Areas of Focus
- Mechanisms of stem cell pluripotency regulation
- Somatic cell reprogramming techniques and mechanisms
- Protein transport mechanisms in normal and cancer cells
- EGFR signaling mechanisms and lung cancer
Publications
- Transcriptional repression and activation by cellular DNA-binding protein C/EBP, Pei, D., C. Shih, 1990
- An attenuator is sandwiched by two transactivation domains in the transcriptional factor C/EBP, Pei, D., C. Shih, 1991
- Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3, Pei, D., Majmudar, G., Weiss, S.J., 1994
- Furin-dependent Intracellular Activation of the Human Stromelysin-3 Zymogen, Pei, D., Weiss, S.J., 1995
- Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity, Pei, D., Weiss, S.J., 1996
- A High Level Mammalian Expression System Based on the Madin-Darby canine kidney (MDCK) cell line, Pei, D., Yi, J., 1998
- Identification and Characterization of a New Splicing Variant of Vascular Endothelial Growth Factor: VEGF183, Lei, J., Jiang, A., and Pei, D., 1998
- Identification and characterization of the fifth member of the membrane-type matrix metalloproteinase MT5-MMP, Pei, D., 1999
- CA-MMP: a matrix metalloproteinase with a novel cysteine-array, but without the classic cysteine switch, Pei, D., 1999
- Expression, Purification and Charaterization of Recombinant Mouse MT5-MMP Protein Products, Wang, X., Lei, L., Yi, J. and Pei, D., 1999
- MMP25/MT6-MMP/Leukolysin: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage, Pei, D., 1999
- CA-MMP/MMP-23 is a Type II Transmembrane Matrix Metalloproteinase Regulated by a Single Cleavage for Both Secretion and Activation, Pei, D., Kang, T., and Qi, H., 2000
- Functional characterization of MT3-MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3-D collagen lattice, Kang, T., Yi, J., Yang, W., Wang, X., Jiang, A., and Pei, D., 2000
- Overexpression of Matrix Metalloproteinases Leads to Lethality in Transgenic Xenopus Laevis: Implications for Tissue-Dependent Functions of Matrix Metalloproteinases during Late Embryonic development, Damjanovski, S., Amano, T., Li, Q., Pei, D., and Shi, Y.-B., 2001
- Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase -Dependent Human Melanoma Invasion into Type I Collagen, Iida, J., Pei, D., Kang, T., Simpson, M.A., Herlyn, M., Furcht, L. T., and McCarthy, J. B., 2001
- Subcellular Distribution, Cytokine- and Chemokine- Regulated Secretion of Leukolysin / MT6-MMP /MMP-25 in Neutrophils, Kang, T., Yi, J., Guo, A., Wang, X., Overall, C.M., Jiang, W., Elde, R., Borregaard, N., and Pei, D., 2001
- Shedding of MT5-MMP by a Furin-Type Convertase: A Potential Mechanism of Down-Regulation, Wang, X., Pei, D., 2001
- Regulation of Membrane-Type Matrix Metalloproteinase 1 Activity by Dynamin-Mediated Endocytosis, Jiang, A., Lehti, K., Wang, X., Weiss, S.J., Keski-Oja, J., and Pei, D., 2001
- Matrix Metalloproteinases: An Introduction, Pei, D., 2001
- Activation of ProMT3-MMP by Proprotein-Convertase Furin in Trans-Golgi Network, Kang, T., Nagase, H., and Pei, D., 2002
- Oligomerization through hemopexin and cytoplasmic domains regulate the activity and turnover of membrane-type-1 matrix metalloproteinase (MT1-MMP), Lehti,K.., Lohi, J., Juntunen, M. M., Pei, D., Keski-Oja, J., 2002
- Expression of matrix metalloprotease-2 and -9 and their inhibitors, tissue inhibitors of metalloprotease-1 and -2, in primary cultures of human prostatic stromal and epithelial cells, Wilson, MJ, RG Sellars, C Wiehr, O Melamud, Pei, D and DM Peehl, 2002
- Intracellular Activation of Human Adamalysin 19/Disintegrin and Metalloproteinase 19 by Furin Occurs via one of the two Consecutive Recognition Sites, Kang, T., Zhao, Y.G., Pei, D., Sucic, F. J., Sang, Q-X. A., 2002
- Therapeutic developments in matrix metalloproteinase inhibition, Doherty, T.M., Asotra, K., Pei, D., Uzui, H., Wilkin, D.J., Shah, P.K., Rajavashisth, T.B., 2002
- Stem cell pluripotency and transcription factor Oct4, Pan, GJ, Chang ZY, Scholer HR, Pei D., 2002
- Distinct Roles of Catalytic and Pexin-like Domains in MT-MMP Mediated proMMP-2 Activation and Collagenolysis, Jiang, A., Pei, D., 2003
- Direct Activation of proMMP-2 by Leukolysin / MT6-MMP at the Asn109-Tyr bond, Nie, J., Pei, D., 2003
- Identification of Two Distinct Transactivation Domains in the Pluripotency Sustaining Factor Nanog, Pan, G., Pei, D., 2003
- Membrane-type Matrix Metalloproteinases (MT1-MMP), Zucker, S., Pei, D., Cao, J., Lopez-Otin, 2003
- Nuclear Localization of the Phosphatidylserine Receptor Protein Via Multiple Nuclear Localization Signals, Cui, P., Qin, B., Pan, G., Liu, N., and Pei, D., 2004
- Memrane-type-1-matrix metalloproteinase (MT1-MMP) promotes human melanoma invasion and growth, Iida, J., Whilhelmson, K. L., Price, M A., Wilson, C. M., Pei, D., Furcht, L T. , and McCarthy, J.B., 2004
- Limited Processing of Pro-Matrix Metalloprotease-2 (Gelatinase A) Overexpressed by Transfection in PC-3 Human Prostate Tumor Cells: Association With Restricted Cell Surface Localization of Membrane-Type Matrix Metalloproteinase-1, Wilson, M.J., Jiang, A., Wiehr, C., Wang, X., Sinha, A.A., And Pei. D., 2004
- Co-recycling of MT1-MMP and MT3-MMP Through the trans-Golgi Network: Identification of DKV582 as a Recycling Signal, Wang, X., Ma, D., Keski-Oja, J., and Pei, D., 2004
- Differential Inhibition of MT3-MMP And MT1-MMP By TIMP-2 and TIMP-3 Regulates Pro-MMP-2 Activation, Zhao, H., Bernardo, M. M., Osenkowski, P., Pei, D., Nagase, H., Kashiwagi, M., Soloway, P. D., DeClerck, Y. A., Fridman, R., 2004
- Proprotein Convertase Furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi Network, Wang, P., Tortorella, M., England, K., Malfait, A.M., Thomas, G., Arner, E., Pei, D., 2004
- Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV, Wang, P., Wang, X., and Pei, D., 2004
- Rapid Inactivation of Alpha-1-Proteinase Inhibitor by Neutrophil Specific Leukolysin / Membrane-Type Matrix Metalloproteinase 6, Nie, J., Pei, D., 2004
- Immobilization of oriented protein molecules on poly(ethylene glycol)-coated Si(111) (p NA), Cha, T., Guo, A., Jun, Y., Pei, D., and Zhu, X. Y., 2004
- An efficient and tunable route to AG7088, a rhinovirus protease inhibitor, Ma, D., Xie, WQ., Zou, B., Lei, Q., and Pei, D., 2004
- Identification of a nuclear localization signal in Oct4 and generation of a dominant negative mutant by its ablation, Pan, G., Qin, B., Liu, N., Scholer, H.R., Pei, D., 2004
- The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen, Wang, P., Nie, J., and Pei, D., 2004
- The Stem Cell Pluripotency Factor Nanog Activates Transcription With Two Unusually Potent Subdomains at its C-terminus, Pan. G., Pei. D., 2005
- Matrix Metalloproteases Target Protease-activated Receptors During Tumor Progression, Pei, D., 2005
- Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy, Qin, B., Chen, X., Zhu, J., and Pei, D., 2005
- Genomic instability in laminopathy-based premature aging, Liu, B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang J, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchinson C, Chen J, Cao Y, Che
