to hepatocellular carcinoma cells via CD147 antibody-conjugated immunoliposomes, 3rd Author, 2018
- 肝样细胞模型在药物肝脏代谢和毒性研究中的进展, Progress of Hepatocyte-like Cell Models in the Research of Hepatic Metabolism and Toxicity of Drugs, 2nd Author, 2018
- 细胞的命运：间充质干细胞的药代动力学, The Fate of Cells: Pharmacokinetics of MSC, 3rd Author, 2018
- The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine, 11th Author, 2018
- Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor Activation., 11th Author, 2018
- Preparation, characterization, biotoxicity, and biodistribution of thermo-responsive magnetic complex micelles formed by Mn0.6Zn0.4Fe2O4 and a PCL/PEG analogue copolymer for controlled drug delivery, 4th Author, 2017
- Fabrication of stable galactosylated alginate microcapsules via covalent coupling onto hydroxyl groups for hepatocytes applications, 8th Author, 2017
- Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, 15th Author, 2017
- An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT), 11th Author, 2017
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, 11th Author, 2016
- Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity, 11th Author, 2016
- Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model, 11th Author, 2016
- Leflunomide-induced hepatotoxicity is attenuated by cytochrome P450-dependent metabolism and increased by inhibition of sodium taurocholate co-transporting polypeptide., 11th Author, 2016
- Hepatocellular Carcinoma Repression by TNF alpha-Mediated Synergistic Lethal Effect of Mitosis Defect-Induced Senescence and Cell Death Sensitization, 13th Author, 2016
- 大分子药物的吸收分布代谢排泄和毒性特征及药代模型的应用, 3rd Author, 2016
- Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity, 11th Author, 2016
- Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example, 11th Author, 2016
- Optimized Hepatocyte-Like Cells with Functional Drug Transporters Directly-Reprogrammed from Mouse Fibroblasts and their Potential in Drug Disposition and Toxicology, 11th Author, 2016
- The Hepatobiliary Disposition of Timosaponin B2 Is Highly Dependent on Influx/Efflux Transporters but Not Metabolism, 11th Author, 2015
- Simultaneous determination of gypenoside LVI, gypenoside XLVI, 2 alpha-OH-protopanaxadiol and their two metabolites in rat plasma by LC-MS/MS and its application to pharmacokinetic studies, 5th Author, 2015
- HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters, 11th Author, 2015
- Improving the dissolution and bioavailability of 6-mercaptopurine via co-crystallization with isonicotinamide, 11th Author, 2015
- Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine, 9th Author, 2015
- Simultaneous determination of gypenoside LVI, gypenoside XLVI, 2 alpha-OH-protopanaxadiol and their two metabolites in rat plasma by LC MS/MS and its application to pharmacokinetic studies, 5th Author, 2015
- 新型肝样细胞在预测药物胆汁分泌风险中的应用, 6th Author, 2015
- The Hepatobiliary disposition of timosaponin B2 is highly dependent on influx/efflux transporters but not metabolism., 11th Author, 2014
- Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters, 8th Author, 2014
- Study on the PK profiles of
