Areas of Focus
- Microtubule dynamics and stability regulation
- Animal peptide neurotoxins and their applications
Work Experience
- 2000-2003: Postdoctoral Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 2003-2006: Postdoctoral Researcher, CNRS, France
- 2006-present: Researcher, Doctoral Supervisor, Deputy Director at Tongji University
Academic Background & Achievements
- 1991-1995: Bachelor's Degree in Biochemistry and Molecular Biology from Jilin University
- 1995-2000: PhD in Biochemistry and Molecular Biology from the Institute of Biophysics, Chinese Academy of Sciences
- Postdoctoral research at Shanghai Institute of Biochemistry, Chinese Academy of Sciences and CNRS, France
Publications
- Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin, Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang*, Benoit Gigant*, 2017
- A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αD-conotoxin GeXXA, Longjin Yang, Han-Shen Tae, Zhou Fan, Xiaoxia Shao, Shaoqiong Xu, Suwen Zhao, David J. Adams*, Chunguang Wang*, 2017
- Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor, Shantong Jiang, Han-Shen Tae, Shaoqiong Xu, Xiaoxia Shao, David J. Adams*, Chunguang Wang*, 2017
- Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein, Xiaoyu Zhao, Miaomiao Jin, Mengzhu Wang, Lili Sun, Xuejiao Hong, Ying Cao, Chunguang Wang*, 2016
- Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors, Shaoqiong Xu, Tianlong Zhang, Shiva N. Kompella, Mengdi Yan, Aiping Lu, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, David J. Adams*, Jianping Ding*, Chunguang Wang*, 2015
- New insights into the coupling between microtubule depolymerization and ATP hydrolysis by kinesin-13 protein Kif2C, Weiyi Wang, Ting Shen, Raphael Guerois, Fuming Zhang, Hureshitanmu Kuerban, Yuncong Lv, Benoît Gigant*, Marcel Knossow*, and Chunguang Wang*, 2015
- Kinesin, 30 years later: Recent insights from structural studies, Luyan Cao, Weiyi Wang, Qiyang Jiang, Chunguang Wang*, Marcel Knossow*, Benoit Gigant*, 2015
- The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement, Luyan Cao, Weiyi Wang, Qiyang Jiang, Chunguang Wang*, Marcel Knossow*, Benoit Gigant*, 2014
- Various conotoxin diversifications revealed by a venomic study of Conus flavidus, Aiping Lu, Longjin Yang, Shaoqiong Xu, and Chunguang Wang*, 2014
- Structural insights into the unusually strong ATPase activity of the AAA domain of the Caenorhabditis elegans fidgetin-like 1 (FIGL-1) protein, Wentao Peng, Zhijie Lin, Weirong Li, Jing Lu, Yueyuan Shen*, Chunguang Wang*, 2013
- Structure of a kinesin–tubulin complex and implications for kinesin motility, Benoît Gigant, Weiyi Wang, Birgit Dreier, Qiyang Jiang, Ludovic Pecqueur, Andreas Plückthun, Chunguang Wang*, Marcel Knossow*, 2013
- The nucleotide cycle of spastin correlates with its microtubule-binding properties, Maorong Wen, Chunguang Wang*, 2013
- Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue Virus NS2B-NS3 protease, Shaoqiong Xu, Hua Li, Xiaoxia Shao, Chongxu Fan, Bryan Ericksen, Jinsong Liu, Chengwu Chi*, Chunguang Wang*, 2012
- A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end, Ludovic Pecqueur, Christian Duellberg, Birgit Dreier, Qiyang Jiang, Chunguang Wang, Andreas Pluckthun, Thomas Surrey, Benoit Gigant, Marcel Knossow*, 2012
- Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization, Weiyi Wang, Qiyang Jiang, Manuela Argentini, David Cornu, Benoît Gigant, Marcel Knossow*, Chunguang Wang*, 2012
- A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily, Mingyu Ye, Keith K. Khoo, Shaoqiong Xu, Mi Zhou, Nonlawat Boonyalai, Matthew A. Perugini, Xiaoxia Shao, Chengwu Chi, Charles A. Galea, Chunguang Wang*, and Raymond S. Norton*, 2012
- The binding of vinca domain agents to tubulin: structural and biochemical studies, Anthony Cormier, Marcel Knossow, Chunguang Wang and Benoit Gigant, 2010
- Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus, Yuhong Han, Feijuan Huang, Hui Jiang, Li Liu, Qi Wang, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, Weihong Du and Chunguang Wang*, 2008
- Insight into the GTPase activity of tubulin from complexes with stathmin-like domains, Chuanguang Wang, Anthony Cormier, Benoit Gigant, Marcel Knossow, 2007
- Structural basis for the regulation of tubulin by vinblastine, Benoît Gigant, Chunguang Wang, Raimond B. G. Ravelli, Fanny Roussi, Michel O. Steinmetz, Patrick A. Curmi, André Sobel, Marcel Knossow, 2005
- Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis, Chunguang Wang, Nicolas Gilles, Alain Hamon, Frédéric Le Gall, Maria Stankiewicz, Marcel Pelhate, Yumei Xiong, Dacheng Wang, Chengwu Chi, 2003
Awards
- 2005: First Prize of Shanghai Science and Technology Progress
- 2006: Selected as 'Shuguang Scholar' in Shanghai
- 2007: Received 'Pujiang Talent' funding in Shanghai
- 2008: Selected as Outstanding Young Teacher at Tongji University
- 2009: Selected for the 'New Century Excellent Talents' by the Ministry of Education
- 2011: Awarded as one of the 'Top Ten Good Supervisors' at Tongji University
