Mechanisms of stem cell pluripotency regulation Somatic cell reprogramming techniques and mechanisms Protein transport mechanisms in normal and cancer cells EGFR signaling mechanisms and lung cancer
Transcriptional repression and activation by cellular DNA-binding protein C/EBP, Pei, D., C. Shih, 1990
An attenuator is sandwiched by two transactivation domains in the transcriptional factor C/EBP, Pei, D., C. Shih, 1991
Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3, Pei, D., Majmudar, G., Weiss, S.J., 1994
Furin-dependent Intracellular Activation of the Human Stromelysin-3 Zymogen, Pei, D., Weiss, S.J., 1995
Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity, Pei, D., Weiss, S.J., 1996
A High Level Mammalian Expression System Based on the Madin-Darby canine kidney (MDCK) cell line, Pei, D., Yi, J., 1998
Identification and Characterization of a New Splicing Variant of Vascular Endothelial Growth Factor: VEGF183, Lei, J., Jiang, A., and Pei, D., 1998
Identification and characterization of the fifth member of the membrane-type matrix metalloproteinase MT5-MMP, Pei, D., 1999
CA-MMP: a matrix metalloproteinase with a novel cysteine-array, but without the classic cysteine switch, Pei, D., 1999
Expression, Purification and Charaterization of Recombinant Mouse MT5-MMP Protein Products, Wang, X., Lei, L., Yi, J. and Pei, D., 1999
MMP25/MT6-MMP/Leukolysin: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage, Pei, D., 1999
CA-MMP/MMP-23 is a Type II Transmembrane Matrix Metalloproteinase Regulated by a Single Cleavage for Both Secretion and Activation, Pei, D., Kang, T., and Qi, H., 2000
Functional characterization of MT3-MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3-D collagen lattice, Kang, T., Yi, J., Yang, W., Wang, X., Jiang, A., and Pei, D., 2000
Overexpression of Matrix Metalloproteinases Leads to Lethality in Transgenic Xenopus Laevis: Implications for Tissue-Dependent Functions of Matrix Metalloproteinases during Late Embryonic development, Damjanovski, S., Amano, T., Li, Q., Pei, D., and Shi, Y.-B., 2001
Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase -Dependent Human Melanoma Invasion into Type I Collagen, Iida, J., Pei, D., Kang, T., Simpson, M.A., Herlyn, M., Furcht, L. T., and McCarthy, J. B., 2001
Subcellular Distribution, Cytokine- and Chemokine- Regulated Secretion of Leukolysin / MT6-MMP /MMP-25 in Neutrophils, Kang, T., Yi, J., Guo, A., Wang, X., Overall, C.M., Jiang, W., Elde, R., Borregaard, N., and Pei, D., 2001
Shedding of MT5-MMP by a Furin-Type Convertase: A Potential Mechanism of Down-Regulation, Wang, X., Pei, D., 2001
Regulation of Membrane-Type Matrix Metalloproteinase 1 Activity by Dynamin-Mediated Endocytosis, Jiang, A., Lehti, K., Wang, X., Weiss, S.J., Keski-Oja, J., and Pei, D., 2001
Matrix Metalloproteinases: An Introduction, Pei, D., 2001
Activation of ProMT3-MMP by Proprotein-Convertase Furin in Trans-Golgi Network, Kang, T., Nagase, H., and Pei, D., 2002
Oligomerization through hemopexin and cytoplasmic domains regulate the activity and turnover of membrane-type-1 matrix metalloproteinase (MT1-MMP), Lehti,K.., Lohi, J., Juntunen, M. M., Pei, D., Keski-Oja, J., 2002
Expression of matrix metalloprotease-2 and -9 and their inhibitors, tissue inhibitors of metalloprotease-1 and -2, in primary cultures of human prostatic stromal and epithelial cells, Wilson, MJ, RG Sellars, C Wiehr, O Melamud, Pei, D and DM Peehl, 2002
Intracellular Activation of Human Adamalysin 19/Disintegrin and Metalloproteinase 19 by Furin Occurs via one of the two Consecutive Recognition Sites, Kang, T., Zhao, Y.G., Pei, D., Sucic, F. J., Sang, Q-X. A., 2002
Therapeutic developments in matrix metalloproteinase inhibition, Doherty, T.M., Asotra, K., Pei, D., Uzui, H., Wilkin, D.J., Shah, P.K., Rajavashisth, T.B., 2002
Stem cell pluripotency and transcription factor Oct4, Pan, GJ, Chang ZY, Scholer HR, Pei D., 2002
Distinct Roles of Catalytic and Pexin-like Domains in MT-MMP Mediated proMMP-2 Activation and Collagenolysis, Jiang, A., Pei, D., 2003
Direct Activation of proMMP-2 by Leukolysin / MT6-MMP at the Asn109-Tyr bond, Nie, J., Pei, D., 2003
Identification of Two Distinct Transactivation Domains in the Pluripotency Sustaining Factor Nanog, Pan, G., Pei, D., 2003
Nuclear Localization of the Phosphatidylserine Receptor Protein Via Multiple Nuclear Localization Signals, Cui, P., Qin, B., Pan, G., Liu, N., and Pei, D., 2004
Memrane-type-1-matrix metalloproteinase (MT1-MMP) promotes human melanoma invasion and growth, Iida, J., Whilhelmson, K. L., Price, M A., Wilson, C. M., Pei, D., Furcht, L T. , and McCarthy, J.B., 2004
Limited Processing of Pro-Matrix Metalloprotease-2 (Gelatinase A) Overexpressed by Transfection in PC-3 Human Prostate Tumor Cells: Association With Restricted Cell Surface Localization of Membrane-Type Matrix Metalloproteinase-1, Wilson, M.J., Jiang, A., Wiehr, C., Wang, X., Sinha, A.A., And Pei. D., 2004
Co-recycling of MT1-MMP and MT3-MMP Through the trans-Golgi Network: Identification of DKV582 as a Recycling Signal, Wang, X., Ma, D., Keski-Oja, J., and Pei, D., 2004
Differential Inhibition of MT3-MMP And MT1-MMP By TIMP-2 and TIMP-3 Regulates Pro-MMP-2 Activation, Zhao, H., Bernardo, M. M., Osenkowski, P., Pei, D., Nagase, H., Kashiwagi, M., Soloway, P. D., DeClerck, Y. A., Fridman, R., 2004
Proprotein Convertase Furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi Network, Wang, P., Tortorella, M., England, K., Malfait, A.M., Thomas, G., Arner, E., Pei, D., 2004
Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV, Wang, P., Wang, X., and Pei, D., 2004
Rapid Inactivation of Alpha-1-Proteinase Inhibitor by Neutrophil Specific Leukolysin / Membrane-Type Matrix Metalloproteinase 6, Nie, J., Pei, D., 2004
Immobilization of oriented protein molecules on poly(ethylene glycol)-coated Si(111) (p NA), Cha, T., Guo, A., Jun, Y., Pei, D., and Zhu, X. Y., 2004
An efficient and tunable route to AG7088, a rhinovirus protease inhibitor, Ma, D., Xie, WQ., Zou, B., Lei, Q., and Pei, D., 2004
Identification of a nuclear localization signal in Oct4 and generation of a dominant negative mutant by its ablation, Pan, G., Qin, B., Liu, N., Scholer, H.R., Pei, D., 2004
The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen, Wang, P., Nie, J., and Pei, D., 2004
The Stem Cell Pluripotency Factor Nanog Activates Transcription With Two Unusually Potent Subdomains at its C-terminus, Pan. G., Pei. D., 2005
Matrix Metalloproteases Target Protease-activated Receptors During Tumor Progression, Pei, D., 2005
Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy, Qin, B., Chen, X., Zhu, J., and Pei, D., 2005
Genomic instability in laminopathy-based premature aging, Liu, B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang J, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchinson C, Chen J, Cao Y, Che
